UniProtKB - Q8WU76 (SCFD2_HUMAN)
Protein
Sec1 family domain-containing protein 2
Gene
SCFD2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in protein transport.
GO - Molecular functioni
- syntaxin binding Source: GO_Central
GO - Biological processi
- intracellular protein transport Source: GO_Central
- vesicle docking involved in exocytosis Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8WU76 |
Names & Taxonomyi
Protein namesi | Recommended name: Sec1 family domain-containing protein 2Alternative name(s): Syntaxin-binding protein 1-like 1 |
Gene namesi | Name:SCFD2 Synonyms:STXBP1L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30676, SCFD2 |
neXtProti | NX_Q8WU76 |
VEuPathDBi | HostDB:ENSG00000184178.15 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- secretory granule Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 152579 |
OpenTargetsi | ENSG00000184178 |
PharmGKBi | PA134953686 |
Miscellaneous databases
Pharosi | Q8WU76, Tdark |
Genetic variation databases
BioMutai | SCFD2 |
DMDMi | 51338675 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206290 | 1 – 684 | Sec1 family domain-containing protein 2Add BLAST | 684 |
Proteomic databases
EPDi | Q8WU76 |
jPOSTi | Q8WU76 |
MassIVEi | Q8WU76 |
MaxQBi | Q8WU76 |
PaxDbi | Q8WU76 |
PeptideAtlasi | Q8WU76 |
PRIDEi | Q8WU76 |
ProteomicsDBi | 74640 [Q8WU76-1] 74641 [Q8WU76-2] |
PTM databases
iPTMneti | Q8WU76 |
PhosphoSitePlusi | Q8WU76 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184178, Expressed in substantia nigra and 216 other tissues |
ExpressionAtlasi | Q8WU76, baseline and differential |
Genevisiblei | Q8WU76, HS |
Organism-specific databases
HPAi | ENSG00000184178, Low tissue specificity |
Interactioni
GO - Molecular functioni
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127454, 26 interactors |
IntActi | Q8WU76, 16 interactors |
STRINGi | 9606.ENSP00000384182 |
Miscellaneous databases
RNActi | Q8WU76, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 120 – 124 | Poly-Ala | 5 |
Sequence similaritiesi
Belongs to the STXBP/unc-18/SEC1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQIB, Eukaryota |
GeneTreei | ENSGT00390000011192 |
HOGENOMi | CLU_027230_1_0_1 |
InParanoidi | Q8WU76 |
OMAi | MIKPSNQ |
OrthoDBi | 277043at2759 |
PhylomeDBi | Q8WU76 |
TreeFami | TF329842 |
Family and domain databases
Gene3Di | 3.40.50.1910, 1 hit |
InterProi | View protein in InterPro IPR027482, Sec-1-like_dom2 IPR001619, Sec1-like IPR036045, Sec1-like_sf |
PANTHERi | PTHR11679, PTHR11679, 1 hit |
Pfami | View protein in Pfam PF00995, Sec1, 1 hit |
SUPFAMi | SSF56815, SSF56815, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WU76-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG
60 70 80 90 100
GPDCHLREFE PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY
110 120 130 140 150
CVVVTTVSHA VHLTANHVPA AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT
160 170 180 190 200
AEVFHVPLLL APVAPHFALT PAFASLFPLL PQDVHLLNSA RPDKRKLGSL
210 220 230 240 250
GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG SLSQVIAADL
260 270 280 290 300
ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL
310 320 330 340 350
PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT
360 370 380 390 400
KHKEAVMEVR RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL
410 420 430 440 450
MNHCGLLQLG LATAQTLKHP QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ
460 470 480 490 500
LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS VTGELTVDKD LCEAEEKVKK
510 520 530 540 550
ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL FTSLRDIAGA
560 570 580 590 600
RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG
610 620 630 640 650
LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK
