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Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.6 Publications

Miscellaneous

Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=29 µM for histone H31 Publication
  2. KM=12 µM for TAF101 Publication
  3. KM=69 µM for p53/TP531 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei245Substrate1
    Binding sitei317Substrate1
    Binding sitei335Substrate; via carbonyl oxygen1
    Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation2 Publications1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • chromatin binding Source: Ensembl
    • histone-lysine N-methyltransferase activity Source: UniProtKB
    • p53 binding Source: UniProtKB
    • protein-lysine N-methyltransferase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionActivator, Chromatin regulator, Methyltransferase, Transferase
    Biological processTranscription, Transcription regulation
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.1.43 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-3214841 PKMTs methylate histone lysines

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q8WTS6

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD7 (EC:2.1.1.43)
    Alternative name(s):
    Histone H3-K4 methyltransferase SETD7
    Short name:
    H3-K4-HMTase SETD7
    Lysine N-methyltransferase 7
    SET domain-containing protein 7
    SET7/9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SETD7
    Synonyms:KIAA1717, KMT7, SET7, SET9
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000145391.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30412 SETD7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606594 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8WTS6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi220E → A: Increases near-attack conformations. 1 Publication1
    Mutagenesisi228E → A: Increases near-attack conformations. 1 Publication1
    Mutagenesisi245Y → A: Significantly reduces the monomethyltransferase activity but increases the dimethyltransferase activity. 2 Publications1
    Mutagenesisi294K → A: Significantly reduces the catalytic activity. 1 Publication1
    Mutagenesisi297H → A or G: Abolishes methyltransferase activity. 5 Publications1
    Mutagenesisi317K → A: Induces a reduction in methyltransferase activity toward TAF10 but an increased methyltransferase activity for H3 and p53/TP53. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    80854

    Open Targets

    More...
    OpenTargetsi
    ENSG00000145391

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA143485615

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5523

    Drug and drug target database

    More...
    DrugBanki
    DB01752 S-Adenosyl-L-Homocysteine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2703

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SETD7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    25091217

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860541 – 366Histone-lysine N-methyltransferase SETD7Add BLAST366

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8WTS6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8WTS6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8WTS6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8WTS6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8WTS6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    74595

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8WTS6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8WTS6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed in pancreatic islets.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000145391 Expressed in 209 organ(s), highest expression level in quadriceps femoris

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_SETD7

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8WTS6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8WTS6 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA058111

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with IPF1/PDX-1.3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123332, 45 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q8WTS6

    Database of interacting proteins

    More...
    DIPi
    DIP-29045N

    Protein interaction database and analysis system

    More...
    IntActi
    Q8WTS6, 21 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q8WTS6

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000274031

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q8WTS6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1366
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q8WTS6

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8WTS6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q8WTS6

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 58MORN 1Add BLAST23
    Repeati59 – 81MORN 2Add BLAST23
    Repeati106 – 128MORN 3Add BLAST23
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 336SETPROSITE-ProRule annotationAdd BLAST123

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni226 – 228S-adenosyl-L-methionine binding3
    Regioni256 – 258Substrate binding3
    Regioni266 – 268Substrate binding3
    Regioni296 – 297S-adenosyl-L-methionine binding2

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 54Poly-Phe4

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The SET domain is necessary but not sufficient for histone methyltransferase activity.

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1079 Eukaryota
    COG2940 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000004827

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000074731

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG028309

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8WTS6

    KEGG Orthology (KO)

    More...
    KOi
    K11431

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SSVYHFD

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G08JN

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8WTS6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106392

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017155 Hist-Lys_N-MeTrfase_SET
    IPR003409 MORN
    IPR001214 SET_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02493 MORN, 4 hits
    PF00856 SET, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF037249 Histone_Lys_mtfrase_SET, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00317 SET, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51577 SAM_MT43_SET7, 1 hit
    PS50280 SET, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

    Q8WTS6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
    60 70 80 90 100
    FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
    110 120 130 140 150
    DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD
    160 170 180 190 200
    ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC
    210 220 230 240 250
    ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI
    260 270 280 290 300
    THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
    310 320 330 340 350
    PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP
    360
    EWYQVELKAF QATQQK
    Length:366
    Mass (Da):40,721
    Last modified:March 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73A1217079E3BA13
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D6RJA0D6RJA0_HUMAN
    Histone-lysine N-methyltransferase
    SETD7
    362Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B5MCZ8B5MCZ8_HUMAN
    Histone-lysine N-methyltransferase ...
    SETD7
    135Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V9GYG1V9GYG1_HUMAN
    Histone-lysine N-methyltransferase ...
    SETD7
    94Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B5MCS2B5MCS2_HUMAN
    Histone-lysine N-methyltransferase ...
    SETD7
    69Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V9GY19V9GY19_HUMAN
    Histone-lysine N-methyltransferase ...
    SETD7
    46Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB21808 differs from that shown. Reason: Erroneous initiation.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF448510 mRNA Translation: AAL56579.1
    AF462150 mRNA Translation: AAL69901.1
    AB051504 mRNA Translation: BAB21808.1 Different initiation.
    AC112236 Genomic DNA No translation available.
    AC114743 Genomic DNA Translation: AAY40937.1
    BC121055 mRNA Translation: AAI21056.1
    BC121056 mRNA Translation: AAI21057.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS3748.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001293128.1, NM_001306199.1
    NP_085151.1, NM_030648.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.480792

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000274031; ENSP00000274031; ENSG00000145391

