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UniProtKB - Q8VYA5 (RSZ33_ARATH)
Protein
Serine/arginine-rich splicing factor RS2Z33
Gene
RS2Z33
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Splicing factor involved in constitutive and/or alternative splicing. Regulates the splicing of its own pre-mRNA and the alternative splicing of RS30, RS31 and RS34. Associates the cyclin-dependent kinase G1 (CDKG1) with the spliceosome and recruits it to U1 snRNP to facilitate splicing.
3 PublicationsMiscellaneous
The splicing pattern of the pre-mRNA is regulated in a tissue-specific manner and by development, and changes in response to various types of abiotic stresses (PubMed:17319848), but is not affected by the light/dark regimes (PubMed:24763593).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 116 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 121 – 138 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 |
GO - Molecular functioni
- mRNA binding Source: TAIR
- RNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- RNA splicing Source: TAIR
- spliceosomal complex assembly Source: TAIR
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/arginine-rich splicing factor RS2Z33Alternative name(s): RS-containing zinc finger protein 33 Short name: At-RS2Z33 Short name: At-RSZ33 Short name: AtRSZ33 |
Gene namesi | Name:RS2Z33 Synonyms:RSZ33 Ordered Locus Names:At2g37340 ORF Names:F3G5.13 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G37340 |
TAIRi | locus:2049766, AT2G37340 |
Subcellular locationi
Nucleus
- Nucleus speckle 4 Publications
Nucleus
- nuclear speck Source: TAIR
- spliceosomal complex Source: UniProtKB-KW
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416998 | 1 – 290 | Serine/arginine-rich splicing factor RS2Z33Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 164 | PhosphoserineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 180 | PhosphoserineBy similarity | 1 | |
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 211 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | PhosphoserineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 230 | PhosphoserineCombined sources | 1 | |
Modified residuei | 239 | PhosphoserineCombined sources | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 256 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Extensively phosphorylated on serine residues in the RS domain.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8VYA5 |
PRIDEi | Q8VYA5 |
ProteomicsDBi | 226631 [Q8VYA5-1] |
PTM databases
iPTMneti | Q8VYA5 |
MetOSitei | Q8VYA5 |
Expressioni
Tissue specificityi
Expressed in roots, flowers, anthers, pollen, ovules, style and developing seeds. Not detected in stems or leaves.2 Publications
Gene expression databases
ExpressionAtlasi | Q8VYA5, baseline and differential |
Genevisiblei | Q8VYA5, AT |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 3655, 16 interactors |
IntActi | Q8VYA5, 11 interactors |
STRINGi | 3702.AT2G37340.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 81 | RRMPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 290 | DisorderedSequence analysisAdd BLAST | 156 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 179 – 217 | Basic and acidic residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 267 – 282 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 116 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 121 – 138 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0107, Eukaryota |
HOGENOMi | CLU_047187_3_0_1 |
InParanoidi | Q8VYA5 |
OMAi | KCATHGG |
PhylomeDBi | Q8VYA5 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50158, ZF_CCHC, 2 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8VYA5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRYDDRYGN TRLYVGRLSS RTRTRDLERL FSRYGRVRDV DMKRDYAFVE
60 70 80 90 100
FGDPRDADDA RHYLDGRDFD GSRITVEFSR GAPRGSRDFD SRGPPPGAGR
110 120 130 140 150
CFNCGVDGHW ARDCTAGDWK NKCYRCGERG HIERNCKNSP KKLRRSGSYS
160 170 180 190 200
RSPVRSRSPR RRRSPSRSLS RSRSYSRSRS PVRRRERSVE ERSRSPKRMD
210 220 230 240 250
DSLSPRARDR SPVLDDEGSP KIIDGSPPPS PKLQKEVGSD RDGGSPQDNG
260 270 280 290
RNSVVSPVVG AGGDSSKEDR SPVDDDYEPN RTSPRGSESP
Sequence cautioni
The sequence BX842467 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | E → V in BAD44429 (Ref. 6) Curated | 1 | |
Sequence conflicti | 139 | S → Q in CAC03605 (PubMed:12176998).Curated | 1 | |
