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Protein

C-type lectin domain family 4 member C

Gene

CLEC4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139CarbohydrateCombined sources1 Publication1
Metal bindingi172CalciumCombined sources1 Publication1
Metal bindingi174CalciumCombined sources1 Publication1
Metal bindingi178CalciumCombined sources1 Publication1
Binding sitei178CarbohydrateCombined sources1 Publication1
Metal bindingi194CalciumCombined sources1 Publication1
Binding sitei194CarbohydrateCombined sources1 Publication1
Metal bindingi195CalciumCombined sources1 Publication1
Binding sitei202CarbohydrateCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity, Innate immunity
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5621480 Dectin-2 family
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI63.002
UniLectiniQ8WTT0

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member C
Alternative name(s):
Blood dendritic cell antigen 2
Short name:
BDCA-2
C-type lectin superfamily member 7
Dendritic lectin
CD_antigen: CD303
Gene namesi
Name:CLEC4C
Synonyms:BDCA2, CLECSF11, CLECSF7, DLEC, HECL
ORF Names:UNQ9361/PRO34150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198178.10
HGNCiHGNC:13258 CLEC4C
MIMi606677 gene
neXtProtiNX_Q8WTT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini45 – 213ExtracellularSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139S → A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man. 1 Publication1
Mutagenesisi184N → A: Abolishes carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man. 1 Publication1
Mutagenesisi186R → A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man. 1 Publication1
Mutagenesisi200V → A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man. 1 Publication1
Mutagenesisi202Q → A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man. 1 Publication1

Organism-specific databases

DisGeNETi170482
OpenTargetsiENSG00000198178
PharmGKBiPA26585

Chemistry databases

ChEMBLiCHEMBL2176855

Polymorphism and mutation databases

BioMutaiCLEC4C
DMDMi59797957

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466151 – 213C-type lectin domain family 4 member CAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 82Combined sources1 Publication
Disulfide bondi83 ↔ 94PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 206PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 198PROSITE-ProRule annotationCombined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTT0
PeptideAtlasiQ8WTT0
PRIDEiQ8WTT0
ProteomicsDBi74596
74597 [Q8WTT0-2]

Expressioni

Tissue specificityi

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.3 Publications

Gene expression databases

BgeeiENSG00000198178 Expressed in 36 organ(s), highest expression level in leukocyte
CleanExiHS_CLEC4C
ExpressionAtlasiQ8WTT0 baseline and differential
GenevisibleiQ8WTT0 HS

Organism-specific databases

HPAiHPA029432

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi128012, 10 interactors
DIPiDIP-29513N
IntActiQ8WTT0, 4 interactors
STRINGi9606.ENSP00000353500

Chemistry databases

BindingDBiQ8WTT0

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WTT0
SMRiQ8WTT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 207C-type lectinPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 186Carbohydrate bindingCombined sources1 Publication3
Regioni194 – 195Carbohydrate bindingCombined sources1 Publication2

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS2V Eukaryota
ENOG410ZBWX LUCA
GeneTreeiENSGT00930000150891
HOGENOMiHOG000059556
HOVERGENiHBG050992
InParanoidiQ8WTT0
KOiK06723
OMAiWTKSQKN
OrthoDBiEOG091G0HG1
PhylomeDBiQ8WTT0
TreeFamiTF333341

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WTT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK
60 70 80 90 100
TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG
110 120 130 140 150
MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR
160 170 180 190 200
RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV
210
PQKSICKMKK IYI
Length:213
Mass (Da):25,038
Last modified:March 1, 2002 - v1
Checksum:i5DC82C95BE2378C1
GO
Isoform 2 (identifier: Q8WTT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-41: Missing.

Show »
Length:182
Mass (Da):21,498
Checksum:i78EB4E4E0109E4E7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGB2H0YGB2_HUMAN
C-type lectin domain family 4 membe...
CLEC4C
138Annotation score:
H0YFH6H0YFH6_HUMAN
C-type lectin domain family 4 membe...
CLEC4C
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66P → S in AAQ88590 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01284511 – 41Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325459 mRNA Translation: AAL37358.1
AF325460 mRNA Translation: AAL37359.1
AF293615 mRNA Translation: AAL37036.1
AY358223 mRNA Translation: AAQ88590.1
CH471116 Genomic DNA Translation: EAW88655.1
CH471116 Genomic DNA Translation: EAW88656.1
BC074967 mRNA Translation: AAH74967.1
BC074968 mRNA Translation: AAH74968.1
BC102015 mRNA Translation: AAI02016.1
BC102016 mRNA Translation: AAI02017.1
BC102017 mRNA Translation: AAI02018.1
BC114338 mRNA Translation: AAI14339.1
CCDSiCCDS8583.1 [Q8WTT0-1]
CCDS8584.1 [Q8WTT0-2]
RefSeqiNP_569708.1, NM_130441.2 [Q8WTT0-1]
NP_987099.1, NM_203503.1 [Q8WTT0-2]
UniGeneiHs.351812

