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Entry version 104 (31 Jul 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Sister chromatid cohesion 1 protein 4

Gene

SYN4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in sister chromatid and centromere cohesion during mitosis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion 1 protein 4
Short name:
AtRAD21-3
Short name:
AtRAD21.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYN4
Ordered Locus Names:At5g16270
ORF Names:T21H19.190
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G16270

The Arabidopsis Information Resource

More...
TAIRi
locus:2181457 AT5G16270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreased sister chromatid alignment along arms in tetraploid cells (4C) nuclei and impaired sister centromere cohesion, associated with a high frequency of anaphases with bridges. Slightly slower development leading to delayed flowering.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004302791 – 1031Sister chromatid cohesion 1 protein 4Add BLAST1031

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8W1Y0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8W1Y0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in tissues containing dividing cells such as seedlings, flower buds, flowers and inflorescence meristem tissue.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8W1Y0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8W1Y0 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cohesin complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G16270.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8W1Y0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi545 – 552Nuclear localization signalBy similarity8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1213 Eukaryota
ENOG410XRB4 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8W1Y0

KEGG Orthology (KO)

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KOi
K06670

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNEPMAV

Database of Orthologous Groups

More...
OrthoDBi
171779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8W1Y0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.580, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039781 Rad21/Rec8-like
IPR006909 Rad21/Rec8_C_eu
IPR006910 Rad21_Rec8_N
IPR023093 ScpA-like_C
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12585 PTHR12585, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04824 Rad21_Rec8, 1 hit
PF04825 Rad21_Rec8_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8W1Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYSQFILAK KGPLGTIWIA AHLERKLRKN QVADTDIGVS VDSILFPEAP
60 70 80 90 100
IALRLSSHLL LGVVRIYSRK VNYLFDDCSE ALLKVKQAFR SAAVDLPPEE
110 120 130 140 150
STAPYHSITL PETFDLDDFE LPDNEIFQGN YVDHHVSTKE QITLQDTMDG
160 170 180 190 200
VVYSTSQFGL DERFGDGDTS QAALDLDEAV FQDKDVIGSD DEGVPGIDHN
210 220 230 240 250
AYLDAAAPGI KDSMEGVSEA MPMDFNEEQV EDLAMNNEFI EDAQAPQTPG
260 270 280 290 300
LVEVPNSSSV REQMACDDHM DVEDLNAEEG IKSSGELNAN EMPKRGEDLS
310 320 330 340 350
SEYNAPESAV TPVEVDKSQI DENVNTQNEP EEERAEHVHV TSPCCSHITT
360 370 380 390 400
EMEDPGQVMN EAGANVVPDK PDAVPPLETP GEENRDHFAI ATEVNQETDS
410 420 430 440 450
SLQGDEQAYS RPDGQLNNAH ETDEQLGNLT GFTDSDFPPP EKVLAVPNRQ
460 470 480 490 500
GDGNDFMVES TPDKEDPGTC NDDAGNNNIT GKKRTFTEST LTAESLNSVE
510 520 530 540 550
SVGLIQSKRT ADSVPDDDDL LSSILVGKSS FLKMRPTPVL EPATTKRLRS
560 570 580 590 600
APRSTATKRK VLMDDPMVLH GDIIRQQLTN TEDIRRVRKK APCTVPEIVM
610 620 630 640 650
LQRQALEDGL FKEPIFTGMS VELVSLHTEP YDLRGIMIIE NDDRHASVGA
660 670 680 690 700
VEDNECSVTA VEENKTEESS DPQAHPNDCE EQPGTAHTHP QEEQTINQQE
710 720 730 740 750
ELKDDNELAE KSDLEVLKEG NGAADEVNLV VIDDVSQIPS EEKLDRVEDL
760 770 780 790 800
QVEESHENHD GEGGQDVCAD PNEKSCTDVI EIAEGDTDIN PIFNEMDLKV
810 820 830 840 850
EDELPHEDEK TDASAEVSEL GRDDQTPCDN TVGSTETGCL EAGDLSNMAL
860 870 880 890 900
ENCNEPLVEA NSDGLNPETE SYNKYEPHNE MSNEEASMQN ALDGEHTSRD
910 920 930 940 950
GLMGDNDEMD TMENAHDTGF LNVDDDEVDE DHEEDDIQYD DETRLLENSG
960 970 980 990 1000
WSSRTRAVAK YLQTLFDKET ENGKNVLVAD KLLAGKTRKE ASRMFFETLV
1010 1020 1030
LKTRDYIQVE QGKPYESIII KPRPKLTKSI F
Length:1,031
Mass (Da):114,059
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i029B2A9229649AD1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK96855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC01868 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1030I → V in AAK96855 (PubMed:14593172).Curated1
Sequence conflicti1030I → V in AAL66884 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF400129 mRNA Translation: AAL62060.1
AL391148 Genomic DNA Translation: CAC01868.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92267.1
AY054664 mRNA Translation: AAK96855.1 Different initiation.
AY072469 mRNA Translation: AAL66884.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T51497

NCBI Reference Sequences

More...
RefSeqi
NP_197131.2, NM_121632.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G16270.1; AT5G16270.1; AT5G16270

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831487

Gramene; a comparative resource for plants

More...
Gramenei
AT5G16270.1; AT5G16270.1; AT5G16270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G16270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF400129 mRNA Translation: AAL62060.1
AL391148 Genomic DNA Translation: CAC01868.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92267.1
AY054664 mRNA Translation: AAK96855.1 Different initiation.
AY072469 mRNA Translation: AAL66884.1
PIRiT51497
RefSeqiNP_197131.2, NM_121632.4

3D structure databases

SMRiQ8W1Y0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G16270.1

PTM databases

iPTMnetiQ8W1Y0

Proteomic databases

PaxDbiQ8W1Y0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16270.1; AT5G16270.1; AT5G16270
GeneIDi831487
GrameneiAT5G16270.1; AT5G16270.1; AT5G16270
KEGGiath:AT5G16270

Organism-specific databases

AraportiAT5G16270
TAIRilocus:2181457 AT5G16270

Phylogenomic databases

eggNOGiKOG1213 Eukaryota
ENOG410XRB4 LUCA
HOGENOMiHOG000090768
InParanoidiQ8W1Y0
KOiK06670
OMAiHNEPMAV
OrthoDBi171779at2759
PhylomeDBiQ8W1Y0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8W1Y0

Gene expression databases

ExpressionAtlasiQ8W1Y0 baseline and differential
GenevisibleiQ8W1Y0 AT

Family and domain databases

Gene3Di1.10.10.580, 1 hit
InterProiView protein in InterPro
IPR039781 Rad21/Rec8-like
IPR006909 Rad21/Rec8_C_eu
IPR006910 Rad21_Rec8_N
IPR023093 ScpA-like_C
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12585 PTHR12585, 1 hit
PfamiView protein in Pfam
PF04824 Rad21_Rec8, 1 hit
PF04825 Rad21_Rec8_N, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSC14_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8W1Y0
Secondary accession number(s): Q940G1, Q9LF01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: March 1, 2002
Last modified: July 31, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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