Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (12 Aug 2020)
Sequence version 2 (11 Apr 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Disease resistance protein RPP8

Gene

RPP8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. The interaction with TIP (TCV-interacting protein) may be essential for the recognition of the avirulence proteins, and the triggering of the defense response. Triggers resistance to turnip crinkle virus (TCV) via a SAG101-dependent pathway.2 Publications

Miscellaneous

In cv. Columbia and cv. Landsberg erecta, RPP8 specifically recognizes the Emco5 avirulence protein from Hyaloperonospora parasitica, while it is not the case in cv. Di-17, where it confers resistance to Turnip Crinkle Virus upon recognition of the viral capsid protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi192 – 199ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHypersensitive response, Plant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disease resistance protein RPP8
Alternative name(s):
Resistance to Peronospora parasitica protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPP8
Synonyms:HRT
Ordered Locus Names:At5g43470
ORF Names:MWF20.19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G43470

The Arabidopsis Information Resource

More...
TAIRi
locus:2176486, AT5G43470

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi418D → N in rpp8-1; loss of function. 1 Publication1
Mutagenesisi553R → K in rpp8-2; loss of function. 1 Publication1
Mutagenesisi830S → L in rpp8-1; loss of function. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002127191 – 908Disease resistance protein RPP8Add BLAST908

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8W4J9

PRoteomics IDEntifications database

More...
PRIDEi
Q8W4J9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
226905 [Q8W4J9-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in leaves, and, to a lower extent, in roots.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By salicylic acid (SA) (PubMed:22072959, PubMed:20831409). Induced by Hyaloperonospora arabidopsidis, benzothiadiazole (BTH) and wounding (PubMed:20831409). Degraded in darkness and in blue-light (PubMed:20624951).3 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8W4J9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8W4J9, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the NAC protein TIP (PubMed:11041886).

Interacts with MORC1/CRT1 (PubMed:18191794, PubMed:20332379).

Interacts with COP1 and is subsequently degraded in a 26s proteasome dependent manner (PubMed:20624951).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
19617, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-59355N

Protein interaction database and analysis system

More...
IntActi
Q8W4J9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G43470.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 459NB-ARCSequence analysisAdd BLAST314
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati575 – 600LRR 1Sequence analysisAdd BLAST26
Repeati601 – 623LRR 2Sequence analysisAdd BLAST23
Repeati648 – 673LRR 3Sequence analysisAdd BLAST26
Repeati693 – 718LRR 4Sequence analysisAdd BLAST26
Repeati722 – 746LRR 5Sequence analysisAdd BLAST25
Repeati748 – 770LRR 6Sequence analysisAdd BLAST23
Repeati793 – 820LRR 7Sequence analysisAdd BLAST28
Repeati842 – 867LRR 8Sequence analysisAdd BLAST26
Repeati882 – 905LRR 9Sequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 57Sequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LRR repeats probably act as specificity determinant of pathogen recognition.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4658, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000837_25_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8W4J9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFINCDQ

