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Entry version 143 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Scavenger receptor cysteine-rich domain-containing group B protein

Gene

SSC4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WTU2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor cysteine-rich domain-containing group B protein1 PublicationImported
Alternative name(s):
Four scavenger receptor cysteine-rich domains-containing proteinImported
S4D-SRCRB1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSC4DImported
Synonyms:SRCRB4DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146700.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14461, SSC4D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607639, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTU2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
136853

Open Targets

More...
OpenTargetsi
ENSG00000146700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37883

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WTU2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSC4D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 47Sequence analysisAdd BLAST47
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500006753548 – 575Scavenger receptor cysteine-rich domain-containing group B proteinSequence analysisAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi83 ↔ 147PROSITE-ProRule annotation
Disulfide bondi96 ↔ 157PROSITE-ProRule annotation
Disulfide bondi127 ↔ 137PROSITE-ProRule annotation
Disulfide bondi214 ↔ 278PROSITE-ProRule annotation
Disulfide bondi227 ↔ 288PROSITE-ProRule annotation
Disulfide bondi258 ↔ 268PROSITE-ProRule annotation
Disulfide bondi369 ↔ 433PROSITE-ProRule annotation
Disulfide bondi382 ↔ 443PROSITE-ProRule annotation
Disulfide bondi413 ↔ 423PROSITE-ProRule annotation
Disulfide bondi498 ↔ 562PROSITE-ProRule annotation
Disulfide bondi511 ↔ 572PROSITE-ProRule annotation
Disulfide bondi542 ↔ 552PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WTU2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WTU2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WTU2

PeptideAtlas

More...
PeptideAtlasi
Q8WTU2

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTU2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74600 [Q8WTU2-1]
74601 [Q8WTU2-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8WTU2, 1 site, 1 O-linked glycan (1 site)

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not induced by a combination of IL1A/interleukin-1 alpha, IL6/interleukin-6 and dexamethasone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146700, Expressed in layer of synovial tissue and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTU2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146700, Tissue enhanced (salivary gland, seminal vesicle, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126464, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8WTU2, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8WTU2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000275560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WTU2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WTU2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 158SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini189 – 289SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini344 – 444SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini473 – 573SRCR 4PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU9F, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002555_11_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTU2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSHIRWN

Database of Orthologous Groups

More...
OrthoDBi
158600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTU2

TreeFam database of animal gene trees

More...
TreeFami
TF329295

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530, SRCR, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202, SR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487, SSF56487, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420, SRCR_1, 4 hits
PS50287, SRCR_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q8WTU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHKEAEMLIG PQLDEKRWGW RLGDGSAAPP FLPQALSFLL LLPLASALQP
60 70 80 90 100
TPLPFQELRL VGGPSRCRGR LEVMHGGSWG SVCDDDWDVV DANVVCRQLG
110 120 130 140 150
CGLALPVPRP LAFGQGRGPI LLDNVECRGQ EAALSECGSR GWGVHNCFHY
160 170 180 190 200
EDVAVLCDEF LPTQPPTRKM LTSRAPPTTL PNGKSEGSVR LVGGANLCQG
210 220 230 240 250
RVEILHSGLW GTVCDDDWGL PDAAVVCRQL GCGAAMAATT NAFFGYGTGH
260 270 280 290 300
ILLDNVHCEG GEPRLAACQS LGWGVHNCGH HEDAGALCAG LGPPTLTALP
310 320 330 340 350
SSATREDWAW QTDPSATGVG PQPSRETALL TTAAWAAGKK SGRLRLVGGP
360 370 380 390 400
GPCRGRVEVL HAGGWGTVCD DDWDFADARV ACREAGCGPA LGATGLGHFG
410 420 430 440 450
YGRGPVLLDN VGCAGTEARL SDCFHLGWGQ HNCGHHEDAG ALCAGPEELG
460 470 480 490 500
LQVQQDGSET TRVPTPRPRD GHLRLVNGAH RCEGRVELYL GQRWGTVCDD
510 520 530 540 550
AWDLRAAGVL CRQLGCGQAL AAPGEAHFGP GRGPILLDNV KCRGEESALL
560 570
LCSHIRWDAH NCDHSEDASV LCQPS
Length:575
Mass (Da):60,819
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i013BD759EFDB4331
GO
Isoform 21 Publication (identifier: Q8WTU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-274: LGWG → KTVS
     275-575: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:274
Mass (Da):29,264
Checksum:i71B000803F0117FF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15651 differs from that shown. Intron retention.Curated
The sequence BAD18764 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti520L → I in BAD18764 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052063128R → H. Corresponds to variant dbSNP:rs4728712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052695271 – 274LGWG → KTVS in isoform 2. 1 Publication4
Alternative sequenceiVSP_052696275 – 575Missing in isoform 2. 1 PublicationAdd BLAST301

