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Protein

Mineralocorticoid receptor

Gene

Nr3c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei764SteroidBy similarity1
Binding sitei770SteroidBy similarity1
Binding sitei811SteroidBy similarity1
Binding sitei939SteroidBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi603 – 666Nuclear receptorPROSITE-ProRule annotationAdd BLAST64
Zinc fingeri603 – 623NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri637 – 661NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mineralocorticoid receptor
Short name:
MR
Alternative name(s):
Nuclear receptor subfamily 3 group C member 2
Gene namesi
Name:Nr3c2
Synonyms:Mlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99459 Nr3c2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536831 – 978Mineralocorticoid receptorAdd BLAST978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei250PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VII8
PaxDbiQ8VII8
PRIDEiQ8VII8

PTM databases

iPTMnetiQ8VII8
PhosphoSitePlusiQ8VII8

Expressioni

Tissue specificityi

Expressed in heart and kidney.1 Publication

Gene expression databases

CleanExiMM_NR3C2

Interactioni

Subunit structurei

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. Binds the coactivator NCOA2. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, TIF1 and NRIP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105538

Structurei

3D structure databases

ProteinModelPortaliQ8VII8
SMRiQ8VII8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini720 – 958NR LBDPROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 602ModulatingAdd BLAST602
Regioni667 – 719HingeAdd BLAST53
Regioni776 – 779Important for coactivator bindingBy similarity4

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri603 – 623NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri637 – 661NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000247011
HOVERGENiHBG006336
InParanoidiQ8VII8

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

Q8VII8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKGYHSLP EGLDMERRWS QVSQTLERSS LGPAERTNEN SYMEIVNVSC
60 70 80 90 100
VSGATPNNST QGSSKEKHEL LPCLQQDNSR SGILPSDIKT ELESKELSAT
110 120 130 140 150
VAESMGLYMD SVRDAEYTYD QQNQQGSLSP AKIYQNMEQL VKFYKENGHR
160 170 180 190 200
SSTLSAISRP LRSFMPDSGT SMNGGALRAI VKSPIICHEK SPSVCSPLNM
210 220 230 240 250
PSSVCSPAGI NSMSSSTASF GSFPVHSPIT QGTSLTCSPS VENRGSRSHS
260 270 280 290 300
PVHASNVGSP LSSPLSSMKS PISSPPSHCS VKSPVSSPNN VPLRSSVSSP
310 320 330 340 350
ANLNNSRCSV SSPSNTNNRS TLSSPTASTV GSIGSPISNA FSYTTSGASA
360 370 380 390 400
GAGAIQDMVP SPDTHEKGAH DVPFPKTEEV EKAISNGVTG QLNIVQYIKP
410 420 430 440 450
EPDGAFSSSC LGGNNKINPS SPFSVPIKQE SSKHSCSGAS FKGNPTVNPF
460 470 480 490 500
PFMDGSYFSF MDDKDYYSLS GILGPPVPGF DSSCEGSAFP GGIKQEPDDG
510 520 530 540 550
SYFPETSIPS SAIIGVNSGG QSFHYRIGAQ GTISLSRSPR DQSFQHLSSF
560 570 580 590 600
PPVNALVESW KPHGDLSSRR SDGYPVLEYI PENVSSSTLR SVSTGSSRPS
610 620 630 640 650
KICLVCGDEA SGCHYGVVTC GSCKVFFKRA VEHNYLCAGR NDCIIDKIRR
660 670 680 690 700
KNCPACRLQK CLQAGMNLGA RKSKKLGKLK GLHEEQPQQP PPPPPQSPEE
710 720 730 740 750
GTTYIAPTKE PSVNSALVPQ LASITRALTP SPSMILENIE PEIVYAGYDN
760 770 780 790 800
SKPDTAESLL STLNRLAGKQ MIQVVKWAKV LPGFKNLPLE DQITLIQYSW
810 820 830 840 850
MCLSSFALSW RSYKHTNSQF LYFAPDLVFN EEKMHQSAMY ELCQGMRQIS
860 870 880 890 900
LQFVRLQLTF EEYSIMKVLL LLSTVPKDGL KSQAAFEEMR TNYIKELRKM
910 920 930 940 950
VTKCPNSSGQ SWQRFYQLTK LLDSMHDLVN DLLEFCFYTF RESQALKVEF
960 970
PAMLVEIISD QLPKVESGNA KPLYFHRK
Length:978
Mass (Da):106,447
Last modified:April 30, 2003 - v2
Checksum:i4D6F2C870FB4050A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3KN90A3KN90_MOUSE
Mineralocorticoid receptor
Nr3c2
980Annotation score:
E9Q8M8E9Q8M8_MOUSE
Mineralocorticoid receptor
Nr3c2
984Annotation score:
D3Z473D3Z473_MOUSE
Mineralocorticoid receptor
Nr3c2
867Annotation score:
D6RIL1D6RIL1_MOUSE
Mineralocorticoid receptor
Nr3c2
698Annotation score:
D3Z7F2D3Z7F2_MOUSE
Mineralocorticoid receptor
Nr3c2
128Annotation score:
D3Z7J4D3Z7J4_MOUSE
Mineralocorticoid receptor
Nr3c2
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103E → Q in CAC86374 (PubMed:11997477).Curated1
Sequence conflicti106G → D in CAC86374 (PubMed:11997477).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113941 Genomic DNA No translation available.
AC116768 Genomic DNA No translation available.
AC118019 Genomic DNA No translation available.
AC119248 Genomic DNA No translation available.
AJ311855 mRNA Translation: CAC86374.1
AJ311856 mRNA Translation: CAC86375.1
UniGeneiMm.324393

Similar proteinsi

Entry informationi

Entry nameiMCR_MOUSE
AccessioniPrimary (citable) accession number: Q8VII8
Secondary accession number(s): Q8VII9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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