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Entry version 116 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

ND1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNADUniRule annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1UniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ND1Imported
Synonyms:NADH1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Transmembranei68 – 86HelicalSequence analysisAdd BLAST19
Transmembranei98 – 119HelicalSequence analysisAdd BLAST22
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Transmembranei220 – 243HelicalSequence analysisAdd BLAST24
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Transmembranei293 – 314HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4770 Eukaryota
COG1005 LUCA

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01350 NDH1_NuoH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11432 PTHR11432, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00146 NADHdh, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8WCX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMANLLLLI VPILIAMAFL MLTERKILGY MQLRKGPNVV GPYGLLQPFA
60 70 80 90 100
DAMKLFTKEP LKPATSTITL YITAPTLALT IALLLWTPLP MPNPLVNLNL
110 120 130 140 150
GLLFILATSS LAVYSILWSG WASNSNYALI GALRAVAQTI SYEVTLAIIL
160 170 180 190 200
LSTLLMSGSF NLSTLITTQE HLWLLLPSWP LAMMWFISTL AETNRTPFDL
210 220 230 240 250
AEGESELVSG FNIEYAAGPF ALFFMAEYTN IIMMNTLTTM IFLGTTYDAL
260 270 280 290 300
SPELYTTYFV TKTLLLTSLF LWIRTAYPRF RYDQLMHLLW KNFLPLTLAL
310
LMWYVSMPIT ISSIPPQT
Length:318
Mass (Da):35,691
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0895BF8C65003AB3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF382000 Genomic DNA Translation: AAL54631.1
AY714006 Genomic DNA Translation: AAU02514.1
DQ112895 Genomic DNA Translation: AAZ02503.1
EF661012 Genomic DNA Translation: ABR58810.1
EU440736 Genomic DNA Translation: ABZ05740.1
FJ748725 Genomic DNA Translation: ACN37389.1
GQ337672 Genomic DNA Translation: ACU11302.1
HM852846 Genomic DNA Translation: ADL31064.1
HM238197 Genomic DNA Translation: ADV35148.1
HM238212 Genomic DNA Translation: ADV35343.1
JQ044990 Genomic DNA Translation: AEV49437.1
JQ701864 Genomic DNA Translation: AFF62190.1
JQ705425 Genomic DNA Translation: AFG08483.1
JQ705999 Genomic DNA Translation: AFG15945.1
JQ706025 Genomic DNA Translation: AFG16283.1
JQ706026 Genomic DNA Translation: AFG16296.1
JQ706032 Genomic DNA Translation: AFG16374.1
JQ706041 Genomic DNA Translation: AFG16489.1
JQ706045 Genomic DNA Translation: AFG16541.1
JQ706046 Genomic DNA Translation: AFG16554.1
JQ706047 Genomic DNA Translation: AFG16567.1
JQ706062 Genomic DNA Translation: AFG16761.1
JQ706067 Genomic DNA Translation: AFG16826.1
JX153805 Genomic DNA Translation: AFO33638.1
JX900529 Genomic DNA Translation: AGC17891.1
KC257364 Genomic DNA Translation: AGE02092.1
KC994073 Genomic DNA Translation: AGO23934.1
KC994080 Genomic DNA Translation: AGO24025.1
KC911405 Genomic DNA Translation: AGO92005.1
KC911489 Genomic DNA Translation: AGO93097.1
KC911602 Genomic DNA Translation: AGO94566.1
KF161161 Genomic DNA Translation: AGW55659.1
KF161287 Genomic DNA Translation: AGW57297.1
KF161593 Genomic DNA Translation: AGW61274.1
