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UniProtKB - Q8WTR2 (DUS19_HUMAN)

Protein

Dual specificity protein phosphatase 19

Gene

DUSP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei150Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8WTR2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8WTR2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase TS-DSP1
Low molecular weight dual specificity phosphatase 3
Short name:
LMW-DSP3
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Short name:
SAPK pathway-regulating phosphatase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUSP19
Synonyms:DUSP17, LMWDSP3, SKRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000162999.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:18894 DUSP19

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611437 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8WTR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		142679

Open Targets

More...OpenTargetsi		ENSG00000162999

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134895660

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DUSP19

Domain mapping of disease mutations (DMDM)

More...DMDMi		29840769

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948321 – 217Dual specificity protein phosphatase 19Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8WTR2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8WTR2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8WTR2

PeptideAtlas

More...PeptideAtlasi		Q8WTR2

PRoteomics IDEntifications database

More...PRIDEi		Q8WTR2

ProteomicsDB human proteome resource

More...ProteomicsDBi		74584
74585 [Q8WTR2-2]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		Q8WTR2

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8WTR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8WTR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162999 Expressed in 136 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...CleanExi		HS_DUSP19

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8WTR2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA021501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131966EBI-8654968,EBI-3905054

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		126770, 77 interactors

Protein interaction database and analysis system

More...IntActi		Q8WTR2, 6 interactors

Molecular INTeraction database

More...MINTi		Q8WTR2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8WTR2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8WTR2

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 197Tyrosine-protein phosphataseAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1716 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000233765

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051424

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8WTR2

KEGG Orthology (KO)

More...KOi		K14165

Identification of Orthologs from Complete Genome Data

More...OMAi		PSICPNA

Database of Orthologous Groups

More...OrthoDBi		EOG091G0249

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8WTR2

TreeFam database of animal gene trees

More...TreeFami		TF354211

Family and domain databases

Conserved Domains Database

More...CDDi		cd00127 DSPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom

The PANTHER Classification System

More...PANTHERi		PTHR10159 PTHR10159, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00782 DSPc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01908 ADSPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00195 DSPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS 
        60         70         80         90        100
GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY 
       110        120        130        140        150
GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC 
       160        170        180        190        200
NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY 
       210 
QEGKESNKCD RIQENSS
Length:217
Mass (Da):24,194
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9FAB082D35EC442
GO
Isoform 2 (identifier: Q8WTR2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Show »
Length:166
Mass (Da):18,296
Checksum:i76E894A1DF10E70F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051755216S → R. Corresponds to variant dbSNP:rs16823987Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00513891 – 141Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB063186 mRNA Translation: BAB83498.1
AB063187 mRNA Translation: BAB83499.1
AB038770 mRNA Translation: BAB82499.1
AF486808 mRNA Translation: AAO49450.1
AK314078 mRNA Translation: BAG36776.1
AC064871 Genomic DNA Translation: AAY24197.1
BC035000 mRNA Translation: AAH35000.1
BC093958 mRNA Translation: AAH93958.1
BC112005 mRNA Translation: AAI12006.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2289.1 [Q8WTR2-1]
CCDS46469.1 [Q8WTR2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001135786.1, NM_001142314.1 [Q8WTR2-2]
NP_001308448.1, NM_001321519.1
NP_543152.1, NM_080876.3 [Q8WTR2-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.132237

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		142679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:142679

UCSC genome browser

More...UCSCi		uc002upd.4 human [Q8WTR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA Translation: BAB83498.1
AB063187 mRNA Translation: BAB83499.1
AB038770 mRNA Translation: BAB82499.1
AF486808 mRNA Translation: AAO49450.1
AK314078 mRNA Translation: BAG36776.1
AC064871 Genomic DNA Translation: AAY24197.1
BC035000 mRNA Translation: AAH35000.1
BC093958 mRNA Translation: AAH93958.1
BC112005 mRNA Translation: AAI12006.1
CCDSiCCDS2289.1 [Q8WTR2-1]
CCDS46469.1 [Q8WTR2-2]
RefSeqiNP_001135786.1, NM_001142314.1 [Q8WTR2-2]
NP_001308448.1, NM_001321519.1
NP_543152.1, NM_080876.3 [Q8WTR2-1]
UniGeneiHs.132237

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
4D3PX-ray1.27A65-205[»]
4D3QX-ray1.64A/B65-205[»]
4D3RX-ray1.67A65-204[»]
ProteinModelPortaliQ8WTR2
SMRiQ8WTR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126770, 77 interactors
IntActiQ8WTR2, 6 interactors
MINTiQ8WTR2
STRINGi9606.ENSP00000346160

PTM databases

DEPODiQ8WTR2
iPTMnetiQ8WTR2
PhosphoSitePlusiQ8WTR2

Polymorphism and mutation databases

BioMutaiDUSP19
DMDMi29840769

Proteomic databases

EPDiQ8WTR2
MaxQBiQ8WTR2
PaxDbiQ8WTR2
PeptideAtlasiQ8WTR2
PRIDEiQ8WTR2
ProteomicsDBi74584
74585 [Q8WTR2-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		142679
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1]
GeneIDi142679
KEGGihsa:142679
UCSCiuc002upd.4 human [Q8WTR2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		142679
DisGeNETi142679
EuPathDBiHostDB:ENSG00000162999.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		DUSP19
HGNCiHGNC:18894 DUSP19
HPAiHPA021501
MIMi611437 gene
neXtProtiNX_Q8WTR2
OpenTargetsiENSG00000162999
PharmGKBiPA134895660

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000156472
HOGENOMiHOG000233765
HOVERGENiHBG051424
InParanoidiQ8WTR2
KOiK14165
OMAiPSICPNA
OrthoDBiEOG091G0249
PhylomeDBiQ8WTR2
TreeFamiTF354211

Enzyme and pathway databases

SignaLinkiQ8WTR2
SIGNORiQ8WTR2

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DUSP19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		142679

Protein Ontology

More...PROi		PR:Q8WTR2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162999 Expressed in 136 organ(s), highest expression level in oocyte
CleanExiHS_DUSP19
GenevisibleiQ8WTR2 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUS19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTR2
Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: December 5, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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