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Entry version 89 (18 Sep 2019)
Sequence version 1 (01 Mar 2002)
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Protein

Citrate-sodium symporter

Gene

citW

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system).UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCitrate utilizationUniRule annotation, SymportUniRule annotation, Transport

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.61 2814

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.24.2.5 the 2-hydroxycarboxylate transporter (2-hct) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Citrate-sodium symporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:citWImported
Synonyms:cimHImported, cimH_2Imported
ORF Names:B4U21_00425Imported, BANRA_04494Imported, BL124_00028140Imported, C1459_13920Imported, C3483_22255Imported, C3F39_10700Imported, C4Y50_026755Imported, C7V41_14605Imported, CSC88_14475Imported, DD581_06410Imported, DM059_00305Imported, DXF97_05565Imported, E0760_00900Imported, E1814_00925Imported, EAO17_18050Imported, EXT45_14820Imported, NCTC11679_04802Imported, NCTC13443_01623Imported, NCTC5052_02824Imported, NCTC5053_04266Imported, NCTC9601_05843Imported, NCTC9637_05666Imported, NCTC9645_05359Imported, NCTC9661_05320Imported, PMK1_02363Imported, SAMEA104305404_09875Imported, SAMEA104567806_01318Imported, SAMEA23986918_05464Imported, SAMEA24002668_02881Imported, SAMEA4364603_03476Imported, SAMEA4364652_04268Imported, SAMEA4394730_05338Imported, SK89_01914Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000035995 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000290276 Componenti: Unassembled WGS sequence
  • UP000276286 Componenti: Unassembled WGS sequence
  • UP000293472 Componenti: Unassembled WGS sequence
  • UP000238271 Componenti: Unassembled WGS sequence
  • UP000292131 Componenti: Unassembled WGS sequence
  • UP000294951 Componenti: Unassembled WGS sequence
  • UP000252603 Componenti: Unassembled WGS sequence
  • UP000254103 Componenti: Unassembled WGS sequence
  • UP000258067 Componenti: Unassembled WGS sequence
  • UP000245017 Componenti: Unassembled WGS sequence
  • UP000275975 Componenti: Unassembled WGS sequence
  • UP000255137 Componenti: Unassembled WGS sequence
  • UP000255239 Componenti: Unassembled WGS sequence
  • UP000295363 Componenti: Unassembled WGS sequence
  • UP000253217 Componenti: Unassembled WGS sequence
  • UP000252126 Componenti: Unassembled WGS sequence
  • UP000255518 Componenti: Unassembled WGS sequence
  • UP000283322 Componenti: Unassembled WGS sequence
  • UP000239813 Componenti: Chromosome
  • UP000196863 Componenti: Unassembled WGS sequence
  • UP000250675 Componenti: Unassembled WGS sequence
  • UP000253632 Componenti: Unassembled WGS sequence
  • UP000255489 Componenti: Unassembled WGS sequence
  • UP000294891 Componenti: Unassembled WGS sequence
  • UP000254387 Componenti: Unassembled WGS sequence
  • UP000238332 Componenti: Chromosome
  • UP000029666 Componenti: Chromosome
  • UP000255099 Componenti: Unassembled WGS sequence
  • UP000286610 Componenti: Unassembled WGS sequence
  • UP000251123 Componenti: Unassembled WGS sequence
  • UP000262540 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 51HelicalSequence analysisAdd BLAST19
Transmembranei63 – 80HelicalSequence analysisAdd BLAST18
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei127 – 143HelicalSequence analysisAdd BLAST17
Transmembranei155 – 178HelicalSequence analysisAdd BLAST24
Transmembranei184 – 211HelicalSequence analysisAdd BLAST28
Transmembranei223 – 244HelicalSequence analysisAdd BLAST22
Transmembranei291 – 319HelicalSequence analysisAdd BLAST29
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei365 – 388HelicalSequence analysisAdd BLAST24
Transmembranei432 – 453HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni252 – 274DisorderedSequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:citrate (SCF) symporter family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D2K Bacteria
COG3493 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1093189at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004679 2-OHcarboxylate_transport

