UniProtKB - Q8WU20 (FRS2_HUMAN)
Fibroblast growth factor receptor substrate 2
FRS2
Functioni
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: MGI
- neurotrophin TRKA receptor binding Source: UniProtKB
- phosphatase activator activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase adaptor activity Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- activation of MAPKK activity Source: Reactome
- anterior/posterior axis specification, embryo Source: Ensembl
- axon guidance Source: Reactome
- fibroblast growth factor receptor signaling pathway Source: MGI
- forebrain development Source: Ensembl
- gastrulation with mouth forming second Source: Ensembl
- G protein-coupled receptor signaling pathway Source: UniProtKB
- lens fiber cell development Source: Ensembl
- MAPK cascade Source: Reactome
- negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
- neuroblast proliferation Source: Ensembl
- neurotrophin TRK receptor signaling pathway Source: Reactome
- optic placode formation involved in camera-type eye formation Source: Ensembl
- organ induction Source: Ensembl
- positive regulation of protein kinase B signaling Source: Reactome
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
- regulation of apoptotic process Source: Ensembl
- regulation of epithelial cell proliferation Source: Ensembl
- regulation of ERK1 and ERK2 cascade Source: Ensembl
- transmembrane receptor protein tyrosine phosphatase signaling pathway Source: UniProtKB
- ventricular septum development Source: Ensembl
Enzyme and pathway databases
Reactomei | R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-170968 Frs2-mediated activation R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853334 Signaling by FGFR3 fusions in cancer R-HSA-8853338 Signaling by FGFR3 point mutants in cancer R-HSA-8853659 RET signaling R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 |
SignaLinki | Q8WU20 |
SIGNORi | Q8WU20 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor receptor substrate 2Short name: FGFR substrate 2 Alternative name(s): FGFR-signaling adaptor SNT Suc1-associated neurotrophic factor target 1 Short name: SNT-1 |
Gene namesi | Name:FRS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16971 FRS2 |
MIMi | 607743 gene |
neXtProti | NX_Q8WU20 |
Subcellular locationi
Other locations
Note: Cytoplasmic, membrane-bound.
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell-cell adherens junction Source: BHF-UCL
- endomembrane system Source: UniProtKB-SubCell
- membrane Source: ProtInc
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10818 |
OpenTargetsi | ENSG00000166225 |
PharmGKBi | PA134850063 |
Miscellaneous databases
Pharosi | Q8WU20 |
Polymorphism and mutation databases
BioMutai | FRS2 |
DMDMi | 209572769 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000087344 | 2 – 508 | Fibroblast growth factor receptor substrate 2Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine2 Publications | 1 | |
Modified residuei | 177 | PhosphoserineCombined sources | 1 | |
Modified residuei | 196 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 211 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 349 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 392 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 436 | Phosphotyrosine; by FGFR1By similarity | 1 | |
Modified residuei | 471 | Phosphotyrosine; by FGFR1By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8WU20 |
jPOSTi | Q8WU20 |
MassIVEi | Q8WU20 |
MaxQBi | Q8WU20 |
PaxDbi | Q8WU20 |
PeptideAtlasi | Q8WU20 |
PRIDEi | Q8WU20 |
ProteomicsDBi | 74624 |
PTM databases
iPTMneti | Q8WU20 |
PhosphoSitePlusi | Q8WU20 |
SwissPalmi | Q8WU20 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166225 Expressed in 194 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q8WU20 baseline and differential |
Genevisiblei | Q8WU20 HS |
Organism-specific databases
HPAi | HPA038323 |
Interactioni
Subunit structurei
Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1.
Part of a complex containing GRB2 and CBL.
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.
Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).