660 670 680
PGTQVIVLST RLLKPLNIPE LLFATDRLHP DLGF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUD7 | A0A087WUD7_HUMAN | Sec1 family domain-containing prote... | SCFD2 | 440 | Annotation score: | ||
D6RCK6 | D6RCK6_HUMAN | Sec1 family domain-containing prote... | SCFD2 | 28 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024687 | 512 | L → S. Corresponds to variant dbSNP:rs7675987Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010710 | 570 – 614 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY299407 mRNA Translation: AAP57259.1 AK096833 mRNA Translation: BAC04872.1 BC012458 mRNA Translation: AAH12458.1 BC021137 mRNA Translation: AAH21137.2 BC032453 mRNA Translation: AAH32453.1 |
CCDSi | CCDS33984.1 [Q8WU76-1] |
RefSeqi | NP_689753.2, NM_152540.3 [Q8WU76-1] |
Genome annotation databases
Ensembli | ENST00000388940; ENSP00000373592; ENSG00000184178 [Q8WU76-2] ENST00000401642; ENSP00000384182; ENSG00000184178 [Q8WU76-1] |
GeneIDi | 152579 |
KEGGi | hsa:152579 |
UCSCi | uc003gzu.4, human [Q8WU76-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY299407 mRNA Translation: AAP57259.1 AK096833 mRNA Translation: BAC04872.1 BC012458 mRNA Translation: AAH12458.1 BC021137 mRNA Translation: AAH21137.2 BC032453 mRNA Translation: AAH32453.1 |
CCDSi | CCDS33984.1 [Q8WU76-1] |
RefSeqi | NP_689753.2, NM_152540.3 [Q8WU76-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127454, 26 interactors |
IntActi | Q8WU76, 16 interactors |
STRINGi | 9606.ENSP00000384182 |
PTM databases
iPTMneti | Q8WU76 |
PhosphoSitePlusi | Q8WU76 |
Genetic variation databases
BioMutai | SCFD2 |
DMDMi | 51338675 |
Proteomic databases
EPDi | Q8WU76 |
jPOSTi | Q8WU76 |
MassIVEi | Q8WU76 |
MaxQBi | Q8WU76 |
PaxDbi | Q8WU76 |
PeptideAtlasi | Q8WU76 |
PRIDEi | Q8WU76 |
ProteomicsDBi | 74640 [Q8WU76-1] 74641 [Q8WU76-2] |
Protocols and materials databases
Antibodypediai | 23902, 70 antibodies |
DNASUi | 152579 |
Genome annotation databases
Ensembli | ENST00000388940; ENSP00000373592; ENSG00000184178 [Q8WU76-2] ENST00000401642; ENSP00000384182; ENSG00000184178 [Q8WU76-1] |
GeneIDi | 152579 |
KEGGi | hsa:152579 |
UCSCi | uc003gzu.4, human [Q8WU76-1] |
Organism-specific databases
CTDi | 152579 |
DisGeNETi | 152579 |
GeneCardsi | SCFD2 |
HGNCi | HGNC:30676, SCFD2 |
HPAi | ENSG00000184178, Low tissue specificity |
neXtProti | NX_Q8WU76 |
OpenTargetsi | ENSG00000184178 |
PharmGKBi | PA134953686 |
VEuPathDBi | HostDB:ENSG00000184178.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQIB, Eukaryota |
GeneTreei | ENSGT00390000011192 |
HOGENOMi | CLU_027230_1_0_1 |
InParanoidi | Q8WU76 |
OMAi | MIKPSNQ |
OrthoDBi | 277043at2759 |
PhylomeDBi | Q8WU76 |
TreeFami | TF329842 |
Enzyme and pathway databases
PathwayCommonsi | Q8WU76 |
Miscellaneous databases
BioGRID-ORCSi | 152579, 5 hits in 872 CRISPR screens |
ChiTaRSi | SCFD2, human |
GenomeRNAii | 152579 |
Pharosi | Q8WU76, Tdark |
PROi | PR:Q8WU76 |
RNActi | Q8WU76, protein |
Gene expression databases
Bgeei | ENSG00000184178, Expressed in substantia nigra and 216 other tissues |
ExpressionAtlasi | Q8WU76, baseline and differential |
Genevisiblei | Q8WU76, HS |
Family and domain databases
Gene3Di | 3.40.50.1910, 1 hit |
InterProi | View protein in InterPro IPR027482, Sec-1-like_dom2 IPR001619, Sec1-like IPR036045, Sec1-like_sf |
PANTHERi | PTHR11679, PTHR11679, 1 hit |
Pfami | View protein in Pfam PF00995, Sec1, 1 hit |
SUPFAMi | SSF56815, SSF56815, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCFD2_HUMAN | |
Accessioni | Q8WU76Primary (citable) accession number: Q8WU76 Secondary accession number(s): Q8N5F3, Q8N8H0, Q96ED3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | March 1, 2004 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM