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Entry version 66 (02 Jun 2021)
Sequence version 1 (01 Mar 2002)
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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Staphylococcus epidermidis
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity, Fe3+By similarityNote: Binds 1 Mn2+ or Fe3+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi27Fe(3+); via tele nitrogenBy similarity1
Metal bindingi27Manganese; via tele nitrogenBy similarity1
Metal bindingi81Fe(3+); via tele nitrogenBy similarity1
Metal bindingi81Manganese; via tele nitrogenBy similarity1
Metal bindingi161Fe(3+)By similarity1
Metal bindingi161ManganeseBy similarity1
Metal bindingi165Fe(3+); via tele nitrogenBy similarity1
Metal bindingi165Manganese; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandIron, Manganese, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.12 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sodA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus epidermidis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1282 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002234651 – 199Superoxide dismutase [Mn/Fe]Add BLAST199

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VQ15

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.990, 1 hit
2.40.500.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001189, Mn/Fe_SOD
IPR019833, Mn/Fe_SOD_BS
IPR019832, Mn/Fe_SOD_C
IPR019831, Mn/Fe_SOD_N
IPR036324, Mn/Fe_SOD_N_sf
IPR036314, SOD_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02777, Sod_Fe_C, 1 hit
PF00081, Sod_Fe_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000349, SODismutase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01703, MNSODISMTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46609, SSF46609, 1 hit
SSF54719, SSF54719, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00088, SOD_MN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VQ15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFELPKLPY AFDALEPHID KETMEIHHDK HHNTYVTKLN AVVEGTDLEA
60 70 80 90 100
KSIEEIVANL DSVPSDIQTA VRNNGGGHLN HSLFWELLTP NSEEKGEVVE
110 120 130 140 150
KIKEQWGSLD EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPL
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIS AFWNVVNWEK VDELYNAAK
Length:199
Mass (Da):22,706
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36B438907574560F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12F → Y in CAA65734 (PubMed:8764488).Curated1
Sequence conflicti22E → Q (PubMed:8764488).Curated1
Sequence conflicti22E → Q (PubMed:11724835).Curated1
Sequence conflicti41 – 42AV → SA (PubMed:8764488).Curated2
Sequence conflicti41 – 42AV → SA (PubMed:11724835).Curated2
Sequence conflicti66D → N in CAC86481 (PubMed:11724835).Curated1
Sequence conflicti66D → N in CAC86528 (PubMed:11724835).Curated1
Sequence conflicti66D → N in CAC86529 (PubMed:11724835).Curated1
Sequence conflicti66D → N in CAC86530 (PubMed:11724835).Curated1
Sequence conflicti89T → S in CAC86481 (PubMed:11724835).Curated1
Sequence conflicti89T → S in CAC86528 (PubMed:11724835).Curated1
Sequence conflicti89T → S in CAC86529 (PubMed:11724835).Curated1
Sequence conflicti89T → S in CAC86530 (PubMed:11724835).Curated1
Sequence conflicti100E → D in CAC86481 (PubMed:11724835).Curated1
Sequence conflicti100E → D in CAC86528 (PubMed:11724835).Curated1
Sequence conflicti100E → D in CAC86529 (PubMed:11724835).Curated1
Sequence conflicti100E → D in CAC86530 (PubMed:11724835).Curated1
Sequence conflicti150L → I in CAC86481 (PubMed:11724835).Curated1
Sequence conflicti150L → I in CAC86528 (PubMed:11724835).Curated1
Sequence conflicti150L → I in CAC86529 (PubMed:11724835).Curated1
Sequence conflicti150L → I in CAC86530 (PubMed:11724835).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF462457 Genomic DNA Translation: AAL68691.1
X97011 Genomic DNA Translation: CAA65734.1
AJ343906 Genomic DNA Translation: CAC86481.1
AJ343946 Genomic DNA Translation: CAC86528.1
AJ343947 Genomic DNA Translation: CAC86529.1
AJ343948 Genomic DNA Translation: CAC86530.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462457 Genomic DNA Translation: AAL68691.1
X97011 Genomic DNA Translation: CAA65734.1
AJ343906 Genomic DNA Translation: CAC86481.1
AJ343946 Genomic DNA Translation: CAC86528.1
AJ343947 Genomic DNA Translation: CAC86529.1
AJ343948 Genomic DNA Translation: CAC86530.1

3D structure databases

SMRiQ8VQ15
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189, Mn/Fe_SOD
IPR019833, Mn/Fe_SOD_BS
IPR019832, Mn/Fe_SOD_C
IPR019831, Mn/Fe_SOD_N
IPR036324, Mn/Fe_SOD_N_sf
IPR036314, SOD_C_sf
PfamiView protein in Pfam
PF02777, Sod_Fe_C, 1 hit
PF00081, Sod_Fe_N, 1 hit
PIRSFiPIRSF000349, SODismutase, 1 hit
PRINTSiPR01703, MNSODISMTASE
SUPFAMiSSF46609, SSF46609, 1 hit
SSF54719, SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088, SOD_MN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSODM_STAEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VQ15
Secondary accession number(s): Q54103, Q8VLL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: June 2, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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