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Protein

Aquaporin NIP1-1

Gene

NIP1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Water channel probably required to promote glycerol permeability and water transport across cell membranes.1 Publication

GO - Molecular functioni

  • arsenite transmembrane transporter activity Source: TAIR
  • water channel activity Source: TAIR

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi1.A.8.12.8 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin NIP1-1
Alternative name(s):
NOD26-like intrinsic protein 1-1
Short name:
AtNIP1;1
Nodulin-26-like major intrinsic protein 1
Short name:
NodLikeMip1
Short name:
Protein NLM1
Gene namesi
Name:NIP1-1
Synonyms:NLM1
Ordered Locus Names:At4g19030
ORF Names:F13C5.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G19030
TAIRilocus:2117119 AT4G19030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei136 – 156Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei249 – 269Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640621 – 296Aquaporin NIP1-1Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei286PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8VZW1

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Gene expression databases

ExpressionAtlasiQ8VZW1 differential
GenevisibleiQ8VZW1 AT

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi12934, 184 interactors
IntActiQ8VZW1, 184 interactors
STRINGi3702.AT4G19030.1

Structurei

3D structure databases

ProteinModelPortaliQ8VZW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116NPA 13
Motifi233 – 235NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala/Gly (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
HOGENOMiHOG000288286
InParanoidiQ8VZW1
KOiK09874
OMAiGYGNARE
OrthoDBiEOG09360N7X
PhylomeDBiQ8VZW1

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q8VZW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADISGNGYG NAREEVVMVN LKDEVEHQQE MEDIHNPRPL KKQDSLLSVS
60 70 80 90 100
VPFLQKLIAE FLGTYFLVFT GCASVVVNMQ NDNVVTLPGI AIVWGLTIMV
110 120 130 140 150
LIYSLGHISG AHINPAVTIA FASCGRFPLK QVPAYVISQV IGSTLAAATL
160 170 180 190 200
RLLFGLDHDV CSGKHDVFIG SSPVGSDLQA FTMEFIVTFY LMFIISGVAT
210 220 230 240 250
DNRAIGELAG LAIGSTVLLN VLIAAPVSSA SMNPGRSLGP ALVYGCYKGI
260 270 280 290
WIYLVAPTLG AIAGAWVYNT VRYTDKPLRE ITKSGSFLKT VRIGST
Length:296
Mass (Da):31,715
Last modified:March 1, 2002 - v1
Checksum:i4D66695D9E879C68
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B5K6A0A1P8B5K6_ARATH
NOD26-like major intrinsic protein ...
NLM1 AT-NLM1, ATNLM1, NIP1:1, At4g19030, F13C5.200 NLM1 AT-NLM1, ATNLM1, NIP1:1, At4g19030, F13C5.200, F13C5_200
225Annotation score:
A0A1P8B5K3A0A1P8B5K3_ARATH
NOD26-like major intrinsic protein ...
NLM1 AT-NLM1, ATNLM1, NIP1:1, At4g19030, F13C5.200 NLM1 AT-NLM1, ATNLM1, NIP1:1, At4g19030, F13C5.200, F13C5_200
220Annotation score:

Sequence cautioni

The sequence CAA16760 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA68906 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB78905 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07625 mRNA Translation: CAA68906.1 Different initiation.
AL021711 Genomic DNA Translation: CAA16760.2 Sequence problems.
AL161550 Genomic DNA Translation: CAB78905.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84127.1
AY063796 mRNA Translation: AAL36152.1
AY117197 mRNA Translation: AAM51272.1
AY084497 mRNA Translation: AAM61066.1
PIRiH85214
T05040
RefSeqiNP_567572.1, NM_118021.4
UniGeneiAt.5405

Genome annotation databases

EnsemblPlantsiAT4G19030.1; AT4G19030.1; AT4G19030
GeneIDi827641
GrameneiAT4G19030.1; AT4G19030.1; AT4G19030
KEGGiath:AT4G19030

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07625 mRNA Translation: CAA68906.1 Different initiation.
AL021711 Genomic DNA Translation: CAA16760.2 Sequence problems.
AL161550 Genomic DNA Translation: CAB78905.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84127.1
AY063796 mRNA Translation: AAL36152.1
AY117197 mRNA Translation: AAM51272.1
AY084497 mRNA Translation: AAM61066.1
PIRiH85214
T05040
RefSeqiNP_567572.1, NM_118021.4
UniGeneiAt.5405

3D structure databases

ProteinModelPortaliQ8VZW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12934, 184 interactors
IntActiQ8VZW1, 184 interactors
STRINGi3702.AT4G19030.1

Protein family/group databases

TCDBi1.A.8.12.8 the major intrinsic protein (mip) family

Proteomic databases

PaxDbiQ8VZW1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G19030.1; AT4G19030.1; AT4G19030
GeneIDi827641
GrameneiAT4G19030.1; AT4G19030.1; AT4G19030
KEGGiath:AT4G19030

Organism-specific databases

AraportiAT4G19030
TAIRilocus:2117119 AT4G19030

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
HOGENOMiHOG000288286
InParanoidiQ8VZW1
KOiK09874
OMAiGYGNARE
OrthoDBiEOG09360N7X
PhylomeDBiQ8VZW1

Miscellaneous databases

PROiPR:Q8VZW1

Gene expression databases

ExpressionAtlasiQ8VZW1 differential
GenevisibleiQ8VZW1 AT

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIP11_ARATH
AccessioniPrimary (citable) accession number: Q8VZW1
Secondary accession number(s): O48595, O49416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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