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ306913 AJ306922 Genomic DNA Translation: CAC88128.1
AJ312755 mRNA Translation: CAC84764.1
AK172783 mRNA Translation: BAD18764.1 Frameshift.
AC005522 Genomic DNA No translation available.
CH471220 Genomic DNA Translation: EAW71806.1
BC015651 mRNA Translation: AAH15651.1 Sequence problems.
BC113840 mRNA Translation: AAI13841.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5585.1 [Q8WTU2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_542782.1, NM_080744.1 [Q8WTU2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275560; ENSP00000275560; ENSG00000146700 [Q8WTU2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
136853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:136853

UCSC genome browser

More...
UCSCi
uc003ufb.4, human [Q8WTU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306913 AJ306922 Genomic DNA Translation: CAC88128.1
AJ312755 mRNA Translation: CAC84764.1
AK172783 mRNA Translation: BAD18764.1 Frameshift.
AC005522 Genomic DNA No translation available.
CH471220 Genomic DNA Translation: EAW71806.1
BC015651 mRNA Translation: AAH15651.1 Sequence problems.
BC113840 mRNA Translation: AAI13841.1
CCDSiCCDS5585.1 [Q8WTU2-1]
RefSeqiNP_542782.1, NM_080744.1 [Q8WTU2-1]

3D structure databases

SMRiQ8WTU2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126464, 1 interactor
IntActiQ8WTU2, 1 interactor
MINTiQ8WTU2
STRINGi9606.ENSP00000275560

PTM databases

GlyGeniQ8WTU2, 1 site, 1 O-linked glycan (1 site)

Polymorphism and mutation databases

BioMutaiSSC4D
DMDMi74751496

Proteomic databases

MassIVEiQ8WTU2
MaxQBiQ8WTU2
PaxDbiQ8WTU2
PeptideAtlasiQ8WTU2
PRIDEiQ8WTU2
ProteomicsDBi74600 [Q8WTU2-1]
74601 [Q8WTU2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14947, 91 antibodies

The DNASU plasmid repository

More...
DNASUi
136853

Genome annotation databases

EnsembliENST00000275560; ENSP00000275560; ENSG00000146700 [Q8WTU2-1]
GeneIDi136853
KEGGihsa:136853
UCSCiuc003ufb.4, human [Q8WTU2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
136853
DisGeNETi136853
EuPathDBiHostDB:ENSG00000146700.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SSC4D
HGNCiHGNC:14461, SSC4D
HPAiENSG00000146700, Tissue enhanced (salivary gland, seminal vesicle, thyroid gland)
MIMi607639, gene
neXtProtiNX_Q8WTU2
OpenTargetsiENSG00000146700
PharmGKBiPA37883

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QU9F, Eukaryota
GeneTreeiENSGT00940000160521
HOGENOMiCLU_002555_11_2_1
InParanoidiQ8WTU2
OMAiCSHIRWN
OrthoDBi158600at2759
PhylomeDBiQ8WTU2
TreeFamiTF329295

Enzyme and pathway databases

PathwayCommonsiQ8WTU2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
136853, 7 hits in 868 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
136853
PharosiQ8WTU2, Tdark

Protein Ontology

More...
PROi
PR:Q8WTU2
RNActiQ8WTU2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146700, Expressed in layer of synovial tissue and 175 other tissues
GenevisibleiQ8WTU2, HS

Family and domain databases

Gene3Di3.10.250.10, 4 hits
InterProiView protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF00530, SRCR, 4 hits
PRINTSiPR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 4 hits
SUPFAMiSSF56487, SSF56487, 4 hits
PROSITEiView protein in PROSITE
PS00420, SRCR_1, 4 hits
PS50287, SRCR_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRB4D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTU2
Secondary accession number(s): Q2HIZ5, Q6ZMG3, Q96BF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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