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UniProtKB - Q8VZG1 (DGK3_ARATH)

Entry version 120 (25 May 2022)
Sequence version 1 (01 Mar 2002)
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Protein

Diacylglycerol kinase 3

Gene

DGK3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPlant defense, Stress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ARA:AT2G18730-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase 3 (EC:2.7.1.107)
Short name:
AtDGK3
Short name:
DAG kinase 3
Alternative name(s):
Diglyceride kinase 3
Short name:
DGK 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGK3
Ordered Locus Names:At2g18730
ORF Names:MSF3.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT2G18730

The Arabidopsis Information Resource

More...TAIRi		locus:2053978, AT2G18730

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004221111 – 488Diacylglycerol kinase 3Add BLAST488

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VZG1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		224037

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8VZG1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8VZG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8VZG1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VZG1, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		1745, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8VZG1, 7 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT2G18730.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8VZG1

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 245DAGKcPROSITE-ProRule annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1169, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002706_46_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VZG1

Identification of Orthologs from Complete Genome Data

More...OMAi		LMMPEYL

Database of Orthologous Groups

More...OrthoDBi		633642at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VZG1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016961, Diacylglycerol_kinase_pln
IPR016064, NAD/diacylglycerol_kinase_sf

The PANTHER Classification System

More...PANTHERi		PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF030829, Diacylglycerol_kinase_pln, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50146, DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VZG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPVSKTDA SKEKFVASRP STADSKTMRG CGLANLAWVG VDKVELRQRL 
        60         70         80         90        100
MMPEYLRLAM RDCIKRKDSS AIPDHLLLPG GAVADMAPHA PMVVFINPNS 
       110        120        130        140        150
GGRHGPVLKE RLQQLMSEEQ VFDLTEVKPH EFVRYGLGCL EKVAAEGDEC 
       160        170        180        190        200
AKECRARLRI MVAGGDGTVG WVLGCLGELN KDGKSQIPPV GVIPLGTGND 
       210        220        230        240        250
LSRSFGWGGS FPFAWRSAVK RTLHRASMGP VARLDSWKIL VSMPSGEVVD 
       260        270        280        290        300
PPYSLKPAEE NELDQGLDAG IDAPPLAKAY EGVFYNYLSI GMDAQVAYGF 
       310        320        330        340        350
HHLRNTKPYL AQGPISNKII YSSFGCSQGW FCTPCVNDPG LRGLRNIMKI 
       360        370        380        390        400
HIKKVNCSQW EEIAVPKNVR SIVALNLHSY GSGSHPWGNL KPDYLEKRGF 
       410        420        430        440        450
VEAHCDDGLI EIFGFKQGWH ASFVMAELIS AKHIAQAAAV RFELRGGDWR 
       460        470        480 
DAFLQMDGEP WKQPMSTEYS TFVEIKKVPY QSLMINNE
Length:488
Mass (Da):53,881
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i126012C84473CA3F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD08942 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005724 Genomic DNA Translation: AAD08942.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06799.1
AY064982 mRNA Translation: AAL57635.1
AY141990 mRNA Translation: AAM98254.1

Protein sequence database of the Protein Information Resource

More...PIRi		H84567

NCBI Reference Sequences

More...RefSeqi		NP_849980.1, NM_179649.4

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT2G18730.1; AT2G18730.1; AT2G18730

Database of genes from NCBI RefSeq genomes

More...GeneIDi		816388

Gramene; a comparative resource for plants

More...Gramenei		AT2G18730.1; AT2G18730.1; AT2G18730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT2G18730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005724 Genomic DNA Translation: AAD08942.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06799.1
AY064982 mRNA Translation: AAL57635.1
AY141990 mRNA Translation: AAM98254.1
PIRiH84567
RefSeqiNP_849980.1, NM_179649.4

3D structure databases

AlphaFoldDBiQ8VZG1
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi1745, 7 interactors
IntActiQ8VZG1, 7 interactors
STRINGi3702.AT2G18730.1

PTM databases

iPTMnetiQ8VZG1
SwissPalmiQ8VZG1

Proteomic databases

PaxDbiQ8VZG1
ProteomicsDBi224037

Genome annotation databases

EnsemblPlantsiAT2G18730.1; AT2G18730.1; AT2G18730
GeneIDi816388
GrameneiAT2G18730.1; AT2G18730.1; AT2G18730
KEGGiath:AT2G18730

Organism-specific databases

AraportiAT2G18730
TAIRilocus:2053978, AT2G18730

Phylogenomic databases

eggNOGiKOG1169, Eukaryota
HOGENOMiCLU_002706_46_3_1
InParanoidiQ8VZG1
OMAiLMMPEYL
OrthoDBi633642at2759
PhylomeDBiQ8VZG1

Enzyme and pathway databases

BioCyciARA:AT2G18730-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q8VZG1

Gene expression databases

ExpressionAtlasiQ8VZG1, baseline and differential
GenevisibleiQ8VZG1, AT

Family and domain databases

Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016961, Diacylglycerol_kinase_pln
IPR016064, NAD/diacylglycerol_kinase_sf
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PIRSFiPIRSF030829, Diacylglycerol_kinase_pln, 1 hit
SMARTiView protein in SMART
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGK3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VZG1
Secondary accession number(s): Q9ZV46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 1, 2002
Last modified: May 25, 2022
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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