KF161736 Genomic DNA Translation: AGW63133.1
KF162884 Genomic DNA Translation: AGW78057.1
KF451075 Genomic DNA Translation: AGZ67608.1
KF451764 Genomic DNA Translation: AGZ76565.1
KJ154797 Genomic DNA Translation: AHW38020.1
KJ154800 Genomic DNA Translation: AHW38059.1
KJ154802 Genomic DNA Translation: AHW38085.1
KJ154804 Genomic DNA Translation: AHW38111.1
KJ154808 Genomic DNA Translation: AHW38163.1
KJ154816 Genomic DNA Translation: AHW38267.1
KJ154819 Genomic DNA Translation: AHW38306.1
KJ154825 Genomic DNA Translation: AHW38384.1
KJ154828 Genomic DNA Translation: AHW38423.1
KJ154834 Genomic DNA Translation: AHW38501.1
KJ154867 Genomic DNA Translation: AHW38930.1
KJ154877 Genomic DNA Translation: AHW39060.1
KJ676824 Genomic DNA Translation: AHW57227.1
KJ446128 Genomic DNA Translation: AHX47718.1
KJ446554 Genomic DNA Translation: AHX53256.1
KJ716338 Genomic DNA Translation: AHX59016.1
KT779176 Genomic DNA Translation: AMA97424.1
KT779190 Genomic DNA Translation: AMA97606.1
KU683456 Genomic DNA Translation: AOR48859.1
KX456593 Genomic DNA Translation: APD54739.1
KX457355 Genomic DNA Translation: APD64644.1
KX457374 Genomic DNA Translation: APD64891.1
KX457494 Genomic DNA Translation: APD66450.1
KY408604 Genomic DNA Translation: AQU21262.1
KY409299 Genomic DNA Translation: AQU30297.1
KY409948 Genomic DNA Translation: AQU38734.1
KY849396 Genomic DNA Translation: ARD70912.1
KY824997 Genomic DNA Translation: ARK17340.1
KY411439 Genomic DNA Translation: ARM18895.1
KY411446 Genomic DNA Translation: ARM18974.1
MF112252 Genomic DNA Translation: ARS25221.1
KY671105 Genomic DNA Translation: ASC48014.1
MF362793 Genomic DNA Translation: ASF85003.1
MF057719 Genomic DNA Translation: ASS19445.1
KY680797 Genomic DNA Translation: ASZ80450.1
MG015877 Genomic DNA Translation: ATG80607.1
MG272752 Genomic DNA Translation: AVL87196.1
MH322053 Genomic DNA Translation: AWJ95140.1
MH449037 Genomic DNA Translation: AYW05193.1
MH043569 Genomic DNA Translation: AZM31882.1
AP008594 Genomic DNA Translation: BAE11707.1
AJ842747 Genomic DNA Translation: CAH59658.1
MK890795 Genomic DNA Translation: QCT84267.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF382000 Genomic DNA Translation: AAL54631.1
AY714006 Genomic DNA Translation: AAU02514.1
DQ112895 Genomic DNA Translation: AAZ02503.1
EF661012 Genomic DNA Translation: ABR58810.1
EU440736 Genomic DNA Translation: ABZ05740.1
FJ748725 Genomic DNA Translation: ACN37389.1
GQ337672 Genomic DNA Translation: ACU11302.1
HM852846 Genomic DNA Translation: ADL31064.1
HM238197 Genomic DNA Translation: ADV35148.1
HM238212 Genomic DNA Translation: ADV35343.1
JQ044990 Genomic DNA Translation: AEV49437.1
JQ701864 Genomic DNA Translation: AFF62190.1
JQ705425 Genomic DNA Translation: AFG08483.1
JQ705999 Genomic DNA Translation: AFG15945.1
JQ706025 Genomic DNA Translation: AFG16283.1
JQ706026 Genomic DNA Translation: AFG16296.1
JQ706032 Genomic DNA Translation: AFG16374.1
JQ706041 Genomic DNA Translation: AFG16489.1
JQ706045 Genomic DNA Translation: AFG16541.1
JQ706046 Genomic DNA Translation: AFG16554.1
JQ706047 Genomic DNA Translation: AFG16567.1
JQ706062 Genomic DNA Translation: AFG16761.1