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    80854

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:80854

    UCSC genome browser

    More...
    UCSCi
    uc003ihw.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF448510 mRNA Translation: AAL56579.1
    AF462150 mRNA Translation: AAL69901.1
    AB051504 mRNA Translation: BAB21808.1 Different initiation.
    AC112236 Genomic DNA No translation available.
    AC114743 Genomic DNA Translation: AAY40937.1
    BC121055 mRNA Translation: AAI21056.1
    BC121056 mRNA Translation: AAI21057.1
    CCDSiCCDS3748.1
    RefSeqiNP_001293128.1, NM_001306199.1
    NP_085151.1, NM_030648.3
    UniGeneiHs.480792

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1H3IX-ray2.10A/B52-344[»]
    1MT6X-ray2.20A58-337[»]
    1MUFX-ray2.26A81-337[»]
    1N6AX-ray1.70A108-366[»]
    1N6CX-ray2.30A70-366[»]
    1O9SX-ray1.75A/B108-366[»]
    1XQHX-ray1.75A/E108-366[»]
    2F69X-ray1.30A110-366[»]
    3CBMX-ray1.69A111-366[»]
    3CBOX-ray1.65A111-366[»]
    3CBPX-ray1.42A111-366[»]
    3M53X-ray1.85A110-366[»]
    3M54X-ray1.60A110-366[»]
    3M55X-ray1.55A110-366[»]
    3M56X-ray1.65A110-366[»]
    3M57X-ray1.70A110-366[»]
    3M58X-ray1.40A110-366[»]
    3M59X-ray1.70A110-366[»]
    3M5AX-ray1.75A110-366[»]
    3OS5X-ray1.69A111-366[»]
    3VUZX-ray2.50A111-366[»]
    3VV0X-ray2.00A111-366[»]
    4E47X-ray2.00A/B/C/D109-366[»]
    4J7FX-ray1.59A110-366[»]
    4J7IX-ray2.56A110-366[»]
    4J83X-ray1.70A110-366[»]
    4J8OX-ray1.63A110-366[»]
    4JDSX-ray1.70A/B/C/D109-366[»]
    4JLGX-ray1.90A/B109-366[»]
    5AYFX-ray2.00A111-366[»]
    5EG2X-ray1.55A110-366[»]
    5YLTX-ray1.69A111-366[»]
    ProteinModelPortaliQ8WTS6
    SMRiQ8WTS6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123332, 45 interactors
    CORUMiQ8WTS6
    DIPiDIP-29045N
    IntActiQ8WTS6, 21 interactors
    MINTiQ8WTS6
    STRINGi9606.ENSP00000274031

    Chemistry databases

    BindingDBiQ8WTS6
    ChEMBLiCHEMBL5523
    DrugBankiDB01752 S-Adenosyl-L-Homocysteine
    GuidetoPHARMACOLOGYi2703

    PTM databases

    iPTMnetiQ8WTS6
    PhosphoSitePlusiQ8WTS6

    Polymorphism and mutation databases

    BioMutaiSETD7
    DMDMi25091217

    Proteomic databases

    EPDiQ8WTS6
    MaxQBiQ8WTS6
    PaxDbiQ8WTS6
    PeptideAtlasiQ8WTS6
    PRIDEiQ8WTS6
    ProteomicsDBi74595

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000274031; ENSP00000274031; ENSG00000145391
    GeneIDi80854
    KEGGihsa:80854
    UCSCiuc003ihw.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    80854
    DisGeNETi80854
    EuPathDBiHostDB:ENSG00000145391.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SETD7
    HGNCiHGNC:30412 SETD7
    HPAiHPA058111
    MIMi606594 gene
    neXtProtiNX_Q8WTS6
    OpenTargetsiENSG00000145391
    PharmGKBiPA143485615

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1079 Eukaryota
    COG2940 LUCA
    GeneTreeiENSGT00390000004827
    HOGENOMiHOG000074731
    HOVERGENiHBG028309
    InParanoidiQ8WTS6
    KOiK11431
    OMAiSSVYHFD
    OrthoDBiEOG091G08JN
    PhylomeDBiQ8WTS6
    TreeFamiTF106392

    Enzyme and pathway databases

    BRENDAi2.1.1.43 2681
    ReactomeiR-HSA-3214841 PKMTs methylate histone lysines
    SABIO-RKiQ8WTS6

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SETD7 human
    EvolutionaryTraceiQ8WTS6

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SETD7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    80854

    Protein Ontology

    More...
    PROi
    PR:Q8WTS6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000145391 Expressed in 209 organ(s), highest expression level in quadriceps femoris
    CleanExiHS_SETD7
    ExpressionAtlasiQ8WTS6 baseline and differential
    GenevisibleiQ8WTS6 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR017155 Hist-Lys_N-MeTrfase_SET
    IPR003409 MORN
    IPR001214 SET_dom
    PfamiView protein in Pfam
    PF02493 MORN, 4 hits
    PF00856 SET, 1 hit
    PIRSFiPIRSF037249 Histone_Lys_mtfrase_SET, 1 hit
    SMARTiView protein in SMART
    SM00317 SET, 1 hit
    PROSITEiView protein in PROSITE
    PS51577 SAM_MT43_SET7, 1 hit
    PS50280 SET, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD7_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTS6
    Secondary accession number(s): B5WWL3
    , Q0VAH3, Q4W5A9, Q9C0E6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: March 1, 2002
    Last modified: December 5, 2018
    This is version 165 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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