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Entry version 185 (25 May 2022)
Sequence version 1 (01 Mar 2002)
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Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

6 Publications

Miscellaneous

Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=29 µM for histone H31 Publication
  2. KM=12 µM for TAF101 Publication
  3. KM=69 µM for p53/TP531 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei245Substrate1
Binding sitei317Substrate1
Binding sitei335Substrate; via carbonyl oxygen1
Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.364, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8WTS6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214841, PKMTs methylate histone lysines

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q8WTS6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8WTS6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD7 (EC:2.1.1.364PROSITE-ProRule annotation1 Publication)
Alternative name(s):
Histone H3-K4 methyltransferase SETD7
Short name:
H3-K4-HMTase SETD7
Lysine N-methyltransferase 7
SET domain-containing protein 7
SET7/9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD7
Synonyms:KIAA1717, KMT7, SET7, SET9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30412, SETD7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606594, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTS6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145391

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi220E → A: Increases near-attack conformations. 1 Publication1
Mutagenesisi228E → A: Increases near-attack conformations. 1 Publication1
Mutagenesisi245Y → A: Significantly reduces the monomethyltransferase activity but increases the dimethyltransferase activity. 2 Publications1
Mutagenesisi294K → A: Significantly reduces the catalytic activity. 1 Publication1
Mutagenesisi297H → A or G: Abolishes methyltransferase activity. 5 Publications1
Mutagenesisi317K → A: Induces a reduction in methyltransferase activity toward TAF10 but an increased methyltransferase activity for H3 and p53/TP53. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
80854

Open Targets

More...
OpenTargetsi
ENSG00000145391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WTS6, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5523

Drug and drug target database

More...
DrugBanki
DB01752, S-adenosyl-L-homocysteine

DrugCentral

More...
DrugCentrali
Q8WTS6

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2703

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SETD7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25091217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860541 – 366Histone-lysine N-methyltransferase SETD7Add BLAST366

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WTS6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WTS6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8WTS6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WTS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WTS6

PeptideAtlas

More...
PeptideAtlasi
Q8WTS6

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTS6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74595

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8WTS6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WTS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WTS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in pancreatic islets.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145391, Expressed in quadriceps femoris and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WTS6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTS6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145391, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IPF1/PDX-1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123332, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WTS6

Database of interacting proteins

More...
DIPi
DIP-29045N

Protein interaction database and analysis system

More...
IntActi
Q8WTS6, 39 interactors

Molecular INTeraction database

More...
MINTi
Q8WTS6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274031

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8WTS6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8WTS6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q8WTS6

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q8WTS6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WTS6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8WTS6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 58MORN 1Add BLAST23
Repeati59 – 81MORN 2Add BLAST23
Repeati106 – 128MORN 3Add BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 336SETPROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni226 – 228S-adenosyl-L-methionine binding3
Regioni256 – 258Substrate binding3
Regioni266 – 268Substrate binding3
Regioni296 – 297S-adenosyl-L-methionine binding2

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SET domain is necessary but not sufficient for histone methyltransferase activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1079, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004827

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_803117_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTS6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGIRITH

Database of Orthologous Groups

More...
OrthoDBi
675418at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTS6

TreeFam database of animal gene trees

More...
TreeFami
TF106392

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10530, SET_SETD7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.270.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID00128

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017155, Hist-Lys_N-MeTrfase_SET
IPR003409, MORN
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR044436, SETD7_SET

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02493, MORN, 4 hits
PF00856, SET, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037249, Histone_Lys_mtfrase_SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82199, SSF82199, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51577, SAM_MT43_SET7, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8WTS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
60 70 80 90 100
FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
110 120 130 140 150
DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD
160 170 180 190 200
ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC
210 220 230 240 250
ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI
260 270 280 290 300
THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
310 320 330 340 350
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP
360
EWYQVELKAF QATQQK
Length:366
Mass (Da):40,721
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73A1217079E3BA13
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJA0D6RJA0_HUMAN
[Histone H3]-lysine(4) N-methyltran...
SETD7
362Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCZ8B5MCZ8_HUMAN
Histone-lysine N-methyltransferase ...
SETD7
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYG1V9GYG1_HUMAN
Histone-lysine N-methyltransferase ...
SETD7
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY19V9GY19_HUMAN
Histone-lysine N-methyltransferase ...
SETD7
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21808 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF448510 mRNA Translation: AAL56579.1
AF462150 mRNA Translation: AAL69901.1
AB051504 mRNA Translation: BAB21808.1 Different initiation.
AC112236 Genomic DNA No translation available.
AC114743 Genomic DNA Translation: AAY40937.1
BC121055 mRNA Translation: AAI21056.1
BC121056 mRNA Translation: AAI21057.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3748.1

NCBI Reference Sequences

More...
RefSeqi
NP_001293128.1, NM_001306199.1
NP_085151.1, NM_030648.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274031.8; ENSP00000274031.3; ENSG00000145391.14

Database of genes from NCBI RefSeq genomes

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GeneIDi
80854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80854

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000274031.8; ENSP00000274031.3; NM_030648.4; NP_085151.1

