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Entry version 153 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Conserved oligomeric Golgi complex subunit 1

Gene

COG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 1
Short name:
COG complex subunit 1
Alternative name(s):
Component of oligomeric Golgi complex 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG1
Synonyms:KIAA1381, LDLB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6545 COG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606973 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTW3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2G (CDG2G)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia, growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in O-glycosylation as well as N-glycosylation.
Related information in OMIM

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9382

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
COG1

MalaCards human disease database

More...
MalaCardsi
COG1
MIMi611209 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166685

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
263508 COG1-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26696

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WTW3

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105805

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22653695

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002134912 – 980Conserved oligomeric Golgi complex subunit 1Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WTW3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WTW3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WTW3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WTW3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WTW3

PeptideAtlas

More...
PeptideAtlasi
Q8WTW3

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTW3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74609

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WTW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WTW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166685 Expressed in 196 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WTW3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTW3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029224

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H9E32EBI-368371,EBI-368382

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114783, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WTW3

Protein interaction database and analysis system

More...
IntActi
Q8WTW3, 22 interactors

Molecular INTeraction database

More...
MINTi
Q8WTW3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299886

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2033 Eukaryota
ENOG410XR7E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017136

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231051

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTW3

KEGG Orthology (KO)

More...
KOi
K20288

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDCIDPF

Database of Orthologous Groups

More...
OrthoDBi
221637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTW3

TreeFam database of animal gene trees

More...
TreeFami
TF314678

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033370 COG1

The PANTHER Classification System

More...
PANTHERi
PTHR31658 PTHR31658, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WTW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAATSPAL KRLDLRDPAA LFETHGAEEI RGLERQVRAE IEHKKEELRQ
60 70 80 90 100
MVGERYRDLI EAADTIGQMR RCAVGLVDAV KATDQYCARL RQAGSAAPRP
110 120 130 140 150
PRAQQPQQPS QEKFYSMAAQ IKLLLEIPEK IWSSMEASQC LHATQLYLLC
160 170 180 190 200
CHLHSLLQLD SSSSRYSPVL SRFPILIRQV AAASHFRSTI LHESKMLLKC
210 220 230 240 250
QGVSDQAVAE ALCSIMLLEE SSPRQALTDF LLARKATIQK LLNQPHHGAG
260 270 280 290 300
IKAQICSLVE LLATTLKQAH ALFYTLPEGL LPDPALPCGL LFSTLETITG
310 320 330 340 350
QHPAGKGTGV LQEEMKLCSW FKHLPASIVE FQPTLRTLAH PISQEYLKDT
360 370 380 390 400
LQKWIHMCNE DIKNGITNLL MYVKSMKGLA GIRDAMWELL TNESTNHSWD
410 420 430 440 450
VLCRRLLEKP LLFWEDMMQQ LFLDRLQTLT KEGFDSISSS SKELLVSALQ
460 470 480 490 500
ELESSTSNSP SNKHIHFEYN MSLFLWSESP NDLPSDAAWV SVANRGQFAS
510 520 530 540 550
SGLSMKAQAI SPCVQNFCSA LDSKLKVKLD DLLAYLPSDD SSLPKDVSPT
560 570 580 590 600
QAKSSAFDRY ADAGTVQEML RTQSVACIKH IVDCIRAELQ SIEEGVQGQQ
610 620 630 640 650
DALNSAKLHS VLFMARLCQS LGELCPHLKQ CILGKSESSE KPAREFRALR
660 670 680 690 700
KQGKVKTQEI IPTQAKWQEV KEVLLQQSVM GYQVWSSAVV KVLIHGFTQS
710 720 730 740 750
LLLDDAGSVL ATATSWDELE IQEEAESGSS VTSKIRLPAQ PSWYVQSFLF
760 770 780 790 800
SLCQEINRVG GHALPKVTLQ EMLKSCMVQV VAAYEKLSEE KQIKKEGAFP
810 820 830 840 850
VTQNRALQLL YDLRYLNIVL TAKGDEVKSG RSKPDSRIEK VTDHLEALID
860 870 880 890 900
PFDLDVFTPH LNSNLHRLVQ RTSVLFGLVT GTENQLAPRS STFNSQEPHN
910 920 930 940 950
ILPLASSQIR FGLLPLSMTS TRKAKSTRNI ETKAQVVPPA RSTAGDPTVP
960 970 980
GSLFRQLVSE EDNTSAPSLF KLGWLSSMTK
Length:980
Mass (Da):108,978
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68C066504260E36E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92619 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059231357M → L. Corresponds to variant dbSNP:rs4375725Ensembl.1
Natural variantiVAR_020415392N → S. Corresponds to variant dbSNP:rs1026128EnsemblClinVar.1
Natural variantiVAR_048756744Y → C. Corresponds to variant dbSNP:rs7208207Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC021985 mRNA Translation: AAH21985.1
AB037802 mRNA Translation: BAA92619.1 Frameshift.
AL359611 mRNA Translation: CAB94881.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11692.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T50629

NCBI Reference Sequences

More...
RefSeqi
NP_061184.1, NM_018714.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9382

UCSC genome browser

More...
UCSCi
uc002jjg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021985 mRNA Translation: AAH21985.1
AB037802 mRNA Translation: BAA92619.1 Frameshift.
AL359611 mRNA Translation: CAB94881.1
CCDSiCCDS11692.1
PIRiT50629
RefSeqiNP_061184.1, NM_018714.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114783, 33 interactors
CORUMiQ8WTW3
IntActiQ8WTW3, 22 interactors
MINTiQ8WTW3
STRINGi9606.ENSP00000299886

Chemistry databases

ChEMBLiCHEMBL4105805

PTM databases

iPTMnetiQ8WTW3
PhosphoSitePlusiQ8WTW3

Polymorphism and mutation databases

BioMutaiCOG1
DMDMi22653695

Proteomic databases

EPDiQ8WTW3
jPOSTiQ8WTW3
MassIVEiQ8WTW3
MaxQBiQ8WTW3
PaxDbiQ8WTW3
PeptideAtlasiQ8WTW3
PRIDEiQ8WTW3
ProteomicsDBi74609

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9382

Genome annotation databases

GeneIDi9382
KEGGihsa:9382
UCSCiuc002jjg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9382
DisGeNETi9382

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COG1
GeneReviewsiCOG1
HGNCiHGNC:6545 COG1
HPAiHPA029224
MalaCardsiCOG1
MIMi606973 gene
611209 phenotype
neXtProtiNX_Q8WTW3
OpenTargetsiENSG00000166685
Orphaneti263508 COG1-CDG
PharmGKBiPA26696

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2033 Eukaryota
ENOG410XR7E LUCA
GeneTreeiENSGT00390000017136
HOGENOMiHOG000231051
InParanoidiQ8WTW3
KOiK20288
OMAiRDCIDPF
OrthoDBi221637at2759
PhylomeDBiQ8WTW3
TreeFamiTF314678

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COG1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9382
PharosiQ8WTW3

Protein Ontology

More...
PROi
PR:Q8WTW3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166685 Expressed in 196 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ8WTW3 baseline and differential
GenevisibleiQ8WTW3 HS

Family and domain databases

InterProiView protein in InterPro
IPR033370 COG1
PANTHERiPTHR31658 PTHR31658, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTW3
Secondary accession number(s): Q9NPV9, Q9P2G6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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