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Entry version 136 (29 Sep 2021)
Sequence version 1 (01 Mar 2002)
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Protein

Cationic amino acid transporter 4, vacuolar

Gene

CAT4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Permease involved in the transport of the cationic amino acids.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.3.14, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 4, vacuolar
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAT4
Ordered Locus Names:At3g03720
ORF Names:F20H23.25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G03720

The Arabidopsis Information Resource

More...
TAIRi
locus:2079414, AT3G03720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 60VacuolarSequence analysis7
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 92CytoplasmicSequence analysisAdd BLAST11
Transmembranei93 – 115HelicalSequence analysisAdd BLAST23
Topological domaini116 – 152VacuolarSequence analysisAdd BLAST37
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 184CytoplasmicSequence analysisAdd BLAST11
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 220VacuolarSequence analysisAdd BLAST15
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 264CytoplasmicSequence analysisAdd BLAST23
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 308VacuolarSequence analysisAdd BLAST23
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 360CytoplasmicSequence analysisAdd BLAST31
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382VacuolarSequence analysis1
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Topological domaini404 – 462CytoplasmicSequence analysisAdd BLAST59
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 492VacuolarSequence analysis9
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 528CytoplasmicSequence analysisAdd BLAST15
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550VacuolarSequence analysis1
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 600CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004157801 – 600Cationic amino acid transporter 4, vacuolarAdd BLAST600

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8W4K3

PRoteomics IDEntifications database

More...
PRIDEi
Q8W4K3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
240537

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8W4K3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, stems, flowers, and leaves.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8W4K3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8W4K3, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
6509, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8W4K3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G03720.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007946_15_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8W4K3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHSVEAS

Database of Orthologous Groups

More...
OrthoDBi
439017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8W4K3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293, AA/rel_permease1
IPR029485, CAT_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520, AA_permease_2, 1 hit
PF13906, AA_permease_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8W4K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLVRRKQV DSVHLIKNDG PHQLAKKLSA VDLVAIGVGT TIGAGVYILV
60 70 80 90 100
GTVAREHTGP ALAVSFFIAG VAAALSACCY AELASRCPSA GSAYHYAYIC
110 120 130 140 150
LGEGIAWLVG WALVLDYTIG GSAIARGITP NLASFFGGLD NLPVFLARQT
160 170 180 190 200
IPGVGIVVDP CAALLIMIVT ILLCFGIKES STVQAIVTSV NVCTLVFIIV
210 220 230 240 250
VGGYLACKTG WVGYDLPSGY FPFGLNGILA GSAVVFFSYI GFDTVTSTAE
260 270 280 290 300
EVKNPQRDLP LGIGIALLIC CILYMLLSVV IVGLVPYYSL NPDTPISSAF
310 320 330 340 350
GDSGMQWAAY ILTTGAITAL CASLLGSLLA QPRIFMAMAR DGLLPAFFSE
360 370 380 390 400
ISPRTQVPVK STIAIGVLAA ALAFFMDVAQ LSEMVSVGTL MAFTAVAVCV
410 420 430 440 450
LVLRYVPPDG VPLSSSSQTL SDTDESRAET ENFLVDAIES SDSPLLGNET
460 470 480 490 500
ARDEKYFGKR RKIAAWSIAL VCIGVLGLAS AASAERLPSF PRFTICGVSA
510 520 530 540 550
VILLGSLITL GYIDEDEERH NFGHKGGFLC PFVPYLPVLC ILINTYLIIN
560 570 580 590 600
IGAGTWIRVL IWLLIGSMIY IFYGRSHSLL NNAVYVPTMT CTRKTTDHLA
Length:600
Mass (Da):63,639
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB74D371C3067D882
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF00645 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009540 Genomic DNA Translation: AAF00645.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE73975.2
AY062508 mRNA Translation: AAL32586.1
BT008369 mRNA Translation: AAP37728.1

NCBI Reference Sequences

More...
RefSeqi
NP_001154586.1, NM_001161114.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G03720.1; AT3G03720.1; AT3G03720

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
821176

Gramene; a comparative resource for plants

More...
Gramenei
AT3G03720.1; AT3G03720.1; AT3G03720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G03720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA Translation: AAF00645.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE73975.2
AY062508 mRNA Translation: AAL32586.1
BT008369 mRNA Translation: AAP37728.1
RefSeqiNP_001154586.1, NM_001161114.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi6509, 2 interactors
IntActiQ8W4K3, 2 interactors
STRINGi3702.AT3G03720.1

Protein family/group databases

TCDBi2.A.3.3.14, the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ8W4K3

Proteomic databases

PaxDbiQ8W4K3
PRIDEiQ8W4K3
ProteomicsDBi240537

Genome annotation databases

EnsemblPlantsiAT3G03720.1; AT3G03720.1; AT3G03720
GeneIDi821176
GrameneiAT3G03720.1; AT3G03720.1; AT3G03720
KEGGiath:AT3G03720

Organism-specific databases

AraportiAT3G03720
TAIRilocus:2079414, AT3G03720

Phylogenomic databases

eggNOGiKOG1286, Eukaryota
HOGENOMiCLU_007946_15_1_1
InParanoidiQ8W4K3
OMAiWHSVEAS
OrthoDBi439017at2759
PhylomeDBiQ8W4K3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8W4K3

Gene expression databases

ExpressionAtlasiQ8W4K3, baseline and differential
GenevisibleiQ8W4K3, AT

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
IPR029485, CAT_C
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit
PF13906, AA_permease_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAAT4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8W4K3
Secondary accession number(s): F4J170, Q9SRU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2002
Last modified: September 29, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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