By similarity7 PublicationsBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q06124 | 4 | EBI-1104330,EBI-297779 |
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: MGI
- neurotrophin TRKA receptor binding Source: UniProtKB
- transmembrane receptor protein tyrosine kinase adaptor activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 116031, 36 interactors |
ELMi | Q8WU20 |
IntActi | Q8WU20, 9 interactors |
MINTi | Q8WU20 |
STRINGi | 9606.ENSP00000447241 |
Structurei
Secondary structure
3D structure databases
SMRi | Q8WU20 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8WU20 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 115 | IRS-type PTBPROSITE-ProRule annotationAdd BLAST | 103 |
Phylogenomic databases
eggNOGi | KOG4047 Eukaryota ENOG410XS2S LUCA |
GeneTreei | ENSGT00940000157033 |
HOGENOMi | HOG000290694 |
InParanoidi | Q8WU20 |
KOi | K12461 |
OMAi | SAHKIDY |
OrthoDBi | 473504at2759 |
PhylomeDBi | Q8WU20 |
TreeFami | TF324994 |
Family and domain databases
CDDi | cd01202 PTB_FRS2, 1 hit |
InterProi | View protein in InterPro IPR038742 FRS2_PTB IPR002404 IRS_PTB |
Pfami | View protein in Pfam PF02174 IRS, 1 hit |
SMARTi | View protein in SMART SM00310 PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064 IRS_PTB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR
60 70 80 90 100
KRDSVKWHYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM
110 120 130 140 150
LQEIMQNNSI NVVEEPVVER NNHQTELEVP RTPRTPTTPG FAAQNLPNGY
160 170 180 190 200
PRYPSFGDAS SHPSSRHPSV GSARLPSVGE ESTHPLLVAE EQVHTYVNTT
210 220 230 240 250
GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP QILLEPEGVK
260 270 280 290 300
FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS
310 320 330 340 350
VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE
360 370 380 390 400
NLPSLPPVWE ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV
410 420 430 440 450
PASAHKIEYS RRRDCTPTVF NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP
460 470 480 490 500
QTPKTPTTPL PQTPTRRTEL YAVIDIERTA AMSNLQKALP RDDGTSRKTR
HNSTDLPM
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VX65 | F8VX65_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 183 | Annotation score: | ||
F8VS98 | F8VS98_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 91 | Annotation score: | ||
F8VZ12 | F8VZ12_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 31 | Annotation score: | ||
F8VYZ7 | F8VYZ7_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 40 | Annotation score: | ||
F8VW66 | F8VW66_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 33 | Annotation score: | ||
F8VZI4 | F8VZI4_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 36 | Annotation score: | ||
F8VP54 | F8VP54_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 12 | Annotation score: | ||
A0A0G2JL00 | A0A0G2JL00_HUMAN | Fibroblast growth factor receptor s... | FRS2 | 10 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046966 | 303 | K → N. Corresponds to variant dbSNP:rs12580717Ensembl. | 1 | |
Natural variantiVAR_046967 | 449 | N → D. Corresponds to variant dbSNP:rs35232109Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036717 mRNA Translation: AAB92554.1 AK312477 mRNA Translation: BAG35381.1 Sequence problems. EU332842 Genomic DNA Translation: ABY87531.1 AC018921 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97225.1 BC021562 mRNA Translation: AAH21562.1 Sequence problems. |
CCDSi | CCDS41809.1 |
RefSeqi | NP_001036020.1, NM_001042555.2 NP_001265280.1, NM_001278351.1 NP_001265282.1, NM_001278353.1 NP_001265283.1, NM_001278354.1 NP_001265284.1, NM_001278355.1 NP_001265285.1, NM_001278356.1 NP_001265286.1, NM_001278357.1 NP_006645.3, NM_006654.4 XP_016874206.1, XM_017018717.1 XP_016874207.1, XM_017018718.1 XP_016874208.1, XM_017018719.1 |
