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UniProtKB - Q8WTR8 (NET5_HUMAN)
Protein
Netrin-5
Gene
NTN5
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.
By similarityGO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- dendrite development Source: GO_Central
- motor neuron axon guidance Source: GO_Central
- neurogenesis Source: UniProtKB
- tissue development Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8WTR8 |
SignaLinki | Q8WTR8 |
Names & Taxonomyi
Protein namesi | Recommended name: Netrin-5Alternative name(s): Netrin-1-like protein |
Gene namesi | Name:NTN5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25208, NTN5 |
neXtProti | NX_Q8WTR8 |
VEuPathDBi | HostDB:ENSG00000142233 |
Subcellular locationi
Extracellular region or secreted
- Secreted Sequence analysis
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- basement membrane Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 126147 |
OpenTargetsi | ENSG00000142233 |
PharmGKBi | PA164724232 |
Miscellaneous databases
Pharosi | Q8WTR8, Tdark |
Genetic variation databases
BioMutai | NTN5 |
DMDMi | 74730628 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000320575 | 17 – 489 | Netrin-5Add BLAST | 473 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 157 ↔ 166 | By similarity | ||
Disulfide bondi | 159 ↔ 175 | By similarity | ||
Disulfide bondi | 177 ↔ 186 | By similarity | ||
Disulfide bondi | 189 ↔ 209 | By similarity | ||
Disulfide bondi | 212 ↔ 221 | By similarity | ||
Disulfide bondi | 214 ↔ 239 | By similarity | ||
Disulfide bondi | 242 ↔ 251 | By similarity | ||
Disulfide bondi | 254 ↔ 272 | By similarity | ||
Disulfide bondi | 275 ↔ 287 | By similarity | ||
Disulfide bondi | 277 ↔ 294 | By similarity | ||
Disulfide bondi | 296 ↔ 305 | By similarity | ||
Disulfide bondi | 308 ↔ 322 | By similarity | ||
Disulfide bondi | 345 ↔ 418 | By similarity | ||
Disulfide bondi | 349 ↔ 420 | By similarity | ||
Disulfide bondi | 364 ↔ 475 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q8WTR8 |
PaxDbi | Q8WTR8 |
PRIDEi | Q8WTR8 |
ProteomicsDBi | 74592 [Q8WTR8-1] 74593 [Q8WTR8-2] |
PTM databases
GlyGeni | Q8WTR8, 1 site |
PhosphoSitePlusi | Q8WTR8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142233, Expressed in right uterine tube and 107 other tissues |
ExpressionAtlasi | Q8WTR8, baseline and differential |
Genevisiblei | Q8WTR8, HS |
Organism-specific databases
HPAi | ENSG00000142233, Tissue enhanced (pituitary) |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 125960, 23 interactors |
STRINGi | 9606.ENSP00000270235 |
Miscellaneous databases
RNActi | Q8WTR8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 157 – 211 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 212 – 274 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 275 – 324 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 345 – 475 | NTRPROSITE-ProRule annotationAdd BLAST | 131 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 470 – 489 | DisorderedSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3512, Eukaryota |
GeneTreei | ENSGT00940000161874 |
HOGENOMi | CLU_018213_0_0_1 |
InParanoidi | Q8WTR8 |
OMAi | SCPQACA |
OrthoDBi | 858946at2759 |
PhylomeDBi | Q8WTR8 |
TreeFami | TF352481 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 2 hits |
Gene3Di | 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR002049, LE_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01248, EGF_LAM_1, 2 hits PS50027, EGF_LAM_2, 3 hits PS50189, NTR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8WTR8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS
60 70 80 90 100
PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG
110 120 130 140 150
PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA
160 170 180 190 200
AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP
210 220 230 240 250
ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH
