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Protein

Homeobox protein NOBOX

Gene

Nobox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 195HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • oogenesis Source: UniProtKB-KW
  • ovarian follicle development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Oogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein NOBOX
Alternative name(s):
Homeodomain-containing protein OG-2
Newborn ovary homeobox protein
Oocyte-specific homeobox protein
Gene namesi
Name:Nobox
Synonyms:Og2x
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:108011 Nobox

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are fertile and show no obvious abnormality. Female mice lacking Nobox have normal gross anatomy and histology, but are infertile with atrophic ovaries that lack oocytes at 6 weeks of age.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi186N → Q: Abolishes DNA-binding. 1 Publication1
Mutagenesisi187R → H: Abolishes DNA-binding. 1 Publication1
Mutagenesisi192R → Q: No effect on DNA-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688661 – 527Homeobox protein NOBOXAdd BLAST527

Proteomic databases

PaxDbiQ8VIH1
PRIDEiQ8VIH1

PTM databases

iPTMnetiQ8VIH1
PhosphoSitePlusiQ8VIH1

Expressioni

Tissue specificityi

Specifically expressed in ovaries and testes. In ovaries, expressed in oocytes from primordial through antral follicles but not in granulosa cells, theca cells and corpora lutea.1 Publication

Developmental stagei

Expressed from E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000029736
CleanExiMM_NOBOX
ExpressionAtlasiQ8VIH1 baseline and differential
GenevisibleiQ8VIH1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031749

Structurei

3D structure databases

ProteinModelPortaliQ8VIH1
SMRiQ8VIH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 465Pro-richAdd BLAST246

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00650000093445
HOGENOMiHOG000113810
HOVERGENiHBG082039
InParanoidiQ8VIH1
OMAiCLPELPF
OrthoDBiEOG091G0ANP
PhylomeDBiQ8VIH1
TreeFamiTF337576

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VIH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPTEKLCKK MQGQEAGDKP RTAALETEGP LQDSALPIQD DQDKQSSLPR
60 70 80 90 100
ASLGKRPLSK TSEELMDAGT CRVHKAPTAA ACGPQSEEEG CSPPERKAES
110 120 130 140 150
LKPSISAVPG QATAGSLNSH EGDLKKESLE VTCQFRKKTR TLYRSDQLEE
160 170 180 190 200
LERIFQEDHY PDSDKRHEIS QMVGVTPQRI MVWFQNRRAK WRKVEKLNEK
210 220 230 240 250
ETKNGPAAPS ADSSQHRSAP ELLDPMPTDL EPGPVPPENI LDVFPEPPML
260 270 280 290 300
LTSEQTLTPF QNNEGAERVA VTPPLLSPPP IRRANLPLPL GPVQTPQVLP
310 320 330 340 350
PMRDVPGSDS IYKDKAYVSW GTSIASPPTY SNLEDLGSQD YQASSQLGSF
360 370 380 390 400
QLSQAPHLPL FPSLQSQFPY LPPFPYPIPS SMPFLPPEDS LFSFPFGFSG
410 420 430 440 450
DSSQDYCPGP PPGQILLQPP AENMGTGPWS GHCLPEPPFP RPHYPQALGQ
460 470 480 490 500
PLGAEGYFPN LLPTPYALTM SKQSSLGLNG LLEGTRVETG SSLSKMSDEQ
510 520
TSSSLEQPAL EEVRDKNKNS HAAGAKE
Length:527
Mass (Da):57,565
Last modified:March 1, 2002 - v1
Checksum:i1B6AF1323F785290
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323 – 326SIAS → RYGT in AAC52828 (PubMed:8855241).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061761 mRNA Translation: AAL29683.1
BC125280 mRNA Translation: AAI25281.1
BC125282 mRNA Translation: AAI25283.1
U65067 Genomic DNA Translation: AAC52828.1
CCDSiCCDS20093.1
RefSeqiNP_570939.1, NM_130869.3
UniGeneiMm.17715

Genome annotation databases

EnsembliENSMUST00000031749; ENSMUSP00000031749; ENSMUSG00000029736
GeneIDi18291
KEGGimmu:18291
UCSCiuc009bsp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNOBOX_MOUSE
AccessioniPrimary (citable) accession number: Q8VIH1
Secondary accession number(s): P70367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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