Genome annotation databases

EnsembliENST00000354629; ENSP00000346648; ENSG00000198178 [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178 [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178 [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178 [Q8WTT0-1]
GeneIDi170482
KEGGihsa:170482
UCSCiuc001qtg.2 human [Q8WTT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

BDCA-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325459 mRNA Translation: AAL37358.1
AF325460 mRNA Translation: AAL37359.1
AF293615 mRNA Translation: AAL37036.1
AY358223 mRNA Translation: AAQ88590.1
CH471116 Genomic DNA Translation: EAW88655.1
CH471116 Genomic DNA Translation: EAW88656.1
BC074967 mRNA Translation: AAH74967.1
BC074968 mRNA Translation: AAH74968.1
BC102015 mRNA Translation: AAI02016.1
BC102016 mRNA Translation: AAI02017.1
BC102017 mRNA Translation: AAI02018.1
BC114338 mRNA Translation: AAI14339.1
CCDSiCCDS8583.1 [Q8WTT0-1]
CCDS8584.1 [Q8WTT0-2]
RefSeqiNP_569708.1, NM_130441.2 [Q8WTT0-1]
NP_987099.1, NM_203503.1 [Q8WTT0-2]
UniGeneiHs.351812

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WBPX-ray1.80A/B83-210[»]
3WBQX-ray2.30A/B83-210[»]
3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
4ZESX-ray1.65A/B67-213[»]
4ZETX-ray2.90A/B67-213[»]
ProteinModelPortaliQ8WTT0
SMRiQ8WTT0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128012, 10 interactors
DIPiDIP-29513N
IntActiQ8WTT0, 4 interactors
STRINGi9606.ENSP00000353500

Chemistry databases

BindingDBiQ8WTT0
ChEMBLiCHEMBL2176855

Protein family/group databases

MEROPSiI63.002
UniLectiniQ8WTT0

Polymorphism and mutation databases

BioMutaiCLEC4C
DMDMi59797957

Proteomic databases

PaxDbiQ8WTT0
PeptideAtlasiQ8WTT0
PRIDEiQ8WTT0
ProteomicsDBi74596
74597 [Q8WTT0-2]

Protocols and materials databases

DNASUi170482
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354629; ENSP00000346648; ENSG00000198178 [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178 [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178 [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178 [Q8WTT0-1]
GeneIDi170482
KEGGihsa:170482
UCSCiuc001qtg.2 human [Q8WTT0-1]

Organism-specific databases

CTDi170482
DisGeNETi170482
EuPathDBiHostDB:ENSG00000198178.10
GeneCardsiCLEC4C
HGNCiHGNC:13258 CLEC4C
HPAiHPA029432
MIMi606677 gene
neXtProtiNX_Q8WTT0
OpenTargetsiENSG00000198178
PharmGKBiPA26585
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS2V Eukaryota
ENOG410ZBWX LUCA
GeneTreeiENSGT00930000150891
HOGENOMiHOG000059556
HOVERGENiHBG050992
InParanoidiQ8WTT0
KOiK06723
OMAiWTKSQKN
OrthoDBiEOG091G0HG1
PhylomeDBiQ8WTT0
TreeFamiTF333341

Enzyme and pathway databases

ReactomeiR-HSA-5621480 Dectin-2 family
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAii170482
PROiPR:Q8WTT0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198178 Expressed in 36 organ(s), highest expression level in leukocyte
CleanExiHS_CLEC4C
ExpressionAtlasiQ8WTT0 baseline and differential
GenevisibleiQ8WTT0 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4C_HUMAN
AccessioniPrimary (citable) accession number: Q8WTT0
Secondary accession number(s): D3DUU3
, Q3T1C3, Q6UXS8, Q8WXX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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