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Protein

Protein HYPER-SENSITIVITY-RELATED 4

Gene

HSR4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 313ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB-EC
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: TAIR

GO - Biological processi

  • cell death Source: TAIR
  • plant-type hypersensitive response Source: UniProtKB
  • response to bacterium Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • response to UV Source: TAIR
  • salicylic acid mediated signaling pathway Source: TAIR

Keywordsi

Molecular functionHydrolase
Biological processHypersensitive response, Plant defense
LigandATP-binding, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HYPER-SENSITIVITY-RELATED 41 Publication (EC:3.6.1.3By similarity)
Short name:
AtHSR41 Publication
Alternative name(s):
BCS1-like protein
Gene namesi
Name:HSR41 Publication
Synonyms:BCS1
Ordered Locus Names:At3g50930Imported
ORF Names:F18B3.210Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G50930
TAIRilocus:2077997 AT3G50930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004347021 – 576Protein HYPER-SENSITIVITY-RELATED 4Add BLAST576

Proteomic databases

PaxDbiQ8VZG2

Expressioni

Inductioni

Accumulates in response to flg22, thus being a FLARE (flagellin rapidly elicited gene) (PubMed:15181213). Up-regulated by the Yariv phenylglycoside (beta-D-Glc)3 (PubMed:15235117). Expressed during hypersensitive response (HR) mediated by the bacterial pathogen Xanthomonas campestris pv. campestris (PubMed:10518009). Slightly induced by the virulent pathogen Erwinia carotovora subsp. carotovora (PubMed:16270229). Triggered by benzothiadiazole S-methylester (BTH) (PubMed:16766691). Accumulates in the presence of 2,4,6-trinitrotoluene (TNT) (PubMed:18702669).6 Publications

Gene expression databases

ExpressionAtlasiQ8VZG2 baseline and differential
GenevisibleiQ8VZG2 AT

Interactioni

Subunit structurei

Binds to the Yariv phenylglycoside (beta-D-Glc)3.1 Publication

GO - Molecular functioni

  • identical protein binding Source: TAIR

Protein-protein interaction databases

STRINGi3702.AT3G50930.1

Structurei

3D structure databases

ProteinModelPortaliQ8VZG2
SMRiQ8VZG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0743 Eukaryota
COG0465 LUCA
HOGENOMiHOG000237995
OMAiHVYNAVR
OrthoDBiEOG093609HW
PhylomeDBiQ8VZG2

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR025753 AAA_N_dom
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF14363 AAA_assoc, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VZG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSKLLPCV HKSPVPTSHQ LYINYEILGL TKLKKHKYTQ NKMSSSDSSS
60 70 80 90 100
AESRLATAKT VLTTAASVAA TAMLARSLVQ DYLPDEVHHY ISYGFRSIFG
110 120 130 140 150
YFSSQMTIII EEFEGFAHNE VFEAAEAYLA TKISPSNKRI KVSKHEKENN
160 170 180 190 200
YNVTVERDEE VVDTYNGVKF QWILHCRHVE SKHFHNPRDL NSTLRSEVRS
210 220 230 240 250
FELNFHKKFK DVALESYLPF MVKRATLMKQ EKKTLKIFTL SPENMYGNYS
260 270 280 290 300
DAWTSVTLDH PSTFKTLAMD SDVKTSVMED LDKFVKRRDF YKRVGKAWKR
310 320 330 340 350
GYLLYGPPGT GKSSLIAAMA NHLNFDIYDL ELTAVNNNSE LRRLLIATAN
360 370 380 390 400
RSILIVEDID CSLELKDRTS DEPPRESDDI EDPRYKKVTL SGLLNFIDGL
410 420 430 440 450
WSSCGDERII IFTTNYKEKL DAALLRPGRM DMHIHMSYCT PSTFKALALN
460 470 480 490 500
YLEIKEHRLF SKIEEGIEAT EVTPAEVAEQ LMRNDSVDKV LEGLIEFLKV
510 520 530 540 550
KKIENEQDKA KTEKQELENK KKTKEGTDSV VKKEVDEQLV RNDRVDKVLE
560 570
GLVELLKAKK IEDDQDKAKH EEVEQH
Length:576
Mass (Da):66,136
Last modified:March 1, 2002 - v1
Checksum:i90B8C6DC41A05C9C
GO

Sequence cautioni

The sequence AAM26687 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM64718 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB42922 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti522K → R in AAM64718 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049862 Genomic DNA Translation: CAB42922.1 Different initiation.
CP002686 Genomic DNA Translation: AEE78728.1
AF370607 mRNA Translation: AAK43926.1
AY064981 mRNA Translation: AAL57634.1
AY102119 mRNA Translation: AAM26687.1 Different initiation.
BT002611 mRNA Translation: AAO11527.1
AY087160 mRNA Translation: AAM64718.1 Different initiation.
PIRiT08414
RefSeqiNP_190662.2, NM_114953.3
UniGeneiAt.23776

Genome annotation databases

EnsemblPlantsiAT3G50930.1; AT3G50930.1; AT3G50930
GeneIDi824257
GrameneiAT3G50930.1; AT3G50930.1; AT3G50930
KEGGiath:AT3G50930

Similar proteinsi

Entry informationi

Entry nameiHSR4_ARATH
AccessioniPrimary (citable) accession number: Q8VZG2
Secondary accession number(s): Q8LBK2, Q9SVK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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