UniProtKB - Q8VIH9 (UR2R_MOUSE)
Protein
Urotensin-2 receptor
Gene
Uts2r
Organism
Mus musculus (Mouse)
Status
Functioni
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- urotensin II receptor activity Source: MGI
GO - Biological processi
- negative regulation of blood pressure Source: MGI
- negative regulation of glomerular filtration Source: MGI
- negative regulation of renal sodium excretion Source: MGI
- negative regulation of urine volume Source: MGI
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of angiogenesis Source: MGI
- positive regulation of blood pressure Source: MGI
- positive regulation of cell growth Source: MGI
- positive regulation of circadian sleep/wake cycle, REM sleep Source: MGI
- positive regulation of circadian sleep/wake cycle, wakefulness Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of vasoconstriction Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Urotensin-2 receptorShort name: UR-2-R Alternative name(s): G-protein coupled receptor 14 Urotensin II receptor Short name: UR-II-R |
Gene namesi | Name:Uts2r Synonyms:Gpr14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2183450, Uts2r |
Subcellular locationi
Plasma membrane
Endosome
- early endosome Source: MGI
- recycling endosome Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 53 | ExtracellularSequence analysisAdd BLAST | 53 | |
Transmembranei | 54 – 76 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 77 – 86 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 87 – 112 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 113 – 123 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 124 – 145 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 146 – 166 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 185 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 186 – 208 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 209 – 231 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 232 – 257 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 258 – 283 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 284 – 298 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 299 – 320 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 321 – 385 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070195 | 1 – 385 | Urotensin-2 receptorAdd BLAST | 385 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 122 ↔ 198 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8VIH9 |
PRIDEi | Q8VIH9 |
PTM databases
GlyGeni | Q8VIH9, 2 sites |
iPTMneti | Q8VIH9 |
PhosphoSitePlusi | Q8VIH9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039321, Expressed in zygote and 48 other tissues |
ExpressionAtlasi | Q8VIH9, baseline and differential |
Genevisiblei | Q8VIH9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046920 |
Chemistry databases
BindingDBi | Q8VIH9 |
Miscellaneous databases
RNActi | Q8VIH9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156819 |
HOGENOMi | CLU_009579_1_0_1 |
InParanoidi | Q8VIH9 |
OMAi | PMMLAIR |
OrthoDBi | 1076228at2759 |
PhylomeDBi | Q8VIH9 |
TreeFami | TF334200 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000670, Urot_II_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00647, UROTENSIN2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8VIH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSLESTSF PMLAVSRSTA SELPGGFNVS HNSSWTGPTD PSSLQDLVAT
60 70 80 90 100
GVIGAVLSTM GVVGVVGNVY TLVVMCRFLR ASASMYVYVV NLALADLLYL
110 120 130 140 150
LSIPFIVATY VTKDWHFGDV GCRVLFSLDF LTMHASIFTL TIMSSERYAA
160 170 180 190 200
VLRPLDTVQR SKGYRKLLAL GTWLLALLLT LPMMLAIRLV RRGSKSLCLP
210 220 230 240 250
AWGPRAHRTY LTLLFGTSIV GPGLVIGLLY IRLARAYWLS QQASFKQTRR
260 270 280 290 300
LPNPRVLYLI LGIVLLFWAC FLPFWLWQLL AQYHQAMPLT PETARIINYL
310 320 330 340 350
TACLTYGNSC INPFLYTLLT KNYREYLRGR QRSLGSSCRG PGSAGSFLSS
360 370 380
RVHLQQDSGR SLSSNSQQAT ETLVLSPVPP NGAFV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441863 mRNA Translation: AAL34551.1 AY065981 mRNA Translation: AAL55427.1 |
CCDSi | CCDS25769.1 |
RefSeqi | NP_663415.1, NM_145440.1 |
Genome annotation databases
Ensembli | ENSMUST00000039044; ENSMUSP00000046920; ENSMUSG00000039321 |
GeneIDi | 217369 |
KEGGi | mmu:217369 |
UCSCi | uc007mvj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441863 mRNA Translation: AAL34551.1 AY065981 mRNA Translation: AAL55427.1 |
CCDSi | CCDS25769.1 |
RefSeqi | NP_663415.1, NM_145440.1 |
3D structure databases
SMRi | Q8VIH9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046920 |
Chemistry databases
BindingDBi | Q8VIH9 |
ChEMBLi | CHEMBL2346494 |
GuidetoPHARMACOLOGYi | 365 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8VIH9, 2 sites |
iPTMneti | Q8VIH9 |
PhosphoSitePlusi | Q8VIH9 |
Proteomic databases
PaxDbi | Q8VIH9 |
PRIDEi | Q8VIH9 |
Genome annotation databases
Ensembli | ENSMUST00000039044; ENSMUSP00000046920; ENSMUSG00000039321 |
GeneIDi | 217369 |
KEGGi | mmu:217369 |
UCSCi | uc007mvj.1, mouse |
Organism-specific databases
CTDi | 2837 |
MGIi | MGI:2183450, Uts2r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156819 |
HOGENOMi | CLU_009579_1_0_1 |
InParanoidi | Q8VIH9 |
OMAi | PMMLAIR |
OrthoDBi | 1076228at2759 |
PhylomeDBi | Q8VIH9 |
TreeFami | TF334200 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 217369, 0 hits in 17 CRISPR screens |
PROi | PR:Q8VIH9 |
RNActi | Q8VIH9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039321, Expressed in zygote and 48 other tissues |
ExpressionAtlasi | Q8VIH9, baseline and differential |
Genevisiblei | Q8VIH9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000670, Urot_II_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00647, UROTENSIN2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UR2R_MOUSE | |
Accessioni | Q8VIH9Primary (citable) accession number: Q8VIH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries