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UniProtKB - Q8WMN1 (GTR5_SHEEP)
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Gene
SLC2A5
Organism
Ovis aries (Sheep)
Status
Functioni
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | D-fructoseBy similarity | 1 | |
Binding sitei | 167 | D-fructoseBy similarity | 1 | |
Binding sitei | 288 | D-fructoseBy similarity | 1 | |
Binding sitei | 387 | D-fructoseBy similarity | 1 |
GO - Molecular functioni
- fructose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- cellular response to fructose stimulus Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 5CuratedAlternative name(s): Fructose transporterCurated Glucose transporter type 5, small intestine1 Publication Short name: GLUT-51 Publication |
Gene namesi | Name:SLC2A5By similarity Synonyms:GLUT51 Publication |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Multi-pass membrane protein By similarity
- Cell membrane By similarity; Multi-pass membrane protein By similarity
- sarcolemma By similarity
Note: Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 18 | CytoplasmicBy similarityAdd BLAST | 18 | |
Transmembranei | 19 – 39 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 40 – 68 | ExtracellularBy similarityAdd BLAST | 29 | |
Transmembranei | 69 – 91 | Helical; Name=2By similarityAdd BLAST | 23 | |
Topological domaini | 92 – 98 | CytoplasmicBy similarity | 7 | |
Transmembranei | 99 – 119 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 120 – 126 | ExtracellularBy similarity | 7 | |
Transmembranei | 127 – 149 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 150 – 161 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 162 – 182 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 183 – 192 | ExtracellularBy similarity | 10 | |
Transmembranei | 193 – 213 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 214 – 277 | CytoplasmicBy similarityAdd BLAST | 64 | |
Transmembranei | 278 – 298 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 299 – 313 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 314 – 334 | Helical; Name=8By similarityAdd BLAST | 21 | |
Topological domaini | 335 – 342 | CytoplasmicBy similarity | 8 | |
Transmembranei | 343 – 363 | Helical; Name=9By similarityAdd BLAST | 21 | |
Topological domaini | 364 – 371 | ExtracellularBy similarity | 8 | |
Transmembranei | 372 – 394 | Helical; Name=10By similarityAdd BLAST | 23 | |
Topological domaini | 395 – 412 | CytoplasmicBy similarityAdd BLAST | 18 | |
Transmembranei | 413 – 433 | Helical; Name=11By similarityAdd BLAST | 21 | |
Topological domaini | 434 – 439 | ExtracellularBy similarity | 6 | |
Transmembranei | 440 – 460 | Helical; Name=12By similarityAdd BLAST | 21 | |
Topological domaini | 461 – 501 | CytoplasmicBy similarityAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317271 | 1 – 501 | Solute carrier family 2, facilitated glucose transporter member 5Add BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Acetylation, GlycoproteinFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 296 – 298 | D-fructose bindingBy similarity | 3 | |
Regioni | 419 – 420 | D-fructose bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
OMAi | PTEMRGK |
OrthoDBi | 326501at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002442, Fru_transpt_5 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01194, GLUCTRSPORT5 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8WMN1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPQDPVKRE GRLTPVIVLA TLIAAFGSSF QYGYNVATIN SPSEFMKDFY
60 70 80 90 100
NYTYYDRVGE YMNEFYLTLL WSVTVSMFPF GGFLGSLMVG PLVNNLGRKG
110 120 130 140 150
TLLFNNIFSI VPALLMGFSD LAKSFEMIIV ARVLVGICAG LSSNVVPMYL
160 170 180 190 200
GELAPKNWRG ALGVVPQLFI TIGILVAQIF GLRSLLANEE GWPILLGLTG
210 220 230 240 250
IPAVLQLLFL PFFPESPRYL LIQKKDEEAA KRALRRLRGW HDVDAEIEEI
260 270 280 290 300
LEEDRAEKAA GFISVLKLFK MRSLRWQVIS IIVLMAGQQL SGVNAIYYYA
310 320 330 340 350
DQIYLSAGVK EDDVQYVTAG TGAVNVLITV CAIFVVELMG RRFLLLLGFS
360 370 380 390 400
VCFTACCVLT GALAMQDVIS WMPYVSIACV ISYVIGHALG PSPIPALLVT
410 420 430 440 450
EIFLQSSRPA AYMVAGTVHW LSNFTVGLVF PFIQVGLGAY SFVIFAVICF
460 470 480 490 500
LTTVYIFLII PETKSKTFIE INQIFIKMNK VPGVHPEKEE LKEFPPSTAR
Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315928 mRNA Translation: CAC86964.1 |
RefSeqi | NP_001009451.1, NM_001009451.1 |
Genome annotation databases
Ensembli | ENSOART00020029058; ENSOARP00020024057; ENSOARG00020018688 ENSOART00020029119; ENSOARP00020024113; ENSOARG00020018688 |
GeneIDi | 443507 |
KEGGi | oas:443507 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315928 mRNA Translation: CAC86964.1 |
RefSeqi | NP_001009451.1, NM_001009451.1 |
3D structure databases
SMRi | Q8WMN1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000009608 |
Genome annotation databases
Ensembli | ENSOART00020029058; ENSOARP00020024057; ENSOARG00020018688 ENSOART00020029119; ENSOARP00020024113; ENSOARG00020018688 |
GeneIDi | 443507 |
KEGGi | oas:443507 |
Organism-specific databases
CTDi | 6518 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
OMAi | PTEMRGK |
OrthoDBi | 326501at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002442, Fru_transpt_5 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01194, GLUCTRSPORT5 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR5_SHEEP | |
Accessioni | Q8WMN1Primary (citable) accession number: Q8WMN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families