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UniProtKB - Q8VZG1 (DGK3_ARATH)
Protein
Diacylglycerol kinase 3
Gene
DGK3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity).
By similarityCatalytic activityi
- EC:2.7.1.107
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- diacylglycerol kinase activity Source: UniProtKB-EC
- NAD+ kinase activity Source: InterPro
GO - Biological processi
- defense response Source: UniProtKB-KW
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Plant defense, Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT2G18730-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol kinase 3 (EC:2.7.1.107)Short name: AtDGK3 Short name: DAG kinase 3 Alternative name(s): Diglyceride kinase 3 Short name: DGK 3 |
Gene namesi | Name:DGK3 Ordered Locus Names:At2g18730 ORF Names:MSF3.11 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G18730 |
TAIRi | locus:2053978, AT2G18730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422111 | 1 – 488 | Diacylglycerol kinase 3Add BLAST | 488 |
Proteomic databases
PaxDbi | Q8VZG1 |
ProteomicsDBi | 224037 |
PTM databases
iPTMneti | Q8VZG1 |
SwissPalmi | Q8VZG1 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8VZG1, baseline and differential |
Genevisiblei | Q8VZG1, AT |
Interactioni
Subunit structurei
Monomer.
By similarityBinary interactionsi
Q8VZG1
With | #Exp. | IntAct |
---|---|---|
MPK6 [Q39026] | 4 | EBI-4441630,EBI-349548 |
Protein-protein interaction databases
BioGRIDi | 1745, 7 interactors |
IntActi | Q8VZG1, 7 interactors |
STRINGi | 3702.AT2G18730.1 |
Structurei
3D structure databases
AlphaFoldDBi | Q8VZG1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 245 | DAGKcPROSITE-ProRule annotationAdd BLAST | 159 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the eukaryotic diacylglycerol kinase family.Curated
Phylogenomic databases
eggNOGi | KOG1169, Eukaryota |
HOGENOMi | CLU_002706_46_3_1 |
InParanoidi | Q8VZG1 |
OMAi | LMMPEYL |
OrthoDBi | 633642at2759 |
PhylomeDBi | Q8VZG1 |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016961, Diacylglycerol_kinase_pln IPR016064, NAD/diacylglycerol_kinase_sf |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
PIRSFi | PIRSF030829, Diacylglycerol_kinase_pln, 1 hit |
SMARTi | View protein in SMART SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8VZG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSPVSKTDA SKEKFVASRP STADSKTMRG CGLANLAWVG VDKVELRQRL
60 70 80 90 100
MMPEYLRLAM RDCIKRKDSS AIPDHLLLPG GAVADMAPHA PMVVFINPNS
110 120 130 140 150
GGRHGPVLKE RLQQLMSEEQ VFDLTEVKPH EFVRYGLGCL EKVAAEGDEC
160 170 180 190 200
AKECRARLRI MVAGGDGTVG WVLGCLGELN KDGKSQIPPV GVIPLGTGND
210 220 230 240 250
LSRSFGWGGS FPFAWRSAVK RTLHRASMGP VARLDSWKIL VSMPSGEVVD
260 270 280 290 300
PPYSLKPAEE NELDQGLDAG IDAPPLAKAY EGVFYNYLSI GMDAQVAYGF
310 320 330 340 350
HHLRNTKPYL AQGPISNKII YSSFGCSQGW FCTPCVNDPG LRGLRNIMKI
360 370 380 390 400
HIKKVNCSQW EEIAVPKNVR SIVALNLHSY GSGSHPWGNL KPDYLEKRGF
410 420 430 440 450
VEAHCDDGLI EIFGFKQGWH ASFVMAELIS AKHIAQAAAV RFELRGGDWR
460 470 480
DAFLQMDGEP WKQPMSTEYS TFVEIKKVPY QSLMINNE
Sequence cautioni
The sequence AAD08942 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005724 Genomic DNA Translation: AAD08942.1 Sequence problems. CP002685 Genomic DNA Translation: AEC06799.1 AY064982 mRNA Translation: AAL57635.1 AY141990 mRNA Translation: AAM98254.1 |
PIRi | H84567 |
RefSeqi | NP_849980.1, NM_179649.4 |
Genome annotation databases
EnsemblPlantsi | AT2G18730.1; AT2G18730.1; AT2G18730 |
GeneIDi | 816388 |
Gramenei | AT2G18730.1; AT2G18730.1; AT2G18730 |
KEGGi | ath:AT2G18730 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005724 Genomic DNA Translation: AAD08942.1 Sequence problems. CP002685 Genomic DNA Translation: AEC06799.1 AY064982 mRNA Translation: AAL57635.1 AY141990 mRNA Translation: AAM98254.1 |
PIRi | H84567 |
RefSeqi | NP_849980.1, NM_179649.4 |
3D structure databases
AlphaFoldDBi | Q8VZG1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 1745, 7 interactors |
IntActi | Q8VZG1, 7 interactors |
STRINGi | 3702.AT2G18730.1 |
PTM databases
iPTMneti | Q8VZG1 |
SwissPalmi | Q8VZG1 |
Proteomic databases
PaxDbi | Q8VZG1 |
ProteomicsDBi | 224037 |
Genome annotation databases
EnsemblPlantsi | AT2G18730.1; AT2G18730.1; AT2G18730 |
GeneIDi | 816388 |
Gramenei | AT2G18730.1; AT2G18730.1; AT2G18730 |
KEGGi | ath:AT2G18730 |
Organism-specific databases
Araporti | AT2G18730 |
TAIRi | locus:2053978, AT2G18730 |
Phylogenomic databases
eggNOGi | KOG1169, Eukaryota |
HOGENOMi | CLU_002706_46_3_1 |
InParanoidi | Q8VZG1 |
OMAi | LMMPEYL |
OrthoDBi | 633642at2759 |
PhylomeDBi | Q8VZG1 |
Enzyme and pathway databases
BioCyci | ARA:AT2G18730-MONOMER |
Miscellaneous databases
PROi | PR:Q8VZG1 |
Gene expression databases
ExpressionAtlasi | Q8VZG1, baseline and differential |
Genevisiblei | Q8VZG1, AT |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016961, Diacylglycerol_kinase_pln IPR016064, NAD/diacylglycerol_kinase_sf |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
PIRSFi | PIRSF030829, Diacylglycerol_kinase_pln, 1 hit |
SMARTi | View protein in SMART SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DGK3_ARATH | |
Accessioni | Q8VZG1Primary (citable) accession number: Q8VZG1 Secondary accession number(s): Q9ZV46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2013 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families