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Protein

UDP-glucuronosyltransferase 2B30

Gene

UGT2B30

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol, androsterone, oestradiol, tetrahydroaldosterone and tetrahydrocortisone. This enzyme is essential to inactivation of several steroids.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKiQ8WN97

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B30 (EC:2.4.1.17)
Short name:
UDPGT 2B30
Gene namesi
Name:UGT2B30
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003604724 – 528UDP-glucuronosyltransferase 2B30Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135N6-succinyllysineBy similarity1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8WN97

Expressioni

Tissue specificityi

Expressed in several tissues, including prostate, testis, mammary gland, kidney, adrenals and intestine.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8WN97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033
KOiK00699

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WN97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKWTSALL LIQLSCYLSS GNCGKVLVWP TEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLAYSP SILPGPNNPS ALKFEICPTS LTETEFEDSV TQLVKRWSDI
110 120 130 140 150
PKDTFWPHFL QVQEMMWTYG DMIRKFCKDV VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DAISPCGELL AELLKIPFVY SLRFSPGYAI EKHGGGFLFP PSYVPVVMSE
210 220 230 240 250
FSDQMTFMER VKNMIYMVYF DFWFQAWDTK KWDQFYSEVL GRPTTLFETM
260 270 280 290 300
AKAEIWLIRN YWDFQFPHPL LPHVELVGGL HCKPAKPLPK EMEGFVQSSG
310 320 330 340 350
DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TQLYKWLPQN DLLGHPKTRA FITHGGANAI YEAIYHGIPM VGVPLFADQL
410 420 430 440 450
DNIAHMKAKG ARVSLDFNTM SSTDLLHALK TVINDPFYKE NAMKLSSIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA YDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIITK CLFCVLKFVR TGKKGKRD
Length:528
Mass (Da):60,366
Last modified:March 1, 2002 - v1
Checksum:i361349D4717C68D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401657 mRNA Translation: AAL60145.1
RefSeqiNP_001306409.1, NM_001319480.1
UniGeneiMfa.4964

Genome annotation databases

GeneIDi102127692
KEGGimcf:102127692

Similar proteinsi

Entry informationi

Entry nameiUDB30_MACFA
AccessioniPrimary (citable) accession number: Q8WN97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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