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Protein

GATOR complex protein NPRL3

Gene

Nprl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GATOR complex protein NPRL3Curated
Alternative name(s):
Nitrogen permease regulator 3-like proteinImported
Gene namesi
Name:Nprl3Imported
Synonyms:MareImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109258 Nprl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002780891 – 569GATOR complex protein NPRL3Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei476PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VIJ8
MaxQBiQ8VIJ8
PaxDbiQ8VIJ8
PRIDEiQ8VIJ8

PTM databases

iPTMnetiQ8VIJ8
PhosphoSitePlusiQ8VIJ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020289 Expressed in 165 organ(s), highest expression level in bone marrow
CleanExiMM_MARE
ExpressionAtlasiQ8VIJ8 baseline and differential
GenevisibleiQ8VIJ8 MM

Interactioni

Subunit structurei

Forms a heterodimer with NPRL2 (By similarity). Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020530

Structurei

3D structure databases

ProteinModelPortaliQ8VIJ8
SMRiQ8VIJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPR3 family.Curated

Phylogenomic databases

eggNOGiKOG3830 Eukaryota
ENOG410XP4E LUCA
GeneTreeiENSGT00390000015916
HOGENOMiHOG000004787
HOVERGENiHBG019399
InParanoidiQ8VIJ8
KOiK20406
OMAiCLPQKVH
OrthoDBiEOG091G03SH
PhylomeDBiQ8VIJ8
TreeFamiTF105965

Family and domain databases

InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR005365 NPR3
PANTHERiPTHR13153 PTHR13153, 1 hit
PfamiView protein in Pfam
PF03666 NPR3, 2 hits
SUPFAMiSSF49785 SSF49785, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q8VIJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTN KPRSRYAVNN
60 70 80 90 100
TGEHADDQDG DSRFSDVILA TILATKSEMC GQKFELKIDN VRFVGHPTLL
110 120 130 140 150
QHALGQVSKT DPSPKREAPT MILFNVVFAL RANADPSVIN CLHNLSRRIA
160 170 180 190 200
TVLQHEERRC QYLTREAKLI LALQDEVSAM ADANEGPQSP FQHILPKCKL
210 220 230 240 250
ARDLKEAYDS LCTSGVVRLH INSWLEVSFC LPHKIHYAAS SLIPPEAIER
260 270 280 290 300
SLKAIRPYHA LLLLSDEKSL LSELPIDCSP ALVRVIKTTS AVKNLQQLAQ
310 320 330 340 350
DADLALLQVF QLAAHLVYWG KAVIIYPLCE NNVYVMSPNA SVCLYSPLAE
360 370 380 390 400
QFSRQFPSHD LPSVLAKFSL PVSLSEFRSP LAPPAQETQL IQMVVWMLQR
410 420 430 440 450
RLLIQLHTYV CLMASPSEEE PRLREDDVPF TARVGGRSLS TPNALSFGSP
460 470 480 490 500
TSSDDMTLTS PSMDNSSAEL LPSGDSPLNK RMTENLLASL SEHERAAILN
510 520 530 540 550
VPAAQNPEDL RMFARLLHYF RGRHHLEEIM YNENTRRSQL LMLFDKFRSV
560
LVVTTHEDPV IAVFQALLT
Length:569
Mass (Da):63,618
Last modified:March 1, 2002 - v1
Checksum:iDEB141AB27539E44
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7M7S2A7M7S2_MOUSE
GATOR complex protein NPRL3
Nprl3
544Annotation score:
D6RGB2D6RGB2_MOUSE
GATOR complex protein NPRL3
Nprl3
80Annotation score:
A2AAX8A2AAX8_MOUSE
GATOR complex protein NPRL3
Nprl3
182Annotation score:
F2Z3Y4F2Z3Y4_MOUSE
GATOR complex protein NPRL3
Nprl3
77Annotation score:
F2Z404F2Z404_MOUSE
GATOR complex protein NPRL3
Nprl3
58Annotation score:
F2Z3V7F2Z3V7_MOUSE
GATOR complex protein NPRL3
Nprl3
69Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY016021 Genomic DNA Translation: AAL32369.1
AK036405 mRNA Translation: BAC29415.1
AK081902 mRNA Translation: BAC38366.1
BC064471 mRNA Translation: AAH64471.1
CCDSiCCDS24521.1
RefSeqiNP_001271288.1, NM_001284359.1
NP_001271289.1, NM_001284360.1
NP_853547.1, NM_181569.3
UniGeneiMm.263161

Genome annotation databases

EnsembliENSMUST00000020530; ENSMUSP00000020530; ENSMUSG00000020289
GeneIDi17168
KEGGimmu:17168
UCSCiuc007ijc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY016021 Genomic DNA Translation: AAL32369.1
AK036405 mRNA Translation: BAC29415.1
AK081902 mRNA Translation: BAC38366.1
BC064471 mRNA Translation: AAH64471.1
CCDSiCCDS24521.1
RefSeqiNP_001271288.1, NM_001284359.1
NP_001271289.1, NM_001284360.1
NP_853547.1, NM_181569.3
UniGeneiMm.263161

3D structure databases

ProteinModelPortaliQ8VIJ8
SMRiQ8VIJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020530

PTM databases

iPTMnetiQ8VIJ8
PhosphoSitePlusiQ8VIJ8

Proteomic databases

EPDiQ8VIJ8
MaxQBiQ8VIJ8
PaxDbiQ8VIJ8
PRIDEiQ8VIJ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020530; ENSMUSP00000020530; ENSMUSG00000020289
GeneIDi17168
KEGGimmu:17168
UCSCiuc007ijc.2 mouse

Organism-specific databases

CTDi8131
MGIiMGI:109258 Nprl3

Phylogenomic databases

eggNOGiKOG3830 Eukaryota
ENOG410XP4E LUCA
GeneTreeiENSGT00390000015916
HOGENOMiHOG000004787
HOVERGENiHBG019399
InParanoidiQ8VIJ8
KOiK20406
OMAiCLPQKVH
OrthoDBiEOG091G03SH
PhylomeDBiQ8VIJ8
TreeFamiTF105965

Miscellaneous databases

PROiPR:Q8VIJ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020289 Expressed in 165 organ(s), highest expression level in bone marrow
CleanExiMM_MARE
ExpressionAtlasiQ8VIJ8 baseline and differential
GenevisibleiQ8VIJ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR005365 NPR3
PANTHERiPTHR13153 PTHR13153, 1 hit
PfamiView protein in Pfam
PF03666 NPR3, 2 hits
SUPFAMiSSF49785 SSF49785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPRL3_MOUSE
AccessioniPrimary (citable) accession number: Q8VIJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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