We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8VZZ4 (AB6C_ARATH)
Protein
ABC transporter C family member 6
Gene
ABCC6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Pump for glutathione S-conjugates.
By similarityCatalytic activityi
- ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2). EC:7.6.2.2
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 636 – 643 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1253 – 1260 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: UniProtKB-EC
- ATPase-coupled transmembrane transporter activity Source: TAIR
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT3G13090-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ABC transporter C family member 6 (EC:7.6.2.2)Short name: ABC transporter ABCC.6 Short name: AtABCC6 Alternative name(s): ATP-energized glutathione S-conjugate pump 8 Glutathione S-conjugate-transporting ATPase 8 Multidrug resistance-associated protein 8 |
Gene namesi | Name:ABCC6 Synonyms:MRP6, MRP8 Ordered Locus Names:At3g13090 ORF Names:MJG19.4 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G13090 |
TAIRi | locus:2090039, AT3G13090 |
Subcellular locationi
Other locations
- Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
Vacuole
- plant-type vacuole Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
- plasmodesma Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 63 – 83 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 91 – 111 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 128 – 148 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 286 – 306 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 322 – 339 | HelicalPROSITE-ProRule annotationAdd BLAST | 18 | |
Transmembranei | 400 – 420 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 425 – 445 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 512 – 532 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 890 – 910 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 937 – 957 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1026 – 1046 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000226079 | 1 – 1466 | ABC transporter C family member 6Add BLAST | 1466 |
Proteomic databases
PaxDbi | Q8VZZ4 |
PRIDEi | Q8VZZ4 |
ProteomicsDBi | 244628 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Inductioni
By salicylic acid (SA).1 Publication
Gene expression databases
ExpressionAtlasi | Q8VZZ4, baseline and differential |
Genevisiblei | Q8VZZ4, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 5831, 2 interactors |
STRINGi | 3702.AT3G13090.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 286 – 567 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 282 | |
Domaini | 601 – 824 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 224 | |
Domaini | 900 – 1182 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 283 | |
Domaini | 1219 – 1453 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 840 – 876 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 842 – 863 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
HOGENOMi | CLU_000604_27_1_1 |
InParanoidi | Q8VZZ4 |
OMAi | VAACAWY |
OrthoDBi | 138195at2759 |
Family and domain databases
CDDi | cd18579, ABC_6TM_ABCC_D1, 1 hit cd18580, ABC_6TM_ABCC_D2, 1 hit |
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR044746, ABCC_6TM_D1 IPR044726, ABCC_6TM_D2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q8VZZ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENPIDSLLL QPIYLSVLSF FLNLVLLLIL FGSWLFKKRV ACEDTDAIMN
60 70 80 90 100
EEFKHISFSY NKLVLICCVS LSVFYSVLSL LSCLHWHTNG WPFLDLLLAA
110 120 130 140 150
LTWGSISVYL FGRYTNSCEQ KVLFLLRVWW VFFFVVSCYH LVVDFVLYKK
160 170 180 190 200
QEMVSVHFVI SDLVGVCAGL FLCCSCLWKK GEGERIDLLK EPLLSSAESS
210 220 230 240 250
DNEEVTAPFS KAGILSRMSF SWMSPLITLG NEKIIDIKDV PQLDRSDTTE
260 270 280 290 300
SLFWIFRSKL EWDDGERRIT TFKLIKALFL SVWRDIVLSA LLAFVYTVSC
310 320 330 340 350
YVAPYLMDNF VQYLNGNRQY KNQGYVLVTT FFVAKLVECQ TQRQWFFRGQ
360 370 380 390 400
