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Entry version 131 (12 Aug 2020)
Sequence version 4 (25 Jan 2012)
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Protein

Probable disease resistance protein At1g58390

Gene

At1g58390

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible disease resistance protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi190 – 197ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable disease resistance protein At1g58390
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g58390
ORF Names:F9K23.8, X7J.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G58390

The Arabidopsis Information Resource

More...
TAIRi
locus:2037639, AT1G58390

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002127391 – 907Probable disease resistance protein At1g58390Add BLAST907

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8W474

PRoteomics IDEntifications database

More...
PRIDEi
Q8W474

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
224348

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8W474

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8W474, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8W474, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
27433, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G58390.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 456NB-ARCAdd BLAST313
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati608 – 631LRR 1Add BLAST24
Repeati843 – 868LRR 2Add BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LRR repeats probably act as specificity determinant of pathogen recognition.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the disease resistance NB-LRR family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4658, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000837_25_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8W474

Identification of Orthologs from Complete Genome Data

More...
OMAi
YARYPLY

Database of Orthologous Groups

More...
OrthoDBi
164862at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14798, RX-CC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8W474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGELVSFGI KKLWDLLSQE CEQFQGVEDQ VTGLKRDLNL LSSFLKDADA
60 70 80 90 100
KKHTTAVVRN VVEEIKEIVY DAEDIIETYL LKEKLWKTSG IKMRIRRHAC
110 120 130 140 150
IISDRRRNAL DVGGIRTRIS DVIRDMQSFG VQQAIVDGGY MQPQGDRQRE
160 170 180 190 200
MRQTFSKDYE SDFVGLEVNV KKLVGYLVDE ENVQVVSITG MGGLGKTTLA
210 220 230 240 250
RQVFNHEDVK HQFDRLAWVC VSQEFTRKNV WQMILQNLTS REKKDEILQM
260 270 280 290 300
EEAELHDKLF QLLETSKSLI VFDDIWKDED WDLIKPIFPP NKGWKVLLTS
310 320 330 340 350
QNESVAVRGD IKYLNFKPEC LAIEDSWTLF QRIAFPKKDA SESKVDEEME
360 370 380 390 400
DMGKQMLKHC GGLPLAIKVL GGLLAAKYTM HDWERLSVNI GSDIVGRTSS
410 420 430 440 450
NNSSIYHVLS MSFEELPSYL KHCFLYLAHF PEDHKINVEK LSYCWAAEGI
460 470 480 490 500
STAEDYHNGE TIQDVGQSYL EELVRRNMII WERDATASRF GTCHLHDMMR
510 520 530 540 550
EVCLFKAKEE NFLQIAVKSV GVTSSSTGNS QSPCRSRRLV YQCPTTLHVE
560 570 580 590 600
RDINNPKLRS LVVLWHDLWV ENWKLLGTSF TRLKLLRVLD LFYVDFEGMK
610 620 630 640 650
LPFGIGNLIH LRYLSLQDAK VSHLPSSLGN LMLLIYLNLD VDTEFIFVPD
660 670 680 690 700
VFMRMHELRY LKLPLHMHKK TRLSLRNLVK LETLVYFSTW HSSSKDLCGM
710 720 730 740 750
TRLMTLAIRL TRVTSTETLS ASISGLRNLE YLYIVGTHSK KMREEGIVLD
760 770 780 790 800
FIHLKHLLLD LYMPRQQHFP SRLTFVKLSE CGLEEDPMPI LEKLLHLKGV
810 820 830 840 850
ILLKGSYCGR RMVCSGGGFP QLKKLEIVGL NKWEEWLVEE GSMPLLETLS
860 870 880 890 900
ILDCEELKEI PDGLRFIYSL ELVMLGTRWK KKFSVGGEDY YKVQHIPSVE

FIGGYLK
Length:907
Mass (Da):104,596
Last modified:January 25, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CA13E4F7A1DF7BA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL32876 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA88265 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587R → K in BAA88265 (PubMed:10548732).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB008018 mRNA Translation: BAA88265.1 Sequence problems.
AB077822 Genomic DNA Translation: BAB83871.1
AC082643 Genomic DNA Translation: AAG50638.1
CP002684 Genomic DNA Translation: AEE33544.1
CP002684 Genomic DNA Translation: ANM60615.1
AY062798 mRNA Translation: AAL32876.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
F96617
T52465

NCBI Reference Sequences

More...
RefSeqi
NP_001319265.1, NM_001333830.1
NP_176135.1, NM_104619.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G58390.1; AT1G58390.1; AT1G58390
AT1G58390.2; AT1G58390.2; AT1G58390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842208

Gramene; a comparative resource for plants

More...
Gramenei
AT1G58390.1; AT1G58390.1; AT1G58390
AT1G58390.2; AT1G58390.2; AT1G58390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G58390

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIB-LRRS

Functional and comparative genomics of disease resistance gene homologs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008018 mRNA Translation: BAA88265.1 Sequence problems.
AB077822 Genomic DNA Translation: BAB83871.1
AC082643 Genomic DNA Translation: AAG50638.1
CP002684 Genomic DNA Translation: AEE33544.1
CP002684 Genomic DNA Translation: ANM60615.1
AY062798 mRNA Translation: AAL32876.1 Different initiation.
PIRiF96617
T52465
RefSeqiNP_001319265.1, NM_001333830.1
NP_176135.1, NM_104619.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi27433, 1 interactor
STRINGi3702.AT1G58390.1

PTM databases

iPTMnetiQ8W474

Proteomic databases

PaxDbiQ8W474
PRIDEiQ8W474
ProteomicsDBi224348

Genome annotation databases

EnsemblPlantsiAT1G58390.1; AT1G58390.1; AT1G58390
AT1G58390.2; AT1G58390.2; AT1G58390
GeneIDi842208
GrameneiAT1G58390.1; AT1G58390.1; AT1G58390
AT1G58390.2; AT1G58390.2; AT1G58390
KEGGiath:AT1G58390

Organism-specific databases

AraportiAT1G58390
TAIRilocus:2037639, AT1G58390

Phylogenomic databases

eggNOGiKOG4658, Eukaryota
HOGENOMiCLU_000837_25_4_1
InParanoidiQ8W474
OMAiYARYPLY
OrthoDBi164862at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8W474

Gene expression databases

ExpressionAtlasiQ8W474, baseline and differential
GenevisibleiQ8W474, AT

Family and domain databases

CDDicd14798, RX-CC_like, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N
PfamiView protein in Pfam
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRL7_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8W474
Secondary accession number(s): F4IBC6, Q9C644, Q9SM05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: January 25, 2012
Last modified: August 12, 2020
This is version 131 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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