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Protein

Sodium channel protein

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei159 – 178HelicalUniRule annotationAdd BLAST20
Transmembranei230 – 247HelicalUniRule annotationAdd BLAST18
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei391 – 419HelicalUniRule annotationAdd BLAST29
Transmembranei721 – 739HelicalUniRule annotationAdd BLAST19
Transmembranei751 – 772HelicalUniRule annotationAdd BLAST22
Transmembranei784 – 801HelicalUniRule annotationAdd BLAST18
Transmembranei841 – 864HelicalUniRule annotationAdd BLAST24
Transmembranei884 – 901HelicalUniRule annotationAdd BLAST18
Transmembranei921 – 944HelicalUniRule annotationAdd BLAST24
Transmembranei1210 – 1229HelicalUniRule annotationAdd BLAST20
Transmembranei1250 – 1266HelicalUniRule annotationAdd BLAST17
Transmembranei1278 – 1299HelicalUniRule annotationAdd BLAST22
Transmembranei1327 – 1353HelicalUniRule annotationAdd BLAST27
Transmembranei1449 – 1475HelicalUniRule annotationAdd BLAST27
Transmembranei1534 – 1552HelicalUniRule annotationAdd BLAST19
Transmembranei1564 – 1586HelicalUniRule annotationAdd BLAST23
Transmembranei1598 – 1614HelicalUniRule annotationAdd BLAST17
Transmembranei1651 – 1679HelicalUniRule annotationAdd BLAST29
Transmembranei1754 – 1777HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ8WMP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 425Ion_transInterPro annotationAdd BLAST296
Domaini481 – 670Na_trans_cytoplInterPro annotationAdd BLAST190
Domaini721 – 948Ion_transInterPro annotationAdd BLAST228
Domaini958 – 1205Na_trans_assocInterPro annotationAdd BLAST248
Domaini1209 – 1484Ion_transInterPro annotationAdd BLAST276
Domaini1533 – 1787Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 41Sequence analysisAdd BLAST21
Coiled coili416 – 450Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
KOiK04838

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequencei

Sequence statusi: Complete.

