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Entry version 108 (16 Oct 2019)
Sequence version 1 (01 Mar 2002)
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Protein

RHOMBOID-like protein 6, mitochondrial

Gene

RBL6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. Might be involved in response to abiotic stimuli.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei164NucleophileBy similarity1
Active sitei216Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S54.A04

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RHOMBOID-like protein 6, mitochondrial2 Publications (EC:3.4.21.-Curated)
Short name:
AtRBL62 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBL62 Publications
Ordered Locus Names:At1g12750Imported
ORF Names:T12C24.28Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G12750

The Arabidopsis Information Resource

More...
TAIRi
locus:2195067 AT1G12750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 62MitochondrionSequence analysisAdd BLAST62
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043332763 – 307RHOMBOID-like protein 6, mitochondrialSequence analysisAdd BLAST245

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VZ48

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8VZ48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VZ48 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VZ48 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8VZ48, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G12750.3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2289 Eukaryota
COG0705 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239666

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VZ48

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIGNTQW

Database of Orthologous Groups

More...
OrthoDBi
1253228at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VZ48

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22936 PTHR22936, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01694 Rhomboid, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VZ48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRDMERGR KHRGDTQWTA WLTPTIVVAN VSIFIVVMYT NDCPKTTTGA
60 70 80 90 100
NGDCVAKLLR RFSFQPLREN PFLGPSSSTL EKLGALDWKK VVQGNEKWRL
110 120 130 140 150
ITAMWLHAGI IHLVMNMFDV IIFGIRLEQQ FGFIRIGLIY LISGFGGSIL
160 170 180 190 200
SALFLQKSIS VGASGALLGL MGAMLSELLT NWTIYKSKLC ALLSFLFIIA
210 220 230 240 250
INLAIGLLPW VDNFAHIGGL LTGFCLGFIL LMQPQSGWEE FRNSSQYGAR
260 270 280 290 300
ARSKYNPCQY VLFFVAAVLV VAGLTVGLVM LFDGENGNKH CKWCHRLDCY

PTSKWSC
Length:307
Mass (Da):34,289
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A6A8EEF7E9F1147
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AUJ6A0A1P8AUJ6_ARATH
RHOMBOID-like protein
RBL6 ATRBL6, RHOMBOID-like protein 6, At1g12750, T12C24.28, T12C24_28
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2H1ZEB4A0A2H1ZEB4_ARATH
RHOMBOID-like protein
RBL6 ATRBL6, RHOMBOID-like protein 6, At1g12750, T12C24.28, T12C24_28
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF88090 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC025417 Genomic DNA Translation: AAF88090.1 Different initiation.
CP002684 Genomic DNA Translation: AEE28921.1
CP002684 Genomic DNA Translation: AEE28923.1
CP002684 Genomic DNA Translation: ANM60285.1
CP002684 Genomic DNA Translation: ANM60286.1
CP002684 Genomic DNA Translation: ANM60288.1
AY065251 mRNA Translation: AAL38727.1
AY091318 mRNA Translation: AAM14257.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G86260

NCBI Reference Sequences

More...
RefSeqi
NP_001184975.1, NM_001198046.2
NP_001322583.1, NM_001332051.1
NP_001322584.1, NM_001332050.1
NP_001322586.1, NM_001332048.1
NP_172735.1, NM_101145.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G12750.1; AT1G12750.1; AT1G12750
AT1G12750.3; AT1G12750.3; AT1G12750
AT1G12750.4; AT1G12750.4; AT1G12750
AT1G12750.6; AT1G12750.6; AT1G12750
AT1G12750.7; AT1G12750.7; AT1G12750

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837831

Gramene; a comparative resource for plants

More...
Gramenei
AT1G12750.1; AT1G12750.1; AT1G12750
AT1G12750.3; AT1G12750.3; AT1G12750
AT1G12750.4; AT1G12750.4; AT1G12750
AT1G12750.6; AT1G12750.6; AT1G12750
AT1G12750.7; AT1G12750.7; AT1G12750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G12750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025417 Genomic DNA Translation: AAF88090.1 Different initiation.
CP002684 Genomic DNA Translation: AEE28921.1
CP002684 Genomic DNA Translation: AEE28923.1
CP002684 Genomic DNA Translation: ANM60285.1
CP002684 Genomic DNA Translation: ANM60286.1
CP002684 Genomic DNA Translation: ANM60288.1
AY065251 mRNA Translation: AAL38727.1
AY091318 mRNA Translation: AAM14257.1
PIRiG86260
RefSeqiNP_001184975.1, NM_001198046.2
NP_001322583.1, NM_001332051.1
NP_001322584.1, NM_001332050.1
NP_001322586.1, NM_001332048.1
NP_172735.1, NM_101145.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8VZ48, 4 interactors
STRINGi3702.AT1G12750.3

Protein family/group databases

MEROPSiS54.A04

PTM databases

SwissPalmiQ8VZ48

Proteomic databases

PaxDbiQ8VZ48

Genome annotation databases

EnsemblPlantsiAT1G12750.1; AT1G12750.1; AT1G12750
AT1G12750.3; AT1G12750.3; AT1G12750
AT1G12750.4; AT1G12750.4; AT1G12750
AT1G12750.6; AT1G12750.6; AT1G12750
AT1G12750.7; AT1G12750.7; AT1G12750
GeneIDi837831
GrameneiAT1G12750.1; AT1G12750.1; AT1G12750
AT1G12750.3; AT1G12750.3; AT1G12750
AT1G12750.4; AT1G12750.4; AT1G12750
AT1G12750.6; AT1G12750.6; AT1G12750
AT1G12750.7; AT1G12750.7; AT1G12750
KEGGiath:AT1G12750

Organism-specific databases

AraportiAT1G12750
TAIRilocus:2195067 AT1G12750

Phylogenomic databases

eggNOGiKOG2289 Eukaryota
COG0705 LUCA
HOGENOMiHOG000239666
InParanoidiQ8VZ48
OMAiNIGNTQW
OrthoDBi1253228at2759
PhylomeDBiQ8VZ48

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8VZ48

Gene expression databases

ExpressionAtlasiQ8VZ48 baseline and differential
GenevisibleiQ8VZ48 AT

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBL6_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VZ48
Secondary accession number(s): Q9LN72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: March 1, 2002
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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