Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional corepressor SEUSS

Gene

SEU

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal blade vasculature. Required for the proper elaboration of petal polarity along the adaxial/abaxial axis. May act through direct or indirect regulation of PHABULOSA and YAB1 and thus regulate cellular proliferation within the developing petal blade. In association with AINTEGUMENTA (ANT), coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium. Required for the development of the medial ridge and subsequent ovule initiation.5 Publications

GO - Molecular functioni

  • DNA binding Source: TAIR
  • molecular adaptor activity Source: UniProtKB
  • protein heterodimerization activity Source: TAIR
  • RNA polymerase II activating transcription factor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Flowering, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional corepressor SEUSS
Short name:
AtSEU
Gene namesi
Name:SEU
Ordered Locus Names:At1g43850
ORF Names:F28H19.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G43850
TAIRilocus:2029137 AT1G43850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Ectopic and precocious expression of AGAMOUS, leading to partial homeotic transformation of the external floral organs.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977001 – 877Transcriptional corepressor SEUSSAdd BLAST877

Proteomic databases

PaxDbiQ8W234
PRIDEiQ8W234

PTM databases

iPTMnetiQ8W234

Expressioni

Tissue specificityi

Expressed in root, leaves, seedlings, vegetative and reproductive shoot apical meristems, seeds, floral meristems and all floral organs.2 Publications

Inductioni

Induced by exposures to biotic stress (e.g. nematode and Botrytis cinerea) and abiotic stress (e.g. salt, genotoxic, wounding, drought and oxidative stress). Repressed by exposures to biotic stress (e.g. Agrobacterium tumefaciens) and abiotic stress (e.g. hypoxia, cycloheximide, 2,4-dichlorophenoxyacetic acid, AgNO3 and aminoethoxyvinylglycine).1 Publication

Gene expression databases

ExpressionAtlasiQ8W234 baseline and differential
GenevisibleiQ8W234 AT

Interactioni

Subunit structurei

Forms a corepressor complex with LUG; LUG is the transcription repressor subunit and SEU the specific DNA-binding adapter. Interacts with AGL24-AP1 and SVP-AP1 dimers when complexed to SEU. Interacts with AP1/AGL7 and SEP3/AGL9 (PubMed:15277686, PubMed:16679456, PubMed:16854969). Binds to LUH (PubMed:18390806).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi26206, 6 interactors
IntActiQ8W234, 3 interactors
STRINGi3702.AT1G43850.1

Structurei

3D structure databases

ProteinModelPortaliQ8W234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 563DimerizationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili582 – 618Sequence analysisAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 344Nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 632Gln-richAdd BLAST519
Compositional biasi718 – 876Asn-richAdd BLAST159

Domaini

Contains a dimerization domain which shares similarity with the LIM-binding domain of animal transcription coregulators.

Sequence similaritiesi

Belongs to the adn1/SEU family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKI Eukaryota
ENOG410XT7C LUCA
HOGENOMiHOG000006265
InParanoidiQ8W234
OMAiPGAGMVQ
OrthoDBiEOG093607R4
PhylomeDBiQ8W234

Family and domain databases

InterProiView protein in InterPro
IPR029005 LIM-bd/SEUSS
PANTHERiPTHR10378 PTHR10378, 1 hit
PfamiView protein in Pfam
PF01803 LIM_bind, 1 hit

Sequencei

Sequence statusi: Complete.