Sequence conflicti | 173 | R → G in CAC03605 (PubMed:12176998).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043112 | 1 – 49 | MPRYD…DYAFV → MWENTPCMWSLLSSHFRNQ in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_043113 | 1 – 41 | Missing in isoform 3. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ293801 mRNA Translation: CAC03605.1 AC005896 Genomic DNA Translation: AAC98054.1 CP002685 Genomic DNA Translation: AEC09385.1 CP002685 Genomic DNA Translation: AEC09386.1 CP002685 Genomic DNA Translation: AEC09387.1 CP002685 Genomic DNA Translation: ANM63217.1 CP002685 Genomic DNA Translation: ANM63218.1 CP002685 Genomic DNA Translation: ANM63219.1 AY072315 mRNA Translation: AAL61922.1 AY114563 mRNA Translation: AAM47882.1 AK176551 mRNA Translation: BAD44314.1 BX842463 mRNA No translation available. BX842467 mRNA No translation available. AK176666 mRNA Translation: BAD44429.1 |
PIRi | F84791 |
RefSeqi | NP_001325321.1, NM_001336655.1 [Q8VYA5-2] NP_001325322.1, NM_001336653.1 [Q8VYA5-2] NP_001325323.1, NM_001336654.1 [Q8VYA5-3] NP_850280.1, NM_179949.3 [Q8VYA5-1] NP_973619.1, NM_201890.2 [Q8VYA5-2] NP_973620.1, NM_201891.2 [Q8VYA5-3] |
Genome annotation databases
EnsemblPlantsi | AT2G37340.1; AT2G37340.1; AT2G37340 [Q8VYA5-1] AT2G37340.2; AT2G37340.2; AT2G37340 [Q8VYA5-2] AT2G37340.3; AT2G37340.3; AT2G37340 [Q8VYA5-3] AT2G37340.4; AT2G37340.4; AT2G37340 [Q8VYA5-2] AT2G37340.5; AT2G37340.5; AT2G37340 [Q8VYA5-3] AT2G37340.6; AT2G37340.6; AT2G37340 [Q8VYA5-2] |
GeneIDi | 818311 |
Gramenei | AT2G37340.1; AT2G37340.1; AT2G37340 [Q8VYA5-1] AT2G37340.2; AT2G37340.2; AT2G37340 [Q8VYA5-2] AT2G37340.3; AT2G37340.3; AT2G37340 [Q8VYA5-3] AT2G37340.4; AT2G37340.4; AT2G37340 [Q8VYA5-2] AT2G37340.5; AT2G37340.5; AT2G37340 [Q8VYA5-3] AT2G37340.6; AT2G37340.6; AT2G37340 [Q8VYA5-2] |
KEGGi | ath:AT2G37340 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ293801 mRNA Translation: CAC03605.1 AC005896 Genomic DNA Translation: AAC98054.1 CP002685 Genomic DNA Translation: AEC09385.1 CP002685 Genomic DNA Translation: AEC09386.1 CP002685 Genomic DNA Translation: AEC09387.1 CP002685 Genomic DNA Translation: ANM63217.1 CP002685 Genomic DNA Translation: ANM63218.1 CP002685 Genomic DNA Translation: ANM63219.1 AY072315 mRNA Translation: AAL61922.1 AY114563 mRNA Translation: AAM47882.1 AK176551 mRNA Translation: BAD44314.1 BX842463 mRNA No translation available. BX842467 mRNA No translation available. AK176666 mRNA Translation: BAD44429.1 |
PIRi | F84791 |
RefSeqi | NP_001325321.1, NM_001336655.1 [Q8VYA5-2] NP_001325322.1, NM_001336653.1 [Q8VYA5-2] NP_001325323.1, NM_001336654.1 [Q8VYA5-3] NP_850280.1, NM_179949.3 [Q8VYA5-1] NP_973619.1, NM_201890.2 [Q8VYA5-2] NP_973620.1, NM_201891.2 [Q8VYA5-3] |
3D structure databases
SMRi | Q8VYA5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3655, 16 interactors |
IntActi | Q8VYA5, 11 interactors |
STRINGi | 3702.AT2G37340.1 |
PTM databases
iPTMneti | Q8VYA5 |
MetOSitei | Q8VYA5 |
Proteomic databases
PaxDbi | Q8VYA5 |
PRIDEi | Q8VYA5 |
ProteomicsDBi | 226631 [Q8VYA5-1] |
Genome annotation databases
EnsemblPlantsi | AT2G37340.1; AT2G37340.1; AT2G37340 [Q8VYA5-1] AT2G37340.2; AT2G37340.2; AT2G37340 [Q8VYA5-2] AT2G37340.3; AT2G37340.3; AT2G37340 [Q8VYA5-3] AT2G37340.4; AT2G37340.4; AT2G37340 [Q8VYA5-2] AT2G37340.5; AT2G37340.5; AT2G37340 [Q8VYA5-3] AT2G37340.6; AT2G37340.6; AT2G37340 [Q8VYA5-2] |
GeneIDi | 818311 |
Gramenei | AT2G37340.1; AT2G37340.1; AT2G37340 [Q8VYA5-1] AT2G37340.2; AT2G37340.2; AT2G37340 [Q8VYA5-2] AT2G37340.3; AT2G37340.3; AT2G37340 [Q8VYA5-3] AT2G37340.4; AT2G37340.4; AT2G37340 [Q8VYA5-2] AT2G37340.5; AT2G37340.5; AT2G37340 [Q8VYA5-3] AT2G37340.6; AT2G37340.6; AT2G37340 [Q8VYA5-2] |
KEGGi | ath:AT2G37340 |
Organism-specific databases
Araporti | AT2G37340 |
TAIRi | locus:2049766, AT2G37340 |
Phylogenomic databases
eggNOGi | KOG0107, Eukaryota |
HOGENOMi | CLU_047187_3_0_1 |
InParanoidi | Q8VYA5 |
OMAi | KCATHGG |
PhylomeDBi | Q8VYA5 |
Miscellaneous databases
PROi | PR:Q8VYA5 |
Gene expression databases
ExpressionAtlasi | Q8VYA5, baseline and differential |
Genevisiblei | Q8VYA5, AT |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50158, ZF_CCHC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RSZ33_ARATH | |
Accessioni | Q8VYA5Primary (citable) accession number: Q8VYA5 Secondary accession number(s): F4IQ37 Q9ZUT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2012 |
Last sequence update: | March 1, 2002 | |
Last modified: | September 29, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families