JQ706067 Genomic DNA Translation: AFG16826.1
JX153805 Genomic DNA Translation: AFO33638.1
JX900529 Genomic DNA Translation: AGC17891.1
KC257364 Genomic DNA Translation: AGE02092.1
KC994073 Genomic DNA Translation: AGO23934.1
KC994080 Genomic DNA Translation: AGO24025.1
KC911405 Genomic DNA Translation: AGO92005.1
KC911489 Genomic DNA Translation: AGO93097.1
KC911602 Genomic DNA Translation: AGO94566.1
KF161161 Genomic DNA Translation: AGW55659.1
KF161287 Genomic DNA Translation: AGW57297.1
KF161593 Genomic DNA Translation: AGW61274.1
KF161736 Genomic DNA Translation: AGW63133.1
KF162884 Genomic DNA Translation: AGW78057.1
KF451075 Genomic DNA Translation: AGZ67608.1
KF451764 Genomic DNA Translation: AGZ76565.1
KJ154797 Genomic DNA Translation: AHW38020.1
KJ154800 Genomic DNA Translation: AHW38059.1
KJ154802 Genomic DNA Translation: AHW38085.1
KJ154804 Genomic DNA Translation: AHW38111.1
KJ154808 Genomic DNA Translation: AHW38163.1
KJ154816 Genomic DNA Translation: AHW38267.1
KJ154819 Genomic DNA Translation: AHW38306.1
KJ154825 Genomic DNA Translation: AHW38384.1
KJ154828 Genomic DNA Translation: AHW38423.1
KJ154834 Genomic DNA Translation: AHW38501.1
KJ154867 Genomic DNA Translation: AHW38930.1
KJ154877 Genomic DNA Translation: AHW39060.1
KJ676824 Genomic DNA Translation: AHW57227.1
KJ446128 Genomic DNA Translation: AHX47718.1
KJ446554 Genomic DNA Translation: AHX53256.1
KJ716338 Genomic DNA Translation: AHX59016.1
KT779176 Genomic DNA Translation: AMA97424.1
KT779190 Genomic DNA Translation: AMA97606.1
KU683456 Genomic DNA Translation: AOR48859.1
KX456593 Genomic DNA Translation: APD54739.1
KX457355 Genomic DNA Translation: APD64644.1
KX457374 Genomic DNA Translation: APD64891.1
KX457494 Genomic DNA Translation: APD66450.1
KY408604 Genomic DNA Translation: AQU21262.1
KY409299 Genomic DNA Translation: AQU30297.1
KY409948 Genomic DNA Translation: AQU38734.1
KY849396 Genomic DNA Translation: ARD70912.1
KY824997 Genomic DNA Translation: ARK17340.1
KY411439 Genomic DNA Translation: ARM18895.1
KY411446 Genomic DNA Translation: ARM18974.1
MF112252 Genomic DNA Translation: ARS25221.1
KY671105 Genomic DNA Translation: ASC48014.1
MF362793 Genomic DNA Translation: ASF85003.1
MF057719 Genomic DNA Translation: ASS19445.1
KY680797 Genomic DNA Translation: ASZ80450.1
MG015877 Genomic DNA Translation: ATG80607.1
MG272752 Genomic DNA Translation: AVL87196.1
MH322053 Genomic DNA Translation: AWJ95140.1
MH449037 Genomic DNA Translation: AYW05193.1
MH043569 Genomic DNA Translation: AZM31882.1
AP008594 Genomic DNA Translation: BAE11707.1
AJ842747 Genomic DNA Translation: CAH59658.1
MK890795 Genomic DNA Translation: QCT84267.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG4770 Eukaryota
COG1005 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ND1 human

Family and domain databases

HAMAPiMF_01350 NDH1_NuoH, 1 hit
InterProiView protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432 PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146 NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8WCX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WCX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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