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Protein

Protein DDI1 homolog 1

Gene

DDI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable aspartic protease.1 Publication

Activity regulationi

Inhibited by the proteinase inhibitors amprenavir, indinavir, lopinavir, isovaleryl pepstatin, ritonavir and saquinavir.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei260Curated1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA28.003

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DDI1 homolog 1 (EC:3.4.23.-By similarity)
Gene namesi
Name:DDI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170967.4
HGNCiHGNC:18961 DDI1
neXtProtiNX_Q8WTU0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170967
PharmGKBiPA142672003

Polymorphism and mutation databases

BioMutaiDDI1
DMDMi74730631

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870861 – 396Protein DDI1 homolog 1Add BLAST396

Proteomic databases

EPDiQ8WTU0
MaxQBiQ8WTU0
PaxDbiQ8WTU0
PeptideAtlasiQ8WTU0
PRIDEiQ8WTU0
ProteomicsDBi74599

PTM databases

iPTMnetiQ8WTU0
PhosphoSitePlusiQ8WTU0

Expressioni

Gene expression databases

BgeeiENSG00000170967 Expressed in 16 organ(s), highest expression level in sperm
CleanExiHS_DDI1
GenevisibleiQ8WTU0 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136043, 18 interactors
DIPiDIP-60626N
IntActiQ8WTU0, 18 interactors
MINTiQ8WTU0
STRINGi9606.ENSP00000302805

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WTU0
SMRiQ8WTU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the DDI1 family.Curated

Phylogenomic databases

eggNOGiKOG0012 Eukaryota
ENOG410XPA0 LUCA
GeneTreeiENSGT00510000047125
HOGENOMiHOG000234736
HOVERGENiHBG058638
InParanoidiQ8WTU0
KOiK11885
OMAiITVYCVR
OrthoDBiEOG091G0CIP
PhylomeDBiQ8WTU0
TreeFamiTF333421

Family and domain databases

CDDicd01796 DDI1_N, 1 hit
cd05479 RP_DDI, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR033322 DDI1
IPR033882 DDI1_N
IPR019103 Peptidase_aspartic_DDI1-type
IPR021109 Peptidase_aspartic_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12917 PTHR12917, 1 hit
PfamiView protein in Pfam
PF09668 Asp_protease, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WTU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM
60 70 80 90 100
ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA
110 120 130 140 150
VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML
160 170 180 190 200
LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL
210 220 230 240 250
YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV
260 270 280 290 300
NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG
310 320 330 340 350
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV
360 370 380 390
IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH
Length:396
Mass (Da):44,124
Last modified:March 1, 2002 - v1
Checksum:i1127CBF7ED3C705D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153N → K in AAP97303 (Ref. 2) Curated1
Sequence conflicti164N → K in AAP97303 (Ref. 2) Curated1
Sequence conflicti170A → T in AAP97303 (Ref. 2) Curated1
Sequence conflicti213K → R in AAP97303 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032259136G → S. Corresponds to variant dbSNP:rs7102675Ensembl.1
Natural variantiVAR_032260142S → G1 PublicationCorresponds to variant dbSNP:rs17856633Ensembl.1
Natural variantiVAR_032261239G → E1 PublicationCorresponds to variant dbSNP:rs17851870Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093336 mRNA Translation: BAC04135.1
AF429972 mRNA Translation: AAP97303.1
BC021172 mRNA Translation: AAH21172.2
BC021710 mRNA Translation: AAH21710.1
BC022017 mRNA Translation: AAH22017.1
BC022018 mRNA Translation: AAH22018.1
CCDSiCCDS31660.1
RefSeqiNP_001001711.1, NM_001001711.2
UniGeneiHs.591941

Genome annotation databases

EnsembliENST00000302259; ENSP00000302805; ENSG00000170967
GeneIDi414301
KEGGihsa:414301
UCSCiuc001phr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093336 mRNA Translation: BAC04135.1
AF429972 mRNA Translation: AAP97303.1
BC021172 mRNA Translation: AAH21172.2
BC021710 mRNA Translation: AAH21710.1
BC022017 mRNA Translation: AAH22017.1
BC022018 mRNA Translation: AAH22018.1
CCDSiCCDS31660.1
RefSeqiNP_001001711.1, NM_001001711.2
UniGeneiHs.591941

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S8IX-ray1.70A/B239-367[»]
ProteinModelPortaliQ8WTU0
SMRiQ8WTU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136043, 18 interactors
DIPiDIP-60626N
IntActiQ8WTU0, 18 interactors
MINTiQ8WTU0
STRINGi9606.ENSP00000302805

Protein family/group databases

MEROPSiA28.003

PTM databases

iPTMnetiQ8WTU0
PhosphoSitePlusiQ8WTU0

Polymorphism and mutation databases

BioMutaiDDI1
DMDMi74730631

Proteomic databases

EPDiQ8WTU0
MaxQBiQ8WTU0
PaxDbiQ8WTU0
PeptideAtlasiQ8WTU0
PRIDEiQ8WTU0
ProteomicsDBi74599

Protocols and materials databases

DNASUi414301
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302259; ENSP00000302805; ENSG00000170967
GeneIDi414301
KEGGihsa:414301
UCSCiuc001phr.3 human

Organism-specific databases

CTDi414301
EuPathDBiHostDB:ENSG00000170967.4
GeneCardsiDDI1
HGNCiHGNC:18961 DDI1
neXtProtiNX_Q8WTU0
OpenTargetsiENSG00000170967
PharmGKBiPA142672003
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0012 Eukaryota
ENOG410XPA0 LUCA
GeneTreeiENSGT00510000047125
HOGENOMiHOG000234736
HOVERGENiHBG058638
InParanoidiQ8WTU0
KOiK11885
OMAiITVYCVR
OrthoDBiEOG091G0CIP
PhylomeDBiQ8WTU0
TreeFamiTF333421

Miscellaneous databases

GenomeRNAii414301
PROiPR:Q8WTU0

Gene expression databases

BgeeiENSG00000170967 Expressed in 16 organ(s), highest expression level in sperm
CleanExiHS_DDI1
GenevisibleiQ8WTU0 HS

Family and domain databases

CDDicd01796 DDI1_N, 1 hit
cd05479 RP_DDI, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR033322 DDI1
IPR033882 DDI1_N
IPR019103 Peptidase_aspartic_DDI1-type
IPR021109 Peptidase_aspartic_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12917 PTHR12917, 1 hit
PfamiView protein in Pfam
PF09668 Asp_protease, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WTU0
Secondary accession number(s): Q7Z4U6, Q8WTS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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