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Protein

Cadmium metallothionein

Gene

MTT1

Organism
Tetrahymena thermophila
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium metallothionein
Alternative name(s):
Cd-MT
MT-Cd
Gene namesi
Name:MTT1
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000186731 – 21 Publication2
ChainiPRO_00000186743 – 162Cadmium metallothioneinAdd BLAST160

Proteomic databases

PRIDEiQ8WSW3

Expressioni

Inductioni

By cadmium, and to a lesser extent by mercury, copper, heat, hydrogen peroxide and IL-6.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ8WSW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WSW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVNSCCCG VNAKPCCTDP NSGCCCVSKT DNCCKSDTKE CCTGTGEGCK
60 70 80 90 100
CVNCKCCKPQ ANCCCGVNAK PCCFDPNSGC CCVSKTNNCC KSDTKECCTG
110 120 130 140 150
TGEGCKCTSC QCCKPVQQGC CCGDKAKACC TDPNSGCCCS NKANKCCDAT
160
SKQECQTCQC CK
Length:162
Mass (Da):16,757
Last modified:March 1, 2002 - v1
Checksum:i9B2DB3C95981FFCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → NN in AAP33500 (Ref. 4) Curated1
Sequence conflicti156Q → K in AAP33500 (Ref. 4) Curated1
Sequence conflicti159Q → E in AAP33500 (Ref. 4) Curated1

Mass spectrometryi

Molecular mass is 16763 Da from positions 3 - 162. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061892 Genomic DNA Translation: AAL31645.1
AY740525 Genomic DNA Translation: AAU87360.1
DQ517937 mRNA Translation: ABF68755.1
EF195745 mRNA Translation: ABN42648.1
DQ022186 mRNA Translation: AAY42865.1
AY273793 mRNA Translation: AAP33500.1
AF537326 mRNA Translation: AAN06822.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061892 Genomic DNA Translation: AAL31645.1
AY740525 Genomic DNA Translation: AAU87360.1
DQ517937 mRNA Translation: ABF68755.1
EF195745 mRNA Translation: ABN42648.1
DQ022186 mRNA Translation: AAY42865.1
AY273793 mRNA Translation: AAP33500.1
AF537326 mRNA Translation: AAN06822.1

3D structure databases

ProteinModelPortaliQ8WSW3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8WSW3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTCD_TETTH
AccessioniPrimary (citable) accession number: Q8WSW3
Secondary accession number(s): Q5XQF6, Q86BU0, Q8IT78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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