Database of Orthologous Groups

More...
OrthoDBi
164862at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8W4J9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14798, RX-CC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8W4J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAFVSFGL EKLWDLLSRE SERLQGIDGQ LDGLKRQLRS LQSLLKDADA
60 70 80 90 100
KKHGSDRVRN FLEDVKDLVF DAEDIIESYV LNKLSGKGKG VKKHVRRLAC
110 120 130 140 150
FLTDRHKVAS DIEGITKRIS EVIGEMQSFG IQQIIDGGRS LSLQERQRVQ
160 170 180 190 200
REIRQTYPDS SESDLVGVEQ SVKELVGHLV ENDVHQVVSI AGMGGIGKTT
210 220 230 240 250
LARQVFHHDL VRRHFDGFAW VCVSQQFTQK HVWQRILQEL QPHDGDILQM
260 270 280 290 300
DEYALQRKLF QLLEAGRYLV VLDDVWKKED WDVIKAVFPR KRGWKMLLTS
310 320 330 340 350
RNEGVGIHAD PTCLTFRASI LNPEESWKLC ERIVFPRRDE TEVRLDEEME
360 370 380 390 400
AMGKEMVTHC GGLPLAVKAL GGLLANKHTV PEWKRVFDNI GSQIVGGSWL
410 420 430 440 450
DDNSLNSVYR ILSLSYEDLP THLKHCFLNL AHFPEDSEIS TYSLFYYWAA
460 470 480 490 500
EGIYDGSTIE DSGEYYLEEL VRRNLVIADD NYLSWQSKYC QMHDMMREVC
510 520 530 540 550
LSKAKEENFL QIIIDPTCTS TINAQSPSRS RRLSIHSGKA FHILGHKNKT
560 570 580 590 600
KVRSLIVPRF EEDYWIRSAS VFHNLTLLRV LDLSWVKFEG GKLPCSIGGL
610 620 630 640 650
IHLRYLSLYE AKVSHLPSTM RNLKLLLYLN LRVDTEEPIH VPNVLKEMIQ
660 670 680 690 700
LRYLSLPLKM DDKTKLELGD LVNLEYLYGF STQHSSVTDL LRMTKLRYLA
710 720 730 740 750
VSLSERCNFE TLSSSLRELR NLETLNFLFS LETYMVDYMG EFVLDHFIHL
760 770 780 790 800
KQLGLAVRMS KIPDQHQFPP HLVHLFLIYC GMEEDPMPIL EKLLHLKSVR
810 820 830 840 850
LARKAFLGSR MVCSKGGFPQ LCVIEISKES ELEEWIVEEG SMPCLRTLTI
860 870 880 890 900
DDCKKLKELP DGLKYITSLK ELKIEGMKRE WKEKLVPGGE DYYKVQHIPD

VQFINCDQ
Length:908
Mass (Da):104,682
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BFA35BB6B0CB5CD
GO
Isoform 2 (identifier: Q8W4J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-308: WKMLLTSRNEGVGIH → ELLWYIHEALFLLNS
     309-908: Missing.

