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Protein

Dual specificity protein phosphatase 19

Gene

DUSP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiQ8WTR2
SIGNORiQ8WTR2

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase TS-DSP1
Low molecular weight dual specificity phosphatase 3
Short name:
LMW-DSP3
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Short name:
SAPK pathway-regulating phosphatase 1
Gene namesi
Name:DUSP19
Synonyms:DUSP17, LMWDSP3, SKRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162999.12
HGNCiHGNC:18894 DUSP19
MIMi611437 gene
neXtProtiNX_Q8WTR2

Pathology & Biotechi

Organism-specific databases

DisGeNETi142679
OpenTargetsiENSG00000162999
PharmGKBiPA134895660

Polymorphism and mutation databases

BioMutaiDUSP19
DMDMi29840769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948321 – 217Dual specificity protein phosphatase 19Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WTR2
MaxQBiQ8WTR2
PaxDbiQ8WTR2
PeptideAtlasiQ8WTR2
PRIDEiQ8WTR2
ProteomicsDBi74584
74585 [Q8WTR2-2]

PTM databases

DEPODiQ8WTR2
iPTMnetiQ8WTR2
PhosphoSitePlusiQ8WTR2

Expressioni

Tissue specificityi

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication

Gene expression databases

BgeeiENSG00000162999 Expressed in 136 organ(s), highest expression level in oocyte
CleanExiHS_DUSP19
GenevisibleiQ8WTR2 HS

Organism-specific databases

HPAiHPA021501

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131966EBI-8654968,EBI-3905054

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126770, 73 interactors
IntActiQ8WTR2, 6 interactors
MINTiQ8WTR2
STRINGi9606.ENSP00000346160

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8WTR2
SMRiQ8WTR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 197Tyrosine-protein phosphataseAdd BLAST65

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233765
HOVERGENiHBG051424
InParanoidiQ8WTR2
KOiK14165
OMAiMEQLRTY
OrthoDBiEOG091G0249
PhylomeDBiQ8WTR2
TreeFamiTF354211

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS
60 70 80 90 100
GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY
110 120 130 140 150
GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC
160 170 180 190 200
NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY
210
QEGKESNKCD RIQENSS
Length:217
Mass (Da):24,194
Last modified:March 1, 2002 - v1
Checksum:iA9FAB082D35EC442
GO
Isoform 2 (identifier: Q8WTR2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Show »
Length:166
Mass (Da):18,296
Checksum:i76E894A1DF10E70F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051755216S → R. Corresponds to variant dbSNP:rs16823987Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00513891 – 141Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA Translation: BAB83498.1
AB063187 mRNA Translation: BAB83499.1
AB038770 mRNA Translation: BAB82499.1
AF486808 mRNA Translation: AAO49450.1
AK314078 mRNA Translation: BAG36776.1
AC064871 Genomic DNA Translation: AAY24197.1
BC035000 mRNA Translation: AAH35000.1
BC093958 mRNA Translation: AAH93958.1
BC112005 mRNA Translation: AAI12006.1
CCDSiCCDS2289.1 [Q8WTR2-1]
CCDS46469.1 [Q8WTR2-2]
RefSeqiNP_001135786.1, NM_001142314.1 [Q8WTR2-2]
NP_001308448.1, NM_001321519.1
NP_543152.1, NM_080876.3 [Q8WTR2-1]
UniGeneiHs.132237

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1]
GeneIDi142679
KEGGihsa:142679
UCSCiuc002upd.4 human [Q8WTR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA Translation: BAB83498.1
AB063187 mRNA Translation: BAB83499.1
AB038770 mRNA Translation: BAB82499.1
AF486808 mRNA Translation: AAO49450.1
AK314078 mRNA Translation: BAG36776.1
AC064871 Genomic DNA Translation: AAY24197.1
BC035000 mRNA Translation: AAH35000.1
BC093958 mRNA Translation: AAH93958.1
BC112005 mRNA Translation: AAI12006.1
CCDSiCCDS2289.1 [Q8WTR2-1]
CCDS46469.1 [Q8WTR2-2]
RefSeqiNP_001135786.1, NM_001142314.1 [Q8WTR2-2]
NP_001308448.1, NM_001321519.1
NP_543152.1, NM_080876.3 [Q8WTR2-1]
UniGeneiHs.132237

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
4D3PX-ray1.27A65-205[»]
4D3QX-ray1.64A/B65-205[»]
4D3RX-ray1.67A65-204[»]
ProteinModelPortaliQ8WTR2
SMRiQ8WTR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126770, 73 interactors
IntActiQ8WTR2, 6 interactors
MINTiQ8WTR2
STRINGi9606.ENSP00000346160

PTM databases

DEPODiQ8WTR2
iPTMnetiQ8WTR2
PhosphoSitePlusiQ8WTR2

Polymorphism and mutation databases

BioMutaiDUSP19
DMDMi29840769

Proteomic databases

EPDiQ8WTR2
MaxQBiQ8WTR2
PaxDbiQ8WTR2
PeptideAtlasiQ8WTR2
PRIDEiQ8WTR2
ProteomicsDBi74584
74585 [Q8WTR2-2]

Protocols and materials databases

DNASUi142679
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1]
GeneIDi142679
KEGGihsa:142679
UCSCiuc002upd.4 human [Q8WTR2-1]

Organism-specific databases

CTDi142679
DisGeNETi142679
EuPathDBiHostDB:ENSG00000162999.12
GeneCardsiDUSP19
HGNCiHGNC:18894 DUSP19
HPAiHPA021501
MIMi611437 gene
neXtProtiNX_Q8WTR2
OpenTargetsiENSG00000162999
PharmGKBiPA134895660
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233765
HOVERGENiHBG051424
InParanoidiQ8WTR2
KOiK14165
OMAiMEQLRTY
OrthoDBiEOG091G0249
PhylomeDBiQ8WTR2
TreeFamiTF354211

Enzyme and pathway databases

SignaLinkiQ8WTR2
SIGNORiQ8WTR2

Miscellaneous databases

GeneWikiiDUSP19
GenomeRNAii142679
PROiPR:Q8WTR2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162999 Expressed in 136 organ(s), highest expression level in oocyte
CleanExiHS_DUSP19
GenevisibleiQ8WTR2 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS19_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR2
Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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