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Entry version 111 (11 Dec 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Uncharacterized protein C16orf78

Gene

C16orf78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C16orf78
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166152.3

Human Gene Nomenclature Database

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HGNCi
HGNC:28479 C16orf78

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000166152

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147358456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8WTQ4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C16orf78

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002966251 – 265Uncharacterized protein C16orf78Add BLAST265

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8WTQ4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8WTQ4

PeptideAtlas

More...
PeptideAtlasi
Q8WTQ4

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTQ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74582

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8WTQ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WTQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WTQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166152 Expressed in 30 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTQ4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125845, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WTQ4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299191

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8WTQ4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2II Eukaryota
ENOG410ZCE7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111903

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTQ4

Identification of Orthologs from Complete Genome Data

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OMAi
KSMWKTA

Database of Orthologous Groups

More...
OrthoDBi
1322508at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTQ4

TreeFam database of animal gene trees

More...
TreeFami
TF328628

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029171 DUF4638

The PANTHER Classification System

More...
PANTHERi
PTHR35679 PTHR35679, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15472 DUF4638, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WTQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQQMDLKD LMPTKRKYMW KTAEDRRMSD LTCVLEWLER RQGKKKQAPE
60 70 80 90 100
KQKPKVVTVL KRNKKKEEKK GKGLMTARGG NRRDTETSQQ ALGKRFRKDA
110 120 130 140 150
ASYRSLYGVE QKGKHLSMVP GSYIKDGPKK SDTDIKDAVD PESTQRPNPF
160 170 180 190 200
RRQSIVLDPM LQEGTFNSQR ATFIRDWSNK MPDMAYERKL KSLMEKSTEP
210 220 230 240 250
KMETMRMLKP EEVLSCRYLR LSKENIRTLL KLCKDAGMNV DIHPHMVEED
260
IDAKKVFTGI PSMAL
Length:265
Mass (Da):30,819
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3B9514F2C4882E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034632152R → Q. Corresponds to variant dbSNP:rs16947350Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC021181 mRNA Translation: AAH21181.1
BC021718 mRNA Translation: AAH21718.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10738.1

NCBI Reference Sequences

More...
RefSeqi
NP_653203.1, NM_144602.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299191; ENSP00000299191; ENSG00000166152

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
123970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:123970

UCSC genome browser

More...
UCSCi
uc002efr.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021181 mRNA Translation: AAH21181.1
BC021718 mRNA Translation: AAH21718.1
CCDSiCCDS10738.1
RefSeqiNP_653203.1, NM_144602.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125845, 3 interactors
IntActiQ8WTQ4, 3 interactors
STRINGi9606.ENSP00000299191

PTM databases

iPTMnetiQ8WTQ4
PhosphoSitePlusiQ8WTQ4

Polymorphism and mutation databases

BioMutaiC16orf78
DMDMi74730626

Proteomic databases

MassIVEiQ8WTQ4
PaxDbiQ8WTQ4
PeptideAtlasiQ8WTQ4
PRIDEiQ8WTQ4
ProteomicsDBi74582
TopDownProteomicsiQ8WTQ4

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
123970

Genome annotation databases

EnsembliENST00000299191; ENSP00000299191; ENSG00000166152
GeneIDi123970
KEGGihsa:123970
UCSCiuc002efr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
123970
EuPathDBiHostDB:ENSG00000166152.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C16orf78
HGNCiHGNC:28479 C16orf78
neXtProtiNX_Q8WTQ4
OpenTargetsiENSG00000166152
PharmGKBiPA147358456

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2II Eukaryota
ENOG410ZCE7 LUCA
GeneTreeiENSGT00390000014556
HOGENOMiHOG000111903
InParanoidiQ8WTQ4
OMAiKSMWKTA
OrthoDBi1322508at2759
PhylomeDBiQ8WTQ4
TreeFamiTF328628

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
123970
PharosiQ8WTQ4 Tdark

Protein Ontology

More...
PROi
PR:Q8WTQ4
RNActiQ8WTQ4 protein

Gene expression databases

BgeeiENSG00000166152 Expressed in 30 organ(s), highest expression level in right testis
GenevisibleiQ8WTQ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR029171 DUF4638
PANTHERiPTHR35679 PTHR35679, 1 hit
PfamiView protein in Pfam
PF15472 DUF4638, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP078_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2002
Last modified: December 11, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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