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Entry version 64 (22 Apr 2020)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Erythrocyte binding antigen 140

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
Q8WS31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erythrocyte binding antigen 140Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1134 – 1153HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi154 ↔ 184Combined sources
Disulfide bondi165 ↔ 175Combined sources
Disulfide bondi227 ↔ 306Combined sources
Disulfide bondi342 ↔ 355Combined sources
Disulfide bondi351 ↔ 421Combined sources
Disulfide bondi359 ↔ 419Combined sources
Disulfide bondi456 ↔ 489Combined sources
Disulfide bondi468 ↔ 480Combined sources
Disulfide bondi532 ↔ 607Combined sources
Disulfide bondi631 ↔ 714Combined sources
Disulfide bondi648 ↔ 653Combined sources
Disulfide bondi658 ↔ 738Combined sources
Disulfide bondi662 ↔ 735Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WS31

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1046 – 1126EBA-175_VIInterPro annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni109 – 131DisorderedSequence analysisAdd BLAST23
Regioni772 – 969DisorderedSequence analysisAdd BLAST198
Regioni1013 – 1042DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili564 – 584Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi772 – 799PolarSequence analysisAdd BLAST28
Compositional biasi815 – 928PolarSequence analysisAdd BLAST114
Compositional biasi939 – 969PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1025 – 1042PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K5CB Eukaryota
ENOG4110H8V LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1740.170, 1 hit
1.20.1310.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen-binding
IPR021620 EBA-175_C
IPR043057 EBA-175_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05424 Duffy_binding, 2 hits
PF11556 EBA-175_VI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WS31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGYFNIYFL IPLIFLYNVI RINESIIGRT LYNRQDESSD ISRVNSPELN
60 70 80 90 100
NNHKTNIYDS DYEDVNNKLI NSFVENKSVK KKRSLSFINN KTKSYDIIPP
110 120 130 140 150
SYSYRNDKFN SLSENEDNSG NTNSNNFANT SEISIGKDNK QYTFIQKRTH
160 170 180 190 200
LFACGIKRKS IKWICRENSE KITVCVPDRK IQLCIANFLN SRLETMEKFK
210 220 230 240 250
EIFLISVNTE AKLLYNKNEG KDPSIFCNEL RNSFSDFRNS FIGDDMDFGG
260 270 280 290 300
NTDRVKGYIN KKFSDYYKEK NVEKLNNIKK EWWEKNKANL WNHMIVNHKG
310 320 330 340 350
NISKECAIIP AEEPQINLWI KEWNENFLME KKRLFLNIKD KCVENKKYEA
360 370 380 390 400
CFGGCRLPCS SYTSFMKKSK TQMEVLTNLY KKKNSGVDKN NFLNDLFKKN
410 420 430 440 450
NKNDLDDFFK NEKEYDDLCD CRYTATIIKS FLNGPAKNDV DIASQINVND
460 470 480 490 500
LRGFGCNYKS NNEKSWNCTG TFTNKFPGTC EPPRRQTLCL GRTYLLHRGH
510 520 530 540 550
EEDYKEHLLG ASIYEAQLLK YKYKEKDENA LCSIIQNSYA DLADIIKGSD
560 570 580 590 600
IIKDYYGKKM EENLNKVNKD KKRNEESLKI FREKWWDENK ENVWKVMSAV
610 620 630 640 650
LKNKETCKDY DKFQKIPQFL RWFKEWGDDF CEKRKEKIYS FESFKVECKK
660 670 680 690 700
KDCDENTCKN KCSEYKKWID LKKSEYEKQV DKYTKDKNKK MYDNIDEVKN
710 720 730 740 750
KEANVYLKEK SKECKDVNFD DKIFNESPNE YEDMCKKCDE IKYLNEIKYP
760 770 780 790 800
KTKHDIYDID TFSDTFGDGT PISINANINE QQSGKDTSNT GNSETSDSPV
810 820 830 840 850
SHEPESDAAI NVEKLSGDES SSETRGILDI NDPSVTNNVN EVHDASNTQG
860 870 880 890 900
SVSNTSDITN GHSESSLNRT TNAQDIKIGR SGNEQSDNQE NSSHSSDNSG
910 920 930 940 950
SLTIGQVPSE DNTQNTYDSQ NPHRDTPNAL ASLPSDDKIN EIEGFDSSRD
960 970 980 990 1000
SENGRGDTTS NTHDVRRTNI VSERRVNSHD FIRNGMANNN AHHQYITQIE
1010 1020 1030 1040 1050
NNGIIRGQEE SAGNSVNYKD NPKRSNFSSE NDHKKNIQEY NSRDTKRVRE
1060 1070 1080 1090 1100
EIIKLSKQNK CNNEYSMEYC TYSDERNSSP GPCSREERKK LCCQISDYCL
1110 1120 1130 1140 1150
KYFNFYSIEY YNCIKSEIKS PEYKCFKSEG QSSIPYFAAG GILVVIVLLL
1160 1170 1180 1190 1200
SSASRMGKSN EEYDIGESNI EATFEENNYL NKLSRIFNQE VQETNISDYS
1210
EYNYNEKNMY
Length:1,210
Mass (Da):140,596
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF44FBB8DA69D605
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF384554 Genomic DNA Translation: AAL58319.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384554 Genomic DNA Translation: AAL58319.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GF2X-ray2.40A141-755[»]
4JNOX-ray3.00A141-755[»]
SMRiQ8WS31
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

UniLectiniQ8WS31

Phylogenomic databases

eggNOGiENOG410K5CB Eukaryota
ENOG4110H8V LUCA

Family and domain databases

Gene3Di1.10.1740.170, 1 hit
1.20.1310.20, 2 hits
InterProiView protein in InterPro
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen-binding
IPR021620 EBA-175_C
IPR043057 EBA-175_C_sf
PfamiView protein in Pfam
PF05424 Duffy_binding, 2 hits
PF11556 EBA-175_VI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8WS31_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WS31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 22, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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