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UniProtKB - Q8VZS0 (PNC2_ARATH)
Protein
Peroxisomal adenine nucleotide carrier 2
Gene
PNC2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP. ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth. Required for the beta-oxidation reactions involved in auxin biosynthesis and for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis.
2 PublicationsKineticsi
- KM=150 µM for ATP1 Publication
GO - Molecular functioni
- ADP transmembrane transporter activity Source: TAIR
- antiporter activity Source: UniProtKB-KW
- ATP transmembrane transporter activity Source: TAIR
GO - Biological processi
- ADP transport Source: TAIR
- ATP transport Source: TAIR
- fatty acid beta-oxidation Source: TAIR
- indolebutyric acid metabolic process Source: TAIR
- peroxisome organization Source: GO_Central
Keywordsi
Biological process | Antiport, Transport |
Protein family/group databases
TCDBi | 2.A.29.20.2, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal adenine nucleotide carrier 2 |
Gene namesi | Name:PNC2 Ordered Locus Names:At5g27520 ORF Names:F15A18, F21A20.230 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G27520 |
TAIRi | locus:2146355, AT5G27520 |
Subcellular locationi
Peroxisome
- Peroxisome membrane 2 Publications; Multi-pass membrane protein 2 Publications
Peroxisome
- integral component of peroxisomal membrane Source: GO_Central
- peroxisome Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 106 – 126 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 160 – 180 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 256 – 276 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 288 – 308 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420693 | 1 – 321 | Peroxisomal adenine nucleotide carrier 2Add BLAST | 321 |
Proteomic databases
PaxDbi | Q8VZS0 |
ProteomicsDBi | 234986 |
Expressioni
Tissue specificityi
Expressed in stamens, pollen grains, seeds, leaves, cotyledons, roots, stems, flowers, hypocotyls and siliques.1 Publication
Developmental stagei
Expressed in the early seedling stage of post-germinative growth.1 Publication
Gene expression databases
ExpressionAtlasi | Q8VZS0, baseline and differential |
Genevisiblei | Q8VZS0, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 96 | Solcar 1Add BLAST | 90 | |
Repeati | 106 – 186 | Solcar 2Add BLAST | 81 | |
Repeati | 204 – 300 | Solcar 3Add BLAST | 97 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0769, Eukaryota |
HOGENOMi | CLU_015166_6_3_1 |
InParanoidi | Q8VZS0 |
OMAi | CNIWKKE |
OrthoDBi | 1126848at2759 |
PhylomeDBi | Q8VZS0 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045900, Peroxisomal_Ade_carrier |
PANTHERi | PTHR46650, PTHR46650, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q8VZS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVDLDLESI SEATSGAIGS LLSTTILYPL DTCKSKFQAE IRVRGQQKYR
60 70 80 90 100
YLSDVFWEAI SSGNVLSLYQ GLGTKNLQSF ISSFIYFYSY SYFKRLHSQR
110 120 130 140 150
IGSKSIGTKA NLLIAAAAGA CTSVLTQPLD TASSRMQTSE FGKSKGLWKT
160 170 180 190 200
LTDGSWGNAF DGLGISLLLT SNPAIQYTVF DQLKQNLLEK GKAKSNKDSS
210 220 230 240 250
PVVLSAFMAF VLGAVSKSAA TVITYPAIRC KVMIQAADDS KENEAKKPRK
260 270 280 290 300
RIRKTIPGVV YAIWKKEGIL GFFKGLQAQI LKTVLSSALL LMIKEKITAT
310 320
TWILILAIRT LFVTKARLKS P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007123 Genomic DNA No translation available. AC007478 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED93696.1 AY063892 mRNA Translation: AAL36248.1 AY122919 mRNA Translation: AAM67452.1 |
RefSeqi | NP_198104.1, NM_122634.4 |
Genome annotation databases
EnsemblPlantsi | AT5G27520.1; AT5G27520.1; AT5G27520 |
GeneIDi | 832812 |
Gramenei | AT5G27520.1; AT5G27520.1; AT5G27520 |
KEGGi | ath:AT5G27520 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007123 Genomic DNA No translation available. AC007478 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED93696.1 AY063892 mRNA Translation: AAL36248.1 AY122919 mRNA Translation: AAM67452.1 |
RefSeqi | NP_198104.1, NM_122634.4 |
3D structure databases
AlphaFoldDBi | Q8VZS0 |
SMRi | Q8VZS0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G27520.1 |
Protein family/group databases
TCDBi | 2.A.29.20.2, the mitochondrial carrier (mc) family |
Proteomic databases
PaxDbi | Q8VZS0 |
ProteomicsDBi | 234986 |
Genome annotation databases
EnsemblPlantsi | AT5G27520.1; AT5G27520.1; AT5G27520 |
GeneIDi | 832812 |
Gramenei | AT5G27520.1; AT5G27520.1; AT5G27520 |
KEGGi | ath:AT5G27520 |
Organism-specific databases
Araporti | AT5G27520 |
TAIRi | locus:2146355, AT5G27520 |
Phylogenomic databases
eggNOGi | KOG0769, Eukaryota |
HOGENOMi | CLU_015166_6_3_1 |
InParanoidi | Q8VZS0 |
OMAi | CNIWKKE |
OrthoDBi | 1126848at2759 |
PhylomeDBi | Q8VZS0 |
Miscellaneous databases
PROi | PR:Q8VZS0 |
Gene expression databases
ExpressionAtlasi | Q8VZS0, baseline and differential |
Genevisiblei | Q8VZS0, AT |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045900, Peroxisomal_Ade_carrier |
PANTHERi | PTHR46650, PTHR46650, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PNC2_ARATH | |
Accessioni | Q8VZS0Primary (citable) accession number: Q8VZS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2013 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families