UniProtKB - Q8WTU0 (DDI1_HUMAN)
Protein
Protein DDI1 homolog 1
Gene
DDI1
Organism
Homo sapiens (Human)
Status
Functioni
Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612).2 Publications1 Publication
Activity regulationi
Inhibited by the proteinase inhibitors amprenavir, indinavir, lopinavir, isovaleryl pepstatin, ritonavir and saquinavir.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 260 | Curated | 1 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to hydroxyurea Source: UniProtKB
- proteasomal protein catabolic process Source: UniProtKB
- regulation of DNA stability Source: UniProtKB
- regulation of protein stability Source: UniProtKB
Keywordsi
Molecular function | Aspartyl protease, Hydrolase, Protease |
Enzyme and pathway databases
PathwayCommonsi | Q8WTU0 |
Protein family/group databases
MEROPSi | A28.003 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DDI1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170967.4 |
HGNCi | HGNC:18961, DDI1 |
neXtProti | NX_Q8WTU0 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 414301 |
OpenTargetsi | ENSG00000170967 |
PharmGKBi | PA142672003 |
Miscellaneous databases
Pharosi | Q8WTU0, Tdark |
Polymorphism and mutation databases
BioMutai | DDI1 |
DMDMi | 74730631 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287086 | 1 – 396 | Protein DDI1 homolog 1Add BLAST | 396 |
Proteomic databases
jPOSTi | Q8WTU0 |
MassIVEi | Q8WTU0 |
MaxQBi | Q8WTU0 |
PaxDbi | Q8WTU0 |
PeptideAtlasi | Q8WTU0 |
PRIDEi | Q8WTU0 |
ProteomicsDBi | 74599 |
PTM databases
iPTMneti | Q8WTU0 |
PhosphoSitePlusi | Q8WTU0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170967, Expressed in sperm and 21 other tissues |
Genevisiblei | Q8WTU0, HS |
Organism-specific databases
HPAi | ENSG00000170967, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ8WTU0
Protein-protein interaction databases
BioGRIDi | 136043, 30 interactors |
DIPi | DIP-60626N |
IntActi | Q8WTU0, 28 interactors |
MINTi | Q8WTU0 |
STRINGi | 9606.ENSP00000302805 |
Miscellaneous databases
RNActi | Q8WTU0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WTU0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 81 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the DDI1 family.Curated
Phylogenomic databases
eggNOGi | KOG0012, Eukaryota |
GeneTreei | ENSGT00950000182999 |
HOGENOMi | CLU_020435_1_0_1 |
InParanoidi | Q8WTU0 |
OMAi | DDHCSLG |
OrthoDBi | 817208at2759 |
PhylomeDBi | Q8WTU0 |
TreeFami | TF333421 |
Family and domain databases
CDDi | cd05479, RP_DDI, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR019103, Peptidase_aspartic_DDI1-type IPR021109, Peptidase_aspartic_dom_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF09668, Asp_protease, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF50630, SSF50630, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WTU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM
60 70 80 90 100
ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA
110 120 130 140 150
VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML
160 170 180 190 200
LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL
210 220 230 240 250
YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV
260 270 280 290 300
NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG
310 320 330 340 350
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV
360 370 380 390
IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | N → K in AAP97303 (Ref. 2) Curated | 1 | |
Sequence conflicti | 164 | N → K in AAP97303 (Ref. 2) Curated | 1 | |
Sequence conflicti | 170 | A → T in AAP97303 (Ref. 2) Curated | 1 | |