KAGLGMRSVL VSMIYEKGLT LPCHSKQGHT SGEIINLMAV DADRISAFSW
410 420 430 440 450
FMHDPWILVL QVSLALWILY KSLGLGSIAA FPATILVMLA NYPFAKLEEK
460 470 480 490 500
FQSSLMKSKD NRMKKTSEVL LNMKILKLQG WEMKFLSKIL ELRHIEAGWL
510 520 530 540 550
KKFVYNSSAI NSVLWAAPSF ISATAFGACL LLKIPLESGK ILAALATFRI
560 570 580 590 600
LQGPIYKLPE TISMIVQTKV SLNRIASFLC LDDLQQDVVG RLPSGSSEMA
610 620 630 640 650
VEISNGTFSW DDSSPIPTLR DMNFKVSQGM NVAICGTVGS GKSSLLSSIL
660 670 680 690 700
GEVPKISGNL KVCGRKAYIA QSPWIQSGKV EENILFGKPM EREWYDRVLE
710 720 730 740 750
ACSLNKDLEI LPFHDQTVIG ERGINLSGGQ KQRIQIARAL YQDADIYLFD
760 770 780 790 800
DPFSAVDAHT GSHLFKEVLL GLLRHKTVIY VTHQVEFLPE ADLILVMKDG
810 820 830 840 850
KITQAGKYHE ILDSGTDFME LVGAHTEALA TIDSCETGYA SEKSTTDKEN
860 870 880 890 900
EVLHHKEKQE NGSDNKPSGQ LVQEEEREKG KVGFTVYKKY MALAYGGAVI
910 920 930 940 950
PLILVVQVLF QLLSIGSNYW MTWVTPVSKD VEPPVSGFTL ILVYVLLAVA
960 970 980 990 1000
SSFCILIRAL LVAMTGFKMA TELFTQMHLR IFRASMSFFD ATPMGRILNR
1010 1020 1030 1040 1050
ASTDQSVADL RLPGQFAYVA IAAINILGII GVIVQVAWQV LIVFIPVVAA
1060 1070 1080 1090 1100
CAWYRQYYIS AARELARLAG ISRSPVVHHF SETLSGITTI RSFDQEPRFR
1110 1120 1130 1140 1150
GDIMRLSDCY SRLKFHSTGA MEWLCFRLEL LSTFAFASSL VILVSAPEGV
1160 1170 1180 1190 1200
INPSLAGLAI TYALNLNTLQ ATLIWTLCDL ENKMISVERM LQYTNIPSEP
1210 1220 1230 1240 1250
PLVIETTRPE KSWPSRGEIT ICNLQVRYGP HLPMVLHGLT CTFPGGLKTG
1260 1270 1280 1290 1300
IVGRTGCGKS TLIQTLFRIV EPAAGEIRID GINILSIGLH DLRSRLSIIP
1310 1320 1330 1340 1350
QDPTMFEGTI RSNLDPLEEY TDDQIWEALD NCQLGDEVRK KELKLDSPVS
1360 1370 1380 1390 1400
ENGQNWSVGQ RQLVCLGRVL LKRSKLLVLD EATASIDTAT DNLIQETLRH
1410 1420 1430 1440 1450
HFADCTVITI AHRISSVIDS DMVLLLDQGL IKEHDSPARL LEDRSSLFSK
1460
LVAEYTTSSE SKSKRS
Sequence cautioni
The sequence BAB01400 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 243 | L → V in AAL14776 (Ref. 1) Curated | 1 | |
Sequence conflicti | 612 | D → E in AAL14776 (Ref. 1) Curated | 1 | |
Sequence conflicti | 809 | H → N in AAL14776 (Ref. 1) Curated | 1 | |
Sequence conflicti | 853 | L → I in AAL14776 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1451 | L → F in AAL14776 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY052368 mRNA Translation: AAL14776.1 AP000375 Genomic DNA Translation: BAB01400.1 Sequence problems. CP002686 Genomic DNA Translation: AEE75295.1 |
RefSeqi | NP_187916.3, NM_112148.4 |
Genome annotation databases
EnsemblPlantsi | AT3G13090.1; AT3G13090.1; AT3G13090 |
GeneIDi | 820497 |
Gramenei | AT3G13090.1; AT3G13090.1; AT3G13090 |
KEGGi | ath:AT3G13090 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY052368 mRNA Translation: AAL14776.1 AP000375 Genomic DNA Translation: BAB01400.1 Sequence problems. CP002686 Genomic DNA Translation: AEE75295.1 |
RefSeqi | NP_187916.3, NM_112148.4 |
3D structure databases
SMRi | Q8VZZ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 5831, 2 interactors |
STRINGi | 3702.AT3G13090.1 |
Proteomic databases
PaxDbi | Q8VZZ4 |
PRIDEi | Q8VZZ4 |
ProteomicsDBi | 244628 |
Genome annotation databases
EnsemblPlantsi | AT3G13090.1; AT3G13090.1; AT3G13090 |
GeneIDi | 820497 |
Gramenei | AT3G13090.1; AT3G13090.1; AT3G13090 |
KEGGi | ath:AT3G13090 |
Organism-specific databases
Araporti | AT3G13090 |
TAIRi | locus:2090039, AT3G13090 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
HOGENOMi | CLU_000604_27_1_1 |
InParanoidi | Q8VZZ4 |
OMAi | VAACAWY |
OrthoDBi | 138195at2759 |
Enzyme and pathway databases
BioCyci | ARA:AT3G13090-MONOMER |
Miscellaneous databases
PROi | PR:Q8VZZ4 |
Gene expression databases
ExpressionAtlasi | Q8VZZ4, baseline and differential |
Genevisiblei | Q8VZZ4, AT |
Family and domain databases
CDDi | cd18579, ABC_6TM_ABCC_D1, 1 hit cd18580, ABC_6TM_ABCC_D2, 1 hit |
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR044746, ABCC_6TM_D1 IPR044726, ABCC_6TM_D2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AB6C_ARATH | |
Accessioni | Q8VZZ4Primary (citable) accession number: Q8VZZ4 Secondary accession number(s): Q9LK63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families