Note: Has been shown to exist only in cv. Columbia so far.Curated
Show »
Length:308
Mass (Da):35,456
Checksum:iF6F99BB4D03F6513
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83K → R in AAL32592 (PubMed:14593172).Curated1
Sequence conflicti686S → G in AAL32592 (PubMed:14593172).Curated1
Sequence conflicti835W → R in AAL32592 (PubMed:14593172).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The strong polymorphisms present in cv. Di-17 and cv. Columbia are probably due to an unequal crossing-over between the highly related RPP8 and RPH8A genes present in cv. Landsberg erecta. Such variations probably modify the specificity of pathogen recognition.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti27 – 31IDGQL → VDEQI in strain: cv. Landsberg erecta. 1 Publication5
Natural varianti29G → E in strain: cv. Di-17. 1 Publication1
Natural varianti85 – 87SGK → RGE in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications3
Natural varianti88 – 91GKGV → EKGI in strain: cv. Landsberg erecta. 1 Publication4
Natural varianti100C → R in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti121E → D in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti129F → L in strain: cv. Di-17. 1 Publication1
Natural varianti133Q → QQ in strain: cv. Di-17. 1 Publication1
Natural varianti138G → V in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti173K → T in strain: cv. Di-17. 1 Publication1
Natural varianti177G → C in strain: cv. Di-17. 1 Publication1
Natural varianti253Y → S in strain: cv. Di-17. 1 Publication1
Natural varianti257R → P in strain: cv. Di-17. 1 Publication1
Natural varianti265A → T in strain: cv. Di-17. 1 Publication1
Natural varianti267R → K in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti270V → L in strain: cv. Di-17. 1 Publication1
Natural varianti283V → R in strain: cv. Di-17. 1 Publication1
Natural varianti369A → V in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti387F → S in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti399W → C in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti426C → R in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti429N → F in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti436 – 446DSEISTYSLFY → YSKISAYDLFN in strain: cv. Landsberg erecta. 1 PublicationAdd BLAST11
Natural varianti438 – 443EISTYS → KITTQE in strain: cv. Di-17. 1 Publication6
Natural varianti450A → V in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti460E → Q in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti480 – 486DNYLSWQ → NKYLRVH in strain: cv. Di-17. 1 Publication7
Natural varianti480 – 481DN → NR in strain: cv. Landsberg erecta. 1 Publication2
Natural varianti485 – 486WQ → SH in strain: cv. Landsberg erecta. 1 Publication2
Natural varianti489Y → N in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti514I → K in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti518C → S in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti519T → I in strain: cv. Di-17. 1 Publication1
Natural varianti528S → R in strain: cv. Di-17. 1 Publication1
Natural varianti537S → R in strain: cv. Di-17. 1 Publication1
Natural varianti542H → Q in strain: cv. Di-17. 1 Publication1
Natural varianti543I → L in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti547 – 550KNKT → RNNA in strain: cv. Di-17. 1 Publication4
Natural varianti549K → N in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti558 – 565PRFEEDYW → WDEDFG in strain: cv. Landsberg erecta. 1 Publication8
Natural varianti558 – 560PRF → SRFK in strain: cv. Di-17. 1 Publication3
Natural varianti564Y → F in strain: cv. Di-17. 1 Publication1
Natural varianti584S → Y in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti595C → S in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti609 – 612YEAK → FLAG in strain: cv. Landsberg erecta. 1 Publication4
Natural varianti630 – 635NLRVDT → DLSVHE in strain: cv. Di-17. 1 Publication6
Natural varianti632 – 636RVDTE → SVNNK in strain: cv. Landsberg erecta. 1 Publication5
Natural varianti650Q → E in strain: cv. Di-17. 1 Publication1
Natural varianti653 – 654YL → HI in strain: cv. Di-17. 1 Publication2
Natural varianti659Missing in strain: cv. Di-17. 1 Publication1
Natural varianti660M → K in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti676 – 678YLY → FLF in strain: cv. Landsberg erecta. 1 Publication3
Natural varianti678 – 679YG → FR in strain: cv. Di-17. 1 Publication2
Natural varianti692R → H in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti697R → Q in strain: cv. Di-17. 1 Publication1
Natural varianti700A → G in strain: cv. Di-17. 1 Publication1
Natural varianti724T → S in strain: cv. Di-17. 1 Publication1
Natural varianti726 – 727NF → YV in strain: cv. Landsberg erecta. 1 Publication2
Natural varianti730 – 731SL → TP in strain: cv. Di-17. 1 Publication2
Natural varianti731 – 734LETY → PEIF in strain: cv. Landsberg erecta. 1 Publication4
Natural varianti752Q → E in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti768F → L in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti773 – 781VHLFLIYCG → AQIYICNCR in strain: cv. Landsberg erecta. 1 Publication9
Natural varianti773 – 781VHLFLIYCG → THIHLLFCR in strain: cv. Di-17. 1 Publication9
Natural varianti800 – 807RLARKAFL → QLTDEAFV in strain: cv. Di-17. 1 Publication8
Natural varianti800 – 803RLAR → KLTF in strain: cv. Landsberg erecta. 1 Publication4
Natural varianti807 – 809LGS → AGR in strain: cv. Landsberg erecta. 1 Publication3
Natural varianti819P → T in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti823 – 824VI → AL in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications2
Natural varianti825E → D in strain: cv. Di-17. 1 Publication1
Natural varianti828 – 829KE → EQ in strain: cv. Landsberg erecta. 1 Publication2
Natural varianti851D → H in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1
Natural varianti854K → E in strain: cv. Di-17 and cv. Landsberg erecta. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007171294 – 308WKMLL…GVGIH → ELLWYIHEALFLLNS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_007172309 – 908Missing in isoform 2. 1 PublicationAdd BLAST600

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF089710 Genomic DNA Translation: AAC83165.1
AF089711 Genomic DNA Translation: AAC78631.1
AF234174 Genomic DNA Translation: AAF36987.1
AB025638 Genomic DNA Translation: BAA97426.1
CP002688 Genomic DNA Translation: AED94967.1
CP002688 Genomic DNA Translation: AED94968.1
CP002688 Genomic DNA Translation: ANM71032.1
CP002688 Genomic DNA Translation: ANM71033.1
AK118862 mRNA Translation: BAC43449.1
AY062514 mRNA Translation: AAL32592.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T48898
T48899

