UniProtKB - Q8WTU0 (DDI1_HUMAN)

BLAST

>sp|Q8WTU0|DDI1_HUMAN Protein DDI1 homolog 1 OS=Homo sapiens OX=9606 GN=DDI1 PE=1 SV=1
MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCS
LGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTP
AAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFS
QVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQ
VTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIG
RVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYF
LPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH

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History
Entry version 140 (07 Nov 2018)
Sequence version 1 (01 Mar 2002)
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Protein

Protein DDI1 homolog 1

Gene

DDI1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable aspartic protease.1 Publication

Activity regulationⁱ

Inhibited by the proteinase inhibitors amprenavir, indinavir, lopinavir, isovaleryl pepstatin, ritonavir and saquinavir.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	260	Curated		1

GO - Molecular functionⁱ

aspartic-type endopeptidase activity Source: UniProtKB-KW
ubiquitin binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aspartyl protease, Hydrolase, Protease

Molecular function

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A28.003

MEROPSⁱ

A28.003

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein DDI1 homolog 1 (EC:3.4.23.-By similarity)
Gene namesⁱ	Name:DDI1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170967.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18961 DDI1
neXtProtⁱ	NX_Q8WTU0

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170967
PharmGKBⁱ	PA142672003

Polymorphism and mutation databases

BioMutaⁱ	DDI1
DMDMⁱ	74730631

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287086	1 – 396	Protein DDI1 homolog 1Add BLAST		396

Proteomic databases

EPDⁱ	Q8WTU0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WTU0
PaxDbⁱ	Q8WTU0
PeptideAtlas More...PeptideAtlasⁱ	Q8WTU0
PRIDEⁱ	Q8WTU0
ProteomicsDBⁱ	74599

PTM databases

iPTMnetⁱ	Q8WTU0
PhosphoSitePlusⁱ	Q8WTU0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170967 Expressed in 16 organ(s), highest expression level in sperm
CleanExⁱ	HS_DDI1
Genevisibleⁱ	Q8WTU0 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCL28	Q9NRJ3	6	EBI-748248,EBI-7783254
CYGB	Q8WWM9	5	EBI-748248,EBI-6309037
KLHL42	Q9P2K6	5	EBI-748248,EBI-739890
UBE2K	P61086	3	EBI-748248,EBI-473850

GO - Molecular functionⁱ

ubiquitin binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	136043, 18 interactors
Database of interacting proteins More...DIPⁱ	DIP-60626N
IntActⁱ	Q8WTU0, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q8WTU0
STRINGⁱ	9606.ENSP00000302805

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	245 – 250	Combined sources	6
Beta strandⁱ	253 – 259	Combined sources	7
Beta strandⁱ	267 – 269	Combined sources	3
Helixⁱ	270 – 275	Combined sources	6
Helixⁱ	279 – 281	Combined sources	3
Helixⁱ	284 – 286	Combined sources	3
Beta strandⁱ	297 – 309	Combined sources	13
Beta strandⁱ	312 – 321	Combined sources	10
Beta strandⁱ	325 – 330	Combined sources	6
Helixⁱ	332 – 337	Combined sources	6
Beta strandⁱ	341 – 343	Combined sources	3
Turnⁱ	344 – 347	Combined sources	4
Beta strandⁱ	348 – 350	Combined sources	3
Turnⁱ	352 – 354	Combined sources	3
Beta strandⁱ	357 – 359	Combined sources	3
Helixⁱ	363 – 365	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8WTU0
SMRⁱ	Q8WTU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 81	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST		81

Sequence similaritiesⁱ

Belongs to the DDI1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0012 Eukaryota ENOG410XPA0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047125
HOGENOMⁱ	HOG000234736
HOVERGENⁱ	HBG058638
InParanoidⁱ	Q8WTU0
KEGG Orthology (KO) More...KOⁱ	K11885
OMAⁱ	ITVYCVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CIP
PhylomeDBⁱ	Q8WTU0
TreeFamⁱ	TF333421

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01796 DDI1_N, 1 hit cd05479 RP_DDI, 1 hit
Gene3Dⁱ	2.40.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR033322 DDI1 IPR033882 DDI1_N IPR019103 Peptidase_aspartic_DDI1-type IPR021109 Peptidase_aspartic_dom_sf IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
PANTHERⁱ	PTHR12917 PTHR12917, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09668 Asp_protease, 1 hit PF00240 ubiquitin, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF50630 SSF50630, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WTU0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM 
        60         70         80         90        100
ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA 
       110        120        130        140        150
VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML 
       160        170        180        190        200
LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL 
       210        220        230        240        250
YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV 
       260        270        280        290        300
NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG 
       310        320        330        340        350
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV 
       360        370        380        390 
IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH

