THAP3

Functionⁱ

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 82	THAP-typePROSITE-ProRule annotationAdd BLAST		82

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: THAP domain-containing protein 3
Gene namesⁱ	Name:THAP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000041988.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20855 THAP3
MIMⁱ	612532 gene
neXtProtⁱ	NX_Q8WTV1

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	177 – 180	DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication	4
Mutagenesisⁱ	178	H → A: Abolishes interaction with HCFC1.	1
Mutagenesisⁱ	180	Y → A: Abolishes interaction with HCFC1.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	90326
Open Targets More...OpenTargetsⁱ	ENSG00000041988
PharmGKBⁱ	PA134987111

Polymorphism and mutation databases

BioMutaⁱ	THAP3
DMDMⁱ	29839586

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068644	1 – 239	THAP domain-containing protein 3Add BLAST		239

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	122	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WTV1
PaxDbⁱ	Q8WTV1
PeptideAtlas More...PeptideAtlasⁱ	Q8WTV1
PRIDEⁱ	Q8WTV1
ProteomicsDBⁱ	74606 74607 [Q8WTV1-3] 74608 [Q8WTV1-4]

PTM databases

iPTMnetⁱ	Q8WTV1
PhosphoSitePlusⁱ	Q8WTV1

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000041988 Expressed in 129 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_THAP3
ExpressionAtlasⁱ	Q8WTV1 baseline and differential
Genevisibleⁱ	Q8WTV1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067114

HPAⁱ

HPA067114

Interactionⁱ

Subunit structureⁱ

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).1 Publication

Protein-protein interaction databases

BioGridⁱ	124694, 6 interactors
ELMⁱ	Q8WTV1
IntActⁱ	Q8WTV1, 1 interactor
STRINGⁱ	9606.ENSP00000054650

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WTV1
SMRⁱ	Q8WTV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	177 – 180	HCFC1-binding motif (HBM)		4

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 82	THAP-typePROSITE-ProRule annotationAdd BLAST		82

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IRYI Eukaryota ENOG410Y1BK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129785
HOVERGENⁱ	HBG100591
InParanoidⁱ	Q8WTV1
OMAⁱ	VLNIGRA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G034R
PhylomeDBⁱ	Q8WTV1
TreeFamⁱ	TF330127

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR026520 THAP3 IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
PANTHERⁱ	PTHR23080:SF64 PTHR23080:SF64, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ 
        60         70         80         90        100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE 
       110        120        130        140        150
RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR 
       160        170        180        190        200
RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE 
       210        220        230 
KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS

Length:239

Mass (Da):27,059

Last modified:March 1, 2002 - v1

Checksum:ⁱ9904C925DF233397

GO

Isoform 2 (identifier: Q8WTV1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
89-89: Missing.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ 
        60         70         80         90        100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQV RENTDPASER 
       110        120        130        140        150
GNASSSQKEK VLPEAGAGED SPGRNMDTAL EELQLPPNAE GHVKQVSPRR 
       160        170        180        190        200
PQATEAVGRP TGPAGLRRTP NKQPSDHSYA LLDLDSLKKK LFLTLKENEK 
       210        220        230 
LRKRLQAQRL VMRRMSSRLR ACKGHQGLQA RLGPEQQS

Note: Gene prediction based on EST data.

Show »

Length:238

Mass (Da):26,931

Checksum:ⁱ54667E778F734995

GO

Isoform 3 (identifier: Q8WTV1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ 
        60         70         80         90        100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE 
       110        120        130        140        150
RGNASSSQKE KTSPCRSQVL PEAGAGEDSP GRNMDTALEE LQLPPNAEGH 
       160        170 
VKQAMLFNVE NGTPASREAL WLSEE

Note: No experimental confirmation available.

Show »

Length:175

Mass (Da):19,729

Checksum:ⁱB6B9A4540DC5A8B4

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	R4GNH0	R4GNH0_HUMAN		THAP domain-containing protein 3 THAP domain-containing protein 3	THAP3	231	Annotation score:
	K7EIZ2	K7EIZ2_HUMAN		THAP domain-containing protein 3 THAP domain-containing protein 3	THAP3	124	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	227	Q → R in AAH05114 (PubMed:15489334).Curated		1
Sequence conflictⁱ	227	Q → R in AAH92427 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015136	89	Missing in isoform 2. Curated	1
Alternative sequenceⁱVSP_015137	111	K → KTSPCRSQ in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_015138	147 – 168	VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_015139	169 – 239	Missing in isoform 3. 1 PublicationAdd BLAST	71

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096217 mRNA Translation: BAC04727.1 AL031447 Genomic DNA No translation available. BC005114 mRNA Translation: AAH05114.1 BC092427 mRNA Translation: AAH92427.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55572.1 [Q8WTV1-1] CCDS55573.1 [Q8WTV1-3] CCDS86.1 [Q8WTV1-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182681.1, NM_001195752.1 [Q8WTV1-3] NP_001182682.1, NM_001195753.1 [Q8WTV1-1] NP_612359.2, NM_138350.3 [Q8WTV1-4] XP_005263589.1, XM_005263532.3 [Q8WTV1-3]
UniGeneⁱ	Hs.689006

