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Protein

Zinc finger protein 473

Gene

ZNF473

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 286C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri758 – 780C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri786 – 808C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri814 – 836C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 864C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-212436 Generic Transcription Pathway
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 473
Alternative name(s):
Zinc finger protein 100 homolog
Short name:
Zfp-100
Gene namesi
Name:ZNF473
Synonyms:KIAA1141, ZFP100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142528.15
HGNCiHGNC:23239 ZNF473
MIMi617908 gene
neXtProtiNX_Q8WTR7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25888
OpenTargetsiENSG00000142528
PharmGKBiPA134987987

Polymorphism and mutation databases

BioMutaiZNF473
DMDMi51702187

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476041 – 871Zinc finger protein 473Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki635Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8WTR7
PaxDbiQ8WTR7
PeptideAtlasiQ8WTR7
PRIDEiQ8WTR7
ProteomicsDBi74591

PTM databases

iPTMnetiQ8WTR7
PhosphoSitePlusiQ8WTR7

Expressioni

Gene expression databases

BgeeiENSG00000142528 Expressed in 167 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF473
ExpressionAtlasiQ8WTR7 baseline and differential
GenevisibleiQ8WTR7 HS

Organism-specific databases

HPAiHPA004191
HPA073309

Interactioni

Subunit structurei

Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi117398, 17 interactors
IntActiQ8WTR7, 21 interactors
STRINGi9606.ENSP00000270617

Structurei

Secondary structure

1871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WTR7
SMRiQ8WTR7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WTR7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 75KRABPROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 552Interaction with SLBP/pre-mRNA complexAdd BLAST241

Domaini

The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 286C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri758 – 780C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri786 – 808C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri814 – 836C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 864C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000130048
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8WTR7
KOiK09228
OMAiERFICSS
OrthoDBiEOG091G02KC
PhylomeDBiQ8WTR7
TreeFamiTF350932

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 20 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8WTR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEFVTLKD VGMDFTLGDW EQLGLEQGDT FWDTALDNCQ DLFLLDPPRP
60 70 80 90 100
NLTSHPDGSE DLEPLAGGSP EATSPDVTET KNSPLMEDFF EEGFSQEIIE
110 120 130 140 150
MLSKDGFWNS NFGEACIEDT WLDSLLGDPE SLLRSDIATN GESPTECKSH
160 170 180 190 200
ELKRGLSPVS TVSTGEDSMV HNVSEKTLTP AKSKEYRGEF FSYSDHSQQD
210 220 230 240 250
SVQEGEKPYQ CSECGKSFSG SYRLTQHWIT HTREKPTVHQ ECEQGFDRNA
260 270 280 290 300
SLSVYPKTHT GYKFYVCNEY GTTFSQSTYL WHQKTHTGEK PCKSQDSDHP
310 320 330 340 350
PSHDTQPGEH QKTHTDSKSY NCNECGKAFT RIFHLTRHQK IHTRKRYECS
360 370 380 390 400
KCQATFNLRK HLIQHQKTHA AKTTSECQEC GKIFRHSSLL IEHQALHAGE
410 420 430 440 450
EPYKCNERGK SFRHNSTLKI HQRVHSGEKP YKCSECGKAF HRHTHLNEHR
460 470 480 490 500
RIHTGYRPHK CQECVRSFSR PSHLMRHQAI HTAEKPYSCA ECKETFSDNN
510 520 530 540 550
RLVQHQKMHT VKTPYECQEC GERFICGSTL KCHESVHARE KQGFFVSGKI
560 570 580 590 600
LDQNPEQKEK CFKCNKCEKT FSCSKYLTQH ERIHTRGVKP FECDQCGKAF
610 620 630 640 650
GQSTRLIHHQ RIHSRVRLYK WGEQGKAISS ASLIKLQSFH TKEHPFKCNE
660 670 680 690 700
CGKTFSHSAH LSKHQLIHAG ENPFKCSKCD RVFTQRNYLV QHERTHARKK
710 720 730 740 750
PLVCNECGKT FRQSSCLSKH QRIHSGEKPY VCDYCGKAFG LSAELVRHQR
760 770 780 790 800
IHTGEKPYVC QECGKAFTQS SCLSIHRRVH TGEKPYRCGE CGKAFAQKAN
810 820 830 840 850
LTQHQRIHTG EKPYSCNVCG KAFVLSAHLN QHLRVHTQET LYQCQRCQKA
860 870
FRCHSSLSRH QRVHNKQQYC L
Length:871
Mass (Da):100,182
Last modified:March 1, 2002 - v1
Checksum:i959AFB7C3C2D5456
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEC7F8WEC7_HUMAN
Zinc finger protein 473
ZNF473
859Annotation score:
M0R032M0R032_HUMAN
Zinc finger protein 473
ZNF473
74Annotation score:
M0R123M0R123_HUMAN
Zinc finger protein 473
ZNF473
77Annotation score:
M0QZY7M0QZY7_HUMAN
Zinc finger protein 473
ZNF473
102Annotation score:
M0R2N2M0R2N2_HUMAN
Zinc finger protein 473
ZNF473
64Annotation score:

