UniProtKB - Q8WTV1 (THAP3_HUMAN)
Protein
THAP domain-containing protein 3
Gene
THAP3
Organism
Homo sapiens (Human)
Status
Functioni
Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 82 | THAP-typePROSITE-ProRule annotationAdd BLAST | 82 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8WTV1 |
Names & Taxonomyi
Protein namesi | Recommended name: THAP domain-containing protein 3 |
Gene namesi | Name:THAP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000041988.15 |
HGNCi | HGNC:20855, THAP3 |
MIMi | 612532, gene |
neXtProti | NX_Q8WTV1 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 177 – 180 | DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication | 4 | |
Mutagenesisi | 178 | H → A: Abolishes interaction with HCFC1. | 1 | |
Mutagenesisi | 180 | Y → A: Abolishes interaction with HCFC1. | 1 |
Organism-specific databases
DisGeNETi | 90326 |
OpenTargetsi | ENSG00000041988 |
PharmGKBi | PA134987111 |
Miscellaneous databases
Pharosi | Q8WTV1, Tdark |
Polymorphism and mutation databases
BioMutai | THAP3 |
DMDMi | 29839586 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068644 | 1 – 239 | THAP domain-containing protein 3Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 122 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8WTV1 |
MassIVEi | Q8WTV1 |
MaxQBi | Q8WTV1 |
PaxDbi | Q8WTV1 |
PeptideAtlasi | Q8WTV1 |
PRIDEi | Q8WTV1 |
ProteomicsDBi | 74606 [Q8WTV1-1] 74607 [Q8WTV1-3] 74608 [Q8WTV1-4] |
PTM databases
iPTMneti | Q8WTV1 |
PhosphoSitePlusi | Q8WTV1 |
Expressioni
Tissue specificityi
Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000041988, Expressed in apex of heart and 148 other tissues |
ExpressionAtlasi | Q8WTV1, baseline and differential |
Genevisiblei | Q8WTV1, HS |
Organism-specific databases
HPAi | ENSG00000041988, Low tissue specificity |
Interactioni
Subunit structurei
Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT.
Interacts directly with OGT and HCFC1 (via its HBM).
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 124694, 15 interactors |
ELMi | Q8WTV1 |
IntActi | Q8WTV1, 3 interactors |
STRINGi | 9606.ENSP00000054650 |
Miscellaneous databases
RNActi | Q8WTV1, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 177 – 180 | HCFC1-binding motif (HBM) | 4 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 82 | THAP-typePROSITE-ProRule annotationAdd BLAST | 82 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502S14P, Eukaryota |
GeneTreei | ENSGT00940000162344 |
HOGENOMi | CLU_076186_1_0_1 |
InParanoidi | Q8WTV1 |
OMAi | VKQVSPW |
OrthoDBi | 1382095at2759 |
PhylomeDBi | Q8WTV1 |
TreeFami | TF330127 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR026520, THAP3 IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
PANTHERi | PTHR47120, PTHR47120, 1 hit |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE
110 120 130 140 150
RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR
160 170 180 190 200
RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE
210 220 230
KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GNH0 | R4GNH0_HUMAN | THAP domain-containing protein 3 | THAP3 | 231 | Annotation score: | ||
K7EIZ2 | K7EIZ2_HUMAN | THAP domain-containing protein 3 | THAP3 | 124 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 227 | Q → R in AAH05114 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 227 | Q → R in AAH92427 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015136 | 89 | Missing in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_015137 | 111 | K → KTSPCRSQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_015138 | 147 – 168 | VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_015139 | 169 – 239 | Missing in isoform 3. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096217 mRNA Translation: BAC04727.1 AL031447 Genomic DNA No translation available. BC005114 mRNA Translation: AAH05114.1 BC092427 mRNA Translation: AAH92427.1 |
