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Protein

Radial spoke head 1 homolog

Gene

Rsph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The specific expression during male germ cell development and its characteristic localization suggest that it may play an important role in male meiosis. It is necessary for proper building of the axonemal central pair and radial spokes (By similarity).By similarity

GO - Biological processi

  • axoneme assembly Source: UniProtKB
  • meiotic cell cycle Source: UniProtKB-KW
  • spermatid development Source: MGI

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head 1 homolog
Alternative name(s):
Male meiotic metaphase chromosome-associated acidic protein
Meichroacidin
Testis-specific gene A2 protein
Gene namesi
Name:Rsph1
Synonyms:Tsga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194909 Rsph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Chromosome, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656631 – 301Radial spoke head 1 homologAdd BLAST301

Proteomic databases

EPDiQ8VIG3
PaxDbiQ8VIG3
PRIDEiQ8VIG3

2D gel databases

REPRODUCTION-2DPAGEiQ8VIG3

PTM databases

iPTMnetiQ8VIG3
PhosphoSitePlusiQ8VIG3

Expressioni

Tissue specificityi

Germ cell specific. Specifically expressed in testis, and to a lower extent in ovary. Not expressed in somatic tissues.

Developmental stagei

During male germ cell development it is not detected until 12 days. Significant expression is detected from 14-day-old through to adult testis. Expression is first detected in the pachytene spermatocytes at stage V, becomes stronger from the late pachytene spermatocytes to round spermatid stage, and then gradually decreases as the morphogenesis proceeds further. Not expressed in germ cells located in the first layer of the seminiferous epithelium (spermatogonia, leptotene and zygotene spermatocytes).

Gene expression databases

BgeeiENSMUSG00000024033 Expressed in 184 organ(s), highest expression level in testis
CleanExiMM_RSPH1
ExpressionAtlasiQ8VIG3 baseline and differential
GenevisibleiQ8VIG3 MM

Interactioni

Protein-protein interaction databases

BioGridi204343, 1 interactor
STRINGi10090.ENSMUSP00000024832

Structurei

3D structure databases

ProteinModelPortaliQ8VIG3
SMRiQ8VIG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 43MORN 1Add BLAST24
Repeati44 – 66MORN 2Add BLAST23
Repeati67 – 89MORN 3Add BLAST23
Repeati90 – 112MORN 4Add BLAST23
Repeati113 – 135MORN 5Add BLAST23
Repeati159 – 181MORN 6Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 201Poly-Glu7

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297
HOGENOMiHOG000007234
HOVERGENiHBG056736
InParanoidiQ8VIG3
KOiK19755
OMAiYEGNYEH
OrthoDBiEOG091G0IUR
PhylomeDBiQ8VIG3
TreeFamiTF329346

Family and domain databases

InterProiView protein in InterPro
IPR003409 MORN
PfamiView protein in Pfam
PF02493 MORN, 7 hits
SMARTiView protein in SMART
SM00698 MORN, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VIG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDLGSEELE EEGENDLGEY EGERNEVGER HGHGKARLPN GDTYEGSYEF
60 70 80 90 100
GKRHGQGTYK FKNGARYTGD YVKNKKHGQG TFIYPDGSRY EGEWADDQRH
110 120 130 140 150
GQGVYYYVNN DTYTGEWFNH QRHGQGTYLY AETGSKYVGT WVHGQQEGAA
160 170 180 190 200
ELIHLNHRYQ GKFMNKNPVG PGKYVFDIGC EQHGEYRLTD TERGEEEEEE
210 220 230 240 250
ETLVNIVPKW KALNITELAL WTPTLSEEQP PPEGQGQEEP QGLTGVGDPS
260 270 280 290 300
EDIQAEGFEG ELEPRGADED VDTFRQESQE NSYDIDQGNL NFDEEPSDLQ

D
Length:301
Mass (Da):34,181
Last modified:June 20, 2002 - v2
Checksum:i704ABEFB94DFC90E
GO
Isoform 2 (identifier: Q8VIG3-2)
Sequence is not available
Note: No experimental confirmation available.
Length:
Mass (Da):

Sequence cautioni

The sequence BAB83693 differs from that shown. Reason: Frameshift at position 283.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39P → S in BAB83693 (PubMed:9578619).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006535 mRNA Translation: BAB83693.1 Frameshift.
AK005739 mRNA Translation: BAB24214.1
BC049584 mRNA Translation: AAH49584.1
CCDSiCCDS28604.1 [Q8VIG3-1]
RefSeqiNP_079566.1, NM_025290.3 [Q8VIG3-1]
UniGeneiMm.12743

Genome annotation databases

EnsembliENSMUST00000024832; ENSMUSP00000024832; ENSMUSG00000024033 [Q8VIG3-1]
GeneIDi22092
KEGGimmu:22092
UCSCiuc008buu.1 mouse [Q8VIG3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006535 mRNA Translation: BAB83693.1 Frameshift.
AK005739 mRNA Translation: BAB24214.1
BC049584 mRNA Translation: AAH49584.1
CCDSiCCDS28604.1 [Q8VIG3-1]
RefSeqiNP_079566.1, NM_025290.3 [Q8VIG3-1]
UniGeneiMm.12743

3D structure databases

ProteinModelPortaliQ8VIG3
SMRiQ8VIG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204343, 1 interactor
STRINGi10090.ENSMUSP00000024832

PTM databases

iPTMnetiQ8VIG3
PhosphoSitePlusiQ8VIG3

2D gel databases

REPRODUCTION-2DPAGEiQ8VIG3

Proteomic databases

EPDiQ8VIG3
PaxDbiQ8VIG3
PRIDEiQ8VIG3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024832; ENSMUSP00000024832; ENSMUSG00000024033 [Q8VIG3-1]
GeneIDi22092
KEGGimmu:22092
UCSCiuc008buu.1 mouse [Q8VIG3-1]

Organism-specific databases

CTDi89765
MGIiMGI:1194909 Rsph1

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297
HOGENOMiHOG000007234
HOVERGENiHBG056736
InParanoidiQ8VIG3
KOiK19755
OMAiYEGNYEH
OrthoDBiEOG091G0IUR
PhylomeDBiQ8VIG3
TreeFamiTF329346

Miscellaneous databases

ChiTaRSiRsph1 mouse
PROiPR:Q8VIG3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024033 Expressed in 184 organ(s), highest expression level in testis
CleanExiMM_RSPH1
ExpressionAtlasiQ8VIG3 baseline and differential
GenevisibleiQ8VIG3 MM

Family and domain databases

InterProiView protein in InterPro
IPR003409 MORN
PfamiView protein in Pfam
PF02493 MORN, 7 hits
SMARTiView protein in SMART
SM00698 MORN, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRSPH1_MOUSE
AccessioniPrimary (citable) accession number: Q8VIG3
Secondary accession number(s): Q9DAL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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