The PANTHER Classification System

More...
PANTHERi
PTHR40033 PTHR40033, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03390 2HCT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005348 YxkH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VS41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTDNAFSA TLEPIDTPKT TLKQRWWHIM DNWKVGIVPL PLFLLAGGLI
60 70 80 90 100
ALDCLGGKLP SDIVVMVATL AFFGFACGEF GKRLPVLGKL GAAAICATFI
110 120 130 140 150
PSALVHYGLL PDVVIESTTK FYKSTNILYL YICCIIVGSI MSMNRTTLIQ
160 170 180 190 200
GFLKIFFPML CGEVVGMLVG IGVGTLLGME PFQVFFFIVL PIMAGGVGEG
210 220 230 240 250
AIPLSMGYAA LMHMEQGVAL GRVLPMVMLG SLTAIVISGC LNQLGKRFPH
260 270 280 290 300
LTGEGQLMPN RSHETRSLSE SEGVSGKTDV GTLASGALLA VLLYMMGMLG
310 320 330 340 350
HKLIGLPAPV GMLFLAVLLK LANVVSPRLQ EGSQMVYKFF RTAVTYPILF
360 370 380 390 400
AVGVAITPWQ ELVNAFTLTN LLVIVSTVSA LVATGFLVGK KIGMHPIDVA
410 420 430 440 450
IVSCCQSGQG GTGDVAILTA GNRMSLMPFA QIATRIGGAI NVSLGLLFLS

HYLA
Length:454
Mass (Da):48,152
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE574B9C010755482
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF411142 Genomic DNA Translation: AAL60462.1
CP008929 Genomic DNA Translation: AIT01828.1
CP026392 Genomic DNA Translation: AUY19212.1
CP026586 Genomic DNA Translation: AVB73908.1
AB373949 Genomic DNA Translation: BAH66562.1
LEUQ01000007 Genomic DNA Translation: KLY18050.1
NBSD01000021 Genomic DNA Translation: OWG12215.1
PDVM01000046 Genomic DNA Translation: PPK23295.1
PYBH01000010 Genomic DNA Translation: PWF58431.1
QOUG01000017 Genomic DNA Translation: RCK03343.1
QRBO01000007 Genomic DNA Translation: RDT68945.1
PTFF02000112 Genomic DNA Translation: ROG80083.1
MPYG04000224 Genomic DNA Translation: ROG87248.1
RDAM01000001 Genomic DNA Translation: RRF07965.1
QFMH01000024 Genomic DNA Translation: RXY87906.1
SGOL01000011 Genomic DNA Translation: RZG36158.1
UASN01000022 Genomic DNA Translation: SQC19190.1
UASO01000009 Genomic DNA Translation: SQC87242.1
UFBE01000007 Genomic DNA Translation: SSF40464.1
UFBK01000018 Genomic DNA Translation: SSG22740.1
UFEU01000009 Genomic DNA Translation: SSK45770.1
UFGU01000053 Genomic DNA Translation: SSN09503.1
UFQE01000355 Genomic DNA Translation: SSW83570.1
UGKT01000001 Genomic DNA Translation: STT01310.1
UGLB01000003 Genomic DNA Translation: STT50666.1
UGLJ01000002 Genomic DNA Translation: STT94389.1
UGLQ01000003 Genomic DNA Translation: STU32632.1
UGMN01000004 Genomic DNA Translation: STV35167.1
UGMG01000001 Genomic DNA Translation: STV70151.1
UIRA01000014 Genomic DNA Translation: SVJ50189.1
POWO01000344 Genomic DNA Translation: TAI77187.1
SKFD01000001 Genomic DNA Translation: TCZ86864.1
SMTN01000001 Genomic DNA Translation: TDK07093.1
UWYB01000001 Genomic DNA Translation: VCZ83915.1
CAAGWD010000004 Genomic DNA Translation: VGC80899.1

