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Entry version 66 (03 Jul 2019)
Sequence version 1 (01 Mar 2002)
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Protein
Submitted name:

Dextranase

Gene

dex

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.11 9449

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH66 Glycoside Hydrolase Family 66

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DextranaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dexImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus downei (Streptococcus sobrinus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1317 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1273 – 1291HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell wallPROSITE-ProRule annotation, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500431455927 – 1296Sequence analysisAdd BLAST1270
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50183710941268 – 1296Removed by sortasePROSITE-ProRule annotationAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1267Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchorPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1264 – 1296GRAM_POS_ANCHORINGInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 143DisorderedSequence analysisAdd BLAST113
Regioni806 – 1091DisorderedSequence analysisAdd BLAST286
Regioni1163 – 1268DisorderedSequence analysisAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili290 – 310Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1264 – 1268LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 60PolarSequence analysisAdd BLAST27
Compositional biasi67 – 143PolarSequence analysisAdd BLAST77
Compositional biasi806 – 863PolarSequence analysisAdd BLAST58
Compositional biasi871 – 990PolarSequence analysisAdd BLAST120
Compositional biasi1009 – 1052PolarSequence analysisAdd BLAST44
Compositional biasi1077 – 1091PolarSequence analysisAdd BLAST15
Compositional biasi1175 – 1223PolyampholyteSequence analysisAdd BLAST49
Compositional biasi1229 – 1243PolarSequence analysisAdd BLAST15
Compositional biasi1244 – 1268PolyampholyteSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14745 GH66, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025092 Glyco_hydro_66
IPR013780 Glyco_hydro_b
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR033031 SCC2/Nipped-B

The PANTHER Classification System

More...
PANTHERi
PTHR21704 PTHR21704, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13199 Glyco_hydro_66, 1 hit
PF00746 Gram_pos_anchor, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VLP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSLPSMLCL LAFGMVFSIS AKPAHADEFA NQPSQVADEA TTVVRPSQGL
60 70 80 90 100
GEQSQPQAEE ASPAKEEETS NLSLKPQNQQ DQDSENSESS TEAQDPIEQT
110 120 130 140 150
PPESVSQAPA SETTSVETLA DPQTQTASQN QSSNTDKNDG PGVIRATSAQ
160 170 180 190 200
LTATRSVLSS QTGDAIVDLS ADKASYRSGE DVNLSVDFKN TTDKEQDITV
210 220 230 240 250
YADVYYVDNK LGTYKFSKHL KAGEGYKMQA GDLKIPGSQF ENNHGYLLKI
260 270 280 290 300
KVADADNNTL SQVNKAIAVE SDWTKFPRYG IVGGSQDTSN SLLSKDADRY
310 320 330 340 350
RAEIEKMKNM NINSYFFYDV YKTATNPFPS DEATFKQDWN TWSGSEIDTQ
360 370 380 390 400
AVKDIVNQVH DGGAVAMLYN MILAENTNTG EAPALPETEY AYNSDDRGYG
410 420 430 440 450
AQGQPMSYTV KIPKDGQEEE VQIQRYYNPT SKLWQDYIAD KMGQAMKNGG
460 470 480 490 500
FDGWQGDTIG DNEVYDYADK DSNDPSKKHW LTEGYAEFLR AIKEKLPNYY
510 520 530 540 550
LTVNDVNGEQ IYRLKDGNQD VIYNEIWPFG GSALGDGRSQ TEYGDLKARV
560 570 580 590 600
DEVRKVTGKS LIVGAYMEGS EKGGSKDDAE AGKALQTDAV LLTSASIAAA
610 620 630 640 650
GGYHMSLAAL ANQQDESGGG QGIGVLQTAY YPTQSLKTSS ELTRKNNDYQ
660 670 680 690 700
QFVTAYENIL RDGVENDDAQ VNTYNSEGQL LSTDAKGING HQVWTYGKKG
710 720 730 740 750
DNFRTVQLLN LMGINSDWKN EDGSAANKTP DEQTNLTVRY ALGDISMEDA
760 770 780 790 800
RRMAKQTYVT SPDDWSKSNL QKVSASVETD ENGKPVLIIN VPKLTLWDVV
810 820 830 840 850
YISNADQKST PQAEQTGTPA AQAGDDKTSQ DQASNAQADQ NQASQPAQEE
860 870 880 890 900
AKAQEQSAPV DQVQAGDKAQ APVAQENSSK EEVAQPAQGQ ATPQAETATP
910 920 930 940 950
AAQAASPSQP TNRQENQAPA GDQVPKAQEN SEQAGSNGPV AQEGSNKEDV
960 970 980 990 1000
APTAQGQASP QADSPAKQAE PTQSGQETGA PSSSEQDKAQ AETGVPRPQA
1010 1020 1030 1040 1050
EAVAPTKQAQ PEAQVSPAPS ESTKTPEASA PSQPASPEQA SGQSDQTPAN
1060 1070 1080 1090 1100
SKPSPEPSTP ANPEQEGDAD KGQASAPEAD QPTTPENTGQ NAEASMLIKT
1110 1120 1130 1140 1150
SPMRLAQILI LTSLIRIQAR TLQPITLAIQ QLQIRSQVTQ VKNLLILNRW
1160 1170 1180 1190 1200
ILMRMPINRN QTEPVLPLVP NPTPDVKKEK ADTPEESDPA KGKKSAADAN
1210 1220 1230 1240 1250
KDKASMETED QQKPAELPKE ATELEKVGQP ASPQISSVQE SVSGKTDKKM
1260 1270 1280 1290
RPVLKNTKTS SDKLPKTGDH KTVGLIILLG LAFVGTTGLL AKRERK
Length:1,296
Mass (Da):139,745
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0648568626385E2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB052705 Genomic DNA Translation: BAB78732.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052705 Genomic DNA Translation: BAB78732.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGH66 Glycoside Hydrolase Family 66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.2.1.11 9449

Family and domain databases

CDDicd14745 GH66, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR025092 Glyco_hydro_66
IPR013780 Glyco_hydro_b
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR033031 SCC2/Nipped-B
PANTHERiPTHR21704 PTHR21704, 1 hit
PfamiView protein in Pfam
PF13199 Glyco_hydro_66, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8VLP4_STRDO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VLP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 3, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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