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Entry version 152 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Myocardin

Gene

Myocd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myocardin
Alternative name(s):
Basic SAP coiled-coil transcription activator 2
SRF cofactor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myocd
Synonyms:Bsac2, Mycd, Srfcp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2137495 Myocd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi387 – 389ELR → PSF: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication3
Mutagenesisi408 – 410DRL → PGH: Activation of ANF promoter abolished, no effect on SM22 promoter. 1 Publication3
Mutagenesisi812S → A: No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-859; A-866 and A-893. 1 Publication1
Mutagenesisi812S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-859; D-866 and D-893. 1 Publication1
Mutagenesisi859S → A: No effect on SRF activation; No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812, A-866 and A-893. 1 Publication1
Mutagenesisi859S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-866 and D-893. 1 Publication1
Mutagenesisi866S → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812; A-859 and A-893. 1 Publication1
Mutagenesisi866S → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-893. 1 Publication1
Mutagenesisi893T → A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-specific genes transcription; when associated with A-812; A-859 and A-866. 1 Publication1
Mutagenesisi893T → D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-866. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266321 – 935MyocardinAdd BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei454Phosphoserine; by GSK3-beta1 Publication1
Modified residuei458Phosphoserine; by GSK3-beta1 Publication1
Modified residuei462Phosphoserine; by GSK3-beta1 Publication1
Modified residuei466Phosphoserine; by GSK3-beta1 Publication1
Modified residuei624Phosphoserine; by GSK3-beta1 Publication1
Modified residuei628Phosphoserine; by GSK3-beta1 Publication1
Modified residuei632Phosphoserine; by GSK3-beta1 Publication1
Modified residuei636Phosphoserine; by GSK3-beta1 Publication1
Modified residuei812Phosphoserine; by MAPK1 AND MAPK31 Publication1
Modified residuei859Phosphoserine; by MAPK1 and MAPK31 Publication1
Modified residuei866Phosphoserine; by MAPK1 and MAPK31 Publication1
Modified residuei893Phosphothreonine; by MAPK1 and MAPK31 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation regulates negatively transcriptional activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8VIM5

PRoteomics IDEntifications database

More...
PRIDEi
Q8VIM5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VIM5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VIM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult.5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the cardiac crescent at 7.75 dpc and in the linear heart tube at 8.0 dpc and the developing atrial and aortic ventricular chambers until birth. Also detected in a subset of vascular and visceral smooth muscle cells: aortic arch arteries at 9.5 dpc; walls of the esophagus, dorsal aorta, pulmonary outflow tract, lung, gut, stomach, small intestine, bladder, and the head mesenchyme at 13.5 dpc until birth. Not detected in skeletal muscle cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020542 Expressed in 116 organ(s), highest expression level in urinary bladder

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8VIM5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VIM5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with MLLT7/FOXO4 (By similarity). Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
229522, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8VIM5

Database of interacting proteins

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DIPi
DIP-29754N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8VIM5

Protein interaction database and analysis system

More...
IntActi
Q8VIM5, 4 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000104335

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8VIM5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VIM5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 43RPEL 1Add BLAST26
Repeati62 – 87RPEL 2Add BLAST26
Repeati106 – 131RPEL 3Add BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini380 – 414SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 201HDAC5-bindingAdd BLAST49

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili287 – 322Sequence analysisAdd BLAST36
Coiled coili519 – 563Sequence analysisAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi12 – 27MEF2C-bindingAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi287 – 320Gln-richAdd BLAST34
Compositional biasi300 – 320Poly-GlnAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE2C Eukaryota
ENOG410XNR1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038001

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG036493

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8VIM5

KEGG Orthology (KO)

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KOi
K22526

Identification of Orthologs from Complete Genome Data

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OMAi
CPKSPGV

Database of Orthologous Groups

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OrthoDBi
190145at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326024

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028721 MYOCD
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR22793:SF11 PTHR22793:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02755 RPEL, 1 hit
PF02037 SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00707 RPEL, 3 hits
SM00513 SAP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51073 RPEL, 3 hits
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VIM5-1) [UniParc]FASTAAdd to basket
Also known as: MYOCD-v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLLGSEHSL LIRRKFRSVL QLRLQQRRTQ EQLANQGLIP PLKGPTEFHD
60 70 80 90 100
PRKQLDSAKT EDSLRRKGRN RSDRASLVTM HILQASTAER SIPTAQMKLK
110 120 130 140 150
RARLADDLNE KIALRPGPLE LVEKNILPMD SSVKEAIKGT EVSLSKAADA
160 170 180 190 200
FAFEDDSSRD GLSPDQARSE DPQGSTGSTP DIKSTEAPLD TIQDLTPGSE
210 220 230 240 250
SDKNDAASQP GNQSDPGKQV LGPLSTPIPV HTAVKSKSLG DSKNRHKKPK
260 270 280 290 300
DPKPKVKKLK YHQYIPPDQK AEKSPPPMDS AYARLLQQQQ LFLQLQILSQ
310 320 330 340 350
QQQQQQQQQQ QQQQQQQQQQ RFSYPGMHQT HLKEPNEQMA RNPNPSSTPL
360 370 380 390 400
SNTPLSPVKN SISGQTGVSS LKPGPLPPNL DDLKVSELRQ QLRIRGLPVS
410 420 430 440 450
GTKTALVDRL RPFQDCAGNP VPNFGDITTV TFPVTPNTLP SYQSSPTGFY
460 470 480 490 500
HFGSTSSSPP ISPASSDLSA AGSLPDTFTD ASPGFGLHAS PVPACTDESL
510 520 530 540 550
LSSLNGGSGP SEPDGLDSEK DKMLVEKQKV INQLTWKLRQ EQRQVEELRM
560 570 580 590 600
QLQKQKSSCS DQKPLPFLAT TIKQEDVSSC PFAPQQASGK GQGHSSDSPP
610 620 630 640 650
PACETAQLLP HCVESSGQTH VLSSTFLSPQ CSPQHSPLGG LKSPQHISLP
660 670 680 690 700
PSPNNHYFLA SSSGAQRENH GVSSPSSSQG CAQMTGLQSS DKVGPTFSIP
710 720 730 740 750
SPTFSKSSSA VSDITQPPSY EDAVKQQMTR SQQMDELLDV LIESGEMPAD
760 770 780 790 800
AREDHSCLQK IPKIPGSSCS PTAIPPKPSA SFEQASSGGQ MAFDHYANDS
810 820 830 840 850
DEHLEVLLNS HSPIGKVSDV TLLKIGSEEP PFDSIMDGFP GKAAEDLFSA
860 870 880 890 900
HELLPGPLSP MHAQLSPPSV DSSGLQLSFT ESPWETMEWL DLTPPSSTPG
910 920 930
FSNLTSSGPS IFNIDFLDVT DLNLNSPMDL HLQQW
Length:935
Mass (Da):101,400
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8FCFC68A923A5CB
GO
Isoform 2 (identifier: Q8VIM5-2) [UniParc]FASTAAdd to basket
Also known as: BSAC2A, Myocardin A, MYOCD-v5

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Note: No experimental confirmation available.
Show »
Length:855
Mass (Da):91,592
Checksum:i73C3AAB62E61DB33
GO
Isoform 3 (identifier: Q8VIM5-3) [UniParc]FASTAAdd to basket
Also known as: =Myocardin A, MYOCD-v1

The sequence of this isoform differs from the canonical sequence as follows:
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Show »
Length:983
Mass (Da):106,223
Checksum:i7640D2863F9DB517
GO
Isoform 4 (identifier: Q8VIM5-4) [UniParc]FASTAAdd to basket
Also known as: MYOCD-v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     683-683: Q → QNSGAHEGHSSSFSSPASSLHQPFSGTQADSSHSAGLNPCPKSPSIHPK

Show »
Length:904
Mass (Da):97,066
Checksum:i535A0D43433EEDD7
GO
Isoform 5 (identifier: Q8VIM5-5) [UniParc]FASTAAdd to basket
Also known as: MYOCD-v4

