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Entry version 122 (07 Oct 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

ITPR3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2227CytoplasmicSequence analysisAdd BLAST2227
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2228 – 2248HelicalSequence analysisAdd BLAST21
Topological domaini2249 – 2256ExtracellularSequence analysis8
Transmembranei2257 – 2277HelicalSequence analysisAdd BLAST21
Topological domaini2278 – 2286CytoplasmicSequence analysis9
Transmembranei2287 – 2304HelicalSequence analysisAdd BLAST18
Topological domaini2305 – 2318ExtracellularSequence analysisAdd BLAST14
Transmembranei2319 – 2339HelicalSequence analysisAdd BLAST21
Topological domaini2340 – 2361CytoplasmicSequence analysisAdd BLAST22
Transmembranei2362 – 2382HelicalSequence analysisAdd BLAST21
Topological domaini2383 – 2489ExtracellularSequence analysisAdd BLAST107
Transmembranei2490 – 2510HelicalSequence analysisAdd BLAST21
Topological domaini2511 – 2664CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2853

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001539271 – 2664Inositol 1,4,5-trisphosphate receptor type 3Add BLAST2664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei909PhosphoserineBy similarity1
Modified residuei927PhosphoserineBy similarity1
Modified residuei1806PhosphoserineBy similarity1
Modified residuei1825PhosphoserineBy similarity1
Modified residuei1827PhosphoserineBy similarity1
Modified residuei2602PhosphoserineBy similarity1
Modified residuei2663PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WN95

PeptideAtlas

More...
PeptideAtlasi
Q8WN95

PRoteomics IDEntifications database

More...
PRIDEi
Q8WN95

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with TRPC1, TRPC3 and TRPC4.

Interacts with TRPV4 (By similarity).

Interacts with SIGMAR1 (By similarity).

Interacts with PML and AKT1 (By similarity).

Interacts with IRAG2 (via coiled-coil domain) (By similarity).

Interacts with CABP1.

Interacts with TMBIM4/LFG4.

Interacts with CEMIP (By similarity).

Interacts with TESPA1 (By similarity).

Interacts with TMEM203 (By similarity).

Interacts with BOK; regulates ITPR3 expression (By similarity).

Interacts with BCL2L10.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000047648

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8WN95

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WN95

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 173MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 224MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini232 – 288MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini295 – 372MIR 4PROSITE-ProRule annotationAdd BLAST78
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 270Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WN95

KEGG Orthology (KO)

