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Protein

Cytosolic arginine sensor for mTORC1 subunit 1

Gene

CASTOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei274Arginine; via carbonyl oxygenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arginine binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

GO - Biological processi

  • cellular response to L-arginine Source: UniProtKB
  • negative regulation of TORC1 signaling Source: UniProtKB
  • regulation of intracellular signal transduction Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic arginine sensor for mTORC1 subunit 1Imported
Alternative name(s):
Cellular arginine sensor for mTORC1 protein 11 Publication
GATS-like protein 3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASTOR11 PublicationImported
Synonyms:GATSL3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000239282.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34423 CASTOR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617034 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTX7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90Q → A: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi96K → A: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi99R → A: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi108 – 110HHV → QNI: Loss of arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication3
Mutagenesisi111S → A: Loss of arginine-binding. Constitutively interacts with the GATOR2 complex. Constitutively inhibits the TORC1 signaling pathway. 1 Publication1
Mutagenesisi113L → F: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi118 – 119YQ → AA: No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway. 1 Publication2
Mutagenesisi121D → A: No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway. 1 Publication1
Mutagenesisi126R → A: Decreased arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi175H → A: Decreased arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi202I → E: No effect on arginine-binding. Loss of homodimerization. Decreased interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway. 1 Publication1
Mutagenesisi207Y → S: No effect on arginine-binding. Loss of homodimerization. Decreased interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway. 1 Publication1
Mutagenesisi261E → A: No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi264R → A: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi276D → A: Decreased arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi277E → A: Decreased arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi278C → A: Decreased arginine-binding. Constitutively interacts with the GATOR2 complex. 1 Publication1
Mutagenesisi280I → A: Loss of arginine-binding. Constitutively inhibits the TORC1 signaling pathway. 1 Publication1
Mutagenesisi292D → A: No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi302N → K: No effect on interaction with the GATOR2 complex. 1 Publication1
Mutagenesisi304D → A: Loss of arginine-binding. Constitutively interacts with the GATOR2 complex. Constitutively inhibits the TORC1 signaling pathway. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000239282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720260

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GATSL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730646

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003485901 – 329Cytosolic arginine sensor for mTORC1 subunit 1Add BLAST329

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WTX7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WTX7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WTX7

PeptideAtlas

More...
PeptideAtlasi
Q8WTX7

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTX7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74612

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8WTX7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WTX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WTX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239282 Expressed in 89 organ(s), highest expression level in esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8WTX7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTX7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with CASTOR2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
535021, 6 interactors

Database of interacting proteins

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DIPi
DIP-62096N

Protein interaction database and analysis system

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IntActi
Q8WTX7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8WTX7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WTX7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 138ACT 1Add BLAST67
Domaini260 – 321ACT 2Add BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 112Arginine-bindingCombined sources1 Publication2
Regioni280 – 281Arginine-bindingCombined sources1 Publication2
Regioni300 – 304Arginine-bindingCombined sources1 Publication5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GATS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9B Eukaryota
ENOG4111D5N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253004

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107937

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTX7

Identification of Orthologs from Complete Genome Data

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OMAi
CVMSLDP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GYO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTX7

TreeFam database of animal gene trees

More...
TreeFami
TF331648

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030415 CASTOR1
IPR027795 CASTOR_ACT_dom
IPR026249 CASTOR_fam

The PANTHER Classification System

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PANTHERi
PTHR31131:SF3 PTHR31131:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13840 ACT_7, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02078 GATSLIKEFMLY

