ID   Q8WPT5_9TRYP            Unreviewed;       818 AA.
AC   Q8WPT5;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   13-SEP-2023, entry version 31.
DE   SubName: Full=H25N7.01 protein {ECO:0000313|EMBL:CAD21858.1};
GN   Name=H25N7.01 {ECO:0000313|EMBL:CAD21858.1};
OS   Trypanosoma brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5691 {ECO:0000313|EMBL:CAD21858.1};
RN   [1] {ECO:0000313|EMBL:CAD21858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=427 {ECO:0000313|EMBL:CAD21858.1};
RX   PubMed=9763292; DOI=10.1016/S0166-6851(98)00099-1;
RA   Rudenko G., Chaves I., Dirks-Mulder A., Borst P.;
RT   "Selection for activation of a new variant surface glycoprotein gene
RT   expression site in Trypanosoma brucei can result in deletion of the old
RT   one.";
RL   Mol. Biochem. Parasitol. 95:97-109(1998).
RN   [2] {ECO:0000313|EMBL:CAD21858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=427 {ECO:0000313|EMBL:CAD21858.1};
RX   PubMed=12106867; DOI=10.1016/S0166-6851(02)00092-0;
RA   Berriman M., Hall N., Sheader K., Bringaud F., Tiwari B., Isobe T.,
RA   Bowman S., Corton C., Clark L., Cross G.A.M., Hoek M., Zanders T.,
RA   Berberof M., Borst P., Rudenko G.;
RT   "The architecture of variant surface glycoprotein gene expression sites in
RT   Trypanosoma brucei.";
RL   Mol. Biochem. Parasitol. 122:131-140(2002).
RN   [3] {ECO:0000313|EMBL:CAD21858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=427 {ECO:0000313|EMBL:CAD21858.1};
RA   Zeng C., Zhao B., Hierl M., Catanese J., Gerrard C., Melville S.E.,
RA   Hoek M., Navarro M., Cross G.A.M., El-Sayed N., Berberof M., Rudenko G.,
RA   Borst P., de Jong P.;
RT   "Construction and Characterization of Three Bacterial Artificial Chromosome
RT   Libraries for Trypanosoma brucei.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AL671259; CAD21858.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WPT5; -.
DR   VEuPathDB; TriTrypDB:Tb1125.Tb11.v5.0594; -.
DR   VEuPathDB; TriTrypDB:Tb1125.Tb11.v5.0800; -.
DR   VEuPathDB; TriTrypDB:Tb427_000742200; -.
DR   VEuPathDB; TriTrypDB:Tb427_000786300; -.
DR   VEuPathDB; TriTrypDB:Tb927.2.280; -.
DR   VEuPathDB; TriTrypDB:Tbg972.11.4360; -.
DR   InterPro; IPR046836; RHS_C.
DR   InterPro; IPR046835; RHS_N.
DR   InterPro; IPR006518; Trypano_RHS.
DR   NCBIfam; TIGR01631; Trypano_RHS; 1.
DR   PANTHER; PTHR33129:SF3; HOT SPOT (RHS) PROTEIN, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR33129; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF20445; RHS_N; 1.
DR   Pfam; PF07999; RHSP; 1.
PE   4: Predicted;
FT   DOMAIN          195..325
FT                   /note="Retrotransposon hot spot protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20445"
FT   DOMAIN          326..635
FT                   /note="Retrotransposon hot spot protein,C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07999"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  93715 MW;  1F193D8A6BF795CC CRC64;
     MNQQVPIEGR GDIEGRRREN EEAARNDAEP PAVQQRVENN NQPQWRLFSC IEAVLLNGLP
     HPQNVMLNDF LRSNFGTRYN VNEENNVSIS VFVQRCEEYI NDVNALNRVF AATEYQVYKR
     FVSVYGFFED EGILNLVRWK QANEEVKARL QVNIRGLRNG EQTWINVTNM LNNALKEALG
     GAAQTAGGAE LKGVYDSIYS ATWGYVESGH NDLPLGLKVV GNCDGEPELW TEEEVNVSHT
     PYDLCDPLPR RGNLEIAVLT SQKGWPYHRF RIPRRVIQED AEEPGDYVFD LDVYIRREVM
     RVWYLVKQRL DLWLESGLIE KQIPCVLVGT AGIGKSVGVG SFLLQRLLHY DSELLRIIAY
     FVKGEAYIFF MATNDHPGRV VFYEKENDGV DAVNDLADEW LLGYIIYDFS KDRHQPIPAD
     LPETWPVIVL TSPDPNNYKE WKEPRGCERF CINCYEEVEL KAAVAWRRLS KLEESKITEA
     HIINVENEWQ KIEGWIKKVG PLPRQVLEGD ERYKGRVRKI NEALAEISRG DDGYYMQVLN
     GQVEWRQDWT TCMLAKLVRV VTENGEECRN RAVSAYIEQK LRVWVDTACM RDNYLRKGFR
     GKAEHTADEF ENVGIYAFTM INVVQTIVAH LRYLPRVGEN MHLHVSVLAS GNAVGRVPTS
     LRHIHPETRG QDIEVGCFYR PAQGNFPVVD AFFFVTEPAV DTEGRAITAT TIVLLQTTVA
     PTHHTTRTKV DKFIKAMKQL FGEWDELAIN LKWELVYIQY SDCKPIDVRQ RCEPVGGRGD
     YTTELWNRIN QFQVKMEGNI VKEITQDEPN AIAGGPAA
//