UniProtKB - Q8WTR2 (DUS19_HUMAN)
Protein
Dual specificity protein phosphatase 19
Gene
DUSP19
Organism
Homo sapiens (Human)
Status
Functioni
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 150 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- JUN kinase phosphatase activity Source: GO_Central
- MAP-kinase scaffold activity Source: BHF-UCL
- mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
- protein kinase activator activity Source: BHF-UCL
- protein kinase inhibitor activity Source: BHF-UCL
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of JNK cascade Source: BHF-UCL
- negative regulation of JUN kinase activity Source: BHF-UCL
- negative regulation of protein kinase activity Source: BHF-UCL
- positive regulation of JNK cascade Source: BHF-UCL
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of protein kinase activity Source: BHF-UCL
- regulation of MAP kinase activity Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
PathwayCommonsi | Q8WTR2 |
SignaLinki | Q8WTR2 |
SIGNORi | Q8WTR2 |
Names & Taxonomyi
Protein namesi | Recommended name: Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)Alternative name(s): Dual specificity phosphatase TS-DSP1 Low molecular weight dual specificity phosphatase 3 Short name: LMW-DSP3 Protein phosphatase SKRP1 Stress-activated protein kinase pathway-regulating phosphatase 1 Short name: SAPK pathway-regulating phosphatase 1 |
Gene namesi | Name:DUSP19 Synonyms:DUSP17, LMWDSP3, SKRP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18894, DUSP19 |
MIMi | 611437, gene |
neXtProti | NX_Q8WTR2 |
VEuPathDBi | HostDB:ENSG00000162999.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 142679 |
OpenTargetsi | ENSG00000162999 |
PharmGKBi | PA134895660 |
Miscellaneous databases
Pharosi | Q8WTR2, Tdark |
Genetic variation databases
BioMutai | DUSP19 |
DMDMi | 29840769 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094832 | 1 – 217 | Dual specificity protein phosphatase 19Add BLAST | 217 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8WTR2 |
MassIVEi | Q8WTR2 |
MaxQBi | Q8WTR2 |
PaxDbi | Q8WTR2 |
PeptideAtlasi | Q8WTR2 |
PRIDEi | Q8WTR2 |
ProteomicsDBi | 74584 [Q8WTR2-1] 74585 [Q8WTR2-2] |
PTM databases
DEPODi | DUSP19 |
iPTMneti | Q8WTR2 |
PhosphoSitePlusi | Q8WTR2 |
Expressioni
Tissue specificityi
Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication
Gene expression databases
Bgeei | ENSG00000162999, Expressed in oocyte and 152 other tissues |
Genevisiblei | Q8WTR2, HS |
Organism-specific databases
HPAi | ENSG00000162999, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 126770, 95 interactors |
IntActi | Q8WTR2, 27 interactors |
MINTi | Q8WTR2 |
STRINGi | 9606.ENSP00000346160 |
Miscellaneous databases
RNActi | Q8WTR2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8WTR2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 206 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 142 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000156472 |
HOGENOMi | CLU_027074_10_0_1 |
InParanoidi | Q8WTR2 |
OMAi | TWKDARM |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q8WTR2 |
TreeFami | TF354211 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000387, TYR_PHOSPHATASE_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS
60 70 80 90 100
GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY
110 120 130 140 150
GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC
160 170 180 190 200
NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY
210
QEGKESNKCD RIQENSS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051755 | 216 | S → R. Corresponds to variant dbSNP:rs16823987Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005138 | 91 – 141 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB063186 mRNA Translation: BAB83498.1 AB063187 mRNA Translation: BAB83499.1 AB038770 mRNA Translation: BAB82499.1 AF486808 mRNA Translation: AAO49450.1 AK314078 mRNA Translation: BAG36776.1 AC064871 Genomic DNA Translation: AAY24197.1 BC035000 mRNA Translation: AAH35000.1 BC093958 mRNA Translation: AAH93958.1 BC112005 mRNA Translation: AAI12006.1 |
CCDSi | CCDS2289.1 [Q8WTR2-1] CCDS46469.1 [Q8WTR2-2] |
RefSeqi | NP_001135786.1, NM_001142314.1 [Q8WTR2-2] NP_001308448.1, NM_001321519.1 NP_543152.1, NM_080876.3 [Q8WTR2-1] |
Genome annotation databases
Ensembli | ENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2] ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1] |
GeneIDi | 142679 |
KEGGi | hsa:142679 |
UCSCi | uc002upd.4, human [Q8WTR2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB063186 mRNA Translation: BAB83498.1 AB063187 mRNA Translation: BAB83499.1 AB038770 mRNA Translation: BAB82499.1 AF486808 mRNA Translation: AAO49450.1 AK314078 mRNA Translation: BAG36776.1 AC064871 Genomic DNA Translation: AAY24197.1 BC035000 mRNA Translation: AAH35000.1 BC093958 mRNA Translation: AAH93958.1 BC112005 mRNA Translation: AAI12006.1 |
CCDSi | CCDS2289.1 [Q8WTR2-1] CCDS46469.1 [Q8WTR2-2] |
RefSeqi | NP_001135786.1, NM_001142314.1 [Q8WTR2-2] NP_001308448.1, NM_001321519.1 NP_543152.1, NM_080876.3 [Q8WTR2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3S4E | X-ray | 1.26 | A | 65-206 | [»] | |
4D3P | X-ray | 1.27 | A | 65-205 | [»] | |
4D3Q | X-ray | 1.64 | A/B | 65-205 | [»] | |
4D3R | X-ray | 1.67 | A | 65-204 | [»] | |
SMRi | Q8WTR2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126770, 95 interactors |
IntActi | Q8WTR2, 27 interactors |
MINTi | Q8WTR2 |
STRINGi | 9606.ENSP00000346160 |
PTM databases
DEPODi | DUSP19 |
iPTMneti | Q8WTR2 |
PhosphoSitePlusi | Q8WTR2 |
Genetic variation databases
BioMutai | DUSP19 |
DMDMi | 29840769 |
Proteomic databases
EPDi | Q8WTR2 |
MassIVEi | Q8WTR2 |
MaxQBi | Q8WTR2 |
PaxDbi | Q8WTR2 |
PeptideAtlasi | Q8WTR2 |
PRIDEi | Q8WTR2 |
ProteomicsDBi | 74584 [Q8WTR2-1] 74585 [Q8WTR2-2] |
Protocols and materials databases
Antibodypediai | 19768, 182 antibodies |
DNASUi | 142679 |
Genome annotation databases
Ensembli | ENST00000342619; ENSP00000343905; ENSG00000162999 [Q8WTR2-2] ENST00000354221; ENSP00000346160; ENSG00000162999 [Q8WTR2-1] |
GeneIDi | 142679 |
KEGGi | hsa:142679 |
UCSCi | uc002upd.4, human [Q8WTR2-1] |
Organism-specific databases
CTDi | 142679 |
DisGeNETi | 142679 |
GeneCardsi | DUSP19 |
HGNCi | HGNC:18894, DUSP19 |
HPAi | ENSG00000162999, Low tissue specificity |
MIMi | 611437, gene |
neXtProti | NX_Q8WTR2 |
OpenTargetsi | ENSG00000162999 |
PharmGKBi | PA134895660 |
VEuPathDBi | HostDB:ENSG00000162999.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000156472 |
HOGENOMi | CLU_027074_10_0_1 |
InParanoidi | Q8WTR2 |
OMAi | TWKDARM |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q8WTR2 |
TreeFami | TF354211 |
Enzyme and pathway databases
PathwayCommonsi | Q8WTR2 |
SignaLinki | Q8WTR2 |
SIGNORi | Q8WTR2 |
Miscellaneous databases
BioGRID-ORCSi | 142679, 4 hits in 991 CRISPR screens |
ChiTaRSi | DUSP19, human |
GeneWikii | DUSP19 |
GenomeRNAii | 142679 |
Pharosi | Q8WTR2, Tdark |
PROi | PR:Q8WTR2 |
RNActi | Q8WTR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162999, Expressed in oocyte and 152 other tissues |
Genevisiblei | Q8WTR2, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000387, TYR_PHOSPHATASE_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DUS19_HUMAN | |
Accessioni | Q8WTR2Primary (citable) accession number: Q8WTR2 Secondary accession number(s): B2RA79, Q547H4, Q8WYN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families