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Protein

Phospholipase ABHD3

Gene

ABHD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.1 Publication
Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220Charge relay systemBy similarity1
Active sitei346Charge relay systemBy similarity1
Active sitei375Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1483191 Synthesis of PC

Protein family/group databases

ESTHERihuman-ABHD3 abh_upf0017

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase ABHD3Curated (EC:3.1.1.321 Publication, EC:3.1.1.41 Publication)
Alternative name(s):
Abhydrolase domain-containing protein 3Curated
Gene namesi
Name:ABHD3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000158201.9
HGNCiHGNC:18718 ABHD3
MIMi612197 gene
neXtProtiNX_Q8WU67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi220S → A: Loss of phospholipase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000158201
PharmGKBiPA38659

Polymorphism and mutation databases

BioMutaiABHD3
DMDMi134035377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802081 – 409Phospholipase ABHD3Add BLAST409

Proteomic databases

EPDiQ8WU67
MaxQBiQ8WU67
PaxDbiQ8WU67
PeptideAtlasiQ8WU67
PRIDEiQ8WU67
ProteomicsDBi74636

PTM databases

iPTMnetiQ8WU67
PhosphoSitePlusiQ8WU67

Expressioni

Gene expression databases

BgeeiENSG00000158201 Expressed in 218 organ(s), highest expression level in colonic mucosa
CleanExiHS_ABHD3
ExpressionAtlasiQ8WU67 baseline and differential
GenevisibleiQ8WU67 HS

Organism-specific databases

HPAiHPA010729

Interactioni

Protein-protein interaction databases

BioGridi128149, 8 interactors
IntActiQ8WU67, 1 interactor
STRINGi9606.ENSP00000289119

Structurei

3D structure databases

ProteinModelPortaliQ8WU67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 233AB hydrolase-1Sequence analysisAdd BLAST94

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1838 Eukaryota
COG0429 LUCA
GeneTreeiENSGT00530000062981
HOGENOMiHOG000230596
HOVERGENiHBG053994
InParanoidiQ8WU67
KOiK13696
OMAiILHMIHL
OrthoDBiEOG091G08YN
PhylomeDBiQ8WU67
TreeFamiTF313195

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000952 AB_hydrolase_4_CS
IPR012020 ABHD4
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF005211 Ab_hydro_YheT, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01133 UPF0017, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8WU67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS
60 70 80 90 100
SIAKKPQLVT GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT
110 120 130 140 150
SKPPVQYRNE LIKTADGGQI SLDWFDNDNS TCYMDASTRP TILLLPGLTG
160 170 180 190 200
TSKESYILHM IHLSEELGYR CVVFNNRGVA GENLLTPRTY CCANTEDLET
210 220 230 240 250
VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM AAATFSVGWN
260 270 280 290 300
TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS
310 320 330 340 350
IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP
360 370 380 390 400
SHAIPIETAK QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA

MVEHGHELS
Length:409
Mass (Da):46,009
Last modified:March 20, 2007 - v2
Checksum:i9A3920EB7528273B
GO
Isoform 2 (identifier: Q8WU67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-136: PQLVTGGESF...NDNSTCYMDA → RTTRRSGAGR...EQARSHISFI
     137-409: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,525
Checksum:i61776799A97CA0A2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTE1J3KTE1_HUMAN
Phospholipase ABHD3
ABHD3
356Annotation score:
J3KSP1J3KSP1_HUMAN
Phospholipase ABHD3
ABHD3
214Annotation score:
J3QQR0J3QQR0_HUMAN
Phospholipase ABHD3
ABHD3
112Annotation score:
J3QR14J3QR14_HUMAN
Phospholipase ABHD3
ABHD3
37Annotation score:

Sequence cautioni

The sequence AAC19155 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0310893R → C1 PublicationCorresponds to variant dbSNP:rs17851878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05613756 – 136PQLVT…CYMDA → RTTRRSGAGRVEDRPCLDLS SLRSPRCSTGMNLLKLQMED RFHWTGLIMITVRVIWMPAP DLLSYCCLASREQARSHISF I in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_056138137 – 409Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007152 mRNA Translation: AAC19155.1 Different initiation.
AK298728 mRNA Translation: BAH12858.1
EF444943 Genomic DNA Translation: ACA05928.1
AC106037 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01131.1
BC021196 mRNA Translation: AAH21196.1
CCDSiCCDS32802.1 [Q8WU67-1]
RefSeqiNP_001295185.1, NM_001308256.1
NP_001295186.1, NM_001308257.1
NP_612213.2, NM_138340.4 [Q8WU67-1]
UniGeneiHs.397978

Genome annotation databases

EnsembliENST00000289119; ENSP00000289119; ENSG00000158201 [Q8WU67-1]
ENST00000577891; ENSP00000463365; ENSG00000158201 [Q8WU67-2]
GeneIDi171586
KEGGihsa:171586
UCSCiuc002ktl.2 human [Q8WU67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABHD3_HUMAN
AccessioniPrimary (citable) accession number: Q8WU67
Secondary accession number(s): B0YIV0, B7Z5C2, O43411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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