260 270 280 290 300
CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
310 320 330 340 350
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN
360 370 380 390 400
MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ
410 420 430 440 450
PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG
460 470 480
LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QXZ9 | M0QXZ9_HUMAN | Netrin-5 | NTN5 | 75 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031667 | 342 – 350 | DPQCQNYCN → GKTVWHGGP in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_031668 | 351 – 489 | Missing in isoform 2. 1 PublicationAdd BLAST | 139 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471177 Genomic DNA Translation: EAW52386.1 CH471177 Genomic DNA Translation: EAW52387.1 BC018654 mRNA Translation: AAH18654.2 BC018697 mRNA Translation: AAH18697.2 BC021210 mRNA Translation: AAH21210.2 BC033207 mRNA Translation: AAH33207.1 |
CCDSi | CCDS33068.1 [Q8WTR8-1] |
RefSeqi | NP_665806.1, NM_145807.2 [Q8WTR8-1] |
Genome annotation databases
Ensembli | ENST00000270235.11; ENSP00000270235.4; ENSG00000142233.14 |
GeneIDi | 126147 |
KEGGi | hsa:126147 |
MANE-Selecti | ENST00000270235.11; ENSP00000270235.4; NM_145807.4; NP_665806.1 |
UCSCi | uc002pkb.3, human [Q8WTR8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471177 Genomic DNA Translation: EAW52386.1 CH471177 Genomic DNA Translation: EAW52387.1 BC018654 mRNA Translation: AAH18654.2 BC018697 mRNA Translation: AAH18697.2 BC021210 mRNA Translation: AAH21210.2 BC033207 mRNA Translation: AAH33207.1 |
CCDSi | CCDS33068.1 [Q8WTR8-1] |
RefSeqi | NP_665806.1, NM_145807.2 [Q8WTR8-1] |
3D structure databases
AlphaFoldDBi | Q8WTR8 |
SMRi | Q8WTR8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125960, 23 interactors |
STRINGi | 9606.ENSP00000270235 |
PTM databases
GlyGeni | Q8WTR8, 1 site |
PhosphoSitePlusi | Q8WTR8 |
Genetic variation databases
BioMutai | NTN5 |
DMDMi | 74730628 |
Proteomic databases
MassIVEi | Q8WTR8 |
PaxDbi | Q8WTR8 |
PRIDEi | Q8WTR8 |
ProteomicsDBi | 74592 [Q8WTR8-1] 74593 [Q8WTR8-2] |
Protocols and materials databases
Antibodypediai | 31764, 50 antibodies from 13 providers |
DNASUi | 126147 |
Genome annotation databases
Ensembli | ENST00000270235.11; ENSP00000270235.4; ENSG00000142233.14 |
GeneIDi | 126147 |
KEGGi | hsa:126147 |
MANE-Selecti | ENST00000270235.11; ENSP00000270235.4; NM_145807.4; NP_665806.1 |
UCSCi | uc002pkb.3, human [Q8WTR8-1] |
Organism-specific databases
CTDi | 126147 |
DisGeNETi | 126147 |
GeneCardsi | NTN5 |
HGNCi | HGNC:25208, NTN5 |
HPAi | ENSG00000142233, Tissue enhanced (pituitary) |
neXtProti | NX_Q8WTR8 |
OpenTargetsi | ENSG00000142233 |
PharmGKBi | PA164724232 |
VEuPathDBi | HostDB:ENSG00000142233 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3512, Eukaryota |
GeneTreei | ENSGT00940000161874 |
HOGENOMi | CLU_018213_0_0_1 |
InParanoidi | Q8WTR8 |
OMAi | SCPQACA |
OrthoDBi | 858946at2759 |
PhylomeDBi | Q8WTR8 |
TreeFami | TF352481 |
Enzyme and pathway databases
PathwayCommonsi | Q8WTR8 |
SignaLinki | Q8WTR8 |
Miscellaneous databases
BioGRID-ORCSi | 126147, 16 hits in 1067 CRISPR screens |
GenomeRNAii | 126147 |
Pharosi | Q8WTR8, Tdark |
PROi | PR:Q8WTR8 |
RNActi | Q8WTR8, protein |
Gene expression databases
Bgeei | ENSG00000142233, Expressed in right uterine tube and 107 other tissues |
ExpressionAtlasi | Q8WTR8, baseline and differential |
Genevisiblei | Q8WTR8, HS |
Family and domain databases
CDDi | cd00055, EGF_Lam, 2 hits |
Gene3Di | 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR002049, LE_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01248, EGF_LAM_1, 2 hits PS50027, EGF_LAM_2, 3 hits PS50189, NTR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NET5_HUMAN | |
Accessioni | Q8WTR8Primary (citable) accession number: Q8WTR8 Secondary accession number(s): Q8N4X9, Q8WU63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM