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Entry version 112 (13 Feb 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Marginal zone B- and B1-cell-specific protein

Gene

MZB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion and integrin activation.By similarity2 Publications
Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Mesenteric estrogen-dependent adipose 7
Short name:
MEDA-7
Plasma cell-induced resident endoplasmic reticulum protein
Short name:
Plasma cell-induced resident ER protein
Short name:
pERp1
Proapoptotic caspase adapter protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MZB1
Synonyms:MEDA7, PACAP
ORF Names:HSPC190
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170476.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30125 MZB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609447 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WU39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50C → S: Does not affect activity. 1 Publication1
Mutagenesisi53C → S: No significant activity. 1 Publication1
Mutagenesisi95C → S: No significant activity. 1 Publication1
Mutagenesisi143C → S: No significant activity. 1 Publication1
Mutagenesisi171C → S: No significant activity. 1 Publication1
Mutagenesisi178C → S: Does not affect activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51237

Open Targets

More...
OpenTargetsi
ENSG00000170476

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MZB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031874023 – 189Marginal zone B- and B1-cell-specific proteinAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 178By similarity
Disulfide bondi53 ↔ 171By similarity
Disulfide bondi95 ↔ 143By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Forms an interchain disulfide bond with IgM monomers.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WU39

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WU39

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WU39

PeptideAtlas

More...
PeptideAtlasi
Q8WU39

PRoteomics IDEntifications database

More...
PRIDEi
Q8WU39

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74625
74626 [Q8WU39-2]
74627 [Q8WU39-3]
74628 [Q8WU39-4]
74629 [Q8WU39-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WU39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WU39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in primary B-cells early after ligand-stimulated activation. Up-regulated in bacterial lipopolysaccharides (LPS)-stimulated peritoneal macrophages.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170476 Expressed in 156 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WU39 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WU39 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043745
HPA052694

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119399, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WU39, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8WU39

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8WU39

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WU39

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi186 – 189Prevents secretion from ERPROSITE-ProRule annotation4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MZB1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J06F Eukaryota
ENOG4111YKY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002716

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000068171

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108230

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WU39

Identification of Orthologs from Complete Genome Data

More...
OMAi
EKYSAHM

Database of Orthologous Groups

More...
OrthoDBi
1464647at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WU39

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021852 DUF3456

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11938 DUF3456, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00014 ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WU39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLSLPLLLL LLGAWAIPGG LGDRAPLTAT APQLDDEEMY SAHMPAHLRC
60 70 80 90 100
DACRAVAYQM WQNLAKAETK LHTSNSGGRR ELSELVYTDV LDRSCSRNWQ
110 120 130 140 150
DYGVREVDQV KRLTGPGLSE GPEPSISVMV TGGPWPTRLS RTCLHYLGEF
160 170 180
GEDQIYEAHQ QGRGALEALL CGGPQGACSE KVSATREEL
Note: Major.
Length:189
Mass (Da):20,694
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC71AED212D3393D3
GO
Isoform 2 (identifier: Q8WU39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-189: MWQNLAKAET...EKVSATREEL → SLLVPDVAKS...PSETSHRPRT

Show »
Length:123
Mass (Da):13,066
Checksum:iC21A354CE08A95CB
GO
Isoform 3 (identifier: Q8WU39-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     93-101: RSCSRNWQD → MPAELWLTS

Show »
Length:97
Mass (Da):10,488
Checksum:i8BA52E533824C02C
GO
Isoform 4 (identifier: Q8WU39-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-75: MWQNLAKAETKLHTSN → RLCSYPPHLPLTEQQS
     76-189: Missing.

Show »
Length:75
Mass (Da):8,227
Checksum:iC43C7E99CF029FF8
GO
Isoform 5 (identifier: Q8WU39-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-62: MWQ → AHP
     63-189: Missing.

Show »
Length:62
Mass (Da):6,681
Checksum:i7E1F097F7B9F33F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RII0D6RII0_HUMAN
Marginal zone B- and B1-cell-specif...
MZB1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9L3H0Y9L3_HUMAN
Marginal zone B- and B1-cell-specif...
MZB1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36110 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312801 – 92Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_03128160 – 189MWQNL…TREEL → SLLVPDVAKSGKGRDQTSYL KLWGAAGAERVGLHGCPGPE LLPELAGLRSSRSGPSETSH RPRT in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_03833360 – 75MWQNL…LHTSN → RLCSYPPHLPLTEQQS in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_03907360 – 62MWQ → AHP in isoform 5. 1 Publication3
Alternative sequenceiVSP_03907463 – 189Missing in isoform 5. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_03833476 – 189Missing in isoform 4. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_03833293 – 101RSCSRNWQD → MPAELWLTS in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF338109 mRNA Translation: AAK84085.1
AF151024 mRNA Translation: AAF36110.1 Sequence problems.
BP366737 mRNA No translation available.
GQ477350 mRNA Translation: ACY74343.1
AK292706 mRNA Translation: BAF85395.1
AL698690 mRNA No translation available.
AC135457 Genomic DNA No translation available.
BC009931 mRNA Translation: AAH09931.2
BC021275 mRNA Translation: AAH21275.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47273.1 [Q8WU39-1]

NCBI Reference Sequences

More...
RefSeqi
NP_057543.2, NM_016459.3 [Q8WU39-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.409563

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302125; ENSP00000303920; ENSG00000170476 [Q8WU39-1]
ENST00000417694; ENSP00000415420; ENSG00000170476 [Q8WU39-4]
ENST00000503481; ENSP00000423205; ENSG00000170476 [Q8WU39-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51237

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51237

UCSC genome browser

More...
UCSCi
uc003lei.4 human [Q8WU39-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338109 mRNA Translation: AAK84085.1
AF151024 mRNA Translation: AAF36110.1 Sequence problems.
BP366737 mRNA No translation available.
GQ477350 mRNA Translation: ACY74343.1
AK292706 mRNA Translation: BAF85395.1
AL698690 mRNA No translation available.
AC135457 Genomic DNA No translation available.
BC009931 mRNA Translation: AAH09931.2
BC021275 mRNA Translation: AAH21275.1
CCDSiCCDS47273.1 [Q8WU39-1]
RefSeqiNP_057543.2, NM_016459.3 [Q8WU39-1]
UniGeneiHs.409563

3D structure databases

ProteinModelPortaliQ8WU39
SMRiQ8WU39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119399, 2 interactors
IntActiQ8WU39, 2 interactors
MINTiQ8WU39
STRINGi9606.ENSP00000303920

PTM databases

iPTMnetiQ8WU39
PhosphoSitePlusiQ8WU39

Polymorphism and mutation databases

BioMutaiMZB1
DMDMi74730663

Proteomic databases

jPOSTiQ8WU39
MaxQBiQ8WU39
PaxDbiQ8WU39
PeptideAtlasiQ8WU39
PRIDEiQ8WU39
ProteomicsDBi74625
74626 [Q8WU39-2]
74627 [Q8WU39-3]
74628 [Q8WU39-4]
74629 [Q8WU39-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51237
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302125; ENSP00000303920; ENSG00000170476 [Q8WU39-1]
ENST00000417694; ENSP00000415420; ENSG00000170476 [Q8WU39-4]
ENST00000503481; ENSP00000423205; ENSG00000170476 [Q8WU39-2]
GeneIDi51237
KEGGihsa:51237
UCSCiuc003lei.4 human [Q8WU39-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51237
DisGeNETi51237
EuPathDBiHostDB:ENSG00000170476.15

GeneCards: human genes, protein and diseases

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GeneCardsi
MZB1
HGNCiHGNC:30125 MZB1
HPAiHPA043745
HPA052694
MIMi609447 gene
neXtProtiNX_Q8WU39
OpenTargetsiENSG00000170476

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J06F Eukaryota
ENOG4111YKY LUCA
GeneTreeiENSGT00390000002716
HOGENOMiHOG000068171
HOVERGENiHBG108230
InParanoidiQ8WU39
OMAiEKYSAHM
OrthoDBi1464647at2759
PhylomeDBiQ8WU39

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MZB1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51237

Protein Ontology

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PROi
PR:Q8WU39

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170476 Expressed in 156 organ(s), highest expression level in spleen
ExpressionAtlasiQ8WU39 baseline and differential
GenevisibleiQ8WU39 HS

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMZB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WU39
Secondary accession number(s): D2IYS0
, Q7Z6N2, Q96RL5, Q9P0T3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: February 13, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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