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Protein

Aspartic proteinase A2

Gene

APA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107PROSITE-ProRule annotation1
Active sitei294PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-ATH-2132295 MHC class II antigen presentation
R-ATH-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiA01.A02

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase A2 (EC:3.4.23.-)
Alternative name(s):
Aspartic protease 57
Short name:
AtASP57
Gene namesi
Name:APA2
Ordered Locus Names:At1g62290
ORF Names:F19K23.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G62290
TAIRilocus:2018037 AT1G62290

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000042062725 – 71Activation peptideSequence analysisAdd BLAST47
ChainiPRO_000042062872 – 513Aspartic proteinase A2Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 126PROSITE-ProRule annotation
Disulfide bondi285 ↔ 289PROSITE-ProRule annotation
Disulfide bondi324 ↔ 418PROSITE-ProRule annotation
Disulfide bondi349 ↔ 390PROSITE-ProRule annotation
Disulfide bondi355 ↔ 387PROSITE-ProRule annotation
Glycosylationi404N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi432 ↔ 469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8VYL3
PRIDEiQ8VYL3

PTM databases

iPTMnetiQ8VYL3

Expressioni

Tissue specificityi

Expressed in seed pods and dry seeds.1 Publication

Gene expression databases

ExpressionAtlasiQ8VYL3 baseline and differential
GenevisibleiQ8VYL3 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G62290.1

Structurei

3D structure databases

ProteinModelPortaliQ8VYL3
SMRiQ8VYL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 510Peptidase A1PROSITE-ProRule annotationAdd BLAST422
Domaini319 – 424Saposin B-typePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000197681
InParanoidiQ8VYL3
KOiK08245
OMAiLGKYYTE
OrthoDBiEOG093606Q0
PhylomeDBiQ8VYL3

Family and domain databases

CDDicd06098 phytepsin, 1 hit
Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR033869 Phytepsin
IPR007856 SapB_1
IPR008138 SapB_2
IPR011001 Saposin-like
IPR008139 SaposinB_dom
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PF05184 SapB_1, 1 hit
PF03489 SapB_2, 1 hit
PRINTSiPR00792 PEPSIN
SMARTiView protein in SMART
SM00741 SapB, 2 hits
SUPFAMiSSF47862 SSF47862, 1 hit
SSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
PS50015 SAP_B, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VYL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYSRAVAF SVFVSFLLFF TAYSKRNDGT FRVGLKKLKL DPNNRLATRF
60 70 80 90 100
GSKQEEALRS SLRSYNNNLG GDSGDADIVP LKNYLDAQYY GEIAIGTPPQ
110 120 130 140 150
KFTVIFDTGS SNLWVPSGKC FFSLSCYFHA KYKSSRSSTY KKSGKRAAIH
160 170 180 190 200
YGSGSISGFF SYDAVTVGDL VVKDQEFIET TSEPGLTFLV AKFDGLLGLG
210 220 230 240 250
FQEIAVGNAT PVWYNMLKQG LIKRPVFSFW LNRDPKSEEG GEIVFGGVDP
260 270 280 290 300
KHFRGEHTFV PVTQRGYWQF DMGEVLIAGE STGYCGSGCS AIADSGTSLL
310 320 330 340 350
AGPTAVVAMI NKAIGASGVV SQQCKTVVDQ YGQTILDLLL AETQPKKICS
360 370 380 390 400
QIGLCAYDGT HGVSMGIESV VDKENTRSSS GLRDAGCPAC EMAVVWIQSQ
410 420 430 440 450
LRQNMTQERI VNYINEICER MPSPNGESAV DCSQLSKMPT VSFTIGGKVF
460 470 480 490 500
DLAPEEYVLK IGEGPVAQCI SGFTALDIPP PRGPLWILGD VFMGKYHTVF
510
DFGNEQVGFA EAV
Length:513
Mass (Da):55,748
Last modified:March 1, 2002 - v1
Checksum:iD449D42CEB6A7441
GO

Sequence cautioni

The sequence AAB60773 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000375 Genomic DNA Translation: AAB60773.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33946.1
CP002684 Genomic DNA Translation: AEE33947.1
AY070453 mRNA Translation: AAL49856.1
AY142687 mRNA Translation: AAN13225.1
AK317285 mRNA Translation: BAH19961.1
PIRiE96649
RefSeqiNP_001031219.1, NM_001036142.3
NP_176419.2, NM_104909.5
UniGeneiAt.23367

Genome annotation databases

EnsemblPlantsiAT1G62290.1; AT1G62290.1; AT1G62290
AT1G62290.2; AT1G62290.2; AT1G62290
GeneIDi842526
GrameneiAT1G62290.1; AT1G62290.1; AT1G62290
AT1G62290.2; AT1G62290.2; AT1G62290
KEGGiath:AT1G62290

Similar proteinsi

Entry informationi

Entry nameiAPA2_ARATH
AccessioniPrimary (citable) accession number: Q8VYL3
Secondary accession number(s): O04593
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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