UCSC genome browser

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UCSCi
uc003ihw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448510 mRNA Translation: AAL56579.1
AF462150 mRNA Translation: AAL69901.1
AB051504 mRNA Translation: BAB21808.1 Different initiation.
AC112236 Genomic DNA No translation available.
AC114743 Genomic DNA Translation: AAY40937.1
BC121055 mRNA Translation: AAI21056.1
BC121056 mRNA Translation: AAI21057.1
CCDSiCCDS3748.1
RefSeqiNP_001293128.1, NM_001306199.1
NP_085151.1, NM_030648.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H3IX-ray2.10A/B52-344[»]
1MT6X-ray2.20A58-337[»]
1MUFX-ray2.26A81-337[»]
1N6AX-ray1.70A108-366[»]
1N6CX-ray2.30A70-366[»]
1O9SX-ray1.75A/B108-366[»]
1XQHX-ray1.75A/E108-366[»]
2F69X-ray1.30A110-366[»]
3CBMX-ray1.69A111-366[»]
3CBOX-ray1.65A111-366[»]
3CBPX-ray1.42A111-366[»]
3M53X-ray1.85A110-366[»]
3M54X-ray1.60A110-366[»]
3M55X-ray1.55A110-366[»]
3M56X-ray1.65A110-366[»]
3M57X-ray1.70A110-366[»]
3M58X-ray1.40A110-366[»]
3M59X-ray1.70A110-366[»]
3M5AX-ray1.75A110-366[»]
3OS5X-ray1.69A111-366[»]
3VUZX-ray2.50A111-366[»]
3VV0X-ray2.00A111-366[»]
4E47X-ray2.00A/B/C/D109-366[»]
4J7FX-ray1.59A110-366[»]
4J7IX-ray2.56A110-366[»]
4J83X-ray1.70A110-366[»]
4J8OX-ray1.63A110-366[»]
4JDSX-ray1.70A/B/C/D109-366[»]
4JLGX-ray1.90A/B109-366[»]
5AYFX-ray2.00A111-366[»]
5EG2X-ray1.55A110-366[»]
5YLTX-ray1.69A111-366[»]
AlphaFoldDBiQ8WTS6
BMRBiQ8WTS6
SMRiQ8WTS6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123332, 70 interactors
CORUMiQ8WTS6
DIPiDIP-29045N
IntActiQ8WTS6, 39 interactors
MINTiQ8WTS6
STRINGi9606.ENSP00000274031

Chemistry databases

BindingDBiQ8WTS6
ChEMBLiCHEMBL5523
DrugBankiDB01752, S-adenosyl-L-homocysteine
DrugCentraliQ8WTS6
GuidetoPHARMACOLOGYi2703

PTM databases

GlyGeniQ8WTS6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8WTS6
PhosphoSitePlusiQ8WTS6

Genetic variation databases

BioMutaiSETD7
DMDMi25091217

Proteomic databases

EPDiQ8WTS6
jPOSTiQ8WTS6
MassIVEiQ8WTS6
MaxQBiQ8WTS6
PaxDbiQ8WTS6
PeptideAtlasiQ8WTS6
PRIDEiQ8WTS6
ProteomicsDBi74595

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8WTS6, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
16193, 529 antibodies from 40 providers

The DNASU plasmid repository

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DNASUi
80854

Genome annotation databases

EnsembliENST00000274031.8; ENSP00000274031.3; ENSG00000145391.14
GeneIDi80854
KEGGihsa:80854
MANE-SelectiENST00000274031.8; ENSP00000274031.3; NM_030648.4; NP_085151.1
UCSCiuc003ihw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80854
DisGeNETi80854

GeneCards: human genes, protein and diseases

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GeneCardsi
SETD7
HGNCiHGNC:30412, SETD7
HPAiENSG00000145391, Low tissue specificity
MIMi606594, gene
neXtProtiNX_Q8WTS6
OpenTargetsiENSG00000145391
PharmGKBiPA143485615
VEuPathDBiHostDB:ENSG00000145391

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1079, Eukaryota
GeneTreeiENSGT00390000004827
HOGENOMiCLU_803117_0_0_1
InParanoidiQ8WTS6
OMAiNGIRITH
OrthoDBi675418at2759
PhylomeDBiQ8WTS6
TreeFamiTF106392

Enzyme and pathway databases

BRENDAi2.1.1.364, 2681
PathwayCommonsiQ8WTS6
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines
SABIO-RKiQ8WTS6
SignaLinkiQ8WTS6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80854, 19 hits in 1097 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SETD7, human
EvolutionaryTraceiQ8WTS6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SETD7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80854
PharosiQ8WTS6, Tchem

Protein Ontology

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PROi
PR:Q8WTS6
RNActiQ8WTS6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145391, Expressed in quadriceps femoris and 225 other tissues
ExpressionAtlasiQ8WTS6, baseline and differential
GenevisibleiQ8WTS6, HS

Family and domain databases

CDDicd10530, SET_SETD7, 1 hit
Gene3Di2.170.270.10, 1 hit
IDEALiIID00128
InterProiView protein in InterPro
IPR017155, Hist-Lys_N-MeTrfase_SET
IPR003409, MORN
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR044436, SETD7_SET
PfamiView protein in Pfam
PF02493, MORN, 4 hits
PF00856, SET, 1 hit
PIRSFiPIRSF037249, Histone_Lys_mtfrase_SET, 1 hit
SMARTiView protein in SMART
SM00317, SET, 1 hit
SUPFAMiSSF82199, SSF82199, 1 hit
PROSITEiView protein in PROSITE
PS51577, SAM_MT43_SET7, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTS6
Secondary accession number(s): B5WWL3
, Q0VAH3, Q4W5A9, Q9C0E6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: May 25, 2022
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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