Genome annotation databases
Ensembli | ENST00000397997; ENSP00000381083; ENSG00000166225 ENST00000549921; ENSP00000450048; ENSG00000166225 ENST00000550389; ENSP00000447241; ENSG00000166225 |
GeneIDi | 10818 |
KEGGi | hsa:10818 |
UCSCi | uc009zrj.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036717 mRNA Translation: AAB92554.1 AK312477 mRNA Translation: BAG35381.1 Sequence problems. EU332842 Genomic DNA Translation: ABY87531.1 AC018921 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97225.1 BC021562 mRNA Translation: AAH21562.1 Sequence problems. |
CCDSi | CCDS41809.1 |
RefSeqi | NP_001036020.1, NM_001042555.2 NP_001265280.1, NM_001278351.1 NP_001265282.1, NM_001278353.1 NP_001265283.1, NM_001278354.1 NP_001265284.1, NM_001278355.1 NP_001265285.1, NM_001278356.1 NP_001265286.1, NM_001278357.1 NP_006645.3, NM_006654.4 XP_016874206.1, XM_017018717.1 XP_016874207.1, XM_017018718.1 XP_016874208.1, XM_017018719.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XR0 | NMR | - | B | 11-136 | [»] | |
2MFQ | NMR | - | A | 11-122 | [»] | |
SMRi | Q8WU20 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 116031, 36 interactors |
ELMi | Q8WU20 |
IntActi | Q8WU20, 9 interactors |
MINTi | Q8WU20 |
STRINGi | 9606.ENSP00000447241 |
PTM databases
iPTMneti | Q8WU20 |
PhosphoSitePlusi | Q8WU20 |
SwissPalmi | Q8WU20 |
Polymorphism and mutation databases
BioMutai | FRS2 |
DMDMi | 209572769 |
Proteomic databases
EPDi | Q8WU20 |
jPOSTi | Q8WU20 |
MassIVEi | Q8WU20 |
MaxQBi | Q8WU20 |
PaxDbi | Q8WU20 |
PeptideAtlasi | Q8WU20 |
PRIDEi | Q8WU20 |
ProteomicsDBi | 74624 |
Genome annotation databases
Ensembli | ENST00000397997; ENSP00000381083; ENSG00000166225 ENST00000549921; ENSP00000450048; ENSG00000166225 ENST00000550389; ENSP00000447241; ENSG00000166225 |
GeneIDi | 10818 |
KEGGi | hsa:10818 |
UCSCi | uc009zrj.5 human |
Organism-specific databases
CTDi | 10818 |
DisGeNETi | 10818 |
GeneCardsi | FRS2 |
HGNCi | HGNC:16971 FRS2 |
HPAi | HPA038323 |
MIMi | 607743 gene |
neXtProti | NX_Q8WU20 |
OpenTargetsi | ENSG00000166225 |
PharmGKBi | PA134850063 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4047 Eukaryota ENOG410XS2S LUCA |
GeneTreei | ENSGT00940000157033 |
HOGENOMi | HOG000290694 |
InParanoidi | Q8WU20 |
KOi | K12461 |
OMAi | SAHKIDY |
OrthoDBi | 473504at2759 |
PhylomeDBi | Q8WU20 |
TreeFami | TF324994 |
Enzyme and pathway databases
Reactomei | R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-170968 Frs2-mediated activation R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853334 Signaling by FGFR3 fusions in cancer R-HSA-8853338 Signaling by FGFR3 point mutants in cancer R-HSA-8853659 RET signaling R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 |
SignaLinki | Q8WU20 |
SIGNORi | Q8WU20 |
Miscellaneous databases
ChiTaRSi | FRS2 human |
EvolutionaryTracei | Q8WU20 |
GeneWikii | FRS2 |
GenomeRNAii | 10818 |
Pharosi | Q8WU20 |
PROi | PR:Q8WU20 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166225 Expressed in 194 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q8WU20 baseline and differential |
Genevisiblei | Q8WU20 HS |
Family and domain databases
CDDi | cd01202 PTB_FRS2, 1 hit |
InterProi | View protein in InterPro IPR038742 FRS2_PTB IPR002404 IRS_PTB |
Pfami | View protein in Pfam PF02174 IRS, 1 hit |
SMARTi | View protein in SMART SM00310 PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064 IRS_PTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRS2_HUMAN | |
Accessioni | Q8WU20Primary (citable) accession number: Q8WU20 Secondary accession number(s): B0LPF2 Q7LDQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | October 16, 2019 | |
This is version 162 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references