Sequence cautioni

The sequence BAA86455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486P → A (PubMed:17974005).Curated1
Sequence conflicti588V → M in BAA86455 (PubMed:10574461).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05283959S → G. Corresponds to variant dbSNP:rs10419876Ensembl.1
Natural variantiVAR_05284074S → G. Corresponds to variant dbSNP:rs10419911Ensembl.1
Natural variantiVAR_052841164T → M. Corresponds to variant dbSNP:rs16981705Ensembl.1
Natural variantiVAR_052842309E → G. Corresponds to variant dbSNP:rs16981706Ensembl.1
Natural variantiVAR_052843654T → I. Corresponds to variant dbSNP:rs10424809Ensembl.1
Natural variantiVAR_052844662S → A. Corresponds to variant dbSNP:rs10426374Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA Translation: AAL51029.1
AB032967 mRNA Translation: BAA86455.1 Different initiation.
AK292452 mRNA Translation: BAF85141.1
CH471177 Genomic DNA Translation: EAW52593.1
BC018612 mRNA Translation: AAH18612.1
AL080143 mRNA Translation: CAB45736.1
CCDSiCCDS33077.1
PIRiT12527
RefSeqiNP_001006657.1, NM_001006656.3
NP_001295353.1, NM_001308424.2
NP_056243.1, NM_015428.3
UniGeneiHs.440553

Genome annotation databases

EnsembliENST00000270617; ENSP00000270617; ENSG00000142528
ENST00000391821; ENSP00000375697; ENSG00000142528
ENST00000595661; ENSP00000472808; ENSG00000142528
GeneIDi25888
KEGGihsa:25888
UCSCiuc002prm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA Translation: AAL51029.1
AB032967 mRNA Translation: BAA86455.1 Different initiation.
AK292452 mRNA Translation: BAF85141.1
CH471177 Genomic DNA Translation: EAW52593.1
BC018612 mRNA Translation: AAH18612.1
AL080143 mRNA Translation: CAB45736.1
CCDSiCCDS33077.1
PIRiT12527
RefSeqiNP_001006657.1, NM_001006656.3
NP_001295353.1, NM_001308424.2
NP_056243.1, NM_015428.3
UniGeneiHs.440553

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMBNMR-A342-372[»]
2EMCNMR-A641-673[»]
2EMENMR-A725-757[»]
2EOUNMR-A370-400[»]
2EOXNMR-A315-345[»]
2EOYNMR-A557-589[»]
2EOZNMR-A809-841[»]
2YRHNMR-A699-729[»]
2YRJNMR-A781-813[»]
2YSVNMR-A755-783[»]
2YTDNMR-A426-458[»]
2YTENMR-A484-512[»]
2YTTNMR-A204-236[»]
2YU5NMR-A669-699[»]
ProteinModelPortaliQ8WTR7
SMRiQ8WTR7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117398, 17 interactors
IntActiQ8WTR7, 21 interactors
STRINGi9606.ENSP00000270617

PTM databases

iPTMnetiQ8WTR7
PhosphoSitePlusiQ8WTR7

Polymorphism and mutation databases

BioMutaiZNF473
DMDMi51702187

Proteomic databases

EPDiQ8WTR7
PaxDbiQ8WTR7
PeptideAtlasiQ8WTR7
PRIDEiQ8WTR7
ProteomicsDBi74591

Protocols and materials databases

DNASUi25888
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270617; ENSP00000270617; ENSG00000142528
ENST00000391821; ENSP00000375697; ENSG00000142528
ENST00000595661; ENSP00000472808; ENSG00000142528
GeneIDi25888
KEGGihsa:25888
UCSCiuc002prm.4 human

Organism-specific databases

CTDi25888
DisGeNETi25888
EuPathDBiHostDB:ENSG00000142528.15
GeneCardsiZNF473
HGNCiHGNC:23239 ZNF473
HPAiHPA004191
HPA073309
MIMi617908 gene
neXtProtiNX_Q8WTR7
OpenTargetsiENSG00000142528
PharmGKBiPA134987987
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000130048
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8WTR7
KOiK09228
OMAiERFICSS
OrthoDBiEOG091G02KC
PhylomeDBiQ8WTR7
TreeFamiTF350932

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-212436 Generic Transcription Pathway
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

EvolutionaryTraceiQ8WTR7
GeneWikiiZNF473
GenomeRNAii25888
PROiPR:Q8WTR7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142528 Expressed in 167 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF473
ExpressionAtlasiQ8WTR7 baseline and differential
GenevisibleiQ8WTR7 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 20 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN473_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR7
Secondary accession number(s): A8K8T7, Q9ULS9, Q9Y4Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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