Genome annotation databases

Ensemblⁱ	ENST00000054650; ENSP00000054650; ENSG00000041988 [Q8WTV1-1] ENST00000307896; ENSP00000311537; ENSG00000041988 [Q8WTV1-3] ENST00000377627; ENSP00000366854; ENSG00000041988 [Q8WTV1-4]
GeneIDⁱ	90326
KEGGⁱ	hsa:90326
UCSC genome browser More...UCSCⁱ	uc001aoc.4 human [Q8WTV1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8WTV1	THAP domain containing 3		MACMU		283	UniRef90_Q8WTV1
THAP domain containing 3		CHLSB		239
THAP domain containing 3		Cebus capucinus imitator		239
THAP domain containing 3		GORGO		239
THAP domain containing 3		PAPAN		239
+30
Q8WTV1-4	THAP domain containing 3		MACMU		176	UniRef90_Q8WTV1-4
THAP domain containing 3		PANTR		174
THAP3 isoform 4		PONAB		174
THAP domain containing 3		CERAT		174
THAP domain containing 3		RHIRO		174
+8

Protein	Similar proteins		Species	Score	Length	Source
Q8WTV1	THAP domain-containing protein 3		BOVIN		239	UniRef50_Q8WTV1
THAP domain containing 3		MACMU		283
THAP3 isoform 1		PONAB		239
THAP domain containing 3		RHIBE		239
THAP domain containing 3		RHIRO		239
+54
Q8WTV1-4	THAP domain containing 3		MACMU		176	UniRef50_Q8WTV1-4
THAP domain containing 3		MACFA		174
THAP domain containing 3		GORGO		174
THAP domain containing 3		CERAT		174
THAP3 isoform 4		PONAB		174
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096217 mRNA Translation: BAC04727.1 AL031447 Genomic DNA No translation available. BC005114 mRNA Translation: AAH05114.1 BC092427 mRNA Translation: AAH92427.1
CCDSⁱ	CCDS55572.1 [Q8WTV1-1] CCDS55573.1 [Q8WTV1-3] CCDS86.1 [Q8WTV1-4]
RefSeqⁱ	NP_001182681.1, NM_001195752.1 [Q8WTV1-3] NP_001182682.1, NM_001195753.1 [Q8WTV1-1] NP_612359.2, NM_138350.3 [Q8WTV1-4] XP_005263589.1, XM_005263532.3 [Q8WTV1-3]
UniGeneⁱ	Hs.689006

3D structure databases

ProteinModelPortalⁱ	Q8WTV1
SMRⁱ	Q8WTV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124694, 6 interactors
ELMⁱ	Q8WTV1
IntActⁱ	Q8WTV1, 1 interactor
STRINGⁱ	9606.ENSP00000054650

PTM databases

iPTMnetⁱ	Q8WTV1
PhosphoSitePlusⁱ	Q8WTV1

Polymorphism and mutation databases

BioMutaⁱ	THAP3
DMDMⁱ	29839586

Proteomic databases

MaxQBⁱ	Q8WTV1
PaxDbⁱ	Q8WTV1
PeptideAtlasⁱ	Q8WTV1
PRIDEⁱ	Q8WTV1
ProteomicsDBⁱ	74606 74607 [Q8WTV1-3] 74608 [Q8WTV1-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	90326
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000054650; ENSP00000054650; ENSG00000041988 [Q8WTV1-1] ENST00000307896; ENSP00000311537; ENSG00000041988 [Q8WTV1-3] ENST00000377627; ENSP00000366854; ENSG00000041988 [Q8WTV1-4]
GeneIDⁱ	90326
KEGGⁱ	hsa:90326
UCSCⁱ	uc001aoc.4 human [Q8WTV1-1]

Organism-specific databases

CTDⁱ	90326
DisGeNETⁱ	90326
EuPathDBⁱ	HostDB:ENSG00000041988.15
GeneCardsⁱ	THAP3
HGNCⁱ	HGNC:20855 THAP3
HPAⁱ	HPA067114
MIMⁱ	612532 gene
neXtProtⁱ	NX_Q8WTV1
OpenTargetsⁱ	ENSG00000041988
PharmGKBⁱ	PA134987111
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IRYI Eukaryota ENOG410Y1BK LUCA
GeneTreeⁱ	ENSGT00840000129785
HOVERGENⁱ	HBG100591
InParanoidⁱ	Q8WTV1
OMAⁱ	VLNIGRA
OrthoDBⁱ	EOG091G034R
PhylomeDBⁱ	Q8WTV1
TreeFamⁱ	TF330127

Miscellaneous databases

ChiTaRSⁱ	THAP3 human
GenomeRNAiⁱ	90326
Protein Ontology More...PROⁱ	PR:Q8WTV1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000041988 Expressed in 129 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_THAP3
ExpressionAtlasⁱ	Q8WTV1 baseline and differential
Genevisibleⁱ	Q8WTV1 HS

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR026520 THAP3 IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
PANTHERⁱ	PTHR23080:SF64 PTHR23080:SF64, 1 hit
Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THAP3_HUMAN
Accessionⁱ	Q8WTV1Primary (citable) accession number: Q8WTV1 Secondary accession number(s): Q569K1 Q9Y3H3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q8WTV1 (THAP3_HUMAN)

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THAP domain-containing protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