CCDSi | CCDS55572.1 [Q8WTV1-1] CCDS55573.1 [Q8WTV1-3] CCDS86.1 [Q8WTV1-4] |
RefSeqi | NP_001182681.1, NM_001195752.1 [Q8WTV1-3] NP_001182682.1, NM_001195753.1 [Q8WTV1-1] NP_612359.2, NM_138350.3 [Q8WTV1-4] XP_005263589.1, XM_005263532.3 [Q8WTV1-3] |
Genome annotation databases
Ensembli | ENST00000054650; ENSP00000054650; ENSG00000041988 [Q8WTV1-1] ENST00000307896; ENSP00000311537; ENSG00000041988 [Q8WTV1-3] ENST00000377627; ENSP00000366854; ENSG00000041988 [Q8WTV1-4] |
GeneIDi | 90326 |
KEGGi | hsa:90326 |
UCSCi | uc001aoc.4, human [Q8WTV1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096217 mRNA Translation: BAC04727.1 AL031447 Genomic DNA No translation available. BC005114 mRNA Translation: AAH05114.1 BC092427 mRNA Translation: AAH92427.1 |
CCDSi | CCDS55572.1 [Q8WTV1-1] CCDS55573.1 [Q8WTV1-3] CCDS86.1 [Q8WTV1-4] |
RefSeqi | NP_001182681.1, NM_001195752.1 [Q8WTV1-3] NP_001182682.1, NM_001195753.1 [Q8WTV1-1] NP_612359.2, NM_138350.3 [Q8WTV1-4] XP_005263589.1, XM_005263532.3 [Q8WTV1-3] |
3D structure databases
SMRi | Q8WTV1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124694, 15 interactors |
ELMi | Q8WTV1 |
IntActi | Q8WTV1, 3 interactors |
STRINGi | 9606.ENSP00000054650 |
PTM databases
iPTMneti | Q8WTV1 |
PhosphoSitePlusi | Q8WTV1 |
Polymorphism and mutation databases
BioMutai | THAP3 |
DMDMi | 29839586 |
Proteomic databases
jPOSTi | Q8WTV1 |
MassIVEi | Q8WTV1 |
MaxQBi | Q8WTV1 |
PaxDbi | Q8WTV1 |
PeptideAtlasi | Q8WTV1 |
PRIDEi | Q8WTV1 |
ProteomicsDBi | 74606 [Q8WTV1-1] 74607 [Q8WTV1-3] 74608 [Q8WTV1-4] |
Protocols and materials databases
Antibodypediai | 27449, 52 antibodies |
DNASUi | 90326 |
Genome annotation databases
Ensembli | ENST00000054650; ENSP00000054650; ENSG00000041988 [Q8WTV1-1] ENST00000307896; ENSP00000311537; ENSG00000041988 [Q8WTV1-3] ENST00000377627; ENSP00000366854; ENSG00000041988 [Q8WTV1-4] |
GeneIDi | 90326 |
KEGGi | hsa:90326 |
UCSCi | uc001aoc.4, human [Q8WTV1-1] |
Organism-specific databases
CTDi | 90326 |
DisGeNETi | 90326 |
EuPathDBi | HostDB:ENSG00000041988.15 |
GeneCardsi | THAP3 |
HGNCi | HGNC:20855, THAP3 |
HPAi | ENSG00000041988, Low tissue specificity |
MIMi | 612532, gene |
neXtProti | NX_Q8WTV1 |
OpenTargetsi | ENSG00000041988 |
PharmGKBi | PA134987111 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S14P, Eukaryota |
GeneTreei | ENSGT00940000162344 |
HOGENOMi | CLU_076186_1_0_1 |
InParanoidi | Q8WTV1 |
OMAi | VKQVSPW |
OrthoDBi | 1382095at2759 |
PhylomeDBi | Q8WTV1 |
TreeFami | TF330127 |
Enzyme and pathway databases
PathwayCommonsi | Q8WTV1 |
Miscellaneous databases
BioGRID-ORCSi | 90326, 13 hits in 861 CRISPR screens |
ChiTaRSi | THAP3, human |
GenomeRNAii | 90326 |
Pharosi | Q8WTV1, Tdark |
PROi | PR:Q8WTV1 |
RNActi | Q8WTV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000041988, Expressed in apex of heart and 148 other tissues |
ExpressionAtlasi | Q8WTV1, baseline and differential |
Genevisiblei | Q8WTV1, HS |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR026520, THAP3 IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
PANTHERi | PTHR47120, PTHR47120, 1 hit |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THAP3_HUMAN | |
Accessioni | Q8WTV1Primary (citable) accession number: Q8WTV1 Secondary accession number(s): Q569K1 Q9Y3H3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM