Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 115 (08 May 2019)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

X antigen family member 3

Gene

XAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
X antigen family member 3
Short name:
XAGE-3
Alternative name(s):
Cancer/testis antigen 12.3
Short name:
CT12.3
G antigen family D member 4
Placenta-specific gene 6 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XAGE3
Synonyms:GAGED4, PLAC6
ORF Names:PP9012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14618 XAGE3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300740 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WTP9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
170626

Open Targets

More...
OpenTargetsi
ENSG00000171402

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33376

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XAGE3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27805666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001483511 – 111X antigen family member 3Add BLAST111

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WTP9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WTP9

PeptideAtlas

More...
PeptideAtlasi
Q8WTP9

PRoteomics IDEntifications database

More...
PRIDEi
Q8WTP9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74580

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WTP9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WTP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171402 Expressed in 29 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WTP9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052507
HPA059045
HPA060900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128072, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q8WTP9, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WTP9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JJIA Eukaryota
ENOG4111B57 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237345

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WTP9

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTESHEI

Database of Orthologous Groups

More...
OrthoDBi
1551004at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WTP9

TreeFam database of animal gene trees

More...
TreeFami
TF340669

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam

The PANTHER Classification System

More...
PANTHERi
PTHR14047 PTHR14047, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05831 GAGE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01379 GAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WTP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ
60 70 80 90 100
EREEDQGAAE TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK
110
MPEGGDRQPQ V
Length:111
Mass (Da):12,302
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4A3261E6F7ACF5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11P → H in AAL55879 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ318881 mRNA Translation: CAC83008.1
AJ318893 Genomic DNA Translation: CAC83014.1
AF318372 mRNA Translation: AAL55879.1
AL445236 Genomic DNA Translation: CAI41615.1
BC062680 mRNA Translation: AAH62680.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14347.1

NCBI Reference Sequences

More...
RefSeqi
NP_570132.1, NM_130776.1
NP_573440.1, NM_133179.2
XP_011529070.1, XM_011530768.2
XP_011529071.1, XM_011530769.2
XP_011529072.1, XM_011530770.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346279; ENSP00000303061; ENSG00000171402
ENST00000375491; ENSP00000364640; ENSG00000171402

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170626

UCSC genome browser

More...
UCSCi
uc004dre.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318881 mRNA Translation: CAC83008.1
AJ318893 Genomic DNA Translation: CAC83014.1
AF318372 mRNA Translation: AAL55879.1
AL445236 Genomic DNA Translation: CAI41615.1
BC062680 mRNA Translation: AAH62680.1
CCDSiCCDS14347.1
RefSeqiNP_570132.1, NM_130776.1
NP_573440.1, NM_133179.2
XP_011529070.1, XM_011530768.2
XP_011529071.1, XM_011530769.2
XP_011529072.1, XM_011530770.2

3D structure databases

SMRiQ8WTP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128072, 16 interactors
IntActiQ8WTP9, 5 interactors
STRINGi9606.ENSP00000303061

PTM databases

iPTMnetiQ8WTP9
PhosphoSitePlusiQ8WTP9

Polymorphism and mutation databases

BioMutaiXAGE3
DMDMi27805666

Proteomic databases

MaxQBiQ8WTP9
PaxDbiQ8WTP9
PeptideAtlasiQ8WTP9
PRIDEiQ8WTP9
ProteomicsDBi74580

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
170626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346279; ENSP00000303061; ENSG00000171402
ENST00000375491; ENSP00000364640; ENSG00000171402
GeneIDi170626
KEGGihsa:170626
UCSCiuc004dre.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170626
DisGeNETi170626

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XAGE3
HGNCiHGNC:14618 XAGE3
HPAiHPA052507
HPA059045
HPA060900
MIMi300740 gene
neXtProtiNX_Q8WTP9
OpenTargetsiENSG00000171402
PharmGKBiPA33376

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JJIA Eukaryota
ENOG4111B57 LUCA
GeneTreeiENSGT00940000153097
HOGENOMiHOG000237345
InParanoidiQ8WTP9
OMAiPTESHEI
OrthoDBi1551004at2759
PhylomeDBiQ8WTP9
TreeFamiTF340669

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170626

Protein Ontology

More...
PROi
PR:Q8WTP9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171402 Expressed in 29 organ(s), highest expression level in placenta
GenevisibleiQ8WTP9 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXAGE3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WTP9
Secondary accession number(s): Q5JS82, Q8WYS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: May 8, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again