Q8W234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPSEPPNPV GGGENVPPSI LGGQGGAPLP SQPAFPSLVS PRTQFGNNMS
60 70 80 90 100
MSMLGNAPNI SSLLNNQSFV NGIPGSMISM DTSGAESDPM SNVGFSGLSS
110 120 130 140 150
FNASSMVSPR SSGQVQGQQF SNVSANQLLA EQQRNKKMET QSFQHGQQQS
160 170 180 190 200
MQQQFSTVRG GGLAGVGPVK MEPGQVSNDQ QHGQVQQQQQ KMLRNLGSVK
210 220 230 240 250
LEPQQIQAMR NLAQVKMEPQ HSEQSLFLQQ QQRQQQQQQQ QQFLQMPGQS
260 270 280 290 300
PQAQMNIFQQ QRLMQLQQQQ LLKSMPQQRP QLPQQFQQQN LPLRPPLKPV
310 320 330 340 350
YEPGMGAQRL TQYMYRQQHR PEDNNIEFWR KFVAEYFAPN AKKRWCVSMY
360 370 380 390 400
GSGRQTTGVF PQDVWHCEIC NRKPGRGFEA TAEVLPRLFK IKYESGTLEE
410 420 430 440 450
LLYVDMPRES QNSSGQIVLE YAKATQESVF EHLRVVRDGQ LRIVFSPDLK
460 470 480 490 500
IFSWEFCARR HEELIPRRLL IPQVSQLGSA AQKYQQAAQN ATTDSALPEL
510 520 530 540 550
QNNCNMFVAS ARQLAKALEV PLVNDLGYTK RYVRCLQISE VVNSMKDLID
560 570 580 590 600
YSRETRTGPI ESLAKFPRRT GPSSALPGPS PQQASDQLRQ QQQQQQQQQQ
610 620 630 640 650
QQQQQQQQQQ QQQTVSQNTN SDQSSRQVAL MQGNPSNGVN YAFNAASAST
660 670 680 690 700
STSSIAGLIH QNSMKGRHQN AAYNPPNSPY GGNSVQMQSP SSSGTMVPSS
710 720 730 740 750
SQQQHNLPTF QSPTSSSNNN NPSQNGIPSV NHMGSTNSPA MQQAGEVDGN
760 770 780 790 800
ESSSVQKILN EILMNNQAHN NSSGGSMVGH GSFGNDGKGQ ANVNSSGVLL
810 820 830 840 850
MNGQVNNNNN TNIGGAGGFG GGIGQSMAAN GINNINGNNS LMNGRVGMMV
860 870
RDPNGQQDLG NQLLGAVNGF NNFDWNA
Length:877
Mass (Da):96,232
Last modified:March 1, 2002 - v1
Checksum:i636D83BAD3946467
GO

Sequence cautioni

The sequence AAF63115 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378782 mRNA Translation: AAL57277.1
AC006423 Genomic DNA Translation: AAF63115.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32000.1
CP002684 Genomic DNA Translation: AEE32001.1
AK118277 mRNA Translation: BAC42895.1
PIRiD96502
RefSeqiNP_001117434.1, NM_001123962.2
NP_175051.1, NM_103511.4
UniGeneiAt.12073

Genome annotation databases

EnsemblPlantsiAT1G43850.1; AT1G43850.1; AT1G43850
AT1G43850.2; AT1G43850.2; AT1G43850
GeneIDi840981
GrameneiAT1G43850.1; AT1G43850.1; AT1G43850
AT1G43850.2; AT1G43850.2; AT1G43850
KEGGiath:AT1G43850

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378782 mRNA Translation: AAL57277.1
AC006423 Genomic DNA Translation: AAF63115.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32000.1
CP002684 Genomic DNA Translation: AEE32001.1
AK118277 mRNA Translation: BAC42895.1
PIRiD96502
RefSeqiNP_001117434.1, NM_001123962.2
NP_175051.1, NM_103511.4
UniGeneiAt.12073

3D structure databases

ProteinModelPortaliQ8W234
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26206, 6 interactors
IntActiQ8W234, 3 interactors
STRINGi3702.AT1G43850.1

PTM databases

iPTMnetiQ8W234

Proteomic databases

PaxDbiQ8W234
PRIDEiQ8W234

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G43850.1; AT1G43850.1; AT1G43850
AT1G43850.2; AT1G43850.2; AT1G43850
GeneIDi840981
GrameneiAT1G43850.1; AT1G43850.1; AT1G43850
AT1G43850.2; AT1G43850.2; AT1G43850
KEGGiath:AT1G43850

Organism-specific databases

AraportiAT1G43850
TAIRilocus:2029137 AT1G43850

Phylogenomic databases

eggNOGiENOG410IEKI Eukaryota
ENOG410XT7C LUCA
HOGENOMiHOG000006265
InParanoidiQ8W234
OMAiPGAGMVQ
OrthoDBiEOG093607R4
PhylomeDBiQ8W234

Miscellaneous databases

PROiPR:Q8W234

Gene expression databases

ExpressionAtlasiQ8W234 baseline and differential
GenevisibleiQ8W234 AT

Family and domain databases

InterProiView protein in InterPro
IPR029005 LIM-bd/SEUSS
PANTHERiPTHR10378 PTHR10378, 1 hit
PfamiView protein in Pfam
PF01803 LIM_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEUSS_ARATH
AccessioniPrimary (citable) accession number: Q8W234
Secondary accession number(s): Q8GXE8, Q9MAR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again