NCBI Reference Sequences

More...
RefSeqi
NP_001318736.1, NM_001344485.1 [Q8W4J9-1]
NP_001332592.1, NM_001344486.1 [Q8W4J9-1]
NP_199160.1, NM_123713.4 [Q8W4J9-1]
NP_851124.1, NM_180793.1 [Q8W4J9-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G43470.1; AT5G43470.1; AT5G43470 [Q8W4J9-1]
AT5G43470.2; AT5G43470.2; AT5G43470 [Q8W4J9-1]
AT5G43470.3; AT5G43470.3; AT5G43470 [Q8W4J9-1]
AT5G43470.4; AT5G43470.4; AT5G43470 [Q8W4J9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
834367

Gramene; a comparative resource for plants

More...
Gramenei
AT5G43470.1; AT5G43470.1; AT5G43470 [Q8W4J9-1]
AT5G43470.2; AT5G43470.2; AT5G43470 [Q8W4J9-1]
AT5G43470.3; AT5G43470.3; AT5G43470 [Q8W4J9-1]
AT5G43470.4; AT5G43470.4; AT5G43470 [Q8W4J9-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G43470

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIB-LRRS

Functional and comparative genomics of disease resistance gene homologs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089710 Genomic DNA Translation: AAC83165.1
AF089711 Genomic DNA Translation: AAC78631.1
AF234174 Genomic DNA Translation: AAF36987.1
AB025638 Genomic DNA Translation: BAA97426.1
CP002688 Genomic DNA Translation: AED94967.1
CP002688 Genomic DNA Translation: AED94968.1
CP002688 Genomic DNA Translation: ANM71032.1
CP002688 Genomic DNA Translation: ANM71033.1
AK118862 mRNA Translation: BAC43449.1
AY062514 mRNA Translation: AAL32592.1
PIRiT48898
T48899
RefSeqiNP_001318736.1, NM_001344485.1 [Q8W4J9-1]
NP_001332592.1, NM_001344486.1 [Q8W4J9-1]
NP_199160.1, NM_123713.4 [Q8W4J9-1]
NP_851124.1, NM_180793.1 [Q8W4J9-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi19617, 8 interactors
DIPiDIP-59355N
IntActiQ8W4J9, 2 interactors
STRINGi3702.AT5G43470.2

Proteomic databases

PaxDbiQ8W4J9
PRIDEiQ8W4J9
ProteomicsDBi226905 [Q8W4J9-1]

Genome annotation databases

EnsemblPlantsiAT5G43470.1; AT5G43470.1; AT5G43470 [Q8W4J9-1]
AT5G43470.2; AT5G43470.2; AT5G43470 [Q8W4J9-1]
AT5G43470.3; AT5G43470.3; AT5G43470 [Q8W4J9-1]
AT5G43470.4; AT5G43470.4; AT5G43470 [Q8W4J9-1]
GeneIDi834367
GrameneiAT5G43470.1; AT5G43470.1; AT5G43470 [Q8W4J9-1]
AT5G43470.2; AT5G43470.2; AT5G43470 [Q8W4J9-1]
AT5G43470.3; AT5G43470.3; AT5G43470 [Q8W4J9-1]
AT5G43470.4; AT5G43470.4; AT5G43470 [Q8W4J9-1]
KEGGiath:AT5G43470

Organism-specific databases

AraportiAT5G43470
TAIRilocus:2176486, AT5G43470

Phylogenomic databases

eggNOGiKOG4658, Eukaryota
HOGENOMiCLU_000837_25_4_1
InParanoidiQ8W4J9
OMAiQFINCDQ
OrthoDBi164862at2759
PhylomeDBiQ8W4J9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8W4J9

Gene expression databases

ExpressionAtlasiQ8W4J9, baseline and differential
GenevisibleiQ8W4J9, AT

Family and domain databases

CDDicd14798, RX-CC_like, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N
PfamiView protein in Pfam
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPP8_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8W4J9
Secondary accession number(s): Q8GWG5
, Q9M5A1, Q9ZSY3, Q9ZSY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: August 12, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again