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Protein

DNA ligase

Gene

Lig1

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig1Imported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501195001416 – 912DNA ligaseSequence analysisAdd BLAST897

Structurei

3D structure databases

ProteinModelPortaliQ8WQK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini642 – 778DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA

Family and domain databases

Gene3Di1.10.3260.10, 2 hits
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WQK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS
60 70 80 90 100
KNITKNSSSN SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK
110 120 130 140 150
NVKRKIINES SKNKRAKVKN ENDVIKKGSL FNCVVREDEK VNDLSSPKFN
160 170 180 190 200
PVHFNINDLY LSEKDKEKHK FKDSLLFTFL TNAFNQIEEL KGSGTGSKKN
210 220 230 240 250
VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA GVGEALILKT
260 270 280 290 300
MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE
310 320 330 340 350
LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA
360 370 380 390 400
TVVQALSYAF ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK
410 420 430 440 450
TEEWLTQSGD RNCIKEENLN DELLSKDDIN KCENMDSLIN EIRIRNEKIN
460 470 480 490 500
KPNIFYNLIE KVGDTRLLPL FFKELKNIYC EENNDIDIFE CMEKSVKSAL
510 520 530 540 550
CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK PTKGVQEVLD
560 570 580 590 600
RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK
610 620 630 640 650
DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC
660 670 680 690 700
LFPFDLICCN GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED
710 720 730 740 750
IDMFLQDAIE NNCEGLMVKT LVENASYEPS RRSLNWLKVK KDYVEGLSDS
760 770 780 790 800
VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE TENFQTVCKA GTGFSDEILS
810 820 830 840 850
TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA ADLSLSPVHT
860 870 880 890 900
AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN
910
KNIDYNDDTE SE
Length:912
Mass (Da):104,506
Last modified:March 1, 2003 - v2
Checksum:iFFC1EC4B2428DD77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069960 mRNA Translation: AAL59668.2
AY161174 Genomic DNA Translation: AAN64156.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069960 mRNA Translation: AAL59668.2
AY161174 Genomic DNA Translation: AAN64156.1

3D structure databases

ProteinModelPortaliQ8WQK1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA

Family and domain databases

Gene3Di1.10.3260.10, 2 hits
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WQK1_PLAFA
AccessioniPrimary (citable) accession number: Q8WQK1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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