NCBI Reference Sequences

More...
RefSeqi
WP_002888345.1, NZ_UWZM01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AIT01828; AIT01828; PMK1_02363
ALR24579; ALR24579; AGG09_10065
KLY18050; KLY18050; SK89_01914
ODN12554; ODN12554; BCB67_07525
SBZ46343; SBZ46343; SAMEA3531778_04446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
kpb:FH42_21095
kpne:KU54_022645
kpnu:LI86_22485
kpx:PMK1_02363

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|571.67.peg.1975
fig|573.1347.peg.2033

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411142 Genomic DNA Translation: AAL60462.1
CP008929 Genomic DNA Translation: AIT01828.1
CP026392 Genomic DNA Translation: AUY19212.1
CP026586 Genomic DNA Translation: AVB73908.1
AB373949 Genomic DNA Translation: BAH66562.1
LEUQ01000007 Genomic DNA Translation: KLY18050.1
NBSD01000021 Genomic DNA Translation: OWG12215.1
PDVM01000046 Genomic DNA Translation: PPK23295.1
PYBH01000010 Genomic DNA Translation: PWF58431.1
QOUG01000017 Genomic DNA Translation: RCK03343.1
QRBO01000007 Genomic DNA Translation: RDT68945.1
PTFF02000112 Genomic DNA Translation: ROG80083.1
MPYG04000224 Genomic DNA Translation: ROG87248.1
RDAM01000001 Genomic DNA Translation: RRF07965.1
QFMH01000024 Genomic DNA Translation: RXY87906.1
SGOL01000011 Genomic DNA Translation: RZG36158.1
UASN01000022 Genomic DNA Translation: SQC19190.1
UASO01000009 Genomic DNA Translation: SQC87242.1
UFBE01000007 Genomic DNA Translation: SSF40464.1
UFBK01000018 Genomic DNA Translation: SSG22740.1
UFEU01000009 Genomic DNA Translation: SSK45770.1
UFGU01000053 Genomic DNA Translation: SSN09503.1
UFQE01000355 Genomic DNA Translation: SSW83570.1
UGKT01000001 Genomic DNA Translation: STT01310.1
UGLB01000003 Genomic DNA Translation: STT50666.1
UGLJ01000002 Genomic DNA Translation: STT94389.1
UGLQ01000003 Genomic DNA Translation: STU32632.1
UGMN01000004 Genomic DNA Translation: STV35167.1
UGMG01000001 Genomic DNA Translation: STV70151.1
UIRA01000014 Genomic DNA Translation: SVJ50189.1
POWO01000344 Genomic DNA Translation: TAI77187.1
SKFD01000001 Genomic DNA Translation: TCZ86864.1
SMTN01000001 Genomic DNA Translation: TDK07093.1
UWYB01000001 Genomic DNA Translation: VCZ83915.1
CAAGWD010000004 Genomic DNA Translation: VGC80899.1
RefSeqiWP_002888345.1, NZ_UWZM01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.24.2.5 the 2-hydroxycarboxylate transporter (2-hct) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIT01828; AIT01828; PMK1_02363
ALR24579; ALR24579; AGG09_10065
KLY18050; KLY18050; SK89_01914
ODN12554; ODN12554; BCB67_07525
SBZ46343; SBZ46343; SAMEA3531778_04446
KEGGikpb:FH42_21095
kpne:KU54_022645
kpnu:LI86_22485
kpx:PMK1_02363
PATRICifig|571.67.peg.1975
fig|573.1347.peg.2033

Phylogenomic databases

eggNOGiENOG4105D2K Bacteria
COG3493 LUCA
OrthoDBi1093189at2

Enzyme and pathway databases

BRENDAi2.7.7.61 2814

Family and domain databases

InterProiView protein in InterPro
IPR004679 2-OHcarboxylate_transport
PANTHERiPTHR40033 PTHR40033, 1 hit
PfamiView protein in Pfam
PF03390 2HCT, 1 hit
PIRSFiPIRSF005348 YxkH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8VS41_KLEPN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VS41
Secondary accession number(s): A0A0J2G646
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 18, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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