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:856
Mass (Da):92,243
Checksum:iD2243E5464F1297D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TBX6F6TBX6_MOUSE
Myocardin
Myocd
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116P → Q in AAK71683 (PubMed:11439182).Curated1
Sequence conflicti794D → G in AAK71683 (PubMed:11439182).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0076621 – 128Missing in isoform 2. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_0416841 – 79Missing in isoform 4 and isoform 5. CuratedAdd BLAST79
Alternative sequenceiVSP_007663683Q → QNSGAHEGHSSSFSSPASSL HQPFSGTQADSSHSAGLNPC PKSPSIHPK in isoform 2, isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF384055 mRNA Translation: AAK71683.2
AY303755 mRNA Translation: AAQ63841.1
AF437877 mRNA Translation: AAL30892.1
AK084700 mRNA Translation: BAC39258.1
AK142216 mRNA Translation: BAE24980.1
AL669846 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS24843.1 [Q8VIM5-1]
CCDS48819.1 [Q8VIM5-3]

NCBI Reference Sequences

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RefSeqi
NP_660118.3, NM_145136.4 [Q8VIM5-3]
NP_666498.2, NM_146386.3 [Q8VIM5-1]
XP_011247197.1, XM_011248895.1 [Q8VIM5-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.32257

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000101042; ENSMUSP00000098603; ENSMUSG00000020542 [Q8VIM5-2]
ENSMUST00000102635; ENSMUSP00000099695; ENSMUSG00000020542 [Q8VIM5-1]
ENSMUST00000108695; ENSMUSP00000104335; ENSMUSG00000020542 [Q8VIM5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
214384

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:214384

UCSC genome browser

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UCSCi
uc007jky.2 mouse [Q8VIM5-3]
uc007jkz.2 mouse [Q8VIM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384055 mRNA Translation: AAK71683.2
AY303755 mRNA Translation: AAQ63841.1
AF437877 mRNA Translation: AAL30892.1
AK084700 mRNA Translation: BAC39258.1
AK142216 mRNA Translation: BAE24980.1
AL669846 Genomic DNA No translation available.
CCDSiCCDS24843.1 [Q8VIM5-1]
CCDS48819.1 [Q8VIM5-3]
RefSeqiNP_660118.3, NM_145136.4 [Q8VIM5-3]
NP_666498.2, NM_146386.3 [Q8VIM5-1]
XP_011247197.1, XM_011248895.1 [Q8VIM5-4]
UniGeneiMm.32257

3D structure databases

ProteinModelPortaliQ8VIM5
SMRiQ8VIM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229522, 16 interactors
CORUMiQ8VIM5
DIPiDIP-29754N
ELMiQ8VIM5
IntActiQ8VIM5, 4 interactors
STRINGi10090.ENSMUSP00000104335

PTM databases

iPTMnetiQ8VIM5
PhosphoSitePlusiQ8VIM5

Proteomic databases

PaxDbiQ8VIM5
PRIDEiQ8VIM5

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
214384
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101042; ENSMUSP00000098603; ENSMUSG00000020542 [Q8VIM5-2]
ENSMUST00000102635; ENSMUSP00000099695; ENSMUSG00000020542 [Q8VIM5-1]
ENSMUST00000108695; ENSMUSP00000104335; ENSMUSG00000020542 [Q8VIM5-3]
GeneIDi214384
KEGGimmu:214384
UCSCiuc007jky.2 mouse [Q8VIM5-3]
uc007jkz.2 mouse [Q8VIM5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93649
MGIiMGI:2137495 Myocd

Phylogenomic databases

eggNOGiENOG410IE2C Eukaryota
ENOG410XNR1 LUCA
GeneTreeiENSGT00940000155346
HOGENOMiHOG000038001
HOVERGENiHBG036493
InParanoidiQ8VIM5
KOiK22526
OMAiCPKSPGV
OrthoDBi190145at2759
TreeFamiTF326024

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8VIM5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020542 Expressed in 116 organ(s), highest expression level in urinary bladder
ExpressionAtlasiQ8VIM5 baseline and differential
GenevisibleiQ8VIM5 MM

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR028721 MYOCD
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR22793:SF11 PTHR22793:SF11, 1 hit
PfamiView protein in Pfam
PF02755 RPEL, 1 hit
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00707 RPEL, 3 hits
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51073 RPEL, 3 hits
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYCD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VIM5
Secondary accession number(s): Q5SS65
, Q6W8X1, Q8C3W6, Q8VIL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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