Sequence conflicti | 213 | K → R in AAP97303 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032259 | 136 | G → S. Corresponds to variant dbSNP:rs7102675Ensembl. | 1 | |
Natural variantiVAR_032260 | 142 | S → G1 PublicationCorresponds to variant dbSNP:rs17856633Ensembl. | 1 | |
Natural variantiVAR_032261 | 239 | G → E1 PublicationCorresponds to variant dbSNP:rs17851870Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093336 mRNA Translation: BAC04135.1 AF429972 mRNA Translation: AAP97303.1 BC021172 mRNA Translation: AAH21172.2 BC021710 mRNA Translation: AAH21710.1 BC022017 mRNA Translation: AAH22017.1 BC022018 mRNA Translation: AAH22018.1 |
CCDSi | CCDS31660.1 |
RefSeqi | NP_001001711.1, NM_001001711.2 |
Genome annotation databases
Ensembli | ENST00000302259; ENSP00000302805; ENSG00000170967 |
GeneIDi | 414301 |
KEGGi | hsa:414301 |
UCSCi | uc001phr.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093336 mRNA Translation: BAC04135.1 AF429972 mRNA Translation: AAP97303.1 BC021172 mRNA Translation: AAH21172.2 BC021710 mRNA Translation: AAH21710.1 BC022017 mRNA Translation: AAH22017.1 BC022018 mRNA Translation: AAH22018.1 |
CCDSi | CCDS31660.1 |
RefSeqi | NP_001001711.1, NM_001001711.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3S8I | X-ray | 1.70 | A/B | 239-367 | [»] | |
SMRi | Q8WTU0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 136043, 30 interactors |
DIPi | DIP-60626N |
IntActi | Q8WTU0, 28 interactors |
MINTi | Q8WTU0 |
STRINGi | 9606.ENSP00000302805 |
Protein family/group databases
MEROPSi | A28.003 |
PTM databases
iPTMneti | Q8WTU0 |
PhosphoSitePlusi | Q8WTU0 |
Polymorphism and mutation databases
BioMutai | DDI1 |
DMDMi | 74730631 |
Proteomic databases
jPOSTi | Q8WTU0 |
MassIVEi | Q8WTU0 |
MaxQBi | Q8WTU0 |
PaxDbi | Q8WTU0 |
PeptideAtlasi | Q8WTU0 |
PRIDEi | Q8WTU0 |
ProteomicsDBi | 74599 |
Protocols and materials databases
Antibodypediai | 31840, 61 antibodies |
DNASUi | 414301 |
Genome annotation databases
Ensembli | ENST00000302259; ENSP00000302805; ENSG00000170967 |
GeneIDi | 414301 |
KEGGi | hsa:414301 |
UCSCi | uc001phr.3, human |
Organism-specific databases
CTDi | 414301 |
DisGeNETi | 414301 |
EuPathDBi | HostDB:ENSG00000170967.4 |
GeneCardsi | DDI1 |
HGNCi | HGNC:18961, DDI1 |
HPAi | ENSG00000170967, Tissue enriched (testis) |
neXtProti | NX_Q8WTU0 |
OpenTargetsi | ENSG00000170967 |
PharmGKBi | PA142672003 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0012, Eukaryota |
GeneTreei | ENSGT00950000182999 |
HOGENOMi | CLU_020435_1_0_1 |
InParanoidi | Q8WTU0 |
OMAi | DDHCSLG |
OrthoDBi | 817208at2759 |
PhylomeDBi | Q8WTU0 |
TreeFami | TF333421 |
Enzyme and pathway databases
PathwayCommonsi | Q8WTU0 |
Miscellaneous databases
BioGRID-ORCSi | 414301, 0 hits in 840 CRISPR screens |
GenomeRNAii | 414301 |
Pharosi | Q8WTU0, Tdark |
PROi | PR:Q8WTU0 |
RNActi | Q8WTU0, protein |
Gene expression databases
Bgeei | ENSG00000170967, Expressed in sperm and 21 other tissues |
Genevisiblei | Q8WTU0, HS |
Family and domain databases
CDDi | cd05479, RP_DDI, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR019103, Peptidase_aspartic_DDI1-type IPR021109, Peptidase_aspartic_dom_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF09668, Asp_protease, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF50630, SSF50630, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDI1_HUMAN | |
Accessioni | Q8WTU0Primary (citable) accession number: Q8WTU0 Secondary accession number(s): Q7Z4U6, Q8WTS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations