Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine N-acyltransferase-like protein 2

Gene

GLYATL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.1 Publication

Catalytic activityi

Acyl-CoA + glycine = CoA + N-acylglycine.

Kineticsi

  1. KM=4.4 µM for oleoyl-CoA1 Publication
  1. Vmax=933 nmol/min/mg enzyme with oleoyl-CoA as substrate1 Publication

GO - Molecular functioni

  • glycine N-acyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.13 2681
ReactomeiR-HSA-177128 Conjugation of salicylate with glycine
R-HSA-177135 Conjugation of benzoate with glycine

Chemistry databases

SwissLipidsiSLP:000001661

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 2 (EC:2.3.1.13)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 2
Gene namesi
Name:GLYATL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000156689.6
HGNCiHGNC:24178 GLYATL2
MIMi614762 gene
neXtProtiNX_Q8WU03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156689
PharmGKBiPA142671728

Chemistry databases

DrugBankiDB00145 Glycine

Polymorphism and mutation databases

BioMutaiGLYATL2
DMDMi74730653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818751 – 294Glycine N-acyltransferase-like protein 2Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N6-acetyllysine1 Publication1

Post-translational modificationi

Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8WU03
PeptideAtlasiQ8WU03
PRIDEiQ8WU03
ProteomicsDBi74617

PTM databases

iPTMnetiQ8WU03
PhosphoSitePlusiQ8WU03

Expressioni

Tissue specificityi

Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000156689 Expressed in 79 organ(s), highest expression level in minor salivary gland
CleanExiHS_GLYATL2
ExpressionAtlasiQ8WU03 baseline and differential
GenevisibleiQ8WU03 HS

Organism-specific databases

HPAiHPA060292
HPA065454

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287275

Structurei

3D structure databases

ProteinModelPortaliQ8WU03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410J98B Eukaryota
ENOG4111RDK LUCA
GeneTreeiENSGT00390000004997
HOGENOMiHOG000263599
HOVERGENiHBG107953
InParanoidiQ8WU03
KOiK22749
OMAiWIVMEQS
OrthoDBiEOG091G0GJJ
PhylomeDBiQ8WU03
TreeFamiTF353258

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N
PANTHERiPTHR15298 PTHR15298, 1 hit
PfamiView protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WU03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLHNSQKL QILYKSLEKS IPESIKVYGA IFNIKDKNPF NMEVLVDAWP
60 70 80 90 100
DYQIVITRPQ KQEMKDDQDH YTNTYHIFTK APDKLEEVLS YSNVISWEQT
110 120 130 140 150
LQIQGCQEGL DEAIRKVATS KSVQVDYMKT ILFIPELPKK HKTSSNDKME
160 170 180 190 200
LFEVDDDNKE GNFSNMFLDA SHAGLVNEHW AFGKNERSLK YIERCLQDFL
210 220 230 240 250
GFGVLGPEGQ LVSWIVMEQS CELRMGYTVP KYRHQGNMLQ IGYHLEKYLS
260 270 280 290
QKEIPFYFHV ADNNEKSLQA LNNLGFKICP CGWHQWKCTP KKYC
Length:294
Mass (Da):34,277
Last modified:March 1, 2002 - v1
Checksum:iA1F5C3EC989D90D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219Q → R in AAO73139 (Ref. 1) Curated1
Sequence conflicti293Y → C in AAO73139 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03129682P → S1 PublicationCorresponds to variant dbSNP:rs17856514Ensembl.1
Natural variantiVAR_031297160E → K1 PublicationCorresponds to variant dbSNP:rs11229651Ensembl.1
Natural variantiVAR_031298168L → I1 PublicationCorresponds to variant dbSNP:rs17851433Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426250 mRNA Translation: AAO73139.1
AB207211 mRNA Translation: BAF63415.1
CH471076 Genomic DNA Translation: EAW73826.1
BC016789 mRNA Translation: AAH16789.1
BC021682 mRNA Translation: AAH21682.1
CCDSiCCDS41649.1
RefSeqiNP_659453.3, NM_145016.3
XP_016872826.1, XM_017017337.1
XP_016872827.1, XM_017017338.1
UniGeneiHs.254271

Genome annotation databases

EnsembliENST00000287275; ENSP00000287275; ENSG00000156689
ENST00000532258; ENSP00000434277; ENSG00000156689
GeneIDi219970
KEGGihsa:219970
UCSCiuc001nnd.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426250 mRNA Translation: AAO73139.1
AB207211 mRNA Translation: BAF63415.1
CH471076 Genomic DNA Translation: EAW73826.1
BC016789 mRNA Translation: AAH16789.1
BC021682 mRNA Translation: AAH21682.1
CCDSiCCDS41649.1
RefSeqiNP_659453.3, NM_145016.3
XP_016872826.1, XM_017017337.1
XP_016872827.1, XM_017017338.1
UniGeneiHs.254271

3D structure databases

ProteinModelPortaliQ8WU03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287275

Chemistry databases

DrugBankiDB00145 Glycine
SwissLipidsiSLP:000001661

PTM databases

iPTMnetiQ8WU03
PhosphoSitePlusiQ8WU03

Polymorphism and mutation databases

BioMutaiGLYATL2
DMDMi74730653

Proteomic databases

PaxDbiQ8WU03
PeptideAtlasiQ8WU03
PRIDEiQ8WU03
ProteomicsDBi74617

Protocols and materials databases

DNASUi219970
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287275; ENSP00000287275; ENSG00000156689
ENST00000532258; ENSP00000434277; ENSG00000156689
GeneIDi219970
KEGGihsa:219970
UCSCiuc001nnd.6 human

Organism-specific databases

CTDi219970
EuPathDBiHostDB:ENSG00000156689.6
GeneCardsiGLYATL2
HGNCiHGNC:24178 GLYATL2
HPAiHPA060292
HPA065454
MIMi614762 gene
neXtProtiNX_Q8WU03
OpenTargetsiENSG00000156689
PharmGKBiPA142671728
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J98B Eukaryota
ENOG4111RDK LUCA
GeneTreeiENSGT00390000004997
HOGENOMiHOG000263599
HOVERGENiHBG107953
InParanoidiQ8WU03
KOiK22749
OMAiWIVMEQS
OrthoDBiEOG091G0GJJ
PhylomeDBiQ8WU03
TreeFamiTF353258

Enzyme and pathway databases

BRENDAi2.3.1.13 2681
ReactomeiR-HSA-177128 Conjugation of salicylate with glycine
R-HSA-177135 Conjugation of benzoate with glycine

Miscellaneous databases

ChiTaRSiGLYATL2 human
GenomeRNAii219970
PROiPR:Q8WU03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156689 Expressed in 79 organ(s), highest expression level in minor salivary gland
CleanExiHS_GLYATL2
ExpressionAtlasiQ8WU03 baseline and differential
GenevisibleiQ8WU03 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N
PANTHERiPTHR15298 PTHR15298, 1 hit
PfamiView protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLYL2_HUMAN
AccessioniPrimary (citable) accession number: Q8WU03
Secondary accession number(s): A5LGC7, Q86WC3, Q96AT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again