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8WTX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELHILEHRV RVLSVARPGL WLYTHPLIKL LFLPRRSRCK FFSLTETPED
60 70 80 90 100
YTLMVDEEGF KELPPSEFLQ VAEATWLVLN VSSHSGAAVQ AAGVTKIARS
110 120 130 140 150
VIAPLAEHHV SVLMLSTYQT DFILVREQDL SVVIHTLAQE FDIYREVGGE
160 170 180 190 200
PVPVTRDDSS NGFPRTQHGP SPTVHPIQSP QNRFCVLTLD PETLPAIATT
210 220 230 240 250
LIDVLFYSHS TPKEAASSSP EPSSITFFAF SLIEGYISIV MDAETQKKFP
260 270 280 290 300
SDLLLTSSSG ELWRMVRIGG QPLGFDECGI VAQIAGPLAA ADISAYYIST
310 320
FNFDHALVPE DGIGSVIEVL QRRQEGLAS
Length:329
Mass (Da):36,275
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6AE6FE6038C5D3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPJ3B7WPJ3_HUMAN
Cytosolic arginine sensor for mTORC...
CASTOR1
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD52F8WD52_HUMAN
Cytosolic arginine sensor for mTORC...
CASTOR1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2U7H7C2U7_HUMAN
Cytosolic arginine sensor for mTORC...
CASTOR1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2C1F2Z2C1_HUMAN
Cytosolic arginine sensor for mTORC...
CASTOR1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3I9F2Z3I9_HUMAN
Cytosolic arginine sensor for mTORC...
CASTOR1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC23432 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC23433 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB70963 differs from that shown. Reason: Erroneous termination at position 310. Translated as Glu.Curated
The sequence EAW59868 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4H → R in BAB70963 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456449 mRNA Translation: CAG30335.1
AK055587 mRNA Translation: BAB70963.1 Sequence problems.
AC004997 Genomic DNA Translation: AAC23432.1 Sequence problems.
AC004997 Genomic DNA Translation: AAC23433.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59868.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59870.1
BC021927 mRNA Translation: AAH21927.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43001.1

NCBI Reference Sequences

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RefSeqi
NP_001032755.1, NM_001037666.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.444950

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000407689; ENSP00000384183; ENSG00000239282

Database of genes from NCBI RefSeq genomes

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GeneIDi
652968

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:652968

UCSC genome browser

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UCSCi
uc003ahd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456449 mRNA Translation: CAG30335.1
AK055587 mRNA Translation: BAB70963.1 Sequence problems.
AC004997 Genomic DNA Translation: AAC23432.1 Sequence problems.
AC004997 Genomic DNA Translation: AAC23433.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59868.1 Sequence problems.
CH471095 Genomic DNA Translation: EAW59870.1
BC021927 mRNA Translation: AAH21927.1
CCDSiCCDS43001.1
RefSeqiNP_001032755.1, NM_001037666.2
UniGeneiHs.444950

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GS9X-ray2.50A/B/C/D1-329[»]
5GT7X-ray2.05A/B/C/D1-323[»]
5GT8X-ray2.80A/B/C/D1-329[»]
5GV2X-ray2.06A/C1-329[»]
5I2CX-ray1.80A/B/C/D1-329[»]
ProteinModelPortaliQ8WTX7
SMRiQ8WTX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi535021, 6 interactors
DIPiDIP-62096N
IntActiQ8WTX7, 4 interactors
STRINGi9606.ENSP00000384183

PTM databases

iPTMnetiQ8WTX7
PhosphoSitePlusiQ8WTX7

Polymorphism and mutation databases

BioMutaiGATSL3
DMDMi74730646

Proteomic databases

EPDiQ8WTX7
MaxQBiQ8WTX7
PaxDbiQ8WTX7
PeptideAtlasiQ8WTX7
PRIDEiQ8WTX7
ProteomicsDBi74612
TopDownProteomicsiQ8WTX7

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
652968
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407689; ENSP00000384183; ENSG00000239282
GeneIDi652968
KEGGihsa:652968
UCSCiuc003ahd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
652968
EuPathDBiHostDB:ENSG00000239282.7

GeneCards: human genes, protein and diseases

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GeneCardsi
CASTOR1
HGNCiHGNC:34423 CASTOR1
MIMi617034 gene
neXtProtiNX_Q8WTX7
OpenTargetsiENSG00000239282
PharmGKBiPA164720260

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ9B Eukaryota
ENOG4111D5N LUCA
GeneTreeiENSGT00390000006208
HOGENOMiHOG000253004
HOVERGENiHBG107937
InParanoidiQ8WTX7
OMAiCVMSLDP
OrthoDBiEOG091G0GYO
PhylomeDBiQ8WTX7
TreeFamiTF331648

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GATSL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
652968

Protein Ontology

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PROi
PR:Q8WTX7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000239282 Expressed in 89 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ8WTX7 baseline and differential
GenevisibleiQ8WTX7 HS

Family and domain databases

InterProiView protein in InterPro
IPR030415 CASTOR1
IPR027795 CASTOR_ACT_dom
IPR026249 CASTOR_fam
PANTHERiPTHR31131:SF3 PTHR31131:SF3, 1 hit
PfamiView protein in Pfam
PF13840 ACT_7, 2 hits
PRINTSiPR02078 GATSLIKEFMLY

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAST1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTX7
Secondary accession number(s): O76052, Q96ND9, Q9UIE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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