Length:396

Mass (Da):44,124

Last modified:March 1, 2002 - v1

Checksum:ⁱ1127CBF7ED3C705D

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	153	N → K in AAP97303 (Ref. 2) Curated	1
Sequence conflictⁱ	164	N → K in AAP97303 (Ref. 2) Curated	1
Sequence conflictⁱ	170	A → T in AAP97303 (Ref. 2) Curated	1
Sequence conflictⁱ	213	K → R in AAP97303 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032259	136	G → S. Corresponds to variant dbSNP:rs7102675Ensembl.	1
Natural variantⁱVAR_032260	142	S → G1 PublicationCorresponds to variant dbSNP:rs17856633Ensembl.	1
Natural variantⁱVAR_032261	239	G → E1 PublicationCorresponds to variant dbSNP:rs17851870Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093336 mRNA Translation: BAC04135.1 AF429972 mRNA Translation: AAP97303.1 BC021172 mRNA Translation: AAH21172.2 BC021710 mRNA Translation: AAH21710.1 BC022017 mRNA Translation: AAH22017.1 BC022018 mRNA Translation: AAH22018.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31660.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001001711.1, NM_001001711.2
UniGeneⁱ	Hs.591941

Genome annotation databases

Ensemblⁱ	ENST00000302259; ENSP00000302805; ENSG00000170967
GeneIDⁱ	414301
KEGGⁱ	hsa:414301
UCSC genome browser More...UCSCⁱ	uc001phr.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8WTU0	Protein DDI1 homolog 1		MACFA		396	UniRef90_Q8WTU0
Uncharacterized protein		PAPAN		397
Uncharacterized protein		MACNE		396
Uncharacterized protein		COLAP		396
DDI1 isoform 1		PONAB		396
+17

Protein	Similar proteins		Species	Score	Length	Source
Q8WTU0	Protein DDI1 homolog 2	)	HUMAN		399	UniRef50_Q5TDH0
Protein DDI1 homolog 2		MOUSE		399
Protein DDI1 homolog 2		DANRE		411
Protein DDI1 homolog 1		MACFA		396
DDI2 isoform 1		PANTR		399
+308

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093336 mRNA Translation: BAC04135.1 AF429972 mRNA Translation: AAP97303.1 BC021172 mRNA Translation: AAH21172.2 BC021710 mRNA Translation: AAH21710.1 BC022017 mRNA Translation: AAH22017.1 BC022018 mRNA Translation: AAH22018.1
CCDSⁱ	CCDS31660.1
RefSeqⁱ	NP_001001711.1, NM_001001711.2
UniGeneⁱ	Hs.591941

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S8I	X-ray	1.70	A/B	239-367	[»]
ProteinModelPortalⁱ	Q8WTU0
SMRⁱ	Q8WTU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	136043, 18 interactors
DIPⁱ	DIP-60626N
IntActⁱ	Q8WTU0, 18 interactors
MINTⁱ	Q8WTU0
STRINGⁱ	9606.ENSP00000302805

Protein family/group databases

MEROPSⁱ	A28.003

MEROPSⁱ

A28.003

PTM databases

iPTMnetⁱ	Q8WTU0
PhosphoSitePlusⁱ	Q8WTU0

Polymorphism and mutation databases

BioMutaⁱ	DDI1
DMDMⁱ	74730631

Proteomic databases

EPDⁱ	Q8WTU0
MaxQBⁱ	Q8WTU0
PaxDbⁱ	Q8WTU0
PeptideAtlasⁱ	Q8WTU0
PRIDEⁱ	Q8WTU0
ProteomicsDBⁱ	74599

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	414301
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302259; ENSP00000302805; ENSG00000170967
GeneIDⁱ	414301
KEGGⁱ	hsa:414301
UCSCⁱ	uc001phr.3 human

Organism-specific databases

CTDⁱ	414301
EuPathDBⁱ	HostDB:ENSG00000170967.4
GeneCardsⁱ	DDI1
HGNCⁱ	HGNC:18961 DDI1
neXtProtⁱ	NX_Q8WTU0
OpenTargetsⁱ	ENSG00000170967
PharmGKBⁱ	PA142672003
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0012 Eukaryota ENOG410XPA0 LUCA
GeneTreeⁱ	ENSGT00510000047125
HOGENOMⁱ	HOG000234736
HOVERGENⁱ	HBG058638
InParanoidⁱ	Q8WTU0
KOⁱ	K11885
OMAⁱ	ITVYCVR
OrthoDBⁱ	EOG091G0CIP
PhylomeDBⁱ	Q8WTU0
TreeFamⁱ	TF333421

Miscellaneous databases

GenomeRNAiⁱ	414301
Protein Ontology More...PROⁱ	PR:Q8WTU0

Gene expression databases

Bgeeⁱ	ENSG00000170967 Expressed in 16 organ(s), highest expression level in sperm
CleanExⁱ	HS_DDI1
Genevisibleⁱ	Q8WTU0 HS

Family and domain databases

CDDⁱ	cd01796 DDI1_N, 1 hit cd05479 RP_DDI, 1 hit
Gene3Dⁱ	2.40.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR033322 DDI1 IPR033882 DDI1_N IPR019103 Peptidase_aspartic_DDI1-type IPR021109 Peptidase_aspartic_dom_sf IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
PANTHERⁱ	PTHR12917 PTHR12917, 1 hit
Pfamⁱ	View protein in Pfam PF09668 Asp_protease, 1 hit PF00240 ubiquitin, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF50630 SSF50630, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DDI1_HUMAN
Accessionⁱ	Q8WTU0Primary (citable) accession number: Q8WTU0 Secondary accession number(s): Q7Z4U6, Q8WTS3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q8WTU0 (DDI1_HUMAN)

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Protein DDI1 homolog 1

DDI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