More...
KOi
K04960

Database of Orthologous Groups

More...
OrthoDBi
94996at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45816, PTHR45816, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WN95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGTGAQGR TGRRNAGEKI
360 370 380 390 400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS
410 420 430 440 450
TNVPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
460 470 480 490 500
MLASAVEKLH EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK
510 520 530 540 550
PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ
560 570 580 590 600
HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE
660 670 680 690 700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN
710 720 730 740 750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
760 770 780 790 800
ISQQLGVDLI FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA
810 820 830 840 850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVSEAVP
860 870 880 890 900
FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQAYED
910 920 930 940 950
PGGKNVRRST QGVGHMMSTM VLNRKQSVFG GPSLPAGAGA PEPLDGSKFE
960 970 980 990 1000
ENEDIVVMET KLKILEILQF ILNVRLDYRI SYLLSVFKKE FVEVFPMQDS
1010 1020 1030 1040 1050
GADGTAPAFD STTANMNLDR IGEQAEAMFG VGKTSSMLEV DDEGGRMLLR
1060 1070 1080 1090 1100
VLIHLTMHDY APLVSGALQL LFKHFSQRQE VMHTFKQVQL LISAQDVENY
1110 1120 1130 1140 1150
KVIKSELDRL RTMVEKSELW VDKKGASKGE EGEAGPAKDK KERPTDEEGF
1160 1170 1180 1190 1200
LHPPGEKSSE NYQIVKGILE RLNKMCGVGE QMRKKQQRLL KNMDAHKVML
1210 1220 1230 1240 1250
DLLQIPYDKG DAKMMEILRY THQFLQKFCA GNPGNQALLH KHLHLFLTPG
1260 1270 1280 1290 1300
LLEAETMQHI FLNNYQLCSE IGEPVLQHFV HLLATHGHHV QYLDFLHTVI
1310 1320 1330 1340 1350
KAEGKYVKKC QDMIMTEPAN AGDDVVVFYN DKASLAHLLD MMKAARDGVE
1360 1370 1380 1390 1400
DHSPLMYHIS LVDLLAACAE GKNVYTEIKC TSLLPLEDVV SVVTHEDCIT
1410 1420 1430 1440 1450
EVKMAYVNFV NHCYVDTEVE MKEIYTSNHI WTLFENFTLD MARVCSKREK
1460 1470 1480 1490 1500
RLADPALEKY VLTVVLDTIS AFFSSPFSEN STSLQTHQTI VVQLLQSTMR
1510 1520 1530 1540 1550
LLECPWLQQQ HKGSVEACIR TLAMVAKGRA ISLPMDLDAH ISSLLSSGAS
1560 1570 1580 1590 1600
CVAAAQRNAS NYKTATRAFP RVMPTANQWD YKNIIEKLQD IITALEERLR
1610 1620 1630 1640 1650
PLVQAELSVL VDVLHWPELL FLEGSDAYQR CESGGFLSKL IQHTKDLMES
1660 1670 1680 1690 1700
EEKLCVKVLR TLQQMLLKKT KYGDRGNQLR KMLLQNYLQN RKSSSRGDLP
1710 1720 1730 1740 1750
DPMGTGLDQD WSAIAATQCR LDKEGATKLV CDLITSTKNE KIFQESIGLA
1760 1770 1780 1790 1800
IRLLDGGNTE IQKSFYNLMT SDKKSERFFK VLHDRMKRAQ QETKSTVAVN
1810 1820 1830 1840 1850
MSDLGSQPRE DREQADPTSK GRVASFSMPS SSSRYALGPS LRRGHEVGER
1860 1870 1880 1890 1900
VQSNEMGTSV LIMQPILRFL QLLCENHNRD LQNFLRCQNN KTNYNLVCET
1910 1920 1930 1940 1950
LQFLDIMCGS TTGGLGLLGL YINEDNVGLV IQTLETLTEY CQGPCHENQT
1960 1970 1980 1990 2000
CIVTHESNGI DIITALILND ISPLCKYRMD LVLQLKDNAS KLLLALMESR
2010 2020 2030 2040 2050
HDSENAERIL ISLRPQELVD VIKKAYLQEE ERENSDVSPR EVGHNIYILA
2060 2070 2080 2090 2100
LQLSRHNKQL QHLLKPVKRI QEEEAEGISS MLSLNNKQLT QMLKSSAPVQ
2110 2120 2130 2140 2150
EQEEDPLAYY ENHTSQIEIV RQDRSMEQIV FPVPGICQFL TEETKHRLFT
2160 2170 2180 2190 2200
TTEQDEQGSK VSDLFDQPSF LHNEMEWQRK LRSMPLIYWF SRRMTLWGSI
2210 2220 2230 2240 2250
SFNLAVFINI IIAFFYPYVE GASTGVLGSP LISLLFWILI CFSIAALFTK
2260 2270 2280 2290 2300
RYSVRPLIVA LILRSIYYLG IGPTLNILGA LNLTNKIVFV VSFVGNRGTF
2310 2320 2330 2340 2350
IRGYKAMVMD MEFLYHVGYI LTSVLGLFAH ELFYSILLFD LIYREETLFN
2360 2370 2380 2390 2400
VIKSVTRNGR SILLTALLAL ILVYLFSIVG FLFLKDDFIL EVDRLPGNHS
2410 2420 2430 2440 2450
RANPLGMPHG AATFVNTCSG DNVDCVSGVS VPEVLAEDEE PDSTERACDT
2460 2470 2480 2490 2500
LLMCIVTVMN HGLRNGGGVG DILRKPSKDE SLFPARVVYD LLFFFIVIII
2510 2520 2530 2540 2550
VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERDK FDNKTVSFEE
2560 2570 2580 2590 2600
HIKFEHNMWN YLYFIVLVRV KNKTDYTGPE SYVAQMIKNK NLDWFPRMRA
2610 2620 2630 2640 2650
MSLVSSEGEG EQNEIRILQD KLSATMKLVS HLTAQLSELK EQMTEQRKRR
2660
QRLGFVDVQN CMSR
Length:2,664
Mass (Da):303,040
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C2C9979146E19AB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF402601 mRNA Translation: AAL39078.1

NCBI Reference Sequences

More...
RefSeqi
NP_776795.1, NM_174370.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
281879

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281879

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF402601 mRNA Translation: AAL39078.1
RefSeqiNP_776795.1, NM_174370.3

3D structure databases

SMRiQ8WN95
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047648

Chemistry databases

BindingDBiQ8WN95
ChEMBLiCHEMBL2853

Proteomic databases

PaxDbiQ8WN95
PeptideAtlasiQ8WN95
PRIDEiQ8WN95

Genome annotation databases

GeneIDi281879
KEGGibta:281879

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3710

Phylogenomic databases

eggNOGiKOG3533, Eukaryota
InParanoidiQ8WN95
KOiK04960
OrthoDBi94996at2759

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PANTHERiPTHR45816, PTHR45816, 1 hit
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR3_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WN95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2002
Last modified: October 7, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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