Q8WMP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESRDGLPEEE
60 70 80 90 100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LHVLSPFHPI RRVAVKILVH SLFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYIFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTVLNGT NSTNASVEAD
310 320 330 340 350
GLIWASLDDY LNDPENYLLK NGTSDVLLCG NSSDAGTCPE GYRCLKAGGN
360 370 380 390 400
PDHGYTSFDS FAWAFLALFR LMTQDCWERL YQQTLRSAGK IYMIFFMLVI
410 420 430 440 450
FLGSFYLVNL ILAVVAMAYE EQNQATIAET EEKEKRFQEA MELLKKEQEA
460 470 480 490 500
LAIRGVDTVS RSSLEMSPLA PVTTHERRSK RRKRMSSGME ECGDDKFPKS
510 520 530 540 550
DSEDGPRAVN RFSITHGLSR TSMKPRSSHG SIFTFRRRDL GSETDFADDE
560 570 580 590 600
NSTAGDSESH RTSLLVPWPL RRPSTLGQPS PGTSTPGHVL NGKRNSTVDC
610 620 630 640 650
NGVVSLLGAG DPEATSPGSH LLHPMKLERP PDTTTPSEEP GRPQTLTPQA
660 670 680 690 700
PCVDGFEEPG ERQRALSAVS VLTSALEELE ESQRRCPPCW IRFAQHYLIW
710 720 730 740 750
ECCPLWMSIK QKVKFMVMDP FADLTITMCI VLNTLFMALE HYNMTTEFEE
760 770 780 790 800
MLQVGNLVFT GIFTAEMTFK IIALDPYYYF QQGWNIFDSI IVILSLMELG
810 820 830 840 850
LSRMGNLSVL RSFCLLRVFK LAKSWPTLNT LIKIIGNSVG ALGNLTLVLA
860 870 880 890 900
IIVFIFAVVG MQLFGKNYSE QRHRISDSGL LPRWHMMDFF HAFLIIFRIL
910 920 930 940 950
CGEWIETMWD CMEVSGQSLC LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD
960 970 980 990 1000
NLTAPDEDGE MNNLQLALAR IQRGLRFIKR TTWDFCCVLL QRPPQKPAAL
1010 1020 1030 1040 1050
ASQGQLPGCI ATSSPPPQPE SEKAPPARKE TRFEEGQRPG QGAPGDAEPV
1060 1070 1080 1090 1100
CVPIAVAESD TDDPEEDEEN SLSTEEESSK QQESQLASGS PEALPEPRVW
1110 1120 1130 1140 1150
SQVSETTSSG AEASEVQADL RQQRRAEAPA PGCSELPEDS YSEGSTADMT
1160 1170 1180 1190 1200
NTADLLEQIP DLGEDVKDPE DCFTEGCVRR CPCCTVDTTQ AHGKVWWRLR
1210 1220 1230 1240 1250
KTCYRIVEHS WFETFIIFMI LLSSGALAFE DIYLEERKTI KVLLEYADKM
1260 1270 1280 1290 1300
FTYVFVLEML LKWVAYGFKK YFTNAWCWLD FLIVDVLLIS LVANALGFAE
1310 1320 1330 1340 1350
MGPIKSLRTL RALRPLRALS RFEGMRVVVN ALVGAIPSIM NVLLVCLIFW
1360 1370 1380 1390 1400
LIFSIMGVNL FAGKFGRCIN QTEGDLPLNY TIVNNKSDCE SFNVTGELYW
1410 1420 1430 1440 1450
TKVKVNFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRGYE EQPQWEYNLY
1460 1470 1480 1490 1500
MYIYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY
1510 1520 1530 1540 1550
NAMKKLGSKK PQKPIPRPLN KYQGFIFDIV TKQAFDVTIM FLICLNMVTM
1560 1570 1580 1590 1600
MVETDDQSPE KVNILAKINL LFVGIFTAEC IFKMVALRHY YFTNSWNIFD
1610 1620 1630 1640 1650
FVVVILSIVG TVLSDIIQKY FFSPTLFRVI RLARISRILR LIRGAKGIRT
1660 1670 1680 1690 1700
LLFALMMSLP ALFNIGLLLF LVMFIYSIFG MANFAYVKWE AGIDDMFNFQ
1710 1720 1730 1740 1750
TFANSMLCLF QITTSAGWDG LLSPILNTGP PYCDPNLPNS NGSRGNCGSP
1760 1770 1780 1790 1800
AVGILFFTTY IIISFLIVVN MYIAIILENF SVATEESTEP LSEDDFDMFY
1810 1820 1830 1840 1850
EIWEKFDPEA TQFIEYLALS DFADALSEPL RIPKPNQISL INMDLPMVSG
1860 1870 1880 1890 1900
DRIHCMDILF AFTKRVLGES GEMDALKIQM EEKFMAANPS KISYEPITTT
1910 1920 1930 1940 1950
LRRKHEEVSA TIIQRAFRRH LLQRSVKHAS FLYRQQAGSS GLSEEDAPEQ
1960 1970 1980 1990 2000
EGLIAYMMNE NFSRRPGPPS SSSVSSTSFP PSYDSVTRAT SDNPQVRASD
2010 2020
YSPSEDLADF PPTPDRDRES IV
Length:2,022
Mass (Da):227,894
Last modified:March 1, 2002 - v1
Checksum:i5B7C9E08B1998779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251721 mRNA Translation: CAC80974.1
RefSeqiNP_776883.1, NM_174458.2
UniGeneiBt.9562

Genome annotation databases

GeneIDi282061
KEGGibta:282061

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251721 mRNA Translation: CAC80974.1
RefSeqiNP_776883.1, NM_174458.2
UniGeneiBt.9562

3D structure databases

ProteinModelPortaliQ8WMP8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282061
KEGGibta:282061

Organism-specific databases

CTDi6331

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
KOiK04838

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WMP8_BOVIN
AccessioniPrimary (citable) accession number: Q8WMP8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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