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Entry version 129 (26 Feb 2020)
Sequence version 2 (04 Jan 2005)
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Protein

Ethylene-responsive transcription factor 6

Gene

ERF6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi136 – 194AP2/ERFPROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processEthylene signaling pathway, Plant defense, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ethylene-responsive transcription factor 6
Short name:
AtERF6
Alternative name(s):
Ethylene-responsive element-binding factor 6
Short name:
EREBP-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERF6
Synonyms:ERF-6, ERF103
Ordered Locus Names:At4g17490
ORF Names:dl4780c, FCAALL.120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007605 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, ARATH_4, Chromosome 4, ARATH_4P, Chromosome 4, long arm
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G17490

The Arabidopsis Information Resource

More...
TAIRi
locus:2129106 AT4G17490

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001125661 – 282Ethylene-responsive transcription factor 6Add BLAST282

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VZ91

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VZ91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VZ91 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VZ91 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
12756, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8VZ91, 6 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G17490.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VZ91

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYSR Eukaryota
ENOG410YIK7 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058713_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VZ91

KEGG Orthology (KO)

More...
KOi
K09286

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRTEWIQ

Database of Orthologous Groups

More...
OrthoDBi
1169658at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VZ91

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00018 AP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00847 AP2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00367 ETHRSPELEMNT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00380 AP2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171 SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51032 AP2_ERF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VZ91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPNEVSAL FLIKKYLLDE LSPLPTTATT NRWMNDFTSF DQTGFEFSEF
60 70 80 90 100
ETKPEIIDLV TPKPEIFDFD VKSEIPSESN DSFTFQSNPP RVTVQSNRKP
110 120 130 140 150
PLKIAPPNRT KWIQFATGNP KPELPVPVVA AEEKRHYRGV RMRPWGKFAA
160 170 180 190 200
EIRDPTRRGT RVWLGTFETA IEAARAYDKE AFRLRGSKAI LNFPLEVDKW
210 220 230 240 250
NPRAEDGRGL YNKRKRDGEE EEVTVVEKVL KTEESYDVSG GENVESGLTA
260 270 280
IDDWDLTEFL SMPLLSPLSP HPPFGYPQLT VV
Length:282
Mass (Da):32,108
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C785CFA721DC882
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB10530 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g17490 has been split into 2 genes: At4g17486 and At4g17490.Curated
The sequence CAB78752 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g17490 has been split into 2 genes: At4g17486 and At4g17490.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41D → H in BAB12039 (Ref. 1) Curated1
Sequence conflicti41D → H in BAA31525 (Ref. 1) Curated1
Sequence conflicti67F → S in BAB12039 (Ref. 1) Curated1
Sequence conflicti67F → S in BAA31525 (Ref. 1) Curated1
Sequence conflicti70D → E in BAB12039 (Ref. 1) Curated1
Sequence conflicti70D → E in BAA31525 (Ref. 1) Curated1
Sequence conflicti76 – 77PS → SI in BAB12039 (Ref. 1) Curated2
Sequence conflicti76 – 77PS → SI in BAA31525 (Ref. 1) Curated2
Sequence conflicti126V → E in BAB12039 (Ref. 1) Curated1
Sequence conflicti126V → E in BAA31525 (Ref. 1) Curated1
Sequence conflicti212Missing in BAB12039 (Ref. 1) Curated1
Sequence conflicti212Missing in BAA31525 (Ref. 1) Curated1
Sequence conflicti218G → S in BAB12039 (Ref. 1) Curated1
Sequence conflicti218G → S in BAA31525 (Ref. 1) Curated1
Sequence conflicti224T → K in BAB12039 (Ref. 1) Curated1
Sequence conflicti224T → K in BAA31525 (Ref. 1) Curated1
Sequence conflicti225V → M in AAL38331 (PubMed:14593172).Curated1
Sequence conflicti225V → M in AAM47907 (PubMed:14593172).Curated1
Sequence conflicti227E → K in BAB12039 (Ref. 1) Curated1
Sequence conflicti227E → K in BAA31525 (Ref. 1) Curated1
Sequence conflicti232T → K in BAB12039 (Ref. 1) Curated1
Sequence conflicti232T → K in BAA31525 (Ref. 1) Curated1
Sequence conflicti237D → A in BAB12039 (Ref. 1) Curated1
Sequence conflicti237D → A in BAA31525 (Ref. 1) Curated1
Sequence conflicti240G → D in BAB12039 (Ref. 1) Curated1
Sequence conflicti240G → D in BAA31525 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB008316 mRNA Translation: BAB12039.1
AB013301 mRNA Translation: BAA31525.1
Z97343 Genomic DNA Translation: CAB10530.1 Sequence problems.
AL161546 Genomic DNA Translation: CAB78752.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83902.1
AY065155 mRNA Translation: AAL38331.1
AY114588 mRNA Translation: AAM47907.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E71444
T52189

NCBI Reference Sequences

More...
RefSeqi
NP_567529.1, NM_117854.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G17490.1; AT4G17490.1; AT4G17490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
827463

Gramene; a comparative resource for plants

More...
Gramenei
AT4G17490.1; AT4G17490.1; AT4G17490

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G17490

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008316 mRNA Translation: BAB12039.1
AB013301 mRNA Translation: BAA31525.1
Z97343 Genomic DNA Translation: CAB10530.1 Sequence problems.
AL161546 Genomic DNA Translation: CAB78752.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83902.1
AY065155 mRNA Translation: AAL38331.1
AY114588 mRNA Translation: AAM47907.1
PIRiE71444
T52189
RefSeqiNP_567529.1, NM_117854.3

3D structure databases

SMRiQ8VZ91
ModBaseiSearch...

Protein-protein interaction databases

BioGridi12756, 8 interactors
IntActiQ8VZ91, 6 interactors
STRINGi3702.AT4G17490.1

PTM databases

iPTMnetiQ8VZ91

Proteomic databases

PaxDbiQ8VZ91

Genome annotation databases

EnsemblPlantsiAT4G17490.1; AT4G17490.1; AT4G17490
GeneIDi827463
GrameneiAT4G17490.1; AT4G17490.1; AT4G17490
KEGGiath:AT4G17490

Organism-specific databases

AraportiAT4G17490
TAIRilocus:2129106 AT4G17490

Phylogenomic databases

eggNOGiENOG410IYSR Eukaryota
ENOG410YIK7 LUCA
HOGENOMiCLU_058713_0_1_1
InParanoidiQ8VZ91
KOiK09286
OMAiSRTEWIQ
OrthoDBi1169658at2759
PhylomeDBiQ8VZ91

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8VZ91

Gene expression databases

ExpressionAtlasiQ8VZ91 baseline and differential
GenevisibleiQ8VZ91 AT

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEF103_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VZ91
Secondary accession number(s): O23591, O80387
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: February 26, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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