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Entry version 131 (16 Oct 2019)
Sequence version 3 (15 Dec 2009)
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Protein

MDIS1-interacting receptor like kinase 2

Gene

MIK2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the pollen tube perception of the female signal.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei802ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei905Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi781 – 789ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • pollen tube guidance Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MDIS1-interacting receptor like kinase 21 Publication
Short name:
AtMIK21 Publication
Alternative name(s):
Probable LRR receptor-like serine/threonine-protein kinase At4g08850 (EC:2.7.11.1Curated)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIK21 Publication
Ordered Locus Names:At4g08850Imported
ORF Names:T32A17.160Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G08850

The Arabidopsis Information Resource

More...
TAIRi
locus:2138268 AT4G08850

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini44 – 709ExtracellularSequence analysisAdd BLAST666
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 1045CytoplasmicSequence analysisAdd BLAST315

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038755944 – 1045MDIS1-interacting receptor like kinase 2Add BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei772PhosphothreonineBy similarity1
Modified residuei853PhosphotyrosineBy similarity1
Modified residuei892PhosphotyrosineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei946PhosphotyrosineBy similarity1
Modified residuei953PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VZG8

PRoteomics IDEntifications database

More...
PRIDEi
Q8VZG8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VZG8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8VZG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pollen tubes.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VZG8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VZG8 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MDIS1 and LURE1.2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
11755, 12 interactors

Database of interacting proteins

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DIPi
DIP-53470N

Protein interaction database and analysis system

More...
IntActi
Q8VZG8, 12 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G08850.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VZG8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati92 – 116LRR 1Sequence analysisAdd BLAST25
Repeati117 – 140LRR 2Sequence analysisAdd BLAST24
Repeati141 – 165LRR 3Sequence analysisAdd BLAST25
Repeati166 – 189LRR 4Sequence analysisAdd BLAST24
Repeati191 – 212LRR 5Sequence analysisAdd BLAST22
Repeati213 – 237LRR 6Sequence analysisAdd BLAST25
Repeati238 – 260LRR 7Sequence analysisAdd BLAST23
Repeati262 – 285LRR 8Sequence analysisAdd BLAST24
Repeati286 – 309LRR 9Sequence analysisAdd BLAST24
Repeati311 – 333LRR 10Sequence analysisAdd BLAST23
Repeati334 – 356LRR 11Sequence analysisAdd BLAST23
Repeati357 – 381LRR 12Sequence analysisAdd BLAST25
Repeati383 – 405LRR 13Sequence analysisAdd BLAST23
Repeati406 – 429LRR 14Sequence analysisAdd BLAST24
Repeati431 – 452LRR 15Sequence analysisAdd BLAST22
Repeati453 – 476LRR 16Sequence analysisAdd BLAST24
Repeati477 – 501LRR 17Sequence analysisAdd BLAST25
Repeati502 – 525LRR 18Sequence analysisAdd BLAST24
Repeati527 – 549LRR 19Sequence analysisAdd BLAST23
Repeati550 – 573LRR 20Sequence analysisAdd BLAST24
Repeati575 – 597LRR 21Sequence analysisAdd BLAST23
Repeati598 – 620LRR 22Sequence analysisAdd BLAST23
Repeati621 – 644LRR 23Sequence analysisAdd BLAST24
Repeati646 – 670LRR 24Sequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini775 – 1045Protein kinasePROSITE-ProRule annotationAdd BLAST271

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116551

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VZG8

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLVHVNI

Database of Orthologous Groups

More...
OrthoDBi
221253at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VZG8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
PF08263 LRRNT_2, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 16 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VZG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKTNPERKI SLTSFKERMA CKEKPRDLQV LLIISIVLSC SFAVSATVEE
60 70 80 90 100
ANALLKWKST FTNQTSSSKL SSWVNPNTSS FCTSWYGVAC SLGSIIRLNL
110 120 130 140 150
TNTGIEGTFE DFPFSSLPNL TFVDLSMNRF SGTISPLWGR FSKLEYFDLS
160 170 180 190 200
INQLVGEIPP ELGDLSNLDT LHLVENKLNG SIPSEIGRLT KVTEIAIYDN
210 220 230 240 250
LLTGPIPSSF GNLTKLVNLY LFINSLSGSI PSEIGNLPNL RELCLDRNNL
260 270 280 290 300
TGKIPSSFGN LKNVTLLNMF ENQLSGEIPP EIGNMTALDT LSLHTNKLTG
310 320 330 340 350
PIPSTLGNIK TLAVLHLYLN QLNGSIPPEL GEMESMIDLE ISENKLTGPV
360 370 380 390 400
PDSFGKLTAL EWLFLRDNQL SGPIPPGIAN STELTVLQLD TNNFTGFLPD
410 420 430 440 450
TICRGGKLEN LTLDDNHFEG PVPKSLRDCK SLIRVRFKGN SFSGDISEAF
460 470 480 490 500
GVYPTLNFID LSNNNFHGQL SANWEQSQKL VAFILSNNSI TGAIPPEIWN
510 520 530 540 550
MTQLSQLDLS SNRITGELPE SISNINRISK LQLNGNRLSG KIPSGIRLLT
560 570 580 590 600
NLEYLDLSSN RFSSEIPPTL NNLPRLYYMN LSRNDLDQTI PEGLTKLSQL
610 620 630 640 650
QMLDLSYNQL DGEISSQFRS LQNLERLDLS HNNLSGQIPP SFKDMLALTH
660 670 680 690 700
VDVSHNNLQG PIPDNAAFRN APPDAFEGNK DLCGSVNTTQ GLKPCSITSS
710 720 730 740 750
KKSHKDRNLI IYILVPIIGA IIILSVCAGI FICFRKRTKQ IEEHTDSESG
760 770 780 790 800
GETLSIFSFD GKVRYQEIIK ATGEFDPKYL IGTGGHGKVY KAKLPNAIMA
810 820 830 840 850
VKKLNETTDS SISNPSTKQE FLNEIRALTE IRHRNVVKLF GFCSHRRNTF
860 870 880 890 900
LVYEYMERGS LRKVLENDDE AKKLDWGKRI NVVKGVAHAL SYMHHDRSPA
910 920 930 940 950
IVHRDISSGN ILLGEDYEAK ISDFGTAKLL KPDSSNWSAV AGTYGYVAPE
960 970 980 990 1000
LAYAMKVTEK CDVYSFGVLT LEVIKGEHPG DLVSTLSSSP PDATLSLKSI
1010 1020 1030 1040
SDHRLPEPTP EIKEEVLEIL KVALLCLHSD PQARPTMLSI STAFS
Length:1,045
Mass (Da):115,423
Last modified:December 15, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C9E44DE99DAE8BF
GO
Isoform 2 (identifier: Q8VZG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     950-1045: ELAYAMKVTE...TMLSISTAFS → GTLFDPLDKL...LTMGWIWFSF

Note: No experimental confirmation available.
Show »
Length:1,009
Mass (Da):112,115
Checksum:iCFF13C5CC2B0E54D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN60259 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB78010 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB82121 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10I → S in AAN60259 (Ref. 6) Curated1
Sequence conflicti111D → N in AAN60259 (Ref. 6) Curated1
Sequence conflicti389L → V in CAB78010 (PubMed:10617198).Curated1
Sequence conflicti389L → V in CAB82121 (PubMed:10617198).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038295950 – 1045ELAYA…STAFS → GTLFDPLDKLVVDLTRLWSG RVEIMVRFGLFGLNFNQIKT KMFCFGLKFFLTMGWIWFSF in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL161513 Genomic DNA Translation: CAB78010.1 Sequence problems.
AL161813 Genomic DNA Translation: CAB82121.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82682.1
CP002687 Genomic DNA Translation: AEE82683.1
AY064972 mRNA Translation: AAL57627.1
AK317056 mRNA Translation: BAH19749.1
FJ708744 mRNA Translation: ACN59338.1
AF083700 mRNA Translation: AAN60259.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
B85089

NCBI Reference Sequences

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RefSeqi
NP_192625.4, NM_116955.5 [Q8VZG8-2]
NP_849538.2, NM_179207.3 [Q8VZG8-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT4G08850.1; AT4G08850.1; AT4G08850 [Q8VZG8-1]
AT4G08850.2; AT4G08850.2; AT4G08850 [Q8VZG8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
826456

Gramene; a comparative resource for plants

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Gramenei
AT4G08850.1; AT4G08850.1; AT4G08850 [Q8VZG8-1]
AT4G08850.2; AT4G08850.2; AT4G08850 [Q8VZG8-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT4G08850

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161513 Genomic DNA Translation: CAB78010.1 Sequence problems.
AL161813 Genomic DNA Translation: CAB82121.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82682.1
CP002687 Genomic DNA Translation: AEE82683.1
AY064972 mRNA Translation: AAL57627.1
AK317056 mRNA Translation: BAH19749.1
FJ708744 mRNA Translation: ACN59338.1
AF083700 mRNA Translation: AAN60259.1 Different initiation.
PIRiB85089
RefSeqiNP_192625.4, NM_116955.5 [Q8VZG8-2]
NP_849538.2, NM_179207.3 [Q8VZG8-1]

3D structure databases

SMRiQ8VZG8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi11755, 12 interactors
DIPiDIP-53470N
IntActiQ8VZG8, 12 interactors
STRINGi3702.AT4G08850.1

PTM databases

iPTMnetiQ8VZG8
SwissPalmiQ8VZG8

Proteomic databases

PaxDbiQ8VZG8
PRIDEiQ8VZG8

Genome annotation databases

EnsemblPlantsiAT4G08850.1; AT4G08850.1; AT4G08850 [Q8VZG8-1]
AT4G08850.2; AT4G08850.2; AT4G08850 [Q8VZG8-2]
GeneIDi826456
GrameneiAT4G08850.1; AT4G08850.1; AT4G08850 [Q8VZG8-1]
AT4G08850.2; AT4G08850.2; AT4G08850 [Q8VZG8-2]
KEGGiath:AT4G08850

Organism-specific databases

AraportiAT4G08850
TAIRilocus:2138268 AT4G08850

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000116551
InParanoidiQ8VZG8
OMAiGLVHVNI
OrthoDBi221253at2759
PhylomeDBiQ8VZG8

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8VZG8

Gene expression databases

ExpressionAtlasiQ8VZG8 baseline and differential
GenevisibleiQ8VZG8 AT

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
PF08263 LRRNT_2, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 16 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIK2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VZG8
Secondary accession number(s): B9DG82, Q8H7F4, Q9LCZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 15, 2009
